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May 16-31 Postings (Note: Some archived links may become inactive)

05/29/2009 11:33 AM

Temporal alterations in brain water diffusivity in neonatal meningitis

Acta Pediatrica Published Online: 27 May 2009

To compare changes in apparent diffusion coefficient (ADC) in neonatal meningitis using serial diffusion-weighted imaging (DWI).


05/29/2009 11:32 AM

Autologous neural stem cell transplantation: A new treatment option for Parkinson’s disease?

Medical Hypotheses Received 22 March 2009; accepted 18 April 2009. published online 25 May 2009

The clinical motor dysfunction in Parkinson´s disease (PD) is primarily linked to the depletion of dopamine in the striatum consecutive to the loss of the large dopaminergic neurons in the substantia nigra.


05/29/2009 11:31 AM

Changing self-efficacy in individuals following a first time stroke: preliminary study of a novel self-management intervention

Clinical Rehabilitation, Vol. 23, No. 6, 522-533 (2009)

To examine the effects of a self-management workbook intervention designed for use with individuals disabled after first time stroke.


05/29/2009 11:30 AM

Activation of the brainstem but not of the hypothalamus in hemicrania continua without autonomic symptoms

Cephalalgia Published Online: 5 Mar 2009

A 64-year-old woman presented with a 6-month history of right-sided continuous headache, without autonomic symptoms and complete response to indomethacin. Clinical examination and structural brain imaging were normal.


05/29/2009 11:29 AM

Orthostatic hypotension following spinal cord injury: Impact on the use of standing apparatus

NeuroRehabilitation Volume 24, Number 3 / 2009 237-242

Introduction: Upright posture confers numerous medical and social benefits to a spinal cord injured (SCI) patient. Doing so is limited by symptoms of orthostatic hypotension. This is a common secondary impairment among tetraplegic sufferers.


05/29/2009 11:28 AM

Micro lesion effect of the globus pallidus internus and outcome with deep brain stimulation in patients with Parkinson disease and dystonia

Movement Disorders Published Online: 27 May 2009

To determine whether the immediate response to electrode implantation (micro lesion effect, MLE) in the internal segment of the globus pallidus (GPi) predicts symptom improvement with deep brain stimulation (DBS) at 6 months in patients with Parkinson's disease (PD) or generalized dystonia.


05/29/2009 11:27 AM

Pregnancy, Childrearing, and Risk of Stroke in Chinese Women

Stroke doi: 10.1161/STROKEAHA.109.547554

Although it has been suggested that high gravidity and parity increase the risk for coronary heart disease, their associations with stroke are unclear.


05/29/2009 11:26 AM

Racial and Ethnic Disparities in Outcomes and Appropriateness of Carotid Endarterectomy. Impact of Patient and Provider Factors

Stroke doi: 10.1161/STROKEAHA.108.544866

Prior work documented racial and ethnic disparities in incidence of stroke, stroke risk factors, and use of carotid endarterectomy. Less is known about disparities in outcomes and appropriateness of carotid endarterectomy or reasons for such inequalities.


05/29/2009 11:25 AM

MRI evidence of reperfusion injury associated with neurological deficits after carotid revascularization procedures

European Journal of Neurology Published Online: 22 May 2009

Some patients develop major neurological complications after carotid revascularization procedures, despite the lack of new infarcts or classical hyperperfusion syndrome.


05/29/2009 11:24 AM

Cardiac Workup of Ischemic Stroke. Can We Improve Our Diagnostic Yield?

Stroke doi: 10.1161/STROKEAHA.109.551226

Discovering potential cardiac sources of stroke is an important part of the urgent evaluation of the ischemic stroke patient as it often impacts treatment decisions that are essential for determining secondary stroke prevention strategies, yet the optimal approach to the cardiac workup of an ischemic stroke patient is not known.


05/29/2009 11:22 AM

Efficacy and Safety of Tissue Plasminogen Activator 3- to 4.5-Hours After Acute Ischemic Stroke. A Metaanalysis

Stroke doi: 10.1161/STROKEAHA.109.552547

The Third European Cooperative Acute Stroke Study (ECASS-3) demonstrated a benefit of treatment with intravenous tissue plasminogen activator (tPA) for acute stroke in the 3- to 4.5-hour time-window.


05/29/2009 11:18 AM

A genome-wide analysis of brain DNA methylation identifies new candidate genes for sporadic amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis First Published on: 22 May 2009

Genetic variants may underlie sporadic amyotrophic lateral sclerosis (SALS), but in only a few percent of patients have causative mutations been found.


05/29/2009 11:17 AM

Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: A [15O] H2O PET study

Human Brain Mapping Published Online: 28 May 2009

Patients with advanced Parkinson's disease (PD) develop disabling axial symptoms, including gait disturbances, freezing and postural instability poorly responsive to levodopa replacement therapy.


05/29/2009 11:16 AM

Rehabilitation of the central executive of working memory after severe traumatic brain injury: Two single-case studies

Brain Injury, Volume 23, Issue 6 June 2009 , pages 585 - 594

A deficit of the central executive of working memory is a frequent finding in patients with severe traumatic brain injury (TBI). The objective of the present study was to assess the efficacy of a rehabilitation programme of the central executive after severe TBI.


05/29/2009 11:16 AM

Pre-injury estimates of subjective quality of life following traumatic brain injury

Brain Injury, Volume 23, Issue 6 June 2009 , pages 516 - 527

To compare the pre-injury subjective quality of life (SQOL) estimates of a representative sample of adults with TBI, using the Quality of Life Inventory (QOLI) with the measure's generic US-based norms and identify a factor structure for the instrument within the local TBI population.


05/29/2009 11:15 AM

Post-concussion symptoms after traumatic brain injury at 3 and 12 months post-injury: A prospective study

Brain Injury, Volume 23, Issue 6 June 2009 , pages 489 - 497

To examine self-reported post-concussion symptoms from 3-12 months post-injury in adults with traumatic brain injury (TBI) and to identify predictors of these symptoms.


05/29/2009 11:14 AM

Modifying postural adaptation following a CVA through prismatic shift of visuo-spatial egocenter

Brain Injury, Volume 23, Issue 6 June 2009 , pages 566 - 576

To demonstrate that Visual Midline Shift Syndrome (VMSS) following a cerebrovascular accident (CVA) can be corrected with yoked prisms.


05/29/2009 11:14 AM

Limitations of mild traumatic brain injury meta-analyses

Brain Injury, Volume 23, Issue 6 June 2009 , pages 498 - 508

Mild traumatic brain injury (mTBI) meta-analyses are sometimes cited as evidence that by 3 months post-injury the clinical effects are insignificant. In contrast to these conclusions are findings that long-term mTBI outcome can vary depending on (1) the mechanism of the injury, (2) which diagnostic criteria are employed, (3) which assessment tools utilized and (4) whether symptomatic groups are considered separately.


05/29/2009 11:13 AM

How many people return to work after acquired brain injury?: A systematic review

Brain Injury, Volume 23, Issue 6 June 2009 , pages 473 - 488

To investigate how many people return to work (RTW) after acquiring brain injury (ABI) due to traumatic or non-traumatic causes.


05/29/2009 11:12 AM

Head injury attenders in the emergency department: The impact of advice and factors associated with early symptom outcome

Brain Injury, Volume 23, Issue 6 June 2009 , pages 509 - 515

Many who attend hospital after head injury are not admitted to a hospital bed.


05/29/2009 11:12 AM

Effect of amantadine on the sleep-wake cycle of an inpatient with brain injury

Brain Injury, Volume 23, Issue 6 June 2009 , pages 559 - 565

A previous study suggested that the routine use of drugs intended to improve attention and arousal, such as methylphenidate, tend to have a variable but not significant effect on sleep-wake cycles.


05/29/2009 11:11 AM

Cysteinyl-leukotriene receptor antagonist montelukast decreases blood-brain barrier permeability but does not prevent oedema formation in traumatic brain injury

Brain Injury, Volume 23, Issue 6 June 2009 , pages 577 - 584

Traumatic brain injury is highly associated with the over-production of reactive oxygen species. The aim of this study was to investigate the putative neuroprotective effect of montelukast, a cysteinyl-leukotriene receptor antagonist, in a rat model of traumatic brain injury (TBI).


