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J Neuropsychiatry Clin Neurosci 18:547-549, November 2006
In a 6-week open-label, flexible dose pilot study of quetiapine for treatment of aggression secondary to traumatic brain injury
(TBI), seven subjects who were at least 3-months post-injury were enrolled. The Overt Aggression Scale - Modified (OAS-M) and Clinical Global Impression (CGI) were primary outcome measures.
Clinical Nuclear Medicine. 31(12):826-828, December 2006
Epilepsia partialis continua, or "Kozhevnikov syndrome," is a rare condition characterized by persistent localized motor seizures usually localized in a distant limb. It is most often seen in children under 16 years old without gender preference.
Moyamoya disease (MMD) is a cerebrovascular occlusive disease characterized by progressive stenosis or occlusion at the distal ends of bilateral internal arteries.
The purpose of this study was to compare cerebral CT venography with MR venography and determine the reliability of CT venography in the diagnosis of cerebral sinovenous thrombosis.
European Journal of Neurology, Volume 13, Number 12, December 2006, pp. 1271-1283(13)
Neuroimaging techniques are necessary for the evaluation of stroke, one of the leading causes of death and neurological impairment in developed countries. The multiplicity of techniques available has increased the complexity of decision making for physicians.
PEDIATRICS Vol. 118 No. 5 November 2006, pp. 2084-2093
The goals were to identify predictor variables and to develop scoring systems and classification trees to predict death/disability or death in infants with hypoxic-ischemic encephalopathy.
J Neuropsychiatry Clin Neurosci 18:536-542, November 2006
Cognitive auras seem to be associated with depression and anxiety, especially in patients with temporal lobe epilepsy
(TLE). Dissociative symptoms may occur as an aura or in the context of psychiatric disorders such as depression, anxiety or schizophrenia.
Overexpression of drug efflux pumps at the blood brain barrier (BBB) has been suggested to be one important factor contributing to drug resistance in epilepsy. This would imply that resected brain tissue of drug-resistant patients is drug-sensitive in absence of the BBB.
Our aim was to assess the outcome with regard to seizures and neurological function in unselected patients undergoing resective surgery involving the perirolandic area, with or without multiple subpial transections
(MSTs).
Clinical Nuclear Medicine. 31(12):774-780, December 2006
The purpose of this report was to investigate the potential of positron emission tomography using F-18 fluorodeoxythymidine (FLT-PET) in evaluating primary brain tumors.
The purpose of this study was to develop and prospectively evaluate the feasibility of a single-slab three-dimensional (3D) double inversion-recovery, or DIR, sequence for magnetic resonance imaging at 1.5 T.
Seizures are common during childhood. Each year, approximately 150,000 pediatric patients experience their first seizure, and 30,000 are found to have epilepsy. In addition, an estimated 4% to 10% of children have recurrent unprovoked seizures by age 18.
It is not known whether the antiepileptic drug (AED) levetiracetam can be used safely in human pregnancy. As part of a study to determine the risks of major congenital malformations
(MCMs) for infants exposed to AEDs in utero, we identified all cases exposed to
levetiracetam. Three of 117 exposed pregnancies had an MCM (2.7%; 95% CI 0.9% to 7.7%); all 3 were exposed to other AEDs
In the Multi-Centre Study of Early Epilepsy and Single Seizures (MESS), patients were randomly allocated to immediate or delayed antiepileptic drug treatment.
We performed an open-label phase II trial of oral pirfenidone in 24 patients with neurofibromatosis type 1 (NF1). Tumors were monitored by three-dimensional
MRI. At the end of treatment, four patients had a decrease in tumor volume by 15% or more, three had tumor progression, and 17 remained stable. Pirfenidone warrants further investigation in NF1, which has until now lacked an effective control therapy.
Patients with progressive nonfluent aphasia (PNFA) can become mute early in the course of the disease.
Voxel-based morphometry showed that PNFA is associated with left anterior insula and inferior frontal atrophy.
Thin-section noncontrast CT (NCT) can detect thrombi in large arteries and can provide a measure of thrombus composition based on Hounsfield Units
(HU).
We describe a 44-year-old woman with progressive headache, ataxia, and seizures in association with multifocal cerebral and cerebellar
leukoencephalopathy, intracranial calcifications, and cysts.
To investigate the relationship between language lateralization and handedness in patients with epilepsy and a left-sided seizure focus and in healthy control subjects.
