Importance of Low-Range CAG Expansion and CAA Interruption in SCA2 Parkinsonism

10/13/2007 11:27 AM

Journal of Trauma-Injury Infection & Critical Care. 63(4):725-732, October 2007

The combination of coagulopathy and intracranial bleeding (ICB) is a well-recognized cause of morbidity and mortality in the neurosurgical patient because of the risk of hematoma expansion. Although recombinant factor VIIa (rFVIIa) has been shown to be useful in intracerebral hemorrhage, its use in other forms of ICB such as subdural hematomas (SDHs) has rarely been described.

MicroRNA-21 Knockdown Disrupts Glioma Growth In vivo and Displays Synergistic Cytotoxicity with Neural Precursor Cell-Delivered S-TRAIL in Human Gliomas

10/13/2007 11:24 AM

Arch Neurol. 2007;64:1388-1394

Herein, we review advances in understanding a group of disorders collectively known as TAR-DNA binding protein 43 (TDP-43) proteinopathies since the report that TDP-43 is the major disease protein that mechanistically links frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) with and without motor neuron disease to amyotrophic lateral sclerosis.

Prevention of secondary stroke and transient ischaemic attack with antiplatelet therapy the role of the primary care physician role

10/13/2007 11:21 AM

Stroke 2007, doi:10.1161

One in 3 stroke survivors has aphasia (impaired language comprehension and expressive abilities). Conventionally, depression diagnosis uses language-based methods. We aimed to systematically review methods that have been used to diagnose depression and adaptations to these methods intended for people with aphasia.

Allergic Conditions and Brain Tumor Risk

10/11/2007 12:37 PM

International Journal of Radiation OncologyBiologyPhysics, Volume 69, Issue 3, Pages 820-824

To assess the progression patterns in patients with multifocal glioblastoma multiforme who had undergone whole brain radiotherapy (WBRT), the historical standard, versus three-dimensional conformal radiotherapy, and to identify predictive treatment and pretreatment factors.

Phase I Trial of Gross Total Resection Permanent Iodine-125 Brachytherapy and Hyperfractionated Radiotherapy for Newly Diagnosed Glioblastoma Multiforme

10/11/2007 12:34 PM

Carcinogenesis 2007 28(10):2122-2130

Tumor growth and metastasis require that tumor cells must have either the potential to shift genetically or epigenetically between proliferative and invasive phenotypes or both phenotypes simultaneously. In the present study, we demonstrated that neuroblastoma growth and invasion were distinct processes that were carried out by proliferative and invasive phenotypes of tumor cells, respectively.

Results of the Phase I Dose-Escalating Study of Motexafin Gadolinium With Standard Radiotherapy in Patients With Glioblastoma Multiforme

10/11/2007 12:32 PM

Epilepsia Volume 48 Issue 9 Page 1716-1723, September 2007

A multicenter, randomized, open-label, observer-blinded, parallel-group clinical trial was conducted. TPM was introduced at a dose of 12.5 mg/day with the minimum target dose of 50 mg/day in patients <30 kg and 75 mg/day in patients >30 kg over 4 weeks. CBZ was started at a dose of 10 mg/kg/day with the minimum target dose of 20 mg/kg/day over 4 weeks. Additional individual escalation was allowed up to a maximum target dose. The primary study end point was change on a neuropsychological test battery after 28 weeks of treatment.

Status Epilepticus in Children with Epilepsy Dutch Study of Epilepsy in Childhood

10/11/2007 12:30 PM

Epilepsia Volume 48 Issue 9 Page 1686-1690, September 2007

Mutations in the EFHC1 gene have been reported in six juvenile myoclonic epilepsy (JME) families from Mexico and Belize. In this study, we screened 27 unrelated JME Italian families for mutations in the EFHC1 gene.

Maternal Epilepsy and Offsprings' Adult Intelligence A Population-Based Study from Norway

10/11/2007 12:28 PM

Epilepsia Volume 48 Issue 9 Page 1678-1685, September 2007

SCN1A is the most clinically relevant epilepsy gene, most mutations lead to severe myoclonic epilepsy of infancy (SMEI) and generalized epilepsy with febrile seizures plus (GEFS+). We studied 132 patients with epilepsy syndromes with seizures precipitated by fever, and performed phenotype-genotype correlations with SCN1A alterations.

Autism Spectrum Disorders in Children with Seizures in the First Year of Life-A Population-Based Study

10/11/2007 12:25 PM

Psychiatry and Clinical Neurosciences, Volume 61, Number 5, October 2007 , pp. 543-551(9)

The aim of the present study was to assess the relationship between sitting balance at an early stage and activities of daily living (ADL) function in 452 stroke patients. The effect of sitting balance on the two core elements of depression (apathy and depressive mood) was also examined.

