Stroke prediction and stroke prevention with atorvastatin in the Collaborative Atorvastatin Diabetes Study CARDS

11/30/2007 03:03 PM

Journal of Computer Assisted Tomography. 31(6):894-895, November/December 2007

This case study demonstrates the feasibility and diagnostic value of the oblique-plane arterial spin labeling method to visualize individual perfusion territories in a patient with embolic stroke. The perfusion territories obtained with this technique differed significantly from the standard anatomical situation. Imaging findings suggested that all acute embolic lesions in both hemispheres had arisen from one symptomatic internal carotid artery stenosis.

Discrepancy Between the Dynamic Computed Tomography and T2 Magnetic Resonance Perfusion Imaging in Brain Tumors - A Report of 2 Cases

11/30/2007 03:00 PM

Journal of Computer Assisted Tomography. 31(6):888-893, November/December 2007

To look for the clinical implications of increased cortical fractional anisotropy (FA) in meningitis patients associated with brain abscess.

Successful surgical treatment of insular epilepsy with nocturnal hypermotor seizures

11/30/2007 02:58 PM

Journal of Intensive Care Medicine, Vol. 22, No. 6, 319-347 (2007)

Overt status epilepticus and persistent obtundation after a witnessed clinical seizure are neurologic emergencies. Early recognition and intervention in the electroclinical syndrome of status epilepticus reduces morbidity, although treatment of the underlying etiology is also critical.

Neonatal seizure detection using multichannel display of envelope trend

11/30/2007 02:49 PM

Stroke doi: 10.1161/STROKEAHA.107.482570

The International Subarachnoid Aneurysm Trial (ISAT) reported that endovascular coiling yields better clinical outcomes than surgical clipping at 1 year. The high cost of the consumables associated with the endovascular coiling procedure (particularly the coils) led health care purchasers to conclude that coiling was a more costly procedure overall. To examine this assumption and provide evidence for future policy, accurate and comprehensive data are required on the overall resource usage and cost of each strategy.

Prevalence of self-reported epilepsy in a multiracial and multiethnic community in New York City

11/29/2007 01:54 PM

Volume 77, Issue 2, Pages 134-140 (December 2007)
The purpose was to quantify changes of epileptiform activity during ketogenic diet (KD) treatment in children with therapy resistant epilepsy, and evaluate how these changes are related to activity stage and to clinical effects on seizure frequency, seizure severity, attentional behaviour, quality of life (QOL), and beta-hydroxybutyrate.

REM sleep behaviour disorder in elderly subjects with epilepsy - Frequency and clinical aspects of the comorbidity

11/29/2007 01:51 PM

Epilepsy Research Volume 77, Issue 2, Pages 120-127 (December 2007)

The subjects were 106 SMIDS with epilepsy. They were classified into four epileptic syndromes: (1) SE-MISF (34.0%), (2) SGE (25.5%), (3) SLRE (20.7%), and (4) epileptic discharge-free patients (EDFP) (19.8%).

Spontaneous remission of infantile spasms and hypsarrhythmia following acute infection with high-grade fever

11/29/2007 01:49 PM

Epilepsy Research Volume 77, Issue 2, Pages 93-101 (December 2007)

Analysis of grey matter on MRI utilising voxel-based morphometry (VBM) may have insufficient sensitivity for routine clinical application. The aim of this exploratory study was to evaluate combined analysis of grey and white matter using VBM for detecting focal lesions underlying childhood epilepsy, and to establish the optimal statistical parameters in this context.

Effects of rapamycin on gene expression morphology and electrophysiological properties of rat hippocampal neurons

11/29/2007 01:46 PM

Epilepsy Research Volume 77, Issue 2, Pages 75-84 (December 2007)

The effects with pretreatment with nociceptin (0.03-30nmol, i.c.v.) were evaluated on the threshold for eliciting afterdischarge (ADT), generation and spread of seizure activity and postictal depression in rats with kindling stimulation

Evaluating candidate genes in common epilepsies and the nature of evidence

11/29/2007 01:44 PM

Epilepsia doi:10.1111/j.1528-1167.2007.01419.x

We recently demonstrated that in nocturnal frontal lobe epilepsy (NFLE) highly stereotyped minor motor events (MMEs, in the form of short-lasting stereotyped movements involving the limbs, the axial musculature, and/or the head), could occur in either the presence or absence of an epileptiform discharge (ED).

Disruption of Limbic Pathways in a Case of Profound Amnesia

11/29/2007 01:42 PM

The Annals of Pharmacotherapy: Vol. 41, No. 12, pp. 1937-1945

Evidence from randomized, controlled trials suggests that reduction of low-density lipoprotein cholesterol with hydroxymethylglutaryl coenzyme A reductase inhibitor (statin) therapy in patients at high risk for cardiovascular disease reduces the incidence of ischemic stroke; however, data from large epidemiologic observational studies suggest an inverse relationship between risk of hemorrhagic stroke and cholesterol levels.