To present and discuss the case of a patient who sustained a significant flexion compression injury of the cervical spine with resulting tetraplegia and development of cortical blindness.
The few studies concerning maximal static mouth respiratory pressures in patients with spinal cord lesions suggest a marked reduction. We studied the correlation of these parameters with the motor level of injury.
To report a patient whose recurrent and transient episodes of quadriplegia mimicked cervical cord
neurapraxia. Cervical spine neuroimaging revealed congenital intersegmental fusion of C5 through C7 (consistent with Klippel-Feil anomaly), corresponding abnormal spinal cord signals on T2-weighted images and enhancing focal lesion opposite the C4 vertebral body.
Brain Injury Volume 20, Number 11 / October 2006 1111 - 1117
To identify best practices and promising practices to enhance participation in meaningful and productive activities. An electronic search of the ABI rehabilitation research literature since 1990 yielded 974 articles of which 30 focused on interventions that targeted participation and evaluated effectiveness using direct measures of participation. Three reviewers rated these articles according to the standards set out by the Centre for Reviews and Dissemination. Following the systematic review, an interpretive review of the same articles was completed.
Brain Injury Volume 20, Number 11 / October 2006 1119 - 1129
To report the outcome of 232 clients undertaking Rehab UKs Vocational Rehabilitation
Programme, over three consecutive years, in three centres across the UK.
Brain Injury Volume 20, Number 11 / October 2006 1131 - 1137
Mild traumatic brain injury (MTBI) defined as Glasgow Coma Scale (GCS) 14 or 15 has shown contradictory short- and long-term outcomes. The objective of this study was to correlate intra-cranial injuries
(ICI) on CT scan to neurocognitive tests at admission and to complaints after 1 year.
Brain Injury Volume 20, Number 11 / October 2006 1147 - 1154
To examine the role played by two interviewing methods used (spontaneous response and suggested response) in the evaluation of long-term subjective post-mild traumatic brain injury
(mTBI) symptoms.
Brain Injury Volume 20, Number 11 / October 2006 1155 - 1162
Traumatic brain injury (TBI) is a significant health problem disproportionately affecting men and is often associated with changes in masculine role functioning in life domains such as vocational functioning, sexual and inter-personal functioning and personal independence. These changes could have serious implications for men's adjustment following injury. The aim of this study was to examine the relations among traditional masculine role adherence, psychosocial adjustment and rehabilitation outcomes in men with
TBI.
Brain Injury Volume 20, Number 11 / October 2006 1175 - 1182
Agitation following traumatic brain injury (TBI) is perceived to limit the achievement of rehabilitation goals. The aims of this study were: (1) To examine the nature and incidence of agitation during TBI rehabilitation in an Australian sample; and (2) To explore the relationship between agitation and functional outcomes after
TBI.
Brain Injury Volume 20, Number 11 / October 2006 1183 - 1188
To describe the functional outcome of 19 patients with anterior communicating artery aneurysm following the completion of an inter-disciplinary out-patient rehabilitation
programme.
Brain Injury Volume 20, Number 11 / October 2006 1189 - 1205
To examine the utility of a coordinated, family/community-focused programme
(PABICOP) vs. a standard approach for improving outcomes for children with ABI and their families.
Brain Injury Volume 20, Number 11 / October 2006 1207 - 1219
This case study aims to evaluate the effectiveness of the Solhberg and Mateer's Attention Process Training (APT) using a comprehensive evaluation of various attentional processes. Two patients with severe traumatic brain injury were given the APT in a chronic phase. Attentional processes were evaluated at various stages before, during and after treatment, using the Testbatterie zur Aufmerksamkeitsprufung and the Test of everyday attention.
Journal of Infection Volume 53, Issue 6 , December 2006, Pages e247-e249
Leptospirosis is an acute infectious disease caused by a spirochete of the leptospira gender and it is characterized by severe
vasculitis. It is not common for leptospirosis to present as a primary neurological disease. On the other hand, no study has been reported on the progression of cerebral venous thrombosis
(CVT) in patients with leptospirosis so far.
Clinical Neurology and Neurosurgery Volume 108, Issue 8 , December 2006, Pages 750-756
The annual hemorrhage rate of intracranial cavernous malformation (CM) is reported to range from 0.23% to 1.1%. Because of the low hemorrhage rate, operating on a deep symptomatic lesion with or without hemorrhage is considered controversial.
