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The authors present a report of a solitary fibrous tumor (SFT) arising from the intradural component of the VIth cranial nerve as it travels through the prepontine cistern.
Better characterization of the changes that occur in the circulating monocytes of patients with glioblastoma has become more important recently as
monocyte-derived dendritic cells are used as adjuvants in the development of glioma vaccines.
Idiopathic normal pressure hydrocephalus (INPH) is characterized by a classic clinical triad of symptoms, including dementia, urinary incontinence, and gait disturbance. Recent work has demonstrated that the maximal midbrain anteroposterior (AP) diameter is significantly smaller in patients with INPH than in healthy, age-matched controls.
Clinicians and researchers use brief instruments, such as the Mini Mental State Examination
(MMSE) and the Telephone Interview for Cognitive Status (TICS), to measure cognitive functioning in patients with cerebral aneurysms. MMSE and TICS scores are often dichotomized to classify patients as cognitively impaired or not. Frequently, after an initial MMSE face-to-face evaluation, the TICS is used for follow-up assessments by telephone.
In an era in which new computed tomographic scanners approach 100% sensitivity for finding intracranial aneurysms in patients with a perimesencephalic subarachnoid hemorrhage
(SAH) pattern, digital subtraction angiography (DSA) is still considered the gold standard. Our purpose was to investigate whether or not computed tomography angiographic
(CTA) scanning can be used as the sole diagnostic tool in this setting, and thus replace
DSA.
New approaches are focusing on using a combination of medication that lyse fibrin and prevent aggregation of platelets to achieve higher rates of recanalization and improved clinical outcomes.
To evaluate predictors of intraventricular hemorrhage (IVH) and IVH growth, impact of IVH growth on outcome, and impact of recombinant activated factor VII
(rFVIIa) in patients with intracerebral hemorrhage (ICH).
To determine the prevalence of neuropsychiatric (NP) manifestations in children with systemic lupus erythematosus
(SLE) using the 1999 American College of Rheumatology case definitions for NP syndromes in
SLE, and their association with antiphospholipid antibodies (aPL).
American Journal of Neuroradiology 27:1927-1929, October 2006
Intracranial arteriovenous malformations (AVM) are a rare feature of Bannayan-Riley-Ruvalcaba syndrome
(BRRS). Palencia et al reported a case of intracranial arteriovenous malformation in a child with BRRS in a Spanish journal in 1986. However, the occurrence of dural AVM in a patient with BRRS has not since been addressed in the literature.
Current Opinion in Oncology. 18(6):631-636, November 2006
Major advances have been made in the understanding of antitumour immunity in patients with
glioma. Patients with glioblastoma can spontaneously develop antitumour activity with activated CD8+ T cells. Infiltration of myeloid suppressor cells into tumours and increased regulatory T-cell fraction appear to play a critical role in tumour tolerance, however. T-regulatory removal suppresses CD4+ T-cell proliferative defects and can induce tumour rejection in a murine model.
Hearing rehabilitation by cochlear implantation is not always possible in case of total ossification after pneumococcal meningitis. We report 3 cases of postmeningitis profound hearing loss with total cochlear ossification in adults who underwent auditory brainstem implantation (Nucleus 22®, Cochlear Inc., Lane Cove, Australia) between 1999 and 2004.
Data from a clinical sample of children and adolescents were used to examine the characteristics of the Frontal Lobe/Executive Control
(FLEC) scale of the Behavior Assessment System for Children Parent Rating Scales, including preliminary evidence of the scale's clinical utility and relationship to other behavioral measures of executive function and characteristics of Attention Deficit Hyperactivity Disorder (ADHD).
Current Opinion in Psychiatry. 19(6):600-607, November 2006
The study gives an overview of ethical questions raised by the progress of neuroscience in identifying and intervening in neural correlates of the mind.