Cyclopamine-Mediated Hedgehog Pathway Inhibition Depletes Stem-Like Cancer Cells in Glioblastoma

10/11/2007 12:21 PM

International Journal of Radiation OncologyBiologyPhysics, Volume 69, Issue 3, Pages 839-845

To validate the Radiation Therapy Oncology Group Recursive Partitioning Analysis (RTOG RPA) classification and determine independent prognostic factors, to create a simple and specific prognostic score for patients with brain metastases (BM) from breast carcinoma treated with whole-brain radiotherapy (WBRT).

Are Depression and Cognitive Performance Related in Temporal Lobe Epilepsy

10/11/2007 12:19 PM

American Journal of Neuroradiology 28:1743-1746, October 2007

Elevated baseline levels of C-reactive protein (CRP) are associated with an adverse outcome during coronary stent placement. The aim of this study was to evaluate whether preprocedural CRP levels also are predictive of stroke and death in patients undergoing carotid stent placement (CAS).

Aneurysms of the Vertebrobasilar Junction Incidence, Clinical Presentation and Outcome of Endovascular Treatment

10/11/2007 12:16 PM

Stem Cells Vol. 25 No. 10 October 2007, pp. 2396 -2407

Certain regions of the adult brain have the ability for partial self-repair after injury through production of new neurons via activation of neural stem/progenitor cells (NSCs). Nonetheless, there is no evidence yet for pervasive spontaneous replacement of dead neurons by newly formed neurons leading to functional recovery in the injured brain.

Serial Assessments of Delayed Encephalopathy after Carbon Monoxide Poisoning Using Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging on 3 0T System

10/11/2007 12:14 PM

European Neurology 2008;59:18-23

We genetically screened patients with ataxia with ocular motor apraxia type 1 (AOA1)/early-onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH), with a Japanese variant form of Friedreich's ataxia.

Association of MDR1 C3435T Polymorphism and Resistance to Carbamazepine in Epileptic Patients from Turkey

10/11/2007 12:12 PM

European Neurology 2008;59:24-30

To investigate brain activation in the prefrontal cortex (PFC) during the Wisconsin Card Sorting Test (Keio Version) (KWCST), we examined changes in total hemoglobin volume (THV) in 8 patients with traumatic brain injury (TBI) and 20 healthy control subjects using two-channel near-infrared spectroscopy.

Lack of Pharmacokinetic Interaction of Levetiracetam on Carbamazepine Valproic Acid Topiramate and Lamotrigine in Children with Epilepsy

10/11/2007 12:06 PM

Fetal Diagnosis and Therapy 2008;23:23-29

To describe the main perinatal and 1-year outcomes in babies with a prenatal ultrasonographic diagnosis of severe hydrocephalus according to the presence or absence of a neural tube defect (NTD) in a country where abortion is illegal.

Cost-effectiveness of Add-on Therapy with Pregabalin in Patients with Refractory Partial Epilepsy

10/11/2007 12:03 PM

Fetal Diagnosis and Therapy 2008;23:1-4

Congenital intracranial tumors are rare and only account for 0.5-1.5% of all pediatric brain tumors. Teratoma is the most frequently encountered intracranial tumor at birth. Massive congenital intracranial teratoma is an extremely rare neoplasm with a poor prognosis.

Transcutaneous Electrical Nerve Stimulation Combined With Task-Related Training Improves Lower Limb Functions in Subjects With Chronic Stroke

10/11/2007 12:00 PM

QJM 2007 100(10):599-607

Atrial fibrillation (AF) is associated with an increased stroke risk that may be reduced by therapeutic anticoagulation. However, anticoagulation is associated with an increased risk of bleeding that in some patients may outweigh the benefits in reducing the risk of stroke.

Hypothermia to Treat Neonatal Hypoxic Ischemic Encephalopathy

10/11/2007 11:58 AM

European Neurology 2008;59:62-66

We report on management strategies and clinical outcomes in 4 cases of acute symptomatic congestive intracranial hypertension associated with cerebral arteriovenous malformations (AVMs).

Development and Validation of a Short Form of the Fugl-Meyer Motor Scale in Patients With Stroke

10/11/2007 11:42 AM

Disability & Society, Volume 22, Issue 6 October 2007 , pages 595 - 608

This study investigated the experience of personal support provided by paid service providers. Numerous studies have investigated personal care assistance). However, there is a paucity of research on the experience of receiving personal assistance delivered by formal services. People who were using formal personal care services (participants) were engaged in in-depth interviews about their experiences. The results of a thematic analysis of transcript data are reported. Findings indicate that the participants wanted their personal autonomy facilitated when they received assistance. This was achieved when the carer replaced the participant's 'hands' and followed the choices and preferences of the participant when providing assistance. A number of barriers prevented participants from achieving self-determination. This included the carer's attitudes and aversions to tasks, formal training and rules and regulations set down by the personal care service providers.

Involvement of visinin-like protein-1 VSNL-1 in regulating proliferative and invasive properties of neuroblastoma

10/09/2007 02:55 PM

Epilepsia Volume 48 Issue 10 Page 1870-1874, October 2007

A pilot study of the safety, tolerability, dose range and potential efficacy of ganaxolone for the treatment of refractory epilepsy in pediatric and adolescent subjects.