The impact of lipometabolic and glucometabolic disturbances on stroke incidence remains to be characterized in detail. We investigated relations of a comprehensive panel of baseline lipometabolic and glucometabolic variables to incident fatal and nonfatal stroke or transient ischemic attack (TIA), and stroke subtypes.
To evaluate the role of non contrast-enhanced multidetector computed tomography
(MDCT) in the detection of ring lesions in the brain in patients from the Indian subcontinent, presenting with seizures.
Seminars in Fetal and Neonatal Medicine Volume 11, Issue 6 , December 2006, Pages 498-502
The first clinical application of near-infrared spectroscopy (NIRS) was made 20 years ago on the head of newborn infants under intensive care. Since then NIRS has yielded much credible and some important clinical research data.
A treatment combining semantic feature analysis and semantic priming was carried out on three Cantonese-speaking brain-injured individuals with word-finding difficulties. Two of the participants with mild to moderate semantic impairment demonstrated significant progress on naming performance.
In this study we analysed the outcome of computer-assisted therapy (CAT) for anomia on eight acute aphasic patients. Since therapy for anomia generally leads to an item-specific effect, the aim of the present study was to investigate whether it is possible to enhance recovery from anomia by increasing the number of treated items.
A novel modified passive line-bisection test was performed using a computer display with a moving image. In the test, the subjects were required to give verbal responses instead of limb movements. The test, consisting of two subtasks, left-to-right and right-to-left tasks, was applied to patients with unilateral neglect and controls.
A combination of detailed observation of dressing behaviour and neuropsychological assessment was used to identify the cognitive barriers to independent dressing in a series of eight stroke patients. For those with right hemisphere damage, dressing was disrupted by visuospatial problems or poor sustained attention.
A group of 62 adults with significant (i.e., ventilation required for > 24 hours) traumatic brain injury
(TBI) were assessed approximately one year following their injury. The people with TBI and their primary caregivers completed the patient and relative/friend versions respectively, of the 20-item Head Injury Behaviour Rating Scale
(HIBS).
Temozolomide (TMZ) administered daily with radiation therapy (RT) for six weeks, followed by adjuvant TMZ for six months, has become standard therapy for patients with glioblastoma multiforme
(GBM).
Cloretazine (VNP40101M) is a newly synthesized alkylating agent belonging to a novel class of alkylating agents called 1,2-bis(sulfonyl)hydrazines. Agents that belong to this class do not produce vinylation and chloroethylation species, and hence this class of alkylating agents is thought to have minimal systemic toxicity.
Common end points for phase II trials in patients with glioblastoma multiforme
(GBM) are six-month progression-free survival (PFS6) and 12-month overall survival (OS12). OS12 can be accurately measured but may be confounded with subsequent therapies upon progression, whereas the converse is true for PFS6.
Despite multimodal treatment options, the response and survival rates for patients with malignant gliomas remain dismal. Clinical trials with convection-enhanced delivery
(CED) have recently opened a new window in neuro-oncology to the direct delivery of chemotherapeutics to the CNS, circumventing the blood-brain barrier and reducing systemic side effects.
The alkylation products formed by in vitro treatment of DNA with tritium-labeled 1,3-bis(2-chloroethyl)-1-nitrosourea (3H-BCNU) were identified and quantified.
We evaluated the course of neurocognitive functioning in newly diagnosed high-grade glioma patients and specifically the effect of tumor recurrence. Following baseline assessment (after surgery and before radiotherapy), neurocognitive functioning was evaluated at 8 and 16 months.
Clinical Neurology and Neurosurgery Volume 108, Issue 8 , December 2006, Pages 798-802
We describe the use of an artificial dural substitute in order to prevent peridural fibrosis in patients who underwent craniectomy and subsequent
cranioplasty.
Magnetic Resonance Imaging Volume 24, Issue 8 , October 2006, Pages 1015-1022
In survivors of pediatric brain tumors, cranial radiation therapy can cause a debilitating cognitive decline associated with decreased volume in normal-appearing white matter
(NAWM). We applied fractal geometry to quantify white matter (WM) integrity in the brain of medulloblastoma survivors.