Archives of Clinical Neuropsychology Volume 21, Issue 5 , August 2006, Pages 395-404
Effort testing has become commonplace in clinical practice. Recent research has shown that performance on effort tests is highly correlated with performance on neuropsychological measures. Clinical application of effort testing is highly dependent on research derived interpretive guidelines. The Victoria Symptom Validity Test
(VSVT) is one of many measures currently used in clinical practice.
Archives of Clinical Neuropsychology Volume 21, Issue 5 , August 2006, Pages 429-437
It is unclear how well performance on recently developed, specialized executive tests, reflects problems that patients and their relatives complain of in real life. The ecological validity of four specialised tests of executive function: the Hayling and Brixton Tests, and the Zoo Map and Key Search sub-tests from the Behavioural Assessment of Dysexecutive Syndrome
(BADS) battery, was assessed against the Dysexecutive Questionnaire from the BADS in a sample of 59 severely brain injured individuals.
Journal of Trauma-Injury Infection & Critical Care. 61(4):873-878, October 2006
To prospectively identify histologically and endoscopically the effect of omeprazole on the expression of endothelin-1 (ET-1), inducible nitric oxide synthase
(iNOS) and macrophage inflammatory protein-1[alpha] (MIP-1[alpha]) in the gastric mucosa of neurosurgical patients with stress ulcer.
To compare composite subtraction ictal single-photon emission computed tomography coregistered to magnetic resonance imaging (also known as
SISCOM) patterns between right and left medial temporal-onset seizures to document neuroanatomical involvement in perfusion patterns.
Clinical Cancer Research Vol. 12, 5770-5776, October 1, 2006
Drug resistance in brain tumors is partially mediated by the blood-brain barrier of which a key component is P-glycoprotein, which is highly expressed in cerebral capillaries. Tamoxifen is a nontoxic inhibitor of P-glycoprotein. This trial assessed, in primary and metastatic brain tumors, the differential deposition of paclitaxel and whether tamoxifen could increase paclitaxel deposition.
Epileptic Disorders. Volume 8, Number 2, 10-5, Supplement 2, September 2006
In modern times, the determination of the epileptogenic zone demands a sophisticated combination of neurophysiological and neuroimaging tools. Historically however, the concept of the epileptogenic zone was based on and has evolved from the recording of interictal spikes, both in the scalp electroencephalogram (EEG) and, particularly, in the acute electrocorticogram
(ECoG).
Epileptic Disorders. Volume 8, Number 2, 16-26, Supplement 2, September 2006
The definition of the epileptogenic zone, as proposed by Talairach and Bancaud, is an ictal electro-clinical definition based on the results of stereotactic intracerebral EEG
(SEEG) recordings. It takes into account not only the anatomical location of the “site of the beginning and of the primary organization” of the epileptic discharge, but also how this discharge gives rise to the accompanying clinical symptoms.
The relationship between postmenopausal hormone therapy (HT) and cerebrovascular disease has been examined in several epidemiological studies and clinical trials with conflicting results. The authors aimed to evaluate the association between the use of HT and the incidence of first cerebrovascular event.
Acta Neurologica Scandinavica, Volume 114, Number 5, November 2006, pp. 307-314(8)
Length of hospital stay (LOHS) is the largest determinant of direct cost for stroke care. Institutional discharges (acute care and nursing homes) from rehabilitation settings add to the direct cost. It is important to identify potentially preventable medical and non-medical reasons determining LOHS and institutional discharges to reduce the direct cost of stroke care.
A substantial portion of the general population has clinically silent stroke on brain imaging. These lesions may cause symptoms. This study assessed the prevalence of stroke symptoms in a stroke- and transient ischemic attack (TIA) free population and the association of symptoms with risk factors indexed by the Framingham Stroke Risk Score.
Journal of Internal Medicine, Volume 260, Number 4, October 2006, pp. 343-349(7)
The influence of temperature on the outcome observed in experimental models of ischaemic stroke has not been definitively proved in patients with stroke. Interleukin-6 (IL-6) acts as important endogenous
pyrogen, and it is an important regulator of spontaneous body temperature during cerebral
ischaemia. The objective of this study was to determine, during the acute phase of cerebral
ischaemia, the potential relationship between proinflammatory cytokines and hyperthermia as a cause of larger cerebral infarcts.