Stroke Incidence Prognosis 30-Day and 1-Year Case Fatality Rates in Matao Brazil. A Population-Based Prospective Study

10/09/2007 02:53 PM

Skull Base 2007; 17: 285-302

The infratemporal fossa (ITF) is a continuation of the temporal fossa between the internal surface of the zygoma and the external surface of the temporal bone and greater wing of the sphenoid bone that is sitting deep to the ramus of the mandible.

Idiopathic Temporal Bone Encephalocele

10/09/2007 02:51 PM

Neuroepidemiology 2007;28:197-206

The objective of the present study was to investigate the relationship between extremely low-frequency magnetic field (ELF-MF) exposure and mortality from several neurodegenerative conditions in Swiss railway employees.

Establishing a baseline phase behavior in magnetic resonance imaging to determine normal vs abnormal iron content in the brain

10/09/2007 02:47 PM

International Journal of Gynecological Cancer, Volume 17, Number 5, September/October 2007 , pp. 1166-1171(6)

Choriocarcinoma is the most malignant tumor of gestational trophoblastic neoplasia. It grows rapidly and metastasizes to the lung, liver, and, less frequently, to the brain. One rare case of metastatic cerebral choriocarcinoma with initial presentation of intracerebral hemorrhage is reported. A 40-year-old woman initially presented sudden onset of headache.

Euthanasia in intensive care A 56-year-old man with a pontine hemorrhage resulting in a locked-in syndrome

10/09/2007 02:44 PM

International Journal of Cancer Volume 121, Issue 6 , Pages 1390 - 1395

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor and possesses a high incidence of 10p loss. The KLF6 (Kruppel-like transcription factor) tumor suppressor gene on 10p15 is inactivated by loss of heterozygosity (LOH) and/or somatic mutation in a number of human cancers and forced expression of KLF6 in GBM lines inhibits their growth and transformation. In addition, increased expression of its alternatively spliced, cytoplasmic isoform KLF6-SV1 has now been shown to play a role in cancer pathogenesis. On the basis of these findings we examined the role of KLF6 and KLF6-SV1 in the development and progression of GBM.

MELAS syndrome in a patient with a point mutation in MTTS1

10/09/2007 02:41 PM

Brain Injury, Volume 21, Issue 10 September 2007 , pages 1063 - 1068

There is a need to develop reliable outcome measures to determine well-being after brain injury. In 1997, Teasdale et al. published the European Brain Injury Questionnaire (EBIQ), a self-report and relative-report measure of the subjective experience of cognitive, emotional and social difficulties experienced by people with brain injury. It is now used in several rehabilitation centres as an outcome measure, but its test-re-test reliability has yet not been determined. The primary purpose of the present study is to establish this degree of reliability.

Reversed Robin Hood Syndrome in Acute Ischemic Stroke Patients

10/09/2007 02:37 PM

International Journal of Radiation OncologyBiologyPhysics, Volume 69, Issue 3, Pages 944-954

To compare treatment planning between combined photon–proton planning (CP) and proton planning (PP) for skull base tumors, so as to assess the potential limitations of CP for these tumors.

Intra-arterial thrombolysis using rt-PA in patients with acute stroke due to vessel occlusion of anterior and or posterior cerebral circulation

10/09/2007 02:33 PM

European Neurology 2008;59:38-43

The aim of this study is to clarify the relationship between lesion detectability by diffusion-weighted magnetic resonance imaging (DWI) and the etiology of transient ischemic attacks (TIAs).

The Antiepileptic Drug Levetiracetam Stabilizes the Human Epileptic GABAA Receptors upon Repetitive Activation

10/09/2007 02:31 PM

Epilepsia Volume 48 Issue 10 Page 1875-1882, October 2007

Epilepsy, antiepileptic drugs (AEDs), and reproductive endocrine function have complex interactions. In this study, we wanted to investigate the effects of AEDs on reproductive endocrine function after withdrawal of AEDs and look for reversible endocrine effects.

Analysis of Initial Slow Waves ISWs at the Seizure Onset in Patients with Drug Resistant Temporal Lobe Epilepsy

10/09/2007 02:29 PM

Acta Neurologica Scandinavica Volume 116 Issue 5 Page 300-306, November 2007

To describe demographics, injury characteristics and outcome of traumatic brain injury (TBI) in northern Sweden over 10 years.

Spontaneous spinal epidural haematoma a rare cause of quadriplegia in the post-partum period

10/09/2007 02:27 PM

European Neurology 2008;59:4-14

Following the realization that cerebral tissue may survive for hours after an ischaemic insult, several agents with neuroprotective properties in small-animal models of cerebral ischaemia have been tested in patients with acute ischaemic stroke (AIS).

Novel End Point Analytic Techniques and Interpreting Shifts Across the Entire Range of Outcome Scales in Acute Stroke Trials

10/09/2007 02:25 PM

Stroke 2007, doi:10.1161

Cerebral ischemia/reperfusion is associated with reactive oxygen species (ROS) generation, and NADPH oxidases are important sources of ROS. We hypothesized that NADPH oxidases mediate blood-brain barrier (BBB) disruption and contribute to tissue damage in ischemia/reperfusion.