(1) To examine whether the KleinBell ADL Scale (KB Scale) discriminates cervical spinal cord injury (SCI) patients in daily activities and to explore its applicability in this group of patients. (2) To examine the association between basic ADL and upper extremity function. (3) To investigate if grip ability can be discerned in the scale.
Journal of Head Trauma Rehabilitation. Focus on Clinical Research and Practice, Part 3. 21(6):514-526, November/December 2006
To explore the long-term relations among sociodemographic, neurologic, clinical, and neuropsychologic variables, and vocational status in persons with mild traumatic brain injury
(MTBI), and to identify the symptoms that determine whether or not these individuals return to work.
Journal of Head Trauma Rehabilitation. Focus on Clinical Research and Practice, Part 3. 21(6):544-548, November/December 2006
Traumatic brain injury (TBI) is an important public health problem in the United States. In 2003, there were an estimated 1,565,000 TBIs in the United States: 1,224,000 emergency department visits, 290,000 hospitalizations, and 51,000 deaths.
Journal of Head Trauma Rehabilitation. Focus on Clinical Research and Practice, Part 3. 21(6):537-543, November/December 2006
To document age-related patterns of nonfatal hospitalization associated with traumatic brain injury
(TBI) among children younger than 2 years of age, by intent/cause and diagnosis.
Journal of Head Trauma Rehabilitation. Focus on Clinical Research and Practice, Part 3. 21(6):505-513, November/December 2006
To determine whether a dose-response relation exists between the number of reported close friends and traumatic brain injury
(TBI) severity in the postacute phase in school-age children.
Journal of Head Trauma Rehabilitation. Focus on Clinical Research and Practice, Part 3. 21(6):453-466, November/December 2006
To develop a multivariate model of the dynamic interactions among key variables associated with relative distress and disrupted family functioning after traumatic brain injury
(TBI).
Journal of Head Trauma Rehabilitation. Focus on Clinical Research and Practice, Part 3. 21(6):483-490, November/December 2006
To determine national patterns of screening, prophylaxis, and treatment of deep venous thrombosis
(DVT) following traumatic brain injury (TBI) within the Traumatic Brain Injury Model Systems
(TBIMS).
Journal of Neurotrauma Nov 2006, Vol. 23, No. 11 : 1609 -1620
This study examined psychometric properties of a brief version of the World Health Organization Quality of Life questionnaire
(WHOQOL-BREF) among persons with traumatic brain injury (TBI) and the relations of the WHOQOL-BREF domains, including physical capacity, psychological wellbeing, social relationships, and environment, to different indicators of TBI severity.
We present MRI findings in a patient who presented with a remote cervical cord injury and with onset of new symptoms. Imaging showed findings compatible with Wallerian degeneration (WD) above and below the level of the original injury. We review the pathogenesis of spinal cord WD and its implications.
European Journal of Neurology, Volume 13, Number 11, November 2006, pp. 1216-1220(5)
The relationship between the apolipoprotein E (APOE) exon 4 polymorphism and white matter changes
(WMC) in elderly subjects or patients with Alzheimer's disease is controversial.
European Journal of Neurology, Volume 13, Number 11, November 2006, pp. 1221-1225(5)
The incidence of dural carotid-cavernous sinus fistula (DCCF) presenting as isolated ocular motor nerve palsies without congestive ocular features is unknown. We reviewed the DCCF patients in our hospital during the last 10 years to elucidate the clinical and neuroradiological features of DCCF with isolated ocular motor nerve palsy.
European Journal of Neurology, Volume 13, Number 11, November 2006, pp. 1245-1250(6)
Complex painful reflex syndrome is sometimes described in the chronic phase of stroke. Acute autonomic dysfunction
(AAD), which is occasionally present in cases of acute stroke, has not been studied prospectively. The aim of the study was to investigate AAD on the hemibody contralateral to the lesion in the acute phase of stroke.
Cognitive and behavioral impairments are common in patients with epilepsy. Multiple factors may contribute to these difficulties; among them is antiepileptic drug
(AED) treatment.
Despite the importance of early diagnosis in childhood epilepsy, few published studies address the process of the child’s entry into the health care system. The purpose of this article is to describe parental accounts of the diagnostic process and corresponding treatment for their children. We interviewed 21 parents of children who had both epilepsy and significant learning problems using semistructured open-ended interviews.
This prospective, open-label, multicenter study evaluated the efficacy and tolerability of oxcarbazepine as monotherapy in patients with partial seizures who switched from their current antiepileptic drug
(AED) monotherapy because of lack of efficacy or poor tolerability.