Acta Neurologica Scandinavica, Volume 114, Number 5, November 2006, pp. 320-322(3)
Data concerning an association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and ischemic stroke (IS) remain inconsistent. Results of some studies suggest that DD genotype may be a risk factor for small vessel disease
(SVD) stroke. Here, we investigated whether this polymorphism is associated with IS of different etiologies in a Polish population.
Acta Neurologica Scandinavica, Volume 114, Number 5, November 2006, pp. 293-306(14)
This review provides an update on recent research findings concerning the methods used in the assessment of
anosognosia, the occurrence and subtypes of anosognosia, the association between anosognosia and neglect, and the impact of anosognosias on functional outcome.
To compare composite subtraction ictal single-photon emission computed tomography coregistered to magnetic resonance imaging (also known as
SISCOM) patterns between right and left medial temporal-onset seizures to document neuroanatomical involvement in perfusion patterns.
We evaluated the productions of an artist with frontotemporal lobar degeneration from before dementia onset until she was fully symptomatic. We noted an improvement of technique that might be related to sparing and disinhibition of the right posterior
neocortex. There was a reduction of closure (completeness of the painting), possibly induced by impersistence and a decrease in evocative impact that might be explained by frontal and
anterotemporal-limbic dysfunction.
We compared subjective responses to simple questions after stroke with interviewer-assessed stroke outcome measures. Among those in the highest functional category, women were more likely to report incomplete recovery and greater need for help than men. Among these women, depressed mood was associated with a response of a need for help despite a good functional recovery. Self-reported responses in stroke outcome assessments require further validation by gender and may need to consider the confounding effects of depression.
Disclosure: Funding for this study was provided by Novo Nordisk Inc., Princeton, NJ. With the exception of Dr. Joshi (a current employee of the sponsor who participated in research design, interpretation of findings, and manuscript preparation/review), the sponsor played no role in the design or conduct of the study.
The WASID trial showed no advantage of warfarin over aspirin for preventing the primary endpoint of ischemic stroke, brain hemorrhage, or vascular death. In analyses of selected subgroups, there was no definite benefit from
warfarin.
To identify hematoma progression in patients with warfarin-associated intracerebral hemorrhage
(ICH) despite international normalized ratio (INR) normalization with fresh-frozen plasma
(FFP), we reviewed 45 patients with warfarin-associated ICH given
FFP. The median time for door to INR normalization was 30 hours (14 to 49.5), with 4 patients' hematomas enlarging after INR normalization. FFP is associated with substantial time delay to actual administration and pulmonary edema and may not prevent progression of ICH despite INR normalization.
To study the MAL’s reliability and validity for assessing real-world quality of movement (QOM scale) and amount of use
(AOU scale) of the hemiparetic arm in stroke survivors.
To evaluate the frequency, types, and location of posttraumatic cerebral infarction, to assess if secondary cerebral insults were associated with cerebral infarction, and to determine if cerebral infarction affected patients' outcome.
This study aimed to examine early effects of ex vivo-expanded bone marrow-derived endothelial progenitor cells
(EPCs) on focal cerebral ischemia-reperfusion injury.
Endothelial tight junctions form the main barrier of the blood-brain barrier (BBB). In human
hemangioblastomas, cyst formation is a common and important clinical manifestation. Although most researchers consider that the cyst formation in hemangioblastomas may be caused by the breakdown of the BBB, the underlying molecular mechanisms for cyst formation remain unknown.
Neurosurgical resources are concentrated in tertiary referral centers, whereas emergencies identified from district general hospitals are traditionally referred by telephone consultation
(TC). Recent advances in communication technology offer the alternative options of teleradiology
(TR) and video consultation (VC).