A Prospective Study of the Modified Atkins Diet for Intractable Epilepsy in Adults

10/09/2007 02:21 PM

Pediatric and Developmental Pathology Volume 10, Issue 5 (September-October 2007) Article: pp. 348-350

It has been asserted that hypoxic-ischemic encephalopathy (HIE) with cerebral swelling in the absence of marked trauma may be responsible for subural hemorrhage in the young. As this may have considerable implications in determining both the mechanism of death and the degree of force required to cause injury in certain cases of inflicted head injury in infancy, clarification is required.

Diffusion Tensor Magnetic Resonance Imaging Finding of Discrepant Fractional Anisotropy Between the Frontal and Parietal Lobes After Whole-Brain Irradiation in Childhood Medulloblastoma Survivors Reflection of Regional White Matter Radiosensitivity

10/09/2007 02:18 PM

International Journal of Cancer Volume 121, Issue 6 , Pages 1190 - 1196

Induction of proinflammatory cytokines in response to malignant cells is an integral component of immune response to control tumor development. However, recent evidences have suggested that tumor cells may evade the immune system and exploit inflammatory responses to enhance its own growth.

Magnetic Resonance Perfusion Imaging in Malformations of Cortical Development

10/09/2007 01:58 PM

Acta Radiologica, Volume 48, Issue 8 2007 , pages 875 - 893

The radiologist plays a crucial role in identifying and narrowing the differential diagnosis of intracranial infections. A thorough understanding of the intracranial compartment anatomy and characteristic imaging findings of specific pathogens, as well incorporation of the clinical information, is essential to establish correct diagnosis. Specific types of infections have certain propensities for different anatomical regions within the brain. In addition, the imaging findings must be placed in the context of the clinical setting, particularly in immunocompromised and human immunodeficiency virus (HIV)-positive patients.

CT and MR Characteristics of Cerebral Sparganosis

10/09/2007 01:54 PM

Arch Neurol. 2007;64:1545.

There is little doubt that the early appearance of prominent lower motor neuron (LMN) signs in a patient previously found to have a pure upper motor neuron (UMN) syndrome is a poor prognostic factor. The question still remains when, if ever, to draw a line between UMN-predominant ALS and PLS.

TDP-43 Proteinopathy in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

10/09/2007 11:46 AM

NEUROLOGY 2007;69:1480-1490

CEP-1347 inhibits mixed lineage kinases that activate apoptotic pathways implicated in the pathogenesis of Parkinson disease (PD). CEP-1347 enhances neuronal survival in a variety of nonclinical models and was found to be safe and well tolerated during 4 weeks in PD patients. We conducted the Parkinson Research Examination of CEP-1347 Trial (PRECEPT) to assess its disease-modifying potential in early PD.

Hemipseudoathetosis due to a hemorrhage at the cervicomedullary junction

10/09/2007 11:43 AM

Spinal Cord 9 October 2007

To systematically review the psychometric properties of outcome measures used to assess ambulation in people with spinal cord injury (SCI).

Comparison of gait performance on different environmental settings for patients with chronic spinal cord injury

10/09/2007 11:41 AM

Spinal Cord 9 October 2007

To examine the unusual and unknown, severe side effect of a therapeutic dose of oral Baclofen on cardiac function.

Papilloedema in association with spinal lipoma and bilateral chronic subdural bleeding

10/09/2007 11:39 AM

BMC Neurology 2007, 7:32

There is a paucity of clinical studies focused specifically on intracerebral haemorrhages of subcortical topography, a subject matter of interest to clinicians involved in stroke management. This single centre, retrospective study was conducted with the following objectives: a) to describe the aetiological, clinical and prognostic characteristics of patients with thalamic haemorrhage as compared with that of patients with internal capsule-basal ganglia haemorrhage, and b) to identify predictors of in-hospital mortality in patients with thalamic haemorrhage.

Continuity transition and participation Preparing clients for life in the community post-stroke

10/06/2007 10:15 AM

Disability & Rehabilitation, Volume 29, Issue 22 2007 , pages 1751 - 1756

To gauge the understanding and opinions of clinical neuropsychologists and speech and language therapists (SLT) in relation to vegetative (VS) and minimally conscious (MCS) patients relative to available practice guidelines.

Evaluation of virtual shopping in the VMall Comparison of post-stroke participants to healthy control groups

10/06/2007 10:13 AM

Disability & Rehabilitation, Volume 29, Issue 22 2007 , pages 1701 - 1709

To investigate the efficacy of TouchSpeak (TS), a handheld computerised communication aid for aphasia.

To regain participation in occupations through human encounters - narratives from women with spinal cord injury

10/05/2007 02:56 PM

British Journal of Neurosurgery, Volume 21, Issue 5 October 2007 , pages 501 - 503

Primary intracranial plasma cell granuloma (PCG) is a rare form of inflammatory pseudotumour often characterized by non-neoplastic proliferation of plasma cells. The following case indicates a potential role for steroid therapy after subtotal resection.