05/29/2009 11:10 AM

Assessing the relationship between the WNSSP and therapeutic participation in adolescents in low response states following severe traumatic brain injury

Brain Injury, Volume 23, Issue 6 June 2009 , pages 528 - 534

This study examines the relationship between scores on the Western Neuro Sensory Stimulation Profile (WNSSP) and therapeutic participation as it relates to rehabilitation readiness (RR) in adolescents with low response following severe traumatic brain injury (TBI).


05/29/2009 11:09 AM

A randomized controlled trial of rivastigmine for chronic sequels of traumatic brain injury-What it showed and taught?

Brain Injury, Volume 23, Issue 6 June 2009 , pages 548 - 558

To evaluate the effectiveness of rivastigmine for chronic sequels of traumatic brain injury (TBI).


05/29/2009 11:09 AM

A preliminary investigation of the brain injury family intervention: Impact on family members

Brain Injury, Volume 23, Issue 6 June 2009 , pages 535 - 547

To evaluate the benefits of the Brain Injury Family Intervention (BIFI) for families of persons with acquired brain injury and identify factors related to outcomes.


05/28/2009 09:38 AM

Psychometric Properties of a Scale to Assess the Severity of Bathing Disability

Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 987-993 (June 2009)

To develop and evaluate the psychometric properties of a new bathing disability scale.


05/28/2009 09:36 AM

Postural Responses to Dynamic Perturbations in Amputee Fallers Versus Nonfallers: A Comparative Study With Able-Bodied Subjects

Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 1018-1025 (June 2009)

To quantify postural responses in amputee fallers versus nonfallers by using computerized dynamic posturography.


05/28/2009 09:35 AM

Temporal Coordination of the Sit-to-Walk Task in Subjects With Stroke and in Controls

Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 1009-1017 (June 2009)

To explore events and describe phases for temporal coordination of the sit-to-walk (STW) task, within a semistandardized set up, in subjects with stroke and matched controls.


05/28/2009 09:34 AM

Speed of Voluntary Stepping in Chronic Stroke Survivors Under Single- and Dual-Task Conditions: A Case-Control Study

Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 927-933 (June 2009)

To investigate voluntary step behavior of chronic stroke survivors during single- and dual-task conditions and compare the results to healthy age- and sex-matched controls.


05/28/2009 09:33 AM

Reproducibility of the ABILOCO Questionnaire and Comparison Between Self-Reported and Observed Locomotion Ability in Adult Patients With Stroke

Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 1061-1063 (June 2009)

To test the reproducibility of the ABILOCO questionnaire. To validate the patient self-reporting method and the third-party assessment of the stroke patients' locomotion ability by a treating physical therapist.


05/28/2009 09:32 AM

Percutaneous Radiologic Gastrostomy in Patients With Amyotrophic Lateral Sclerosis on Noninvasive Ventilation

Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 1026-1029 (June 2009)

To determine the safety and feasibility of percutaneous radiologic gastrostomy (PRG) tube placement in patients with amyotrophic lateral sclerosis (ALS) with too low a vital capacity to be weaned off noninvasive positive pressure ventilation (NPPV).


05/28/2009 09:31 AM

Light Touch Cue Through a Cane Improves Pelvic Stability During Walking in Stroke

Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 919-926 (June 2009)

To examine the effect of a light touch cue provided through a cane on mediolateral (ML) pelvic stability during walking in subjects poststroke.


05/28/2009 09:30 AM

Family Functioning Is Associated With Depressive Symptoms in Caregivers of Acute Stroke Survivors

Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 947-955 (June 2009)

To determine whether family functioning is uniquely associated with caregiver depressive symptoms in the immediate aftermath of stroke.


05/28/2009 09:29 AM

Caregivers' Well-Being After Traumatic Brain Injury: A Multicenter Prospective Investigation

Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 939-946 (June 2009)

To describe frequency and magnitude of caregivers' emotional distress and life satisfaction using standardized assessment procedures; compare distress levels among spouses, parents, and other caregivers; and identify risk factors.


05/28/2009 09:29 AM

Baseline Predictors of Fatigue 1 Year After Mild Head Injury

Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 956-965 (June 2009)

To compare reports of fatigue 12 months after minor trauma by participants with mild head injury (MHI) with those with other injury, and identify injury and baseline predictors of fatigue.


05/28/2009 09:23 AM

A Preliminary Model of Wheelchair Service Delivery

Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 1030-1038 (June 2009)

To integrate and expand on previously published models of wheelchair service delivery, and provide a preliminary framework for developing more comprehensive, descriptive models of wheelchair service delivery for adults with spinal cord injury within the U.S. health care system.


05/28/2009 09:22 AM

Disproportionate correlation between imaging and outcome in an infant with cerebral abscess

Central European Journal of Medicine 1895-1058 (Print) 10.2478/s11536-009-0038-1

Brain abscesses represent organized foci of suppuration within the parenchyma. In this paper, we describe the case of a 3-month old girl with a large, complicated cerebral abscess.


05/28/2009 09:21 AM

Parkinson's disease: the most common diagnostic mistakes in Lithuania

Central European Journal of Medicine 1895-1058 (Print) 10.2478/s11536-009-0054-1

Parkinson's disease (PD) belongs to group of neurodegenerative diseases. PD diagnosis is clinical, based on these signs: tremor, rigidity, bradykinesia, akinesia or hypokinesia.


05/28/2009 09:20 AM

Astrocytic protection of spinal motor neurons but not cortical neurons against loss of Als2/alsin function

Human Molecular Genetics 2009 18(12):2127-2139

Three neurodegenerative diseases affecting upper and/or lower motor neurons have been associated with loss of ALS2/Alsin function: juvenile amyotrophic lateral sclerosis, primary lateral sclerosis and infantile-onset ascending hereditary spastic paralysis.


05/28/2009 09:18 AM

Incidence of amyotrophic lateral sclerosis in the Limousin region of France, 1997-2007

Amyotrophic Lateral Sclerosis First Published on: 19 May 2009

Our objective was to assess the incidence of amyotrophic lateral sclerosis (ALS), and its temporal variations, between 1997 and 2007. The study was based on data prospectively gathered by the referral ALS 'expert centre' of the Regional University Hospital of Limousin (710,792 inhabitants).


05/28/2009 09:17 AM

Distinction between pyogenic brain abscess and necrotic brain tumour using 3-tesla MR spectroscopy, diffusion and perfusion imaging

British Journal of Radiology 2009, doi:10.1259/bjr/90100265

The purpose of this study is to compare the effectiveness of relative cerebral blood volume, apparent diffusion coefficient and spectroscopic imaging in differentiating between cerebral abscesses and necrotic tumours.


05/28/2009 09:16 AM

Improvement After Constraint-Induced Movement Therapy Is Independent of Infarct Location in Chronic Stroke Patients

Stroke doi: 10.1161/STROKEAHA.109.548347

Disruption of the corticospinal tract at various locations in the brain has been shown to predict worse spontaneous motor recovery after stroke. However, the anatomic specificity of previous findings was limited by the categorical classification of infarct locations.


05/28/2009 09:15 AM

CT Angiography for Intracerebral Hemorrhage Does Not Increase Risk of Acute Nephropathy

Stroke doi: 10.1161/STROKEAHA.108.546127

CT angiography (CTA) is receiving increased attention in intracerebral hemorrhage (ICH) for its role in ruling out vascular abnormalities and potentially predicting ongoing bleeding. Its use is limited by the concern for contrast induced nephropathy (CIN); however, the magnitude of this risk is not known.


05/28/2009 09:14 AM

Relative and Cumulative Effects of Lipid and Blood Pressure Control in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels Trial

Stroke doi: 10.1161/STROKEAHA.108.546135

The relative contributions of on-treatment low- and high-density lipoprotein cholesterol (LDL-C, HDL-C), triglycerides, and blood pressure (BP) control on the risk of recurrent stroke or major cardiovascular events in patients with stroke is not well defined.