The performance of five newer helmets was compared with the baseline VSR-4 helmet in 10 reconstructed cases of National Football League (NFL) collisions causing concussion. The laboratory reconstructions were conducted to determine changes in concussion risk with newer football helmets.
Although radiation injury after stereotactic radiosurgery (SRS), including radiation necrosis (RN), is often treated with surgical resection, detailed outcome data are lacking after resection of symptomatic radiation-injured regions with imaging characteristics suspicious for RN after SRS for arteriovenous malformations (AVM). We present outcomes in seven such patients.
The influence of cerebrovascular disease (CVD) on the short- and long-term results of surgery was evaluated in a series of consecutive patients with idiopathic normal-pressure hydrocephalus
(iNPH).
The surgical management of occlusive hydrocephalus caused by massive cerebellar infarction remains controversial. The procedures that are more commonly used to avoid progressive neurological deterioration are based on transient external ventricular drainage or the placement of permanent shunt systems.
To evaluate which presentation indices, demographics, and clinical information predict 12-month outcome in poor-grade aneurysmal subarachnoid hemorrhage
(SAH), and to provide a preoperative index of prognosis.
Journal of Neurotrauma Oct 2006, Vol. 23, No. 10 : 1468 -1501
There is currently a lack of evidence-based guidelines to guide the pharmacological treatment of neurobehavioral problems that commonly occur after traumatic brain injury
(TBI). It was our objective to review the current literature on the pharmacological treatment of neurobehavioral problems after traumatic brain injury in three key areas: aggression, cognitive disorders, and affective disorders/anxiety/ psychosis.
Journal of Neurotrauma Oct 2006, Vol. 23, No. 10 : 1396 -1411
Quantitative neuroimaging is increasingly used to study the effects of traumatic brain injury
(TBI) on brain structure and function. This paper reviews quantitative structural and functional neuroimaging studies of patients with
TBI, with an emphasis on the effects of diffuse axonal injury (DAI), the primary neuropathology in
TBI. Quantitative structural neuroimaging has evolved from simple planometric measurements through targeted region-of-interest analyses to whole-brain analysis of quantified tissue compartments.
Journal of Neurotrauma Oct 2006, Vol. 23, No. 10 : 1427 -1435
Proton magnetic resonance spectroscopy (1H-MRS) and neuropsychological assessment were utilized in a longitudinal investigation of traumatic brain injury
(TBI) in children.
Journal of Neurotrauma Oct 2006, Vol. 23, No. 10 : 1502 -1509
In patients with traumatic brain injury (TBI), intracranial hypertension secondary to cerebral edema is a major problem. A last-tier treatment in these cases is decompressive
craniectomy. The aim of the present retrospective investigation was to (1) study the long-time outcome in patients with traumatic head injuries with intracranial hypertension treated with decompressive
craniectomy; (2) examine the effects on intracranial pressure (ICP) by the
craniectomy; and (3) investigate the possible relationship between the size of the removed bone-flap and the effects on
ICP. Among the about 150 patients with severe TBI treated at our neurointensive care unit during 1997–2002, 19 patients were treated with decompressive
craniectomy.
Journal of Neurotrauma Oct 2006, Vol. 23, No. 10 : 1436 -1449
We review the emerging applications of functional and structural neuroimaging techniques for the assessment of patients with disorders of consciousness. Measurements of brain function from patients in the vegetative state (VS) and minimally conscious state (MCS) are compared, and a conceptual organization is developed that suggests models of brain mechanisms associated with different functional levels of recovery.
Journal of Neurotrauma Oct 2006, Vol. 23, No. 10 : 1412 -1426
Diffusion tensor imaging (DTI) is a recent imaging technique that assesses the microstructure of the cerebral white matter (WM) based on anisotropic diffusion (i.e., water molecules move faster in parallel to nerve fibers than perpendicular to them). Fractional anisotropy (FA), which ranges from 0 to 1.0, increases with myelination of WM tracts and is sensitive to diffuse axonal injury (DAI) in adults with traumatic brain injury
(TBI).