Isoform-specific increase of spastin stability by N-terminal missense variants including intragenic modifiers of SPG4 hereditary spastic paraplegia

11/29/2007 01:39 PM

Stroke doi: 10.1161/STROKEAHA.107.487827

The pathogenesis of cerebral ischemia associated with subarachnoid hemorrhage (SAH) still remains elusive. The aim of this study was to examine the involvement of mitogen-activated protein kinase (MAPK) and protein kinase C (PKC) subtypes in the pathophysiology of cerebral ischemia after SAH in cerebral arteries and microvessels and to examine temporal activation of the kinases. We hypothesize that treatment with a MAPK or PKC inhibitor will prevent the SAH-induced kinase activation in brain vessels.

Increased 5-year mortality in the migrant South Asian stroke patients with diabetes mellitus in the United Kingdom - The West Birmingham Stroke Project

11/29/2007 01:36 PM

Indian Journal of Orthopaedics Year : 2007 Volume : 41 Issue : 4 Page : 295-299

The spinal cord injured patients if congregated early in spinal units where better facilities and dedicated expert care exist the outcome of treatment and rehabilitation, can be improved. The objective of this study is to find out the various factors responsible for a delay in the presentation of spinal injury patients to the specialized spinal trauma units and to suggest steps to improve the quality of care of the spinal trauma patients in the Indian setup.

MYCN regulates oncogenic MicroRNAs in neuroblastoma

11/29/2007 01:34 PM

International Journal of Geriatric Psychiatry Volume 22, Issue 12 , Pages 1241 - 1246

Awareness may lack in some stroke patients who are not capable of evaluating the nature and severity of illness. Thus, unawareness may have different forms such as anosognosia, neglect, and alexithymia or unawareness of emotions. In this study we investigated the relationship among anosognosia, neglect, alexithymia, and cognition.

Anti-flatulence treatment and status epilepticus - a case of camphor intoxication

11/29/2007 01:31 PM

Critical Care Medicine. 35(12):2830-2836, December 2007

To determine whether nonconvulsive electrographic post-traumatic seizures result in increases in intracranial pressure and microdialysis lactate/pyruvate ratio.

Migraine and delayed ischaemic neurological deficit after subarachnoid haemorrhage in women: a case-control study

11/29/2007 01:28 PM

Epilepsia doi:10.1111/j.1528-1167.2007.01424.x

Previous reports have summarized the seizures types occurring in 1p36 deletion syndrome. To better define the spectrum of epilepsy, we studied 91 patients (median age 7.8 years) with confirmed 1p36 deletion.

Voice abnormalities and their relation with motor dysfunction in Parkinson’s disease

11/29/2007 01:25 PM

Pediatric Neurosurgery 2007;43:507-511

We present the case of a 6-year-old girl who developed bilateral subdural fluid collections following transection of her fatty filum terminale. The patient presented to our emergency department 3 weeks subsequent to surgery, reporting symptoms of headache, nausea, and vomiting.

Hepatic Pseudocyst as a Result of Ventriculoperitoneal Shunts - Case Report and Review of the Literature

11/29/2007 01:23 PM

Neuroepidemiology 2007;29:178-184

This nationwide study aimed to enhance available data by determining sibling risks of subarachnoid hemorrhage in a total population. The MigMed database at the Karolinska Institute, Stockholm, was used to identify all cases of subarachnoid hemorrhage diagnosed in Sweden between 1987 and 2001.

Statin therapy and stroke prevention what was known what is new and what is next

11/29/2007 01:20 PM

Acta Neurologica Scandinavica doi:10.1111/j.1600-0404.2007.00953.x

There is limited information about distribution of etiologies of ischemic stroke in different age groups.

The Cost of Pediatric Stroke Care and Rehabilitation

11/29/2007 01:16 PM

Epilepsia doi:10.1111/j.1528-1167.2007.01417.x

Parents often expect immediate seizure improvement after starting the ketogenic diet (KD) for their children. The purpose of this study was to determine the typical time to seizure reduction as well as the time after which it was unlikely to be helpful in those children started on the KD.

Risk factor status and vascular events in patients with symptomatic intracranial stenosis

11/27/2007 02:49 PM

NEUROLOGY 2007;69:E27-E29

In their article, "Neuropsychological and Neurophysiologic Effects of Carbamazepine and Levetiracetam," Dr. Meador and his colleagues describe the results of a detailed study designed to look at how antiseizure medications affect a person's thinking.

FERTILITY IN WOMEN WITH ACTIVE EPILEPSY

11/27/2007 02:47 PM

NEUROLOGY 2007;69:2054-2062

To delineate factors associated with cognitive function following stroke and test the hypothesis that vascular risk factors associated with oxidative stress impair recovery.