Quality of life (QOL) was assessed in patients who switched to oxcarbazepine monotherapy because of the lack of efficacy or poor tolerability of their current antiepileptic drug
(AED).
Findings of both material- and hemisphere-specific influence on memory performance in children with epilepsy are inconsistent. Verbal memory of 80 children with focal epilepsy, aged 7 to 16, was assessed and compared with verbal memory of 80 healthy schoolchildren.
European Journal of Neurology, Volume 13, Number 11, November 2006, pp. 1251-1255(5)
As hemorrhagic transformation (HTr) is a frequent complication and can worsen the outcome of acute ischemic stroke, our aim was to assess the risk factors of
HTr. Using the database of our neuropathological laboratory, 245 consecutive acute ischemic stroke patients were analyzed.
Intracranial dermoid cyst is a rare entity accounting for 0.1-0.7% of all intracranial tumors. The most common location is in the posterior
fossa, at or near the midline. We present 2 pediatric cases with dermal sinus.
PEDIATRICS Vol. 118 No. 5 November 2006, pp. 1916-1924
Primary hemorrhagic stroke is an uncommon complication of sickle cell disease, with reported mortality rates of 24% to 65%. Most reported cases are in adults; little is known about its occurrence in children. Proposed risk factors include previous ischemic stroke, aneurysms, low steady-state hemoglobin, high steady-state leukocyte count, acute chest syndrome, and
hypertransfusion.
Currently, there is minimal published data on the use of heparin-coated stents in the
neurovasculature; however, these stents have a proven clinical record in the treatment of coronary disease. This article details our experience with the safety and technical aspects of stent deployment in the first 10 patients who had heparin-coated stents placed in the intracranial and cervical vasculature and the preliminary follow-up in most cases.
The hospital-based stroke registry is useful for understanding the diverse clinical characteristics of stroke related to geographical, racial or environmental differences. The Khorasan Stroke Registry
(KSR) was established for the evaluation of incidence, clinical manifestations, risk factors, topography and etiology of ischemic stroke in Southern
Khorasan, Iran, during 2001-2005.
Genetic variation in the renin-angiotensin system (RAS) has been implicated in stroke, particularly the small vessel disease
(SVD) subtype. Furthermore, there may be two distinct subtypes of cerebral
SVD, isolated lacunar infarction (ILI) and ischaemic leukoaraiosis
(ILA).
Factors involved in atherosclerotic plaque progression are still a topic of hot debate. With the advance of new ultrasound techniques it has been possible to identify atherosclerotic plaque characteristics that may reflect a higher risk of vulnerability.
In an era in which new computed tomographic scanners approach 100% sensitivity for finding intracranial aneurysms in patients with a perimesencephalic subarachnoid hemorrhage
(SAH) pattern, digital subtraction angiography (DSA) is still considered the gold standard.
Clinicians and researchers use brief instruments, such as the Mini Mental State Examination
(MMSE) and the Telephone Interview for Cognitive Status (TICS), to measure cognitive functioning in patients with cerebral aneurysms.
Amongst the many fascinating abnormal perceptions of parts of the body which may follow strokes and other cerebral lesions is the rare phenomenon of
misoplegia. Afflicted patients show dislike, amounting to hatred of the affected part, often accompanied by verbal or physical abuse.
American Journal of Neuroradiology 27:2191-2195, November-December 2006
Human herpesvirus-6 (HHV-6)-associated encephalopathy tends to develop in immunocompromised patients. Neurologic symptoms, such as disorientation, short-term memory loss, convulsion, coma, and hypopnea could occur, but they may be nonspecific. We retrospectively reviewed MR images of 6 adults with HHV-6-associated encephalopathy to study characteristic imaging findings that could be useful in making the diagnosis.
American Journal of Neuroradiology 27:2179-2190, November-December 2006
The cause of "posterior reversible encephalopathy syndrome" (PRES) is not established. We recently encountered several patients who developed PRES in the setting of severe infection. In this study, we comprehensively reviewed the clinical and imaging features in a large cohort of patients who developed PRES, with particular attention to those with isolated infection, sepsis, or shock (I/S/S).
Current Opinion in Neurology. 19(6):514-519, December 2006
The scarcity of pharmacological neuroprotective treatments for traumatic brain injury is a concern being targeted on various fronts. This review examines the latest treatments under investigation.