05/28/2009 09:13 AM

Influence of Weekend Hospital Admission on Short-Term Mortality After Intracerebral Hemorrhage

Stroke doi: 10.1161/STROKEAHA.108.546572

There is expanding literature to show that certain patients admitted during the weekend have worse outcomes than similar patients admitted during the week.


05/28/2009 09:12 AM

Prevalence and Risk Factors Associated With Reversed Robin Hood Syndrome in Acute Ischemic Stroke

Stroke doi: 10.1161/STROKEAHA.109.547950

Early deterioration can occur after acute stroke for a variety of reasons. We describe a hemodynamic steal and associated neurological deterioration, the reversed Robin Hood syndrome (RRHS). We aimed to investigate the frequency and factors associated with RRHS.


05/28/2009 09:11 AM

Exon-skipping therapy for Duchenne muscular dystrophy

Neuropathology Published Online: 22 May 2009

Duchenne muscular dystrophy (DMD) is a lethal muscle disorder caused by mutations in the DMD gene for which no mutation-targeted therapy has been available thus far.


05/28/2009 07:30 AM

Hypoventilation after Spinal Cord Injury

Semin Respir Crit Care Med 2009; 30: 330-338

There are ~12,000 new cases per year in the United States of spinal cord injury (SCI) with life expectancies from 11 to 14 years (ventilator dependent) to 44 years (non-ventilator dependent).


05/28/2009 07:28 AM

Seizure Detection in Temporal Lobe Epileptic EEGs Using the Best Basis Wavelet Functions

Journal of Medical Systems 0148-5598 (Print) 10.1007/s10916-009-9290-9

In this paper, we propose a novel method using best basis wavelet functions and double thresholding that are well suited for detecting and localization of important epileptic events from noisy recorded seizure EEG signals.


05/28/2009 07:27 AM

Management of spasticity and dystonia in children with acquired brain injury with rehabilitation and botulinum toxin A

Developmental Neurorehabilitation, Volume 12, Issue 3 June 2009 , pages 128 - 138

To investigate the effect of a combination of botulinum toxin A (BTX-A) and rehabilitation on spasticity, pain and motor functioning in children with acquired brain injury (ABI).


05/28/2009 07:26 AM

Sixteen years on: Has quality of care for rural and non-compensable traumatic brain injury clients improved?

Australian Journal of Rural Health Volume 17 Issue 3, Pages 119 - 123

This review focuses on two factors that influence client access to care following head injury. These factors, namely the degree of rurality of a client's home town and the funding model to which they are allocated, are discussed in light of the results of the 'Head Injury Impact Project'.


05/28/2009 07:25 AM

Cranial Dural Arteriovenous Fistula: Diagnosis and Classification with Time-Resolved MR Angiography at 3T

American Journal of Neuroradiology DOI 10.3174/ajnr.A1646

The diagnosis of dural arteriovenous fistula (DAVF) remains one of the few uncontested indications for catheter based cerebral angiography.


05/28/2009 07:25 AM

Infra-red thermometry: the reliability of tympanic and temporal artery readings for predicting brain temperature after severe traumatic brain injury

Critical Care 2009, 13:R81doi:10.1186/cc7898

Temperature measurement is important during routine neurocritical care especially as differences between brain and systemic temperatures have been observed.


05/28/2009 07:23 AM

Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicentre, randomised controlled trial

The Lancet, Early Online Publication, 27 May 2009 doi:10.1016/S0140-6736(09)60941-7

Deep vein thrombosis (DVT) and pulmonary embolism are common after stroke. In small trials of patients undergoing surgery, graduated compression stockings (GCS) reduce the risk of DVT.


05/28/2009 07:20 AM

White matter diffusion is higher in Binswanger disease than in idiopathic normal pressure hydrocephalus

Acta Neurologica Scandinavica Published Online: 26 May 2009

To explore diagnostic differences in periventricular white matter (PWM) and deep white matter (DWM) diffusion patterns in patients diagnosed with Binswanger disease (BD) and in patients diagnosed with probable idiopathic normal pressure hydrocephalus (INPH) using diffusion-weighted imaging (DWI).


05/28/2009 07:19 AM

Performance of Bedside Transpulmonary Thermodilution Monitoring for Goal-Directed Hemodynamic Management After Subarachnoid Hemorrhage

Stroke doi: 10.1161/STROKEAHA.109.547463

Early goal-directed hemodynamic therapy is of particular importance for adequate cerebral circulation of patients with vasospasm after subarachnoid hemorrhage but is often precluded by the invasiveness of established cardiac output determination using a pulmonary artery catheter.


05/28/2009 07:18 AM

The Performance of MRI-Based Cerebral Blood Flow Measurements in Acute and Subacute Stroke Compared With 15O-Water Positron Emission Tomography. Identification of Penumbral Flow

Stroke doi: 10.1161/STROKEAHA.108.540914

Perfusion-weighted MRI-based maps of cerebral blood flow (CBFMRI) are considered a good MRI measure of penumbral flow in acute ischemic stroke but are seldom used in clinical routine due to methodical issues.


05/28/2009 07:17 AM

Sample Size Estimates for Clinical Trials of Vasospasm in Subarachnoid Hemorrhage

Stroke doi: 10.1161/STROKEAHA.109.547331

Clinical trials for prevention of vasospasm after aneurysmal subarachnoid hemorrhage (SAH) seldom have improved overall outcome; one reason may be inadequate sample size.


05/28/2009 07:17 AM

Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndrome

Brain, doi:10.1093/brain/awp125

Restless leg syndrome (RLS) is a sensorimotor disorder. Clinical studies have implicated the dopaminergic system in RLS, while others have suggested that it is associated with insufficient levels of brain iron.


05/28/2009 07:16 AM

Changes in cortical grey matter density associated with long-standing retinal visual field defects

Brain, doi:10.1093/brain/awp119

Retinal lesions caused by eye diseases such as glaucoma and age-related macular degeneration can, over time, eliminate stimulation of parts of the visual cortex.


05/28/2009 07:14 AM

A randomized controlled trial of quetiapine for psychosis in Parkinson’s disease

Neuropsychiatric Disease and Treatment Published: May 2009

Psychosis (delusions and/or hallucinations) is a well-recognized complication of treatment of Parkinson’s disease (PD).


05/28/2009 07:13 AM

Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer's disease

Brain, doi:10.1093/brain/awp123

Mild cognitive impairment can represent a transitional state between normal ageing and Alzheimer's disease. Non-invasive diagnostic methods are needed to identify mild cognitive impairment individuals for early therapeutic interventions.


05/28/2009 07:11 AM

Renal Dysfunction as an Independent Predictor of Outcome After Aneurysmal Subarachnoid Hemorrhage. A Single-Center Cohort Study

Stroke doi: 10.1161/STROKEAHA.108.545210

Acute kidney injury occurs in 1% to 25% of critically ill patients with small increases in creatinine adversely affecting outcome.


05/28/2009 07:11 AM

VARICELLA ZOSTER INFECTION OF THE BRAINSTEM FOLLOWED BY BROWN-SEQUARD SYNDROME

Neurology.2009; 72: 1874


05/28/2009 07:10 AM

Teaching NeuroImages: Macrocephaly with subcortical calcifications in vein of Galen aneurysmal malformation

NEUROLOGY 2009;72:e111

A previously asymptomatic 3-year-old boy presented with a large head, generalized seizures, and vision impairment for 7 months. Examination revealed macrocephaly (52 cm) and prominent scalp and facial veins.


05/28/2009 07:09 AM

Statins and stroke

NEUROLOGY 2009;72:e112-e113

It is well known that drugs that bring down the bad cholesterol in the blood (statins) can reduce the risk of a second heart attack after a first heart attack occurs.


05/28/2009 07:09 AM

Statin therapy after first stroke reduces 10-year stroke recurrence and improves survival

NEUROLOGY 2009;72:1816-1822

To determine whether statin therapy after hospital discharge affects ischemic stroke recurrence and long-term mortality in patients admitted for a first-ever occurrence of ischemic stroke.