TGF-Beta1 and TGF-Beta2 expression after traumatic human spinal cord injury

11/27/2007 02:45 PM

Spinal Cord 27 November 2007

To create the International Lower Urinary Tract Function Basic Spinal Cord Injury (SCI) Data Set within the framework of the International SCI Data Sets.

Rasmussen encephalitis associated with SCN1A mutation

11/27/2007 02:42 PM

European Journal of Clinical Investigation, Volume 37, Number 12, December 2007 , pp. 925-932(8)

Based on the data of the Prospective Cardiovascular Munster (PROCAM) study, a prospective study of men and women at work in the north-west of Germany, we aimed (i) to develop a refined scoring scheme for calculating the risk of acute coronary events among adult and elderly men and women; and (ii) to generate a new scoring scheme for calculating the risk of ischaemic stroke or transient ischaemic attack (TIA).

Mechanisms underlying reversal of motor unit activation order in electrically evoked contractions after spinal cord injury

11/27/2007 02:39 PM

European Journal of Haematology doi:10.1111/j.1600-0609.2007.00971.x

The aim of this study was to assess the prevalence of inherited thrombophilia in 'peri-neonatal arterial ischemic stroke' (AIS), and its possible correlation with type of stroke and long-term neurological outcome.

Evaluation of 2 whole-brain radiotherapy schedules and prognostic factors for brain metastases in breast cancer patients

11/27/2007 02:37 PM

Cancer Volume 110, Issue 11 , Pages 2535 - 2541

An open-label Phase II study of tipifarnib was conducted to evaluate its safety and efficacy in children with recurrent or refractory medulloblastoma (MB)/primitive neuroectodermal tumor (PNET), high-grade glioma (HGG), and diffuse intrinsic brainstem glioma (BSG).

Is Intracranial Pressure Waveform Analysis Useful in the Management of Pediatric Neurosurgical Patients

11/27/2007 02:34 PM

European Journal of Neurology, Volume 14, Number 12, December 2007 , pp. 1351-1356(6)

Renal dysfunction predicts mortality in patients with myocardial infarction but less is known about the impact of renal dysfunction on in-hospital mortality after ischaemic stroke.

Effect of Antimicrobial Compounds on Balamuthia mandrillaris Encystment and Human Brain Microvascular Endothelial Cell Cytopathogenicity

11/27/2007 02:31 PM

Journal of the Medical Association of Thailand Vol90 No.11 2271 2526

The medical students’ knowledge about basic medical neuroscience in the preclinical level may be fragmented and incomplete.

In-Hospital Stroke in a Statewide Stroke Registry

11/27/2007 02:29 PM

Cerebrovascular Diseases 2008;25:26-31

Mortality studies in lacunar (LAC) stroke are scarce and often characterized by short follow-up time, small patient groups and absence of a nonlacunar stroke group for comparison. Besides, there are no separate long-term prognostic data on LAC stroke subtypes. We performed a long-term mortality study in LAC stroke, subtyping two distinct phenotypes and including nonlacunar ischemic stroke for comparison.

A Randomized Double-Blind Study Comparing the Safety and Efficacy of Clopidogrel versus Ticlopidine in Japanese Patients with Noncardioembolic Cerebral Infarction

11/27/2007 02:25 PM

Stroke doi: 10.1161/STROKEAHA.107.486134

Apposition of endothelial cells and astrocyte foot processes to the basal lamina matrix is postulated to underlie the cerebral microvessel permeability barrier. Focal cerebral ischemia induces rapid loss of select matrix-binding integrins from both cell compartments in the nonhuman primate. This study is the first to examine the conditions underlying integrin loss from these cell-types during ischemia in vitro and their relation to the changes in vivo.

Glioblastoma-derived stem cell-enriched cultures form distinct subgroups according to molecular and phenotypic criteria

11/27/2007 02:22 PM

American Journal of Epidemiology 2007 166(12):1446-1450

Erectile dysfunction is common among individuals with Parkinson's disease, but it is unknown whether it precedes the onset of the classic features of Parkinson's disease. To address this question, the authors examined whether erectile dysfunction was associated with Parkinson's disease risk in the Health Professionals Follow-up Study.

Post-craniotomy headache: characteristics behaviour and effect on quality of life in patients operated for treatment of supratentorial intracranial aneurysms

11/27/2007 02:18 PM

Pediatric Emergency Care. 23(11):820-822, November 2007

Pott puffy tumor is an osteomyelitis of the frontal bone with the development of a subperiosteal abscess manifesting as a puffy swelling of the forehead or scalp. It is believed to occur as a complication of frontal sinusitis. The modern antibiotic era has made it a rarely encountered entity. This case describes a 4-year-old boy who presented in status epilepticus secondary to Pott puffy tumor.