ATP-sensitive potassium channels (KATP) are involved in the regulation of potassium homeostasis in the nervous system, and they may play an important role in acute peripheral nerve and spinal cord injury. Here, the expression of the KATP genes was monitored by reverse transcription polymerase chain reaction
(RT-PCR) in the rat dorsal root ganglion, spinal cord and cerebral cortex following acute sciatic nerve and spinal cord injury.
Current Opinion in Neurology. 19(6):520-527, December 2006
We discuss the problems of evidence-based neurorehabilitation in disorders of consciousness, and recent functional neuroimaging data obtained in the vegetative state and minimally conscious state.
Current Opinion in Neurology. 19(6):534-542, December 2006
The traditional focus of neurorehabilitaion has been on the patients' attention on their deficit, such that they should become aware of their problems and gain intentional control of compensatory strategies (descending approach).
Patients undergoing craniotomies have traditionally received opiates for the management of their postoperative pain. The use of narcotic pain medications can be costly, can decrease early walking, can lengthen hospital stay, and can alter a patient's neurological examination results.
Idiopathic normal pressure hydrocephalus (INPH) is characterized by a classic clinical triad of symptoms, including dementia, urinary incontinence, and gait disturbance.
Extensive research has provided substantial insight into the neurobiological mechanisms underlying the reinforcing,
locomotor-activating and stereotypy-inducing actions of
psychostimulants.
The motor-activating effects of amphetamine and other psychostimulants such as cocaine depend on an increase in dopamine (DA) transmission in the striatum, a key component of the basal ganglia and the forebrain motive circuit.
Current Opinion in Neurology. 19(6):528-533, December 2006
To provide the clinician with a reasonable overview of the modern pharmacological alternatives to treat the cognitive and behavioral sequels of traumatic brain injury.
Paediatric Anaesthesia, Volume 16, Number 10, October 2006, pp. 1057-1062(6)
The aim of this investigation was to verify whether brain hypoxia represented a risk factor for the occurrence and severity of opioid abstinence syndrome.
Executive dysfunction assessed by the Wisconsin Card Sorting Test has been observed in patients with mesial temporal lobe epilepsy
(TLE); however, the mechanism of executive impairment is unclear.
Depression is one of the most frequent neuropsychiatric disturbances in stroke patients. The clinical aspects and correlations of depression in the first days after acute stroke are less known.
Current Opinion in Neurology. 19(6):580-585, December 2006
We review recent important papers pertaining to acquired aphasia, apraxia of speech and dysarthria with special attention to clinically significant work published in the last 12 months.
Current Opinion in Neurology. 19(6):559-564, December 2006
This review of the cognitive status following stroke and vascular cognitive impairment starts by questioning the concept of vascular dementia and related concepts. Our position is that in many cases these labels promote a superficial conceptualization of an inherently complex and heterogeneous phenomenon hampering a more detailed understanding.
Current Opinion in Neurology. 19(6):543-550, December 2006
Transcranial methods of cortical stimulation can induce long-term changes in excitability of the cerebral cortex in humans and may be useful as therapeutic interventions in stroke rehabilitation.
To determine the frequency and predictors of symptomatic intracerebral hemorrhage
(SICH) in patients treated with recombinant tissue plasminogen activator
(rt-PA). Methods: We reviewed the databases of 7 tertiary hospitals that treated ischemic stroke patients with intravenous
rt-PA.
International Journal of Rehabilitation Research. 29(4):335-338, December 2006
This retrospective study aims to assess the relationship of age, gender, lesion location, stroke etiology and recurrence of stroke to post-stroke urinary incontinence, and to evaluate its impact on functional recovery in patient subgroups with different etiologies, lesion locations and ages.
International Journal of Rehabilitation Research. 29(4):329-333, December 2006
Pain and fatigue are two often overlooked symptoms after stroke. Their prevalence and determinants are not well understood. In this study patients with first-ever stroke (n=377) were examined at baseline and after 1 year. General characteristics of the patients, as well as stroke type, stroke severity and risk factors were registered at baseline.
International Journal of Rehabilitation Research. 29(4):309-314, December 2006
Our aim was to explore the informal rehabilitation activities performed by Thai caregivers for stroke survivors at home. Twenty primary informal caregivers were individually interviewed, using semi-structured questions developed by researchers, to investigate the informal rehabilitation activities provided for the stroke survivors at their homes.