05/28/2009 07:07 AM

Silent brain infarcts and leukoaraiosis in young adults with first-ever ischemic stroke

NEUROLOGY 2009;72:1823-1829

We recently observed that 13% of 1,008 consecutive adults aged 15–49 years with first-ever ischemic stroke had one or more silent brain infarcts (SBIs), and more than 5% presented with leukoaraiosis on CT or MRI.


05/28/2009 07:06 AM

Predictors of individual visual memory decline after unilateral anterior temporal lobe resection

NEUROLOGY 2009;72:1837-1842

Different types of neuropsychological visual memory tasks have been created to quantify deficits associated with right hemisphere dysfunction.


05/28/2009 07:05 AM

Interhemispheric and intrahemispheric language reorganization in complex partial epilepsy

NEUROLOGY 2009;72:1830-1836

To investigate interhemispheric and intrahemispheric reorganization in patients with localization-related epilepsy.


05/28/2009 07:04 AM

CLINICAL CONSEQUENCES OF GENERIC SUBSTITUTION OF LAMOTRIGINE FOR PATIENTS WITH EPILEPSY

Neurology.2009; 72: 1876-1877


05/28/2009 06:57 AM

Brain and ventricular volumetric changes in frontotemporal lobar degeneration over 1 year

NEUROLOGY 2009;72:1843-1849

Measurement of volumetric changes with MR might be a useful surrogate endpoint for clinical trials in frontotemporal lobar degeneration (FTLD).


05/28/2009 06:43 AM

Markers of cerebral damage during delirium in elderly patients with hip fracture

BMC Neurology 2009, 9:21doi:10.1186/1471-2377-9-21

S100B protein and Neuron Specific Enolase (NSE) can increase due to brain cell damage and/or increased permeability of the blood-brain-barrier.


05/26/2009 10:12 AM

Quantitative Metrics of Net Proliferation and Invasion Link Biological Aggressiveness Assessed by MRI with Hypoxia Assessed by FMISO-PET in Newly Diagnosed Glioblastomas

Cancer Research 69, 4502, May 15, 2009 doi: 10.1158/0008-5472.CAN-08-3884

Glioblastoma multiforme (GBM) are aggressive and uniformly fatal primary brain tumors characterized by their diffuse invasion of the normal-appearing parenchyma peripheral to the clinical imaging abnormality.


05/26/2009 10:11 AM

Effects of acute tryptophan depletion on neuropsychological and motor function in Parkinson's disease

Journal of Psychopharmacology 2009, doi:10.1177/0269881109105721

Interactions between the 5-HT system and the dopaminergic system and cholinergic system may be important in determining cognitive function and motor function in Parkinson's disease (PD).


05/26/2009 10:10 AM

Incidental hemangioblastoma of the filum terminale

Acta Neurologica Belgica 2009, No 1 (Vol. 109/1) p.55-56

Filum terminale hemangioblastoma is an extremely rare tumour with only a few case reports in the literature.


05/26/2009 10:10 AM

Magnetic Resonance Appearance of Cerebral Cystic Echinococcosis: World Health Organization (WHO) Classification

Acta Radiologica, Volume 50, Issue 5 2009 , pages 549 - 554

Cystic echinococcosis (CE) of the brain is an uncommon parasitic infestation. The World Health Organization (WHO) recently published a classification of hepatic CE based upon ultrasonographic findings.


05/26/2009 10:08 AM

Expert Opinion on Pharmacotherapy

June 2009, Vol. 10, No. 8, Pages 1249-1259

Pharmacotherapy is commonly given to patients recovering from a stroke to prevent further complications (e.g. recurrent stroke, seizures) or enhance recovery.


05/26/2009 10:07 AM

Does sphenopalatine endoscopic ganglion block have an effect in paroxysmal hemicrania? A case report

Cephalalgia Published Online: 5 May 2009

The authors report the case of a 69-year-old woman suffering from paroxysmal hemicrania (PH), intolerant to indomethacin and resistant to multiple therapies, in which sphenopalatine endoscopic ganglion block (SPG) dramatically modified the clinical outcome.


05/26/2009 10:05 AM

High-frequency transcranial magnetic stimulation on motor cortex of patients affected by migraine with aura: a way to restore normal cortical excitability?

Cephalalgia Published Online: 28 Apr 2009

We showed reduced motor intracortical inhibition (ICI) and paradoxical increase of intracortical facilitation (ICF) to 1 Hz repetitive transcranial magnetic stimulation (rTMS) in patients affected by migraine with aura (MA).


05/26/2009 10:05 AM

Depletion of medullary serotonergic neurons in patients with multiple system atrophy who succumbed to sudden death

Brain, doi:10.1093/brain/awp110

Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by prominent autonomic failure with ataxia and/or parkinsonism.


05/26/2009 10:04 AM

Changes in spinal reflex and locomotor activity after a complete spinal cord injury: a common mechanism?

Brain, doi:10.1093/brain/awp124

Locomotor activity and spinal reflexes (SRs) show common features in different mammals, including humans. Here we report the time-course of the development of locomotor activity and SRs after a complete spinal cord injury in humans.


05/26/2009 10:03 AM

Eyelid fluttering, typical EEG pattern, and impaired intellectual function: A homogeneous epileptic condition among the patients presenting with eyelid myoclonia

Epilepsia Published Online: 20 May 2009

This retrospective study aims to review the electroclinical features of patients presenting with eyelid myoclonia (EM) with and without absences.


05/26/2009 10:02 AM

Role of rasagiline in treating Parkinson's disease: effect on disease progression

Therapeutics and Clinical Risk Management Published: May 2009

Rasagiline is a second generation, selective, irreversible monoamine oxidase type B (MAO-B) inhibitor.


05/26/2009 10:01 AM

Slow wave sleep and dopaminergic treatment in Parkinson's disease: a polysomnographic study

Acta Neurologica Scandinavica Published Online: 21 May 2009

In Parkinson's disease (PD), there is entanglement of disease-inherent and treatment-induced sleep abnormalities. So far, there has been no study specifically investigating the influence of diurnal dopaminergic medication (DM) on nocturnal slow wave sleep (SWS).


05/26/2009 10:00 AM

Brain Activity Changes Associated With Treadmill Training After Stroke

Stroke doi: 10.1161/STROKEAHA.109.550053

The mechanisms underlying motor recovery after stroke are not fully understood. Several studies used functional MRI longitudinally to relate brain activity changes with performance gains of the upper limb after therapy, but research into training-induced recovery of lower limb function has been relatively neglected thus far.


05/26/2009 09:59 AM

Atrial septal defect closure and migraine with aura: is there a correlation?

Neurological Sciences 1590-1874 (Print) 10.1007/s10072-009-0094-y

Recently, some authors detected increased frequency or new onset of migraine with aura (MA) after atrial septal defect (ASD) closure.


05/26/2009 09:58 AM

Mirror pattern of cerebral artery atherosclerosis in patients with ischaemic stroke

Mirror pattern of cerebral artery atherosclerosis in patients with ischaemic stroke Published Online: 22 May 2009

Although it has been suggested that bilateral symmetry of atherosclerosis can be found in paired arteries, including external carotid arteries and femoral arteries, it has remained unknown in intracranial arteries. We determined whether bilateral symmetry (a mirror pattern) of atherosclerosis presents in the entire cerebral arterial system.


05/26/2009 09:57 AM

No increased risk of adverse pregnancy outcomes for women with myasthenia gravis: a nationwide population-based study

European Journal of Neurology Published Online: 22 May 2009

This study aims to examine the risk of adverse pregnancy outcomes [low birthweight (LBW), preterm birth, cesarean sections (CS) and babies born small for gestational age (SGA)] in pregnant women with myasthenia gravis (MG), using a 3-year population-based database, taking characteristics of infant and mother into consideration.


05/26/2009 09:56 AM

Lesion patterns in patients with cryptogenic stroke with and without right-to-left-shunt

European Journal of Neurology Published Online: 22 May 2009

Despite numerous studies, the role of patent foramen ovale (PFO) as a risk factor for stroke due to paradoxical embolism is still controversial.