Journal of Neurotrauma Oct 2006, Vol. 23, No. 10 : 1518 -1528
The primary mechanism for eliminating synaptically released glutamate is uptake by
astrocytes. In the present study, we examined whether traumatic brain injury
(TBI) affects the cellular expression of glutamate transporters EAAT1 and EAAT2.
Journal of Neurotrauma Oct 2006, Vol. 23, No. 10 : 1561 -1569
Many patients with mild traumatic brain injury (MTBI) concurrently sustain extracranial injuries; however, little is known about the impact of these additional injuries on outcome. We assessed the impact of additional injuries on the severity of postconcussional symptoms (PCS) and functional outcome 6 months post-injury.
Journal of Neurotrauma Oct 2006, Vol. 23, No. 10 : 1549 -1560
Recent evidence from our laboratory demonstrated in laboratory rats that stimulation of the vagus nerve
(VNS) initiated 2 h after lateral fluid percussion brain injury
(FPI) accelerates the rate of recovery on a variety of behavioral and cognitive tests.
Journal of Neurotrauma Oct 2006, Vol. 23, No. 10 : 1510 -1517
Cerebral microdialysis is increasingly used to monitor several types of neurocritical patients. This study presents the technique used in our unit for percutaneous implantation of cerebral microdialysis catheters using a small twist-drill craniostomy that can be performed in the intensive care unit (ICU).
Patients who have early-stage age-related macular degeneration are almost twice as likely to have a stroke than those who do not have this ocular disease, according to a study in the July 18th Annals of Internal Medicine.
Journal of Trauma-Injury Infection & Critical Care. 61(3):577-581, September 2006
The incidence of readmissions because of delayed intracranial complications within 3 weeks after observation for the sole diagnosis of concussion was examined in a national cohort. A nested case-control design was used to analyze the association between clinical factors as well as early computed tomography (CT) scan examination and these complications.
Journal of Trauma-Injury Infection & Critical Care. 61(3):572-576, September 2006
As obesity continues to run rampant in our society, an understanding of its adverse effect after traumatic injury is starting to unfold. We hypothesize that obesity negatively impacts head-injured patients, and the current study intends to compare obese and lean patients with traumatic brain injury
(TBI).
PEDIATRICS Vol. 118 No. 4 October 2006, pp. 1467-1477
We sought to compare the prognostic utilities of early MRI spin-spin relaxometry and proton magnetic resonance spectroscopy in neonatal encephalopathy.
International Journal of Cardiology Volume 111, Issue 3 , 28 August 2006, Pages 464-467
The optimal anticoagulation following Fontan operation and its modifications remain controversial and it is even less well defined as regards patients with inherited
thrombophilia. We present a case of a child with bidirectional Glenn anastomosis for double inlet left ventricle that suffered a stroke despite aspirin prophylaxis; the patient was combined homozygous for prothrombin G20210A mutation and for methylenetetrahydrofolate reductase C677T mutation as well.
\We report two patients with medically refractory epilepsy who had MRI evidence of unilateral subcortical nodular heterotopia and agenesis of corpus
callosum. The abnormal hemisphere was small, whereas the contralateral normal hemisphere appeared large and crossed the midline. Although the normal hemisphere was initially mistaken for
hemimegalencephaly, there were no typical radiological features.
Magnetoencephalography (MEG) was used to image brain activity associated with delusions in episodic interictal psychosis of epilepsy. Two female patients aged 65 and 68 with temporal lobe epilepsy were studied during and after a delusional state.
Journal of Neurotrauma Oct 2006, Vol. 23, No. 10 : 1468 -1501
There is currently a lack of evidence-based guidelines to guide the pharmacological treatment of neurobehavioral problems that commonly occur after traumatic brain injury
(TBI). It was our objective to review the current literature on the pharmacological treatment of neurobehavioral problems after traumatic brain injury in three key areas: aggression, cognitive disorders, and affective disorders/anxiety/ psychosis.