Blood-Borne Tissue Factor Activity Predicts Major Cerebrovascular Events in Patients Undergoing Carotid Endarterectomy - Results from a 1-Year Follow-Up Study

11/27/2007 02:15 PM

Stroke doi: 10.1161/STROKEAHA.107.493320

Stroke outcome assessment requires some measure of functional recovery. Several instruments are in common use but all have recognized limitations. We examined duration of stay in the patient's own home over the first 90 days since stroke - "home-time" - as an alternative outcome likely to show graded response with improved reliability.

Determinants of Change in Quality of Life from 1 to 6 Months following Acute Stroke

11/27/2007 02:12 PM

Stroke doi: 10.1161/STROKEAHA.106.476648

A previous randomized, placebo-controlled, double-blind study suggested that abciximab may be safe and effective in treatment of acute ischemic stroke. The current phase 3 study was planned to test the relative efficacy and safety of abciximab in patients with acute ischemic stroke with planned treatment within 5 hours since symptoms onset.

Duration of complex partial seizures - An intracranial EEG study

11/27/2007 02:09 PM

Epilepsia doi:10.1111/j.1528-1167.2007.01412.x

This brief report covers an analysis of 7 years outcome data from the Australian Register of Antiepileptic Drugs in Pregnancy.

Unique dual mechanism of action of eprosartan - effects on systolic blood pressure, pulse pressure risk of stroke and cognitive decline

11/24/2007 09:58 AM

Journal of Stroke & Cerebrovascular Diseases Volume 16, Issue 6, Pages 278-284 (November 2007)

POEMS syndrome is a disorder characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. Castleman’s disease is a rare lymphoproliferative disorder that can be present in patients with POEMS syndrome.

Reperfusion Seizures - A Manifestation of Cerebral Reperfusion Injury After Administration of Recombinant Tissue Plasminogen Activator for Acute Ischemic Stroke

11/24/2007 09:54 AM

Journal of Stroke & Cerebrovascular Diseases Volume 16, Issue 6, Pages 263-267 (November 2007)

Secondary stroke prevention is an important goal of poststroke patient treatment. Various pharmacologic approaches have been advocated, but the relative efficacy and safety of these regimens has remained the subject of much debate.

Controversy of Surgical Treatment for Severe Cerebellar Infarction

11/24/2007 09:52 AM

Journal of Stroke & Cerebrovascular Diseases Volume 16, Issue 6, Pages 251-258 (November 2007)

White matter lesions (WMLs) are frequent in elderly people, and have been associated with impaired activities of daily living (ADL) and cognitive decline. We sought to examine the role of WMLs and their extent, in regard to basic ADL, instrumental ADL (IADL), and cognitive functions, in a large well-defined cohort examined 3 months after an ischemic stroke.

Prediction of Subarachnoid Hemorrhage From a Ruptured Cerebral Aneurysm by Discriminant Analysis in Women

11/24/2007 09:50 AM

Journal of Stroke & Cerebrovascular Diseases Volume 16, Issue 6, Pages 239-244 (November 2007)

Hypoxia is common after acute stroke. Most studies of oxygenation after stroke were done at night. The objective of this study was to determine whether there are differences in oxygenation between day and night early after stroke.

Teflon sponge shunt for recurrent arachnoid cyst

11/23/2007 11:57 AM

Neurology India Year : 2007 Volume : 55 Issue : 4 Page : 423-424

Blunt trauma to the head may result in extradural hematomas, which are common over the temporoparietal region and associated with injury to the meningeal arteries. Subperiosteal hematomas of the orbit are rare presentations after head injury, with only a few cases reported in the literature.

Magnetic resonance spectroscopy study in basal ganglia of patients with myoclonic epilepsy with ragged-red fibers

11/23/2007 11:55 AM

Neurology India Year : 2007 Volume : 55 Issue : 4 Page : 431

62-year-old man was admitted to the neurosurgery department for sudden onset headache. Computerized tomography (CT) scan showed a subarachnoid hemorrhage (SAH).

Intracerebral hemorrhage in a patient with Churg-Strauss syndrome

11/23/2007 11:53 AM

Neurology India Year : 2007 Volume : 55 Issue : 4 Page : 349-354

Head injury contributes significantly to mortality and morbidity in India. Evaluation of the available trauma care facilities may help improve outcome.

Health-related quality of life using QOLIE-31 - Before and after epilepsy surgery a prospective study at a tertiary care center

11/23/2007 11:50 AM

Neurology India Year : 2007 Volume : 55 Issue : 4 Page : 429-43

Schwannomas are benign well-encapsulated tumors arising from the schwann cells surrounding the peripheral nerves. Schwannomas of the paranasal sinuses and nasopharynx are very rare lesions, with involvement of the skull base by these tumors very uncommon.

Gender differences in blood lipids and the risk of ischemic stroke among the hypertensive adults in rural China

11/23/2007 11:48 AM

Neurology India Year : 2007 Volume : 55 Issue : 4 Page : 434-435

The authors report a case of intracranial germinoma with raised levels of Beta-human chorionic gonadotrophin (HCG) and placental alkaline phosphatase (PLAP) in cerebrospinal fluid (CSF), with normal levels in the blood.