05/26/2009 09:50 AM

Unusual penetrating head injury in children: personal experience and review of the literature

Child's Nervous System 0256-7040 (Print) 10.1007/s00381-009-0901-z

A penetrating head injury belongs to the most severe traumatic brain injuries, in which communication can arise between the intracranial cavity and surrounding environment.


05/26/2009 09:48 AM

Cognitive deficits in multiple system atrophy correlate with frontal atrophy and disease duration

European Journal of Neurology Published Online: 22 May 2009

Dementia remains an exclusion criterion in diagnosing multiple system atrophy (MSA). This study aimed to determine the cognitive changes and brain atrophy patterns in the Parkinsonian (MSA-P) and cerebellar (MSA-C) variants of MSA.


05/26/2009 09:46 AM

The history of ependymoma management

Child's Nervous System 0256-7040 (Print) 10.1007/s00381-009-0900-0

The ependymomas are relatively not a common tumor. However, most clinicians agree that the radical removal of the tumor is the most important prognostic factor.


05/26/2009 09:45 AM

CSF overdrainage in shunted intracranial arachnoid cysts: a series and review

Child's Nervous System 0256-7040 (Print) 10.1007/s00381-009-0910-y

Cerebrospinal fluid (CSF) overdrainage in hydrocephalus is well recognized. Overshunting following cysto-peritoneal (CP) drainage in patients with arachnoid cysts (AC) is rarely documented.


05/26/2009 09:44 AM

Neuroendocrine Function following Traumatic Brain Injury and Subsequent Intensive Care Treatment: A Prospective Longitudinal Evaluation

Journal of Neurotrauma, ahead of print. doi:10.1089/neu.2008.0601

Neuroendocrine dysfunction following traumatic brain injury (TBI) has been described extensively.


05/26/2009 09:44 AM

Gender Differences in Acute Ischemic Stroke. Etiology, Stroke Patterns and Response to Thrombolysis

Stroke doi: 10.1161/STROKEAHA.109.548750

Differences between women and men in relation to stroke are increasingly being recognized.


05/26/2009 09:43 AM

Relationship of Blood Pressure, Antihypertensive Therapy, and Outcome in Ischemic Stroke Treated With Intravenous Thrombolysis. Retrospective Analysis From Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR)

Stroke doi: 10.1161/STROKEAHA.109.548602

The optimal management of blood pressure (BP) in acute stroke remains unclear.


05/26/2009 09:42 AM

Score for the Targeting of Atrial Fibrillation (STAF). A New Approach to the Detection of Atrial Fibrillation in the Secondary Prevention of Ischemic Stroke

Stroke doi: 10.1161/STROKEAHA.109.552679

The high risk of recurrence and comorbidity after a stroke associated with atrial fibrillation (AF) justifies an aggressive diagnostic approach so that anticoagulant treatment can be initiated.


05/26/2009 09:40 AM

Encoding of human action in Broca's area

Brain, doi:10.1093/brain/awp118

Broca's area has been considered, for over a century, as the brain centre responsible for speech production.


05/26/2009 09:39 AM

Hidden Dysfunctioning in Subacute Stroke

Stroke doi: 10.1161/STROKEAHA.108.541144

Determining cognitive dysfunctioning (CDF) after stroke is an important issue because it influences choices for management in terms of return to previous activities.


05/26/2009 09:38 AM

Effects of Task-Oriented Circuit Class Training on Walking Competency After Stroke. A Systematic Review

Stroke doi: 10.1161/STROKEAHA.108.541946

There is increasing interest in the potential benefits of circuit class training after stroke, but its effectiveness is uncertain.


05/26/2009 09:37 AM

Not on the face alone: perception of contextualized face expressions in Huntington's disease

Brain 2009 132(6):1633-1644; doi:10.1093/brain/awp067

Numerous studies have demonstrated that Huntington's disease mutation-carriers have deficient explicit recognition of isolated facial expressions.


05/26/2009 09:36 AM

Open-Angle Glaucoma and the Risk of Stroke Development. A 5-Year Population-Based Follow-Up Study

Stroke doi: 10.1161/STROKEAHA.109.554642

Although open-angle glaucoma (OAG) is associated with some of the risk factors of stroke development, there is still no published study addressing whether OAG increases the risk of stroke development. We investigated the risk of stroke development after a diagnosis of OAG.


05/26/2009 09:31 AM

Lipoprotein-Associated Phospholipase A2 and C-Reactive Protein for Risk-Stratification of Patients With TIA

Stroke doi: 10.1161/STROKEAHA.109.553545

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a marker of unstable atherosclerotic plaque, and is predictive of both primary and secondary stroke in population-based studies.


05/26/2009 09:30 AM

Input and output modes modulate phonological and semantic contributions to immediate serial recall: Evidence from a brain-damaged patient

Cognitive Neuropsychology, Volume 26, Issue 2 March 2009 , pages 195 - 216

Psycholinguistic models of short-term retention suggest that performance at verbal short-term memory (STM) tasks relies on the activation of phonological, lexical, and semantic representations, the relative impact of each depending on task variables.


05/26/2009 09:29 AM

Is determination between complete and incomplete traumatic spinal cord injury clinically relevant? Validation of the ASIA sacral sparing criteria in a prospective cohort of 432 patients

Spinal Cord advance online publication 26 May 2009; doi: 10.1038/sc.2009.44

To validate the prognostic value of the acute phase sacral sparing measurements with regard to chronic phase-independent ambulation in patients with traumatic spinal cord injury (SCI).


05/22/2009 03:14 PM

Medical and Psychosocial Predictors of Caregiver Distress and Perceived Burden Following Traumatic Brain Injury

Journal of Head Trauma Rehabilitation: May/June 2009 - Volume 24 - Issue 3 - p 145-154

To determine whether caregivers' medical and psychiatric histories, coping style, and social support predict global distress and perceived burden.


05/22/2009 03:14 PM

Traumatic Brain Injury and Sleep Disturbance: A Review of Current Research

Journal of Head Trauma Rehabilitation: May/June 2009 - Volume 24 - Issue 3 - p 155-165

To summarize the current literature regarding the significant prevalence and potential consequences of sleep disturbance following traumatic brain injury (TBI), particularly mild TBI.


05/22/2009 03:13 PM

BrainSTARS: Pilot Data on a Team-Based Intervention Program for Students Who Have Acquired Brain Injury

Journal of Head Trauma Rehabilitation: May/June 2009 - Volume 24 - Issue 3 - p 166-177

To conduct and evaluate an educational/consultation program for parents and teachers of children who have acquired brain injury (ABI).


05/22/2009 03:12 PM

Deep Venous Thrombosis in Asian Traumatic Brain Injury Patients During Rehabilitation: Prevalence and Risk Factors

Journal of Head Trauma Rehabilitation: May/June 2009 - Volume 24 - Issue 3 - p 178-186

To determine the prevalence and risk factors of asymptomatic lower-limb deep venous thrombosis (DVT) among Asians in inpatient rehabilitation after traumatic brain injury (TBI).


05/22/2009 03:12 PM

Factors Affecting Leisure Participation After a Traumatic Brain Injury: An Exploratory Study

Journal of Head Trauma Rehabilitation: May/June 2009 - Volume 24 - Issue 3 - p 187-194

To explore leisure participation by people with traumatic brain injury (TBI) and reasons underlying changes after the trauma.


05/22/2009 03:11 PM

Approaches to Vocational Rehabilitation After Traumatic Brain Injury: A Review of the Evidence

Journal of Head Trauma Rehabilitation: May/June 2009 - Volume 24 - Issue 3 - p 195-212

Return to work after traumatic brain injury (TBI) is an important outcome but frequently problematic to achieve. Vocational rehabilitation is commonly recommended as a means of facilitating return to work after TBI.


05/22/2009 03:10 PM

Misconceptions About Traumatic Brain Injury and Recovery Among Nursing Students

Journal of Head Trauma Rehabilitation: May/June 2009 - Volume 24 - Issue 3 - p 213-220

To identify potential misconceptions that nursing students have regarding traumatic brain injury (TBI) and recovery.