International Journal of Rehabilitation Research. 29(4):275-279, December 2006
There is a high incidence of reflex sympathetic dystrophy of the upper limbs in patients with
hemiplegia, and its painful and functional consequences present a problem to specialists in physical medicine and rehabilitation. This study was designed to assess the role of several factors in the occurrence of reflex sympathetic dystrophy in patients with
hemiplegia.
International Journal of Rehabilitation Research. 29(4):357-361, December 2006
The Wolf motor function test is a new time-based method to evaluate upper extremity function both on a joint-specific level and on total limb movements, while performing some functional tasks.
International Journal of Rehabilitation Research. 29(4):339-342, December 2006
The objective of this study was to investigate the results of transcranial Doppler monitoring during tilt table tests in stroke patients with and without orthostatic hypotension.
Journal of Neurology, Neurosurgery, and Psychiatry 2006;77:1354-1358
Intraventricular haemorrhages (IVHs) caused by bleeding aneurysms are critical conditions that often carry a severe prognosis. Two main problems must be urgently dealt with: the secondary damage caused by intraventricular clotting and the risk of early
rebleeding.
Journal of Neurology, Neurosurgery, and Psychiatry 2006;77:1388-1402
Phenotypic variability contributes to difficulties developing patient specific interventions. Analysis of clinical features in early phase disease may allow prediction of disease severity and inform therapeutic decisions for clinicians and patients prior to onset of axonal degeneration.
Journal of Neurology, Neurosurgery, and Psychiatry 2006;77:1383-1384
The persistent vegetative state (PVS) is a condition in which awareness of the self and the environment is absent. However, neuroimaging studies suggest that normal brain activity in response to speech and faces can remain in the
PVS, although it is not clear if this activity reflects higher levels of perception and cognitive processes, as only meaningless stimuli were used as control conditions.
Journal of Neurology, Neurosurgery, and Psychiatry 2006;77:1305-1306
The proposition that the early diagnosis of brain tumours is desirable is one with which few, if any, neurologists would disagree. Concerns about delayed diagnosis are also a common theme among patients.
Journal of Neurology, Neurosurgery, and Psychiatry 2006;77:1299-1300
Despite their rarity, paraneoplastic syndromes have always intrigued neurologists. Several reasons explain this clinical and scientific interest. From a clinical point of view, the discovery and characterisation of several paraneoplastic antibodies have allowed neurologists to diagnose puzzling neurological syndromes as paraneoplastic and to more easily identify tumours that are often small and occult.
Journal of Neurology, Neurosurgery, and Psychiatry 2006;77:1302-1304
Genetic association studies offer a powerful approach to identify the multiple variants of small effect that modulate susceptibility to common, complex disease.
Journal of Neurology, Neurosurgery, and Psychiatry 2006;77:1300-1301
Delayed cerebral ischaemia (DCI) affects more than one quarter of patients between 3 and 14 days after the onset of their aneurysmal subarachnoid
haemorrhage, and accounts for about one third of patients who are dead or dependent as a result of the
haemorrhage.
Journal of Neurology, Neurosurgery, and Psychiatry 2006;77:1340-1344
Cerebral infarction after aneurysmal subarachnoid haemorrhage (SAH) is presumed to be due to cerebral vasospasm, defined as arterial lumen narrowing from days 3 to 14.
Journal of Neurology, Neurosurgery, and Psychiatry 2006;77:1328
A 24-year-old-woman showed confusion, movement disorders and asthenia related to severe hypocalcaemia (0.95
mmol/l), with low parathyroid hormone concentration (4 pg/ml, normal 15–85 pg/ml) and hyperphosphataemia (1.97
mmol/l). She was hospitalised for depression 1 year previously, but no biological examination was performed during that period.
Journal of Neurology, Neurosurgery, and Psychiatry 2006;77:1329-1335
To comprehensively search, identify, assess and carry out meta-analyses of studies reporting on the association between APOE and the combined outcome of death or dependency, or death alone, several months after ischaemic stroke, intracerebral haemorrhage
(ICH) or subarachnoid haemorrhage (SAH).
Prospectively evaluate survival, complications, re-admissions and maintenance of clinical outcome in people experiencing traumatic spinal cord injury (SCI).
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