Dysmyelinating neuropathy in benign form of megalencephalic leukoencephalopathy with subcortical cysts - A novel observation from south India

11/23/2007 11:45 AM

Neurology India Year : 2007 Volume : 55 Issue : 4 Page : 432-433

Localized progressive intravascular accumulation of atheromatous deposits represents the leading cause of stenosis or occlusion of the brain supplying arteries in adults. These atherosclerotic changes may be found extra- and intracranially within the anterior and the posterior circulation with varying extent.

Brain cells - recently unveiled secrets -Their clinical significance

11/23/2007 11:42 AM

Neurology India Year : 2007 Volume : 55 Issue : 4 Page : 410-412

The co-existence of cerebral aneurysms and pituitary adenomas is rare. Here, we report a patient with a coexisting anterior communicating artery aneurysm and a pituitary adenoma and review the available literature concerning this phenomenon.

Anesthesia for awake craniotomy - A retrospective study

11/23/2007 11:39 AM

Neuron, Vol 56, 726-740, 21 November 2007

The brain's perceptual stimuli are constantly changing: some of these changes are treated as invariances and are suppressed, whereas others are selectively amplified, giving emphasis to the distinctions that matter most. The starkest form of such amplification is categorical perception.

Body Movement Induced by Electrical Stimulation of Toe Muscles During Standing

11/21/2007 03:18 PM

Disability & Rehabilitation, Volume 29, Issue 24 2007 , pages 1847 - 1857

The purpose of this study was to examine the psychosocial adjustment patterns of a community sample of persons with spinal cord injury in Taiwan.

The Spinal Cord Independence Measure SCIM version III - Reliability and validity in a multi-center international study

11/21/2007 03:15 PM

Disability & Rehabilitation, Volume 29, Issue 24 2007 , pages 1858 - 1869

This paper examines respondents' relationship with work following a stroke and explores their experiences including the perceived barriers to and facilitators of a return to employment.

Identification of risk factors related to perceived unmet demands in patients with chronic stroke

11/21/2007 03:08 PM

Disability and Rehabilitation: Assistive Technology, Volume 2, Issue 6 November 2007 , pages 358 - 365

This paper provides an overview of the development of a wheelchair users registry and subsequently describes a population of individuals who use wheelchairs. The characteristics of Americans who permanently use wheelchairs and scooters are currently unknown.

Consumer design priorities for upper limb prosthetics

11/21/2007 12:23 PM

Current Opinion in Neurology. 20(6):609-613, December 2007

Patients in a vegetative or minimally conscious state continue to pose problems in terms of diagnosis, prognosis and treatment. Despite recent waves of international media attention following Terri Schiavo's death and the 'miracle recovery' of Terry Wallis, research efforts aimed at increasing our knowledge about brain function in these conditions remain scarce and must address a series of difficulties, including financial and ethical barriers. Here we review current possibilities and limitations of clinical and para-clinical assessment of chronic disorders of consciousness.

Deep brain stimulation and cognition: moving from animal to patient

11/21/2007 12:21 PM

Current Opinion in Neurology. 20(6):643-649, December 2007

To summarize recent developments and look at important future aspects of brain-computer interfaces.

Testing Graceful Degradation in a Patient with Aphasia

11/21/2007 12:19 PM

Cancer Epidemiology Biomarkers & Prevention 16, 2491-2495, November 1, 2007

Previous studies have been inconclusive in estimating the risk of different cancer sites among close relatives of glioma patients; however, malignant melanoma has consistently been described.

Phosphorylated Pak1 Level in the Cytoplasm Correlates with Shorter Survival Time in Patients with Glioblastoma

11/21/2007 12:17 PM

American Journal of Neuroradiology 28:1880-1881, November-December 2007

Extraosseous chondroblastoma had been reported in different parts of the body but not intracranially. We report a case of a pathologically proven intracranial extraosseous chondroblastoma of the right cavernous sinus in an 18-year-old woman with CT, MR, and conventional angiographic features simulating meningioma.

The role of impaired neuronal communication in neurological disorders

11/21/2007 12:02 PM

Journal of Neurotrauma. 2007, 24(11): 1707-1718

This study performed a comprehensive analysis of cerebrospinal fluid (CSF) cytokine levels after severe traumatic brain injury (TBI) in children using a multiplex bead array assay and to evaluate the effects of moderate hypothermia on cytokine levels.

Early Excision and Late Excision of Heterotopic Ossification after Traumatic Brain Injury Are Equivalent A Systematic Review of the Literature

11/21/2007 11:59 AM

Neurocase, Volume 13, Issue 4 August 2007 , pages 256 - 259

Previous research suggests that the noradrenergic system modulates flexibility of access to the lexical-semantic network, with propranolol benefiting normal subjects in lexical-semantic problem solving tasks. Patients with Broca's aphasia with anomia have impaired ability to access appropriate verbal output for a given visual stimulus in a naming task.