Survival of patients with glioblastoma multiforme has not improved between 1993 and 2004 analysis of 625 cases

10/05/2007 02:38 PM

Acta Neurologica Scandinavica doi:10.1111/j.1600-0404.2007.00923.x

We aimed to evaluate the quality of life among young ischaemic stroke (IS) patients at long-term follow-up by comparing them with multiple sclerosis (MS) patients with secondary progressive course. The mean age at stroke onset was 41.6 years.

Motor Cortical Excitability in Patients with Poststroke Epilepsy

10/05/2007 02:35 PM

Epilepsia Volume 48 Issue 9 Page 1703-1707, September 2007

Myoclonic astatic epilepsy (MAE) is a generalized epilepsy of early childhood. Little is known about the use of newer antiepileptic treatments (AET) in MAE. The purpose of this study was to describe the characteristics, treatment, and outcome of a contemporary MAE cohort exposed to the new generation AET.

Detection of intracranial aneurysms with 64 channel multidetector row computed tomography: Comparison with digital subtraction angiography

10/05/2007 02:32 PM

International Journal of Radiation OncologyBiologyPhysics, Volume 69, Issue 3, Pages 858-864

To review a historical cohort of consecutively accrued patients with high-risk neuroblastoma treated with intraoperative radiotherapy (IORT) to determine the therapeutic effect and late complications of this treatment.

Parental alcohol misuse is a powerful predictor for the risk of traumatic brain injury in childhood

10/05/2007 02:29 PM

British Journal of Neurosurgery, Volume 21, Issue 5 October 2007 , pages 485 - 490

Fractionated split dose radiosurgery in patients with recurrent brain metastases: implications for survival

10/05/2007 02:26 PM

British Journal of Neurosurgery, Volume 21, Issue 5 October 2007 , pages 527 - 531

Decompressive craniectomy (DC) is considered a 'second tier' therapy to control posttraumatic intracranial hypertension refractory to maximal medical treatment. The authors present a case of refractory intracranial hypertension due to diffuse brain swelling and a large (>25 ml) non-surgically-treatable haematoma of the splenium of the corpus callosum successfully treated with bi-occipital DC and augmentative duraplasty.

Opioid receptor binding in parahippocampus of patients with temporal lobe epilepsy Its association with the antiepileptic effects of subacute electrical stimulation

10/04/2007 11:51 AM

American Journal of Neuroradiology 28:1430-1434, September 2007

The purpose of this study was to determine the publication fate of submissions previously rejected from the American Journal of Neuroradiology (AJNR) to provide guidance to authors who receive rejection notices.

Dissociation of neglect subtypes with transcranial magnetic stimulation

10/04/2007 11:48 AM

Spine. 32(21):E619-E622, October 1, 2007

To report an unusual case of spontaneous spinal subdural hematoma and to review relevant literature and discuss the etiology, pathogenesis, clinical features, imaging, and prognosis.

Recent development in chemotherapy of paediatric brain tumours

10/04/2007 11:47 AM

Cerebrovascular Diseases 2007;24:469-476

Aims of the study: to identify with echo color Doppler ultrasound of the supra-aortic vessels and transcranial color-coded duplex sonography (TCCD) various patterns of vessel occlusion within 3 h from stroke onset, to compare each group defined at the admission with clinical findings and outcome, and to study the recanalization process, independent of therapy.

Progress in magnetic resonance imaging of brain tumours

10/04/2007 11:44 AM

Epilepsia Volume 48 Issue 9 Page 1639-1651, September 2007

It is well recognized that children with epilepsy are at heightened risk for developing behavior problems and psychiatric disorders. Studies identifying factors associated with child behavior were reviewed and findings were placed into two broad categories for review and critique: illness-related variables and psychosocial variables.

m THPC mediated photodynamic therapy of malignant gliomas Assessment of a new transfection strategy

10/04/2007 11:42 AM

Epilepsia Volume 48 Issue 9 Page 1652-1663, September 2007

There is ongoing debate regarding the most appropriate definition of status epilepticus. This depends upon the research question being asked. Based on the most widely used "30 min definition," the incidence of childhood convulsive status epilepticus (CSE) in developed countries is approximately 20/100,000/year, but will vary depending, among others, on socioeconomic and ethnic characteristics of the population.

Surgery for medically intractable temporal lobe epilepsy during early life

10/04/2007 11:40 AM

Stroke 2007, doi:10.1161

Leukocyte count is an independent predictor of stroke. We investigated the association between leukocyte count and progression of aortic atheroma over 12 months in stroke/transient ischemic attack (TIA) patients.

Antiedema Therapy in Ischemic Stroke

10/04/2007 11:38 AM

PEDIATRICS Vol. 120 No. 4 October 2007, pp. 770-777

Conventional electroencephalography remains the gold standard for the diagnosis and quantification of neonatal seizures. However, amplitude-integrated electroencephalography (aEEG) is being introduced to neonatal intensive care as an adjunct for neonatal seizure detection.