05/22/2009 03:09 PM

Adolescent Psychiatric Symptoms Following Preschool Childhood Mild Traumatic Brain Injury: Evidence From a Birth Cohort

Journal of Head Trauma Rehabilitation: May/June 2009 - Volume 24 - Issue 3 - p 221-227

To determine whether childhood mild traumatic brain injury (MTBI) is associated with behavioral problems in adolescence.


05/22/2009 03:09 PM

TCD is Used More to Screen for Stroke Risk in Children with Sickle Cell Disease

Neurology Today. 9(9):22, May 4, 2009


05/22/2009 03:08 PM

With CABG, Less Adverse Events But More Strokes

Neurology Today. 9(9):33-34, May 4, 2009


05/22/2009 03:08 PM

Spinal Cord Stimulation Restores Movement in Animal Models of Parkinson Disease

Neurology Today. 9(9):32-33, May 4, 2009


05/22/2009 03:07 PM

Somatostatin Gene Therapy Reduced Seizure Severity in Animal Model of Epilepsy

Neurology Today. 9(9):21, May 4, 2009


05/22/2009 03:06 PM

Most US Hospitals Don't Offer tPA to Ischemic Stroke Patients

Neurology Today. 9(9):10, May 4, 2009


05/22/2009 03:06 PM

Why There is A Gender Gap in Stroke Evaluation and Treatment - And How To Close It

Neurology Today. 9(9):8-9, May 4, 2009


05/22/2009 03:05 PM

FDA Approves Compassionate Use of Growth Factor Therapy for ALS: Specialists Say Evidence to Support Its Use is Weak

Neurology Today. 9(9):5-6, May 4, 2009


05/22/2009 03:04 PM

Richardson Tragedy Promotes Awareness of Head Trauma - When to Seek Treatment, What to Look For

Neurology Today. 9(9):1,12, May 4, 2009


05/22/2009 11:41 AM

Neuro-Optometry and Traumatic Brain Injury PODCAST

Our guest Dr. Neera kapoor presents an overview of Neuro-Optometry and visual impairment after a brain injury. Selecting a Neuro-Optometrist, assessment, the eye examination and treatment options are discussed.


05/22/2009 11:23 AM

The Risk of Stroke in Patients with Psoriasis

Investigative Dermatology advance online publication 21 May 2009; doi: 10.1038/jid.2009.112

Psoriasis is a chronic Th-1 and Th-17 inflammatory disease. Chronic inflammation has also been associated with atherosclerosis and thrombosis.


05/22/2009 11:22 AM

Exploring the Convergence of Posttraumatic Stress Disorder and Mild Traumatic Brain Injury

Am J Psychiatry Published May 15, 2009 doi: 10.1176/appi.ajp.2009.08101604

The authors examine the relationship of the two signature injuries experienced by military personnel serving in Afghanistan and Iraq: posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mild TBI).


05/22/2009 11:21 AM

Low central venous saturation predicts poor outcome in patients with brain injury after major trauma: a prospective observational study

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2009, 17:23doi:10.1186/1757-7241-17-23

Continuous monitoring of central venous oxygen saturation (ScvO2) has been proposed as a prognostic indicator in several pathological conditions, including cardiac diseases, sepsis, trauma.


05/22/2009 11:20 AM

Feasibility of Superficial Temporal Artery as the Input Artery for Cerebral Perfusion CT

AJR 2009; 192:W321-W329

The purpose of this study was to determine whether the superficial temporal artery as a surrogate arterial input function, compared with the anterior cerebral artery as the arterial input function, generates accurate perfusion CT maps with significant correlates for cerebral blood flow, cerebral blood volume, and mean transit time.


05/22/2009 11:19 AM

Relative Maturation of Peripheral and Central Regions of the Human Brainstem From Preterm to Term and the Influence of Preterm Birth

Pediatric Research. 65(6):657-662, June 2009

Relative maturation of peripheral and central regions of the neonatal brainstem was studied using brainstem auditory evoked responses in 174 healthy preterm infants (gestational age 30-36 wk). From 30- to 42-wk postconceptional age (PCA), I-III and III-V intervals shortened with increasing age.


05/22/2009 11:18 AM

Japanese Encephalitis Viruses from Bats in Yunnan, China

Emerging Infectious Diseases Volume 15, Number 6-June 2009 Dispatch

Bats have been increasingly recognized as an important source of zoonotic viruses responsible for some of the recent major disease outbreaks, including Hendra, Nipah, severe acute respiratory syndrome-associated, and Ebola viruses.


05/22/2009 11:17 AM

Fetal Hydrocephalus Caused by Cryptic Intraventricular Hemorrhage

Brain Pathology Published Online: 20 May 2009

Cryptic intracerebral hemorrhage as an etiological factor in fetal hydrocephalus has been postulated but not described at autopsy.


05/22/2009 11:16 AM

Depression, anxiety and quality of life in parents of children with epilepsy

Acta Neurologica Scandinavica Published Online: 20 May 2009

To assess the impact of childhood epilepsy on parental quality of life (QOL) and psychological health, and to investigate possible correlations between parental QOL and background variables as well as parental anxiety and depression.


05/22/2009 11:15 AM

In vivo assessment of hydrocephalus shunt

Acta Neurologica Scandinavica Published Online: 20 May 2009

Over a 3-year period, we have performed 312 tests in 197 shunted patients. The data have been analyzed retrospectively to: (1) investigate the parameters describing CSF dynamics that correlate with shunt under-drainage and (2) estimate accuracy of this method.


05/22/2009 11:15 AM

MRI-based characterization of vascular disruption by 5,6-dimethylxanthenone-acetic acid in gliomas

Journal of Cerebral Blood Flow & Metabolism advance online publication 20 May 2009; doi: 10.1038/jcbfm.2009.68

The well-vascularized nature of gliomas has generated a lot of interest in antiangiogenic therapies. However, the potential of vascular disrupting agents (VDAs) against gliomas has not been investigated extensively.


05/22/2009 11:13 AM

Balance and Motor Speech Impairment in Essential Tremor

The Cerebellum 1473-4222 (Print) 10.1007/s12311-009-0111-y

The pathogenesis of essential tremor (ET) is still under debate. Several lines of evidence indicate that ET is associated with cerebellar dysfunction.


05/22/2009 11:12 AM

Biologic effects of simvastatin in patients with aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled randomized trial

Recently, two randomized controlled phase II studies showed that acute initiation of statin treatment directly after aneurysmal subarachnoid hemorrhage (SAH) decreases the incidence of radiologic vasospasm and clinical signs of delayed cerebral ischemia (DCI), and even reduces mortality.


05/22/2009 11:12 AM

Very Early Constraint-Induced Movement during Stroke Rehabilitation (VECTORS). A single-center RCT

Neurology 2009, doi:10.1212/WNL.0b013e3181ab2b27

Constraint-induced movement therapy (CIMT) is among the most developed training approaches for motor restoration of the upper extremity (UE).


05/22/2009 11:09 AM

Repeatable battery for assessment of neuropsychological status in early Parkinson's disease

Movement Disorders Published Online: 18 May 2009

Adequate reliability and valid factor structure are prerequisites for appropriate use of a measure in a population. Although the Repeatable Battery for Assessment of Neuropsychological Status (RBANS) has been used to examine cognition in Parkinson's disease (PD), its reliability and factor structure have not been examined in this population.


05/22/2009 11:09 AM

Validation of the questionnaire for impulsive-compulsive disorders in Parkinson's disease

Movement Disorders Published Online: 18 May 2009

As no comprehensive assessment instrument for impulse control disorders (ICDs) in Parkinson's disease (PD) exists, the aim of this study was to design and assess the psychometric properties of a self-administered screening questionnaire for ICDs and other compulsive behaviors in PD.


05/22/2009 11:08 AM

Global Differences in Patient Characteristics, Case Management and Outcomes in Intracerebral Hemorrhage: The Factor Seven for Acute Hemorrhagic Stroke (FAST) Trial

Cerebrovasc Dis 2009;28:55-64

The outcomes after stroke vary considerably between countries, yet the extent of the variation after intracerebral hemorrhage (ICH) remains unknown. This study examines differences in outcomes after ICH in a recent multinational trial, and explores the effect of differences in patient severity and case management for the variations observed.