Theoretical Basis of Hemodynamic MR Imaging Techniques to Measure Cerebral Blood Volume Cerebral Blood Flow and Permeability

11/21/2007 11:57 AM

American Journal of Neuroradiology 28:1890-1894, November-December 2007

Anterior cerebral artery (ACA) emboli may occur before or during fibrinolytic revascularization of middle cerebral artery (MCA) and internal carotid artery (ICA) T occlusions.

Flat Panel Detector Angiographic CT for Stent-Assisted Coil Embolization of Broad-Based Cerebral Aneurysms

11/21/2007 11:55 AM

Current Opinion in Neurology. 20(6):614-619, December 2007

The burden of proof for establishing diagnosis and prognosis in patients with disorders of consciousness lies with behavioral assessment methods. The current review discusses recent advances in understanding the strengths and weaknesses of this methodology.

Functional MRI in disorders of consciousness: advantages and limitations

11/21/2007 11:51 AM

Current Opinion in Neurology. 20(6):620-626, December 2007

Pain and suffering controversies in persons with disorders of consciousness continue to be debated by the scientific, legal and medical ethics communities. This review examines the current knowledge base for guiding decisions regarding assessment and management of pain in persons with disorders of consciousness.

N200 latency and P300 amplitude in depressed mood post-traumatic brain injury patients

11/20/2007 09:51 AM

Journal of Head Trauma Rehabilitation. Screening and Identification of TBI. 22(6):350-359, November/December 2007

The Minimum Data Set (MDS) is a standardized, federally mandated assessment tool used to identify the needs of nursing home residents and rehabilitation and nursing services received on a routine basis. These data can be used to identify people with traumatic brain injury (TBI), where a diagnosis is recorded. However, both limitations of the MDS and the presence of other neurological issues that can be confused with TBI can reduce the likelihood that brain injury is identified where it exists. The article discusses innovative methodological approaches and challenges to using the MDS data to identify people with TBI in nursing homes.

Comparison of Nursing Home Residents With and Without Traumatic Brain Injury - Use of the Minimum Data Set

11/20/2007 09:48 AM

Journal of Head Trauma Rehabilitation. Screening and Identification of TBI. 22(6):411-412, November/December 2007

Initial Reliability and Validity of the Ohio State University TBI Identification Method

11/20/2007 09:46 AM

Journal of Head Trauma Rehabilitation. Screening and Identification of TBI. 22(6):339-349, November/December 2007

This study explored the reliability and validity of the Screening Tool for the Identification of Acquired Brain Injury in School-Aged Children (STI).

Brain Injury Medicine - Principles and Practice

11/20/2007 09:45 AM

Journal of Head Trauma Rehabilitation. Screening and Identification of TBI. 22(6):315-317, November/December 2007

Screening for Traumatic Brain Injury in an Offender Sample - A First Look at the Reliability and Validity of the Traumatic Brain Injury Questionnaire

11/20/2007 09:43 AM

Journal of Head Trauma Rehabilitation. Screening and Identification of TBI. 22(6):377-389, November/December 2007

Preliminary assessment of a new instrument, the Brief Traumatic Brain Injury Screen (BTBIS).

Screening Substance Abuse Treatment Clients for Traumatic Brain Injury - Prevalence and Characteristics

11/20/2007 09:41 AM

Journal of Head Trauma Rehabilitation. Screening and Identification of TBI. 22(6):403-408, November/December 2007

The Rehabilitation Research and Training Center on Measuring Rehabilitation Outcomes and Effectiveness along with academic, professional, provider, accreditor, and other organizations sponsored a 2-day State of the Science of Post-Acute Rehabilitation Symposium in February 2007. The aim of this symposium was to serve as a catalyst for expanded research on postacute care (PAC) rehabilitation so that health policy is founded on a solid evidence base.

Topiramate in Traumatic Brain Injury - Adverse Effects on Cognitive Function

11/20/2007 09:39 AM

Journal of Head Trauma Rehabilitation. Screening and Identification of TBI. 22(6):390-402, November/December 2007

Violence, abuse, and neglect (VAN) among people with physical and other disabilities has been reported; however, little is known about VAN experiences among people with traumatic brain injuries (TBI).

Practice Parameter - Evaluating an apparent unprovoked first seizure in adults - an evidence-based review

11/20/2007 09:36 AM

Neurology.2007; 69: 1968-1969

The longitudinal relationship between lipid profile and physical capacity in persons with a recent spinal cord injury

11/20/2007 09:07 AM

Spinal Cord 20 November 2007

Pulmonary functional capacity in 23 Brazilian quadriplegic subjects (ASIA A), aged 30 (9.5) years, weight 66 (10.75) kg, height 176 (7) cm, was investigated at 42 (64) months postinjury.