Website of the Month Arizona Sunshine TBI Blog

10/04/2007 11:37 AM

Stroke 2007, doi:10.1161

Identifying paroxysmal atrial fibrillation/flutter is an essential part of the etiological workup of patients with ischemic stroke. However, there is controversy in the literature regarding the use of noninvasive cardiac rhythm monitoring with previous reviews reporting a low detection rate with routine monitoring. We performed a systematic review to determine the frequency of occult atrial fibrillation/flutter detected by noninvasive methods of continuous cardiac monitoring after acute ischemic stroke or transient ischemic attack.

Lesion Volume Change After Treatment With Tissue Plasminogen Activator Can Discriminate Clinical Responders From Nonresponders

10/04/2007 11:35 AM

Stroke 2007, doi:10.1161

Several recent studies analyzing perfusion changes in acute intracerebral hemorrhage fed the debate whether there is secondary ischemic tissue damage in the vicinity of intracerebral hemorrhage. We used perfusion CT to address this question.

18F FDOPA Kinetics in Brain Tumors

10/04/2007 11:30 AM

European Journal of Radiology Volume 64, Issue 1, Pages 119-125 (October 2007)

Spinal hematomas are rare entities that can be the cause of an acute spinal cord compression syndrome. Therefore, an early diagnosis is of great importance.

Molecular targeted therapies and chemotherapy in malignant gliomas

10/04/2007 11:28 AM

European Journal of Radiology Volume 64, Issue 1, Pages 3-14 (October 2007)

Blunt cerebrovascular injuries are uncommon but potentially devastating injuries that can lead to stroke and death. While uncommon, appreciation of the seriousness of these injuries, a high index of suspicion in high risk patients, and aggressive screening of multitrauma patients leads to early diagnosis of asymptomatic lesions that may be amenable to treatment prior to the onset of ischemia. The radiologist can play a vital role in the early diagnosis, follow-up, and, in some cases, treatment of these challenging injuries.

Functional outcome at 1 vs 2 years after severe traumatic brain injury

10/04/2007 11:26 AM

Stroke 2007, doi:10.1161

Selective serotonin reuptake inhibitors (SSRI) are widely prescribed. Several reports have observed an increased bleeding risk associated with SSRI use, which is hypothesized to be secondary to their antiplatelet effect.

Aggravation of Seizures and or EEG Features in Children Treated with Oxcarbazepine Monotherapy

10/04/2007 11:23 AM

Epilepsia doi:10.1111/j.1528-1167.2007.01321.x

A gap of more than a hundred years occurred between the first accounts of mesial temporal sclerosis and recognition of its role in the pathogenesis of psychomotor seizures. This paper reviews how the understanding and surgical treatment of temporal lobe epilepsy developed, particularly from the work of Penfield, Jasper, and their associates at the Montreal Neurological Institute (MNI).

Age Dependent Seizure Semiology in Temporal Lobe Epilepsy

10/04/2007 11:21 AM

Stroke 2007, doi:10.1161

Stroke units decrease mortality and need for institutional care, but they are not widely available. The objective of the study was to determine, among European hospitals admitting acute stroke patients, how many are able to provide an appropriate level of care.

Sex Differences in Quality of Life in Stroke Survivors Data From the Tinzaparin in Acute Ischaemic Stroke Trial TAIST

10/04/2007 11:19 AM

Stroke 2007, doi:10.1161

Stroke induced by middle cerebral artery occlusion (MCAO) causes long-term formation of new striatal neurons from stem/progenitor cells in the subventricular zone (SVZ). We explored whether MCAO leads to hypoxia, changes in vessel density, and angiogenesis in the ipsilateral SVZ and adjacent striatum, and determined the relation between the migrating neuroblasts and the vasculature.

Focal reduction of neuronal glutamate transporters in human neocortical epilepsy

10/04/2007 11:17 AM

Neuroepidemiology 2007;29:49-54

Animal studies and in vitro experiments indicate that vitamin D is involved in a diverse range of neurobiological functions. We had the opportunity to examine the relationship between serum 25-hydroxyvitamin D3 [25(OH)D] levels and performance on various cognitive tasks, based on a large, representative community sample.

DNA Repair Polymorphisms XRCC1 and MGMT and Risk of Adult Gliomas

10/04/2007 11:14 AM

Neuroepidemiology 2007;29:44-48

We aimed to estimate the incidence and prevalence of amyotrophic lateral sclerosis (ALS) in the South East of England. The reported incidence of ALS varies between 0.44 and 3.2 per 100,000 person years. This can partly be explained by differences in design and diagnostic criteria used. There is little population data concerning England, particularly the South East.