05/22/2009 11:07 AM

Perfusion CT Improves Diagnostic Accuracy for Hyperacute Ischemic Stroke in the 3-Hour Window: Study of 100 Patients with Diffusion MRI Confirmation

Cerebrovasc Dis 2009;28:72-79

Conventional noncontrast CT (NCCT) is insensitive to hyperacute cerebral infarction in the first 3 h.


05/22/2009 11:06 AM

Practice Parameter update: Management issues for women with epilepsy-focus on pregnancy (an evidence-based review): Vitamin K, folic acid, blood levels, and breastfeeding. Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society

Neurology Published online before print April 27, 2009, doi:10.1212/WNL.0b013e3181a6b325

To reassess the evidence for management issues related to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid use, prenatal vitamin K use, risk of hemorrhagic disease of the newborn, clinical implications of placental and breast milk transfer of antiepileptic drugs (AEDs), risks of breastfeeding, and change in AED levels during pregnancy.


05/22/2009 10:53 AM

A novel method improving motor disturbance in Parkinson disease: Application of glycerin poultice to the flexor digitorum profundus in the middle phalanx of the little finger

NeuroRehabilitation Volume 24, Number 3 / 2009 219-223

To investigate whether the application of glycerin poultice to the flexor digitorum profundus in the middle phalanx of the little finger (GFML) improves motor disturbance in Parkinson Disease (PD).


05/22/2009 10:53 AM

Inter-rater reliability of the Modified Modified Ashworth Scale as a clinical tool in measurements of post-stroke elbow flexor spasticity

NeuroRehabilitation Volume 24, Number 3 / 2009 225-229

Patients with neurological conditions may be affected by spasticity. The Modified Modified Ashworth Scale (MMAS) is a clinical tool used to measure spasticity.


05/22/2009 10:52 AM

Orthostatic hypotension following spinal cord injury: Impact on the use of standing apparatus

NeuroRehabilitation Volume 24, Number 3 / 2009 237-242

Upright posture confers numerous medical and social benefits to a spinal cord injured (SCI) patient. Doing so is limited by symptoms of orthostatic hypotension. This is a common secondary impairment among tetraplegic sufferers.


05/22/2009 10:51 AM

FES-propelled cycling of SCI subjects with highly spastic leg musculature

NeuroRehabilitation Volume 24, Number 3 / 2009 243-253

The presence of spasms precludes the use of artificial electrical activation of the muscles to restore mobility.


05/22/2009 10:50 AM

Development and validation of the Online Rivermead Behavioral Memory Test (OL-RBMT) for people with stroke

NeuroRehabilitation Volume 24, Number 3 / 2009 231-236

The purpose of this paper was to examine the reliability and validity (concurrent and construct) of a newly developed online Chinese version of the Rivermead Behavioral Memory Test (OL-RBMT) and its equivalence with the face-to-face version (FTF-RBMT).


05/22/2009 10:49 AM

Sentence planning following traumatic brain injury

NeuroRehabilitation Volume 24, Number 3 / 2009 255-266

Current descriptions of the language problems following traumatic brain injury (TBI) generally emphasize evaluating discourse production and explaining the observed outcomes in terms of disruptions to executive processes.


05/22/2009 10:48 AM

The role of the corticospinal tract in motor recovery in patients with a stroke: A review

NeuroRehabilitation Volume 24, Number 3 / 2009 285-290

The corticospinal tract (CST) is the major neuronal pathway that mediates voluntary movements.


05/22/2009 10:47 AM

Long-term treadmill exercise-induced neuroplasticity and associated memory recovery of streptozotocin-induced diabetic rats: An experimenter blind, randomized controlled study

NeuroRehabilitation Volume 24, Number 3 / 2009 291-297

We investigated a long-term exercise-induced neuroplasticity and spatial memory recovery in 15 rats in a treadmill as follows: normal control rats (NC), streptozotocin (STZ)-induced diabetic control rats (DC), and STZ-induced diabetic rats exercising in a treadmill (DE).


05/22/2009 10:47 AM

Clinical application of diffusion tensor tractography for elucidation of the causes of motor weakness in patients with traumatic brain injury

NeuroRehabilitation Volume 24, Number 3 / 2009 273-278

Diffusion tensor tractography (DTT) is useful for elucidating the status of the corticospinal tract (CST).


05/22/2009 10:46 AM

An ultrasound study of brain tissue biomechanics in patients following craniectomy

NeuroRehabilitation Volume 24, Number 3 / 2009 267-271

In the healthy volunteers, the third ventricle was enlarging after reaching the sitting position. The median diameter was 2.35 mm in the lying and 2.9 mm in the sitting position (p > 0.05).


05/22/2009 10:45 AM

A review of corticospinal tract location at corona radiata and posterior limb of the internal capsule in human brain

NeuroRehabilitation Volume 24, Number 3 / 2009 279-283

The corticospinal tract (CST) is the most important motor pathway in the human brain, therefore, the accurate estimation of the CST state following brain injury would enable us to predict the motor outcome or enable accurate surgical planning.


05/22/2009 10:44 AM

Sensory Segmental Assessments Following Spinal Cord Injury

Topics in Spinal Cord Injury Rehabilitation Volume 14, Number 4 / Spring 2009 - Advancing the Frontier: Research and Clinical Care in Canada 23-33

Advanced electrophysiological recording techniques can assess sensory function from individual spinal segments and track the potential risks or benefits of a therapeutic intervention.


05/22/2009 10:43 AM

Real-Time Two-Dimensional Asynchronous Control of a Remote-Controlled Car Using a Single Electroencephalographic Electrode

Topics in Spinal Cord Injury Rehabilitation Volume 14, Number 4 / Spring 2009 - Advancing the Frontier: Research and Clinical Care in Canada 62-68

A brain-machine interface (BMI) can generate control commands using signals from the brain. These devices have great potential to assist individuals with severe mobility impairments.


05/22/2009 10:42 AM

Home Physical Activity Programs for the Promotion of Health and Wellness in Individuals with Spinal Cord Injury

Topics in Spinal Cord Injury Rehabilitation Volume 14, Number 4 / Spring 2009 - Advancing the Frontier: Research and Clinical Care in Canada 122-132

The purpose of this study was to increase physical activity in individuals with spinal cord injury (SCI) through regular participation in a home exercise program.


05/22/2009 10:41 AM

Experiential Outcomes of the SCI Support Provider Role

Topics in Spinal Cord Injury RehabilitationVolume 14, Number 4 / Spring 2009 - Advancing the Frontier: Research and Clinical Care in Canada 69-87

This article presents the qualitative results of a 2-year mixed methodology study (quantitative and qualitative) examining the personal impact of being a support provider (SP) to a person living in the community with a spinal cord injury (SCI).


05/22/2009 10:40 AM

Detection and Treatment of Sublesional Osteoporosis Among Patients with Chronic Spinal Cord Injury

Topics in Spinal Cord Injury Rehabilitation Volume 14, Number 4 / Spring 2009 - Advancing the Frontier: Research and Clinical Care in Canada 1-22

Low hip and knee region bone mineral density (BMD) after spinal cord injury (SCI) results in an increased risk of lower extremity fragility fractures or sublesional osteoporosis (SLOP).


05/22/2009 10:40 AM

Cellular Transplantation Approaches for Repair of the Injured Spinal Cord

Topics in Spinal Cord Injury Rehabilitation Volume 14, Number 4 / Spring 2009 - Advancing the Frontier: Research and Clinical Care in Canada 47-61

Cell transplantation holds great promise as a treatment strategy for human spinal cord injury (SCI).


05/22/2009 10:39 AM

Assessment of the Hand in Tetraplegia Using the Graded Redefined Assessment of Strength, Sensibility and Prehension (GRASSP)

Topics in Spinal Cord Injury Rehabilitation Volume 14, Number 4 / Spring 2009 - Advancing the Frontier: Research and Clinical Care in Canada 34-46

To refine the Graded and Redefined Assessment of Strength, Sensibility and Prehension (GRASSP) as a measure of upper limb impairment following cervical SCI.