Concussion is a common injury sustained by children participating in many different sports. In children 15 years of age and younger, the estimated incidence of traumatic brain injury, including concussions, is 180 per 100,000 children per year, accounting for more than 10% of all visits to emergency departments (1). A recent Canadian emergency department study (2) demonstrated that 3% of all sport-related injuries were head injuries.
Journal of Neurosurgical Anesthesiology. 18(4):256-261, October 2006
Respiratory dysfunctions in patients with craniovertebral junction (CVJ) anomalies may occur due to compression of brainstem affecting the respiratory centers, and weakening of the muscles of respiration. We assessed pulmonary functions [forced vital capacity
(FVC), forced expiratory volume in first second (FEV1), maximum mid-expiratory flow rate (FEF25%-75%), FEV1%], mouth pressures (maximum inspiratory pressure, maximum expiratory pressure), and diaphragmatic movements in 30 patients of CVJ anomalies and compared them with their mean predictive values.
We examine current understanding of the minority disadvantage in the clinical management of epilepsy. We performed an online literature search using several keywords (race, ethnicity, epilepsy, treatment, and quality of life) and identified additional literature through cross-referencing/manual search.
The goal of this study was to determine if there is a significant difference in the rate of postpartum depression among patients with epilepsy and healthy controls. All patients were recruited from the Epilepsy Center and the Department of Obstetrics and Gynecology, University of Milan, St. Paolo Hospital (Milan, Italy).
Accurate knowledge of the frequency of epileptic seizures is a precondition for evaluating the efficacy of pharmacotherapy. It is a well-known fact that the information provided by epilepsy patients about the number of seizures they experience is often unreliable.
Although mood disorders have a major impact on quality of life in patients with epilepsy, the nature of some aspects, such as mania, has received little attention. With the introduction of several new antiepileptic drugs into clinical practice, attention to psychiatric treatment-emergent adverse effects has been renewed. This article explores the relationship between antiepileptic drugs and mania in patients with epilepsy, with special emphasis on the clinical pathophysiology of this phenomenon.
Analysis of electroencephalographic signals and several brain imaging studies suggest that a preictal state precedes the onset of seizures. In this study, we used phenomenological strategies to detect modifications in patients’ experience before their seizures. We observed that patients with partial epilepsy feeling an aura (n = 9) frequently experienced prodromes (n = 6). Prodromes were subtle preictal symptoms, varying among patients and having common negative features.
A 32-year-old woman with primary generalized epilepsy described absence events precipitated by talking about childhood sexual abuse, her epilepsy, or her father’s difficulties with schizophrenia. She was referred for assessment of suspected psychogenic nonepileptic events. During simultaneous video/EEG monitoring, 30 absence seizures were recorded, 28 of which occurred while discussing one of these three specific precipitants. No nonepileptic events were seen. This finding highlights the importance of thorough investigation of ambiguous events, and confirms that specific emotional precipitants can induce seizures in susceptible people with epilepsy.
Journal of Vascular Surgery Volume 44, Issue 3 , September 2006, Pages 488-493
We examined the outcome of carotid endarterectomy (CEA) in the state of Maryland during the last decade to identify any trends in the incidence of in-hospital stroke and mortality and compared these results with the outcome of the operation throughout the state of California as a control population.
Disability & Rehabilitation Volume 28, Number 21 / November 2006 1349 - 1359
Evaluate clinical service characteristics of a physical rehabilitation outreach clinic. A retrospective analysis on service-related factors and patient information (every clinical encounter between 1983 and 2002) was performed on the Terry Fox Mobile Clinic. The Terry Fox Mobile Clinic provided multidisciplinary physical rehabilitation outreach services for adults with disabilities in Eastern and North Eastern Ontario, Canada (on-site visits by rehabilitation specialists). Subjects include 4816 clients with physical disabilities from Eastern and North Eastern Ontario, Canada. Patient data (age, residence, diagnosis, inpatient/outpatient), clinic data (type, location, totals), team data (clinical disciplines), and assistive device utilization over the last 15 years of data were used for analysis.