Knowledge Attitudes and Practice toward Epilepsy among Adults in BaVi Vietnam First Report from the Population Based EPIBAVI Study

10/04/2007 11:11 AM

Epilepsia Volume 48 Issue 10 Page 1934-1946, October 2007

A common experimental model of status epilepticus (SE) utilizes intraperitoneal administration of the cholinergic agonist pilocarpine preceded by methyl-scopolamine treatment. Currently, activation of cholinergic neurons is recognized as the only factor triggering pilocarpine SE. However, cholinergic receptors are also widely distributed systemically and pretreatment with methyl-scopolamine may not be sufficient to counteract the effects of systemically injected pilocarpine. The extent of such peripheral events and the contribution to SE are unknown and the possibility that pilocarpine also induces SE by peripheral actions is yet untested.

Electrical Stimulation of the Hippocampal Epileptic Foci for Seizure Control A Double Blind, Long Term Follow Up Study

10/04/2007 11:08 AM

Pediatric Emergency Care. 23(9):659-661, September 2007

Malignant hypertension due to autonomic dysfunction is a known complication of Guillain-Barre syndrome. We describe a child who presented with status epilepticus secondary to hypertensive encephalopathy who, in recovery, was found to be areflexic. Nerve conduction studies confirmed the clinical diagnosis of Guillain-Barre syndrome.

Dynamic perfusion CT Optimizing the temporal resolution for the calculation of perfusion CT parameters in stroke patients

10/04/2007 11:06 AM

Anesth Analg 2007; 105:1104-1112

Clinical markers of the adequacy of cerebral perfusion may be misleading. The effects of isolated changes in systemic blood pressure, Paco2, Pao2, and cerebral edema on cerebral blood flow and oxygenation are relatively well known, but the quantitative effects of interactions between these factors are not easily calculated. We aimed to investigate the relationship between these factors using a computational model.

Malignant Progression and Blockade of Angiogenesis in a Murine Transgenic Model of Neuroblastoma

10/04/2007 11:02 AM

Cancer Research 67, 9463-9471, October 1, 2007

Malignant gliomas have been shown to release glutamate, which kills surrounding brain cells, creating room for tumor expansion. This glutamate release occurs primarily via system xC-, a Na+-independent cystine-glutamate exchanger.

Neurodevelopmental Outcome in Survivors of Periventricular Hemorrhagic Infarction

10/04/2007 10:59 AM

Brain Injury, Volume 21, Issue 10 September 2007 , pages 1069 - 1077

To validate the modified 20-metre shuttle test in adults who have sustained a traumatic brain injury (TBI).

Utility of Magnetoencephalography in the Evaluation of Recurrent Seizures after Epilepsy Surgery

10/04/2007 10:54 AM

Epilepsia doi:10.1111/j.1528-1167.2007.01330.x

Ictal asystole (IA) has been implicated as a preventable cause of sudden unexplained death in epilepsy presumably provoked by a direct autonomic effect of the electrical stimulus on the heart. An electronic database search of patients with IA was performed comparing heart rate (HR) characteristics to a group of patients with vasovagal asystole.

A Computerized Algorithm for Etiologic Classification of Ischemic Stroke The Causative Classification of Stroke System

10/04/2007 10:52 AM

Stroke 2007, doi:10.1161

Acute-onset dysphagia after stroke is frequently associated with an increased risk of aspiration pneumonia. Because most screening tools are complex and biased toward fluid swallowing, we developed a simple, stepwise bedside screen that allows a graded rating with separate evaluations for nonfluid and fluid nutrition starting with nonfluid textures. The Gugging Swallowing Screen (GUSS) aims at reducing the risk of aspiration during the test to a minimum; it assesses the severity of aspiration risk and recommends a special diet accordingly.

Analysis of Calcium in Carotid Plaques With Agatston Scores for Appropriate Selection of Surgical Intervention

10/04/2007 10:50 AM

Epilepsia Volume 48 Issue 10 Page 1833-1832, October 2007

The possibility that a recent seizure or a recent change in antiepileptic medication might produce an occult change in neuropsychological performance is of interest, and especially so in the context of evaluation for epilepsy surgery. Such an evaluation is often done in a setting of video-EEG monitoring where a strong effort is made to produce seizures as quickly as possible with abrupt changes in medication, alterations in sleep, etc., which could impact the validity of neuropsychological findings.

A Probable Causative Factor for an Old Problem Selenium and Glutathione Peroxidase Appear to Play Important Roles in Epilepsy Pathogenesis

10/04/2007 10:47 AM

Volume 69, Issue 3, Pages 880-886 (1 November 2007)

We developed a co-culture system to quantitate the growth and invasion of human malignant gliomas into a background of confluent normal human astrocytes, then used this assay to assess independently the effects of irradiating both cell types on glioma invasion.

Ketogenic Diet Electrophysiological Effects on the Normal Human Cortex

10/04/2007 10:45 AM

Epilepsia Volume 48 Issue 9 Page 1764-1767, September 2007

Historical automated AP data from weather stations in the Seattle Metropolitan area were correlated to seizure frequency and type in consecutive patients undergoing video EEG telemetry at our institution from April 2005–April 2006. Daily maximum, minimum and range of atmospheric pressures were correlated to daily number of events (seizures, pseudoseizures, unknown) per patient. Alternatively, whether or not events occurred during a change of greater or less than 5.5 mBar per day were used to evaluate odds ratios of events occurring.