Comparative shoulder kinematics during free standing, standing depression lifts and daily functional activities in persons with paraplegia - considerations for shoulder health

11/20/2007 09:05 AM

Spinal Cord 20 November 2007

The objective of this article is to probe the surgical procedures of treatment for Chiari I malformation (CMI) associated with syringomyelia and evaluate their efficacy based on clinical and neuroradiological results.

Left hemispheric dominance during auditory processing in noisy environment

11/20/2007 09:02 AM

American Journal of Neuroradiology 28:2008-2013, November-December 2007

We assessed the underestimation of cerebral perfusion measured by the flow-sensitive alternating inversion recovery (FAIR) technique in patients with carotid stenosis and compared the technique with dynamic susceptibility contrast (DSC) MR images.

Setting an alert for tick-borne encephalitis

11/20/2007 08:59 AM

Current Opinion in Pediatrics. 19(6):657-662, December 2007

Pediatric arterial ischemic stroke is relatively rare but carries a considerable impact and high risk of recurrence - especially in patients with sickle cell disease and various forms of vasculopathy. We will discuss risk factors, vascular physiology, and primary/secondary/rehabilitative therapies. Goals for future investigation and treatment are suggested.

Tumors in Pediatric Patients at Diffusion-weighted MR Imaging - Apparent Diffusion Coefficient and Tumor Cellularity

11/20/2007 08:56 AM

American Journal of Neuroradiology 28:1964-1967, November-December 2007

Hyperintense CSF in the subarachnoid space (SAS) on fluid-attenuated inversion recovery (FLAIR) imaging has been reported in numerous pathologic conditions, including subarachnoid hemorrhage, meningitis, meningeal carcinomatosis, superior sagittal thrombosis, adjacent tumors, status epilepticus, and stroke.

Blood Vessel Morphologic Changes Depicted with MR Angiography during Treatment of Brain Metastases - A Feasibility Study

11/20/2007 08:54 AM

Indian Journal of Orthopaedics Year : 2007 Volume : 41 Issue : 4 Page : 253-254

The spinal cord and cauda equina are injured by disruption of neural tissues by violation of the spinal canal by bony missiles (pieces) entering into the spinal canal as a result of impact. The acute compression of the spinal cord produces histologically appreciable and irreversible secondary changes in the spinal cord.

Recovery and treatment of aphasia after stroke - functional imaging studies

11/20/2007 08:52 AM

American Journal of Neuroradiology 28:1915-1918, November-December 2007

Marginal sinus fistulas (MSFs) are uncommon vascular anomalies. Occasionally, the dominant venous drainage is forced retrograde up the inferior petrosal sinus and into the cavernous sinus, causing chemosis, proptosis, and ocular hypertension, mimicking a carotid cavernous fistula. This atypical clinical presentation may lead to misdiagnosis and inappropriate hazardous treatment of an MSF. Identifying the site of the fistula and understanding the anatomy of the venous drainage are critical in providing appropriate, safe, and efficacious endovascular treatment.

Exploring impaired consciousness - the MRI approach

11/20/2007 08:49 AM

Current Opinion in Neurology. 20(6):708-711, December 2007

Knowledge of the molecular biology of gliomas may improve therapy. This review highlights several recent studies on this topic.

Acute subcortical stroke and early serotonergic modification - a IDAP study

11/20/2007 08:47 AM

Current Opinion in Pediatrics. 19(6):670-674, December 2007

Childhood primary central nervous system tumors remain a therapeutic conundrum. As the second most common pediatric cancer, brain tumors lead to significantly worse survival and long-term effects compared with those seen with hematologic malignancies and other solid tumors. This review discusses current management strategies in three pediatric brain tumors, the long-term effects of therapy, as well as novel laboratory findings that may alter future treatment strategies.

A Pilot Study of Randomized Clinical Controlled Trial of Gait Training in Subacute Stroke Patients With Partial Body-Weight Support Electromechanical Gait Trainer and Functional Electrical Stimulation. Six-Month Follow-Up

11/20/2007 08:44 AM

Cancer Nursing. 30(6):E33-E39, November/December 2007

The purpose of this pilot study was to assess the level of stress experienced by caregivers of brain tumor patients and to examine both their interest in and preferences for stress reduction programs. Using a convenience sample of 60 adult caregivers, we distributed a study questionnaire that examined the caregivers' level of stress, beliefs, past experiences, and preferences in regard to stress reduction programs.

Concepts in Magnetic Resonance Part A

11/20/2007 08:40 AM

Acta Neurologica Scandinavica doi:10.1111/j.1600-0404.2007.00948.x

To provide functional magnetic resonance imaging-based insight into the impact of left temporal lobe epilepsy (TLE) on language-related functional re-organization.

High risk of pituitary dysfunction due to aneurysmal subarachnoid haemorrhage - a prospective investigation of anterior pituitary function in the acute phase and 12 months after the event

11/20/2007 08:36 AM

Radiology 2007;245:831-838

To prospectively and externally validate published national and international guidelines for the indications of computed tomography (CT) in patients with a minor head injury.