Disability & Rehabilitation Volume 28, Number 21 / November 2006 1311 - 1318
This prospective longitudinal study aimed at a description of ADL-functioning and at an analysis, which clinical instruments predict independency 6 months after discharge from in-patient rehabilitation following disabling first stroke.
Journal of Vascular Surgery Volume 44, Issue 3 , September 2006, Pages 480-487
The optimal timing of carotid endarterectomy (CEA) after ipsilateral hemispheric stroke is controversial. Although early studies suggested that an interval of about 6 weeks after a completed stroke was preferred, more recent data have suggested that delaying CEA for this period of time is not necessary.
We conducted a retrospective cohort study in children <13 yr with traumatic brain injury
(TBI) at a Level 1 pediatric trauma center to describe risk factors for intraoperative hypotension
(IH) during emergent decompressive craniotomy.
Journal of Neurosurgical Anesthesiology. 18(4):235-239, October 2006
We have observed that patients, after retromastoid craniectomy (RMC) with microvascular decompression
(MVD) of cranial nerves, frequently experienced postoperative nausea and vomiting
(PONV).
Resuscitation Volume 70, Issue 2 , August 2006, Pages 254-262
To establish whether there is consensus in the management of body temperature in patients with severe traumatic brain injury
(TBI) admitted to hospitals in the United Kingdom and Ireland for neurosurgical intensive care.
Acta Neurologica Scandinavica, Volume 114, Number 4, October 2006, pp. 250-253(4)
Around 30% of ischemic strokes are considered cryptogenic. We analyzed the diagnostic yield of prothrombotic state (PS) studies in patients with an initial cryptogenic stroke (CS).
Acta Neurologica Scandinavica, Volume 114, Number 4, October 2006, pp. 254-260(7)
Cortical and/or deep vein thrombosis (CDVT) without dural sinus involvement is uncommon and presents diagnostic difficulty for many reasons. Our aim is to determine the relationship between magnetic resonance imaging
(MRI) findings and clinical findings in patients with CDVT.
Medical Hypotheses Volume 67, Issue 5 , 2006, Pages 1065-1071
A new hypothesis is presented on the function of factor XII, which is postulated to be a “missing link” between acute stress and transient
hypercoagulability. The implications of this idea are developed to show how chronic stress, which involves activation of hypertension and migraine as well as
hypercoagulability, can cause of cerebrovascular disease. "Acute stress" is defined as "the normal short-term physiological response to the perception of major threats or demands". "Chronic stress" is "the abnormal ongoing physiological response to the continuing perception of unresolvable major threats or demands".
Medical Hypotheses Volume 67, Issue 5 , 2006, Pages 1072-1075
Cryptogenic stroke (or stroke of undetermined cause) is a common cause of stroke and is statistically associated with patent foramen ovale
(PFO). The largest study of cryptogenic stroke is the Homma study, which is a sub-study of the WARSS trial; it produced the following data: cryptogenic stroke patients with and without
PFO, when treated with either aspirin or warfarin, all had identical recurrence rates. This is puzzling because it seems as though there ought to have been some extra risk in one of the two groups under one of the two treatments. How could everything come out the same?
Annals of Emergency Medicine Volume 48, Issue 3 , September 2006, Pages 245-251
Emergency physicians are concerned about minor head injury patients who present with a Glasgow Coma Scale (GCS) score of 15 yet require neurosurgical intervention. Our objectives are to determine the accuracy of the Canadian CT Head Rule
(CCHR) in this important subset, the prevalence of patients requiring urgent intervention, and their clinical course and possible warning signs.
International Journal of Clinical Practice, Volume 60, Number 10, October 2006, pp. 1281-1286(6)
Stroke is a major cause of morbidity and mortality worldwide. Hypertension is one of the most important risk factors for stroke - increasing the risk significantly. The presence and severity of coronary artery disease (CAD), which often coexists with hypertension, also predicts an increased risk of stroke.
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