Depletion of Peripheral Macrophages and Brain Microglia Increases Brain Tumor Titers of Oncolytic Viruses

10/04/2007 10:43 AM

Epilepsia Volume 48 Issue 9 Page 1774-1784, September 2007

Regional overexpression of the multidrug transporter P-glycoprotein (P-gp) in epileptic brain tissue may lower target site concentrations of antiepileptic drugs and thus contribute to pharmacoresistance in epilepsy.

Exclusion and Inclusion Criteria for People with Aphasia in Studies of Depression after Stroke A Systematic Review and Future Recommendations

10/04/2007 10:40 AM

Neuroepidemiology 2007;29:18-28

Transversal studies have underlined the association between the decline in autonomic nervous system (ANS) activity and all-cause mortality. However, the predictive value of ANS has never been prospectively assessed in a general population-based cohort.

Implicit Learning of Sequential Regularities and Spatial Contexts in Corticobasal Syndrome

10/04/2007 10:37 AM

Epilepsia Volume 48 Issue 9 Page 1807-1809, September 2007

Photosensitive epilepsy is less frequent among males than females. Red is the most epileptogenic color. The X-linked red pigment gene contains the polymorphism Ser180Ala; the Ser180 allele increases red sensitivity.

Impact of Idiopathic Epilepsy on Mothers and Fathers Strain Burden of Care Worries and Perception of Vulnerability

10/04/2007 10:34 AM

Skull Base 2007; 17: 325-330

A case of a patient with a posterior fossa meningioma extending through the hypoglossal canal to the cervical region as described in this article has not been previously described in the literature. Investigations and surgical management are outlined and pathological classifications are discussed.

Timing of Recanalization After Microbubble Enhanced Intravenous Thrombolysis in Basilar Artery Occlusion

10/04/2007 10:32 AM

PEDIATRICS Vol. 120 No. 4 October 2007, pp. e880-e886

Motor function recovery is a key goal during rehabilitation of children and adolescents with traumatic brain injury. To evaluate how well treatment strategies improve motor function, we need validated outcome measures that are responsive to change in pediatric patients with traumatic brain injury. The Gross Motor Function Measure has demonstrated excellent psychometric properties in children with cerebral palsy and Down syndrome, yet its responsiveness in patients with pediatric traumatic brain injury has not been proven irrefutably. Our aim was to validate the Gross Motor Function Measure for this patient group.

Endoscopic Assisted Removal of Orbital Roof Lesions via a Skin Crease Approach

10/04/2007 10:30 AM

Critical Care Medicine. 35(10):2383-2389, October 2007

There are few data regarding anemia and transfusion after subarachnoid hemorrhage (SAH). We addressed the hypothesis that higher hemoglobin (HGB) levels are associated with less death and disability after SAH.

Occupational therapy for patients with problems in personal activities of daily living after stroke systematic review of randomised trials

10/04/2007 10:27 AM

Acta Diabetologica 0940-5429

The role of diabetes mellitus (DM) in the etiopathogenesis of spontaneous intracerebral hemorrhage (SICH) is controversial.

Spasticity outcome measures in spinal cord injury psychometric properties and clinical utility

10/04/2007 10:24 AM

Spinal Cord 2 October 2007

Depression is common after spinal cord injury (SCI), yet it can be difficult and costly to diagnose. Screening tools such as the Center for Epidemiological Studies Depression scale (CESD) can assist with case identification; however, insufficient knowledge of their measurement properties exists to use them in the SCI population.

A review of scales for assessing the risk of developing a pressure ulcer in individuals with SCI

10/04/2007 10:18 AM

Year : 2007 Volume : 55 Issue : 3 Page : 274-281

Craniocerebral aspergillosis is a rare but dangerous variety of central nervous system infections. Surgery is being widely recognized as the cornerstone of management. Due to the rarity of the disease, difficulty and delay in diagnosis and poor outcome, there is very little in the literature regarding the various surgical strategies that may be adopted in these patients. Early aggressive surgery followed by chemotherapy offers the best chances. Surgical planning would depend upon the type and location of the disease process as well as the condition of the patient. Perioperative care holds immense importance and knowledge of possible complications is essential. Aspergillosis of the central nervous system is difficult to diagnose and equally difficult to treat. Surgery remains the cornerstone of management followed by systemic antifungal medications. Results are better in immunocompetent patients as compared to those who are immunocompromised.

Cerebral Aspergillus arteritis with bland infarcts A report of two patients with poor outcome

10/04/2007 10:15 AM

Neurology India Year : 2007 Volume : 55 Issue : 3 Page : 310-311

Aspergillus infections in the posterior fossa are either extensions of lesions from the mastoid sinuses or part of multiple fungal masses in the brain.

Minocycline treatment in acute stroke

10/04/2007 09:59 AM

NEUROLOGY 2007;69:1418-1423

Uric acid (UA) has antioxidant properties yet when elevated is associated with vascular disease and stroke. Further, even high normal UA is associated with increased risk of mild cognitive dysfunction in elderly adult