Sixty-Four-Row Multisection CT Angiography for Detection and Evaluation of Ruptured Intracranial Aneurysms Interobserver and Intertechnique Reproducibility

11/20/2007 08:29 AM

NEUROLOGY 2007;69:2020-2027

Providers are increasingly being held accountable for the quality of care provided. While quality indicators have been used to benchmark the quality of care for a number of other disease states, no such measures are available for evaluating the quality of care provided to adults with epilepsy. In order to assess and improve quality of care, it is critical to develop valid quality indicators.

Why the West in West Nile virus infections

11/17/2007 12:13 PM

Journal of Neurotrauma. 2007, 24(11): 1761-1772

Neuropathic pain and motor dysfunction are difficult problems following spinal cord injury (SCI). Social and environmental enrichment (SEE), which models much of the clinical rehabilitation environment for post-SCI persons, is the focus of the current investigation which examines the effects of multiple-housing and the addition of climbing spaces, improved bedding and crawl toys on the sensory and motor recovery following a severe contusive SCI.

Prolonged Response to Oral Gefitinib Cyclophophamide and Topotecan in Heavily Pretreated Relapsed Stage 4 Neuroblastoma A Case Report

11/17/2007 12:10 PM

Archives of Pathology and Laboratory Medicine: Vol. 131, No. 11, pp. 1686-1690

Brain metastases of adenocarcinoma of unknown primary pose a diagnostic dilemma to the surgical pathologist. Although the most common source in these cases is the lung, determining a primary source is difficult on routinely stained slides. Immunohistochemical stain panels including differential cytokeratins, hormone receptors, and breast-specific proteins are commonly used in these cases. Recently, attention has turned to tissue-specific transcription factors, such as thyroid transcription factor 1 (TTF-1) and Cdx2, in the appraisal of metastatic adenocarcinomas.

Acute stroke patients - Early hospital management

11/17/2007 12:08 PM

Stroke doi: 10.1161/STROKEAHA.107.490334

Several studies indicate that stroke increases the risk of dementia. Most of these studies lacked the ability to take accurately assessed prestroke cognitive function into account. Whether the effects of stroke merely unravel an ongoing underlying dementing process or in fact cause the dementia has implications for the prevention of dementia in persons with cerebrovascular disease.

Ultrasound Diagnosis of Spontaneous Carotid Dissection With Isolated Horner Syndrome

11/17/2007 12:07 PM

Neurotrauma. 2007, 24(11): 1699-1706

Coagulopathy is a common phenomenon in traumatic brain injury (TBI) and a major contributor to a poor outcome. Thrombocytopenia is a strong negative prognostic factor in TBI, but bleeding tendency can be present even with a normal platelet count.

Cranial base approaches to inaccessible intracranial tumors

11/17/2007 12:04 PM

Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:1395-1397

A woman with epilepsy died during a seizure and the event was recorded on ambulatory EEG. The circumstances were typical of sudden death in epilepsy (SUDEP).

Recurrent lacunar infarction following a previous lacunar stroke a clinical study of 122 patients

11/17/2007 12:03 PM

Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:1390-1391

We aimed to validate a previously described six simple variable (SSV) model that was developed from acute and sub-acute stroke patients in our population that included hyper-acute stroke patients.

Distal lenticulostriate artery aneurysm in deep intracerebral haemorrhage

11/17/2007 11:59 AM

Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:1410-1411

Neurological side effects from calcineurin inhibitors (ciclosporin, tacrolimus) are most commonly mild, such as headaches, dysarthria, visual changes or postural tremor.

Incidence of subarachnoid haemorrhage a systematic review with emphasis on region, age, gender and time trends

11/17/2007 11:57 AM

Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:1314-1319

To determine the effect of electrode contact location on efficacy of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) for primary generalised dystonia (PGD).

Differential impact of cerebral white matter changes diabetes hypertension and stroke on cognitive performance among non-disabled elderly The LADIS study

11/17/2007 11:55 AM

Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:1331-1336

Thrombolysis of acute ischaemic stroke is based strictly on body weight to ensure efficacy and to prevent bleeding complications. Many candidate stroke patients are unable to communicate their body weight, and there is often neither the means nor the time to weigh the patient. Instead, weight is estimated visually by the attending physician, but this is known to be inaccurate.

A history of loss of consciousness or post-traumatic amnesia in minor head injury 'conditio sine qua non' or one of the risk factors

11/17/2007 11:53 AM

Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:1372

We recently observed a patient with obvious contralateral tongue deviation with minimal lower facial paresis caused by a small cortical infarction confirmed by MRI. The small cortical lesion, causing obvious tongue deviation in our patient, was located lateral to the precentral knob which is known as a reliable anatomical landmark for the motor hand area.

Stroke in patients with human immunodeficiency virus infection