05/22/2009 10:37 AM

Health and Fitness Benefits of Functional Electrical Stimulation-Evoked Leg Exercise for Spinal Cord-Injured Individuals

Topics in Spinal Cord Injury Rehabilitation Volume 14, Number 4 / Spring 2009 - Advancing the Frontier: Research and Clinical Care in Canada 88-121


05/22/2009 10:35 AM

Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial

The Lancet, Volume 373, Issue 9677, Pages 1780 - 1788, 23 May 2009

Amputations in people with type 2 diabetes mellitus substantially impair their quality of life and impose high costs on health-care systems. Our aim was to assess the effect of fenofibrate on amputation events in a large cohort of patients with type 2 diabetes.


05/22/2009 10:35 AM

Identification of potential neuromotor mechanisms of manual therapy in patients with musculoskeletal disablement: rationale and description of a clinical trial

BMC Neurology 2009, 9:20doi:10.1186/1471-2377-9-20

Many health care practitioners use a variety of hands-on treatments to improve symptoms and disablement in patients with musculoskeletal pathology.


05/21/2009 10:48 AM

Getting to know reality and breaking stereotypes: the experience of two generations of working disabled women

Disability & Society, Volume 24, Issue 4 June 2009 , pages 447 - 459

This paper sets out the results of a Spanish study of the experience and meaning of work among disabled women of two generations, with three types of disability (physical, visual and hearing).


05/21/2009 10:47 AM

Changing perspectives on the child at risk at the end of the nineteenth century. The Belgian Maritime Hospital Roger de Grimberghe (1884-1914) as a space of inclusion and exclusion

Disability & Society, Volume 24, Issue 4 June 2009 , pages 425 - 436

In this historical-geographical approach to the Belgian Maritime Hospital Roger de Grimberghe space is introduced as a conceptual tool to deconstruct the notion of the child at risk. The starting point for the creation of the maritime hospitals lay in the immediate relationship between the idea of improving children's welfare with healthy sea air and concern about declining public health at the end of the nineteenth century, together with a need for the moral reclamation of the nation.


05/21/2009 10:43 AM

Wounded/monstrous/abject: a critique of the disabled body in the sociological imaginary

Disability & Society, Volume 24, Issue 4 June 2009 , pages 399 - 410

Contemporary sociology has made sense of bodily difference by mobilising a number of tropes. 'Wounded' (or vulnerable), 'monstrous' and 'abject' stand out by virtue of their ubiquity though they do not exhaust the repertoire.


05/21/2009 10:42 AM

Neurologic Manifestations Associated with Parvovirus B19 Infection

Clinical Infectious Diseases 2009;48:000-000

Eighty-one cases of neurologic disease, including encephalitis, meningitis, stroke, and peripheral neuropathy, that were associated with parvovirus B19 infection were reviewed.


05/21/2009 10:41 AM

Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma

Oncogene advance online publication 18 May 2009; doi: 10.1038/onc.2009.93

Neuroblastoma, derived from neural crest progenitor cells, is the most common extracranial solid tumor of childhood.


05/21/2009 10:41 AM

Introduction of Endovascular Embolization for Intracranial Aneurysms in a Low-volume Institution

Acta Radiologica, Volume 50, Issue 5 2009 , pages 555 - 561

Studies indicate a relationship between hospital caseload and health outcomes after both surgical and endovascular repair of intracranial aneurysms.


05/21/2009 10:39 AM

Thyroid follicular carcinoma presenting as skull and dural metastasis mimicking a meningioma: a case report

Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-009-9915-3

Follicular thyroid cancer rarely manifests itself as a distant metastatic lesion. We report a case of a 61-year-old woman presented with a solid mass located in the left temporo-occipital region.


05/21/2009 10:31 AM

Skull metastasis of ampulla of Vater adenocarcinoma 5 years after Whipple operation: case report and literature review

Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-009-9906-4

Skull metastases can occur with nearly all types of tumor. They frequently are asymptomatic, causing local swelling, which is usually painless and rarely leads to neurological dysfunction.


05/21/2009 10:29 AM

EGFR-targeted diphtheria toxin stimulates TRAIL killing of glioblastoma cells by depleting anti-apoptotic proteins

Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-009-9914-4

Current treatments for Glioblastoma multiforme (GBM) involve surgery, radiotherapy, and cytotoxic chemotherapy; however, these treatments are not effective and there is an urgent need for better treatments.


05/21/2009 10:28 AM

Headache syndromes after acoustic neuroma surgery and their implications for quality of life

Cephalalgia Published Online: 23 Feb 2009

The patients of this prospective study were analysed for headache as a sequela of surgery for acoustic neuroma (AN). Thirty-two per cent (30/95) of patients complained about a persisting headache syndrome with a severity of at least 6/10 on the nominal analogue scale 6 months after surgery.


05/21/2009 10:27 AM

Quality of life and seizure control in patients with brain tumor-related epilepsy treated with levetiracetam monotherapy: preliminary data of an open-label study

Neurological Sciences 1590-1874 (Print) 10.1007/s10072-009-0087-x

The aim of this pilot study was to investigate the effects of levetiracetam monotherapy on seizure control, quality of life and neurocognitive performance in patients with brain tumor-related epilepsy.


05/21/2009 10:26 AM

Determination of nerve conduction abnormalities in patients with impaired glucose tolerance

Neurological Sciences 1590-1874 (Print) 10.1007/s10072-009-0089-8

Recent studies have shown that impaired glucose tolerance (IGT) is associated with dysfunction in the peripheral and autonomic nerves.


05/21/2009 10:23 AM

Pathogenesis and radiobiology of brain arteriovenous malformations: implications for risk stratification in natural history and posttreatment course

Neurosurgical Focus May 2009 Volume 26, Number 5

Brain arteriovenous malformations (BAVMs) are an important cause of intracerebral hemorrhage (ICH) in young adults. Biological predictors of future ICH risk are lacking, and controversy exists over previous studies of natural history risk among predominantly ruptured BAVM cohorts.


05/21/2009 10:22 AM

Reduced Platelet Activity Is Associated With Early Clot Growth and Worse 3-Month Outcome After Intracerebral Hemorrhage

Stroke doi: 10.1161/STROKEAHA.109.550939

Antiplatelet medication use and reduced platelet activity may be associated with mortality after intracerebral hemorrhage (ICH). We tested the hypothesis that reduced platelet activity is associated with early ICH clot growth and worse outcomes.


05/21/2009 10:21 AM

Change in Diffusion-Weighted Imaging Infarct Volume Predicts Neurologic Outcome at 90 Days. Results of the Acute Stroke Accurate Prediction (ASAP) Trial Serial Imaging Substudy

Stroke doi: 10.1161/STROKEAHA.109.548933

Predictive models of outcome after ischemic stroke have incorporated acute diffusion-weighted MRI (DWI) information with mixed results. We hypothesized that serial measurements of DWI infarct volume would be predictive of functional outcome after ischemic stroke.


05/21/2009 10:19 AM

Lifestyle Factors and Risk of Amyotrophic Lateral Sclerosis: A Case-Control Study in Japan

Annals of Epidemiology Volume 19, Issue 6, Pages 359-364 (June 2009)

We examined the associations between lifestyle factors and the risk of amyotrophic lateral sclerosis (ALS) using a case-control study in Aichi Prefecture, Japan.


05/21/2009 10:18 AM

A Phase I Trial of Enzastaurin in Patients with Recurrent Gliomas

Clinical Cancer Research 15, 3617, May 15, 2009. Published Online First May 5, 2009; doi: 10.1158/1078-0432.CCR-08-3071

Enzastaurin is a selective inhibitor of protein kinase C {beta}. Prior phase I studies did not show increased drug exposures with escalating once daily administration. Limits from gastrointestinal absorption may be overcome by twice daily dosing, potentially improving antitumor effects.


05/21/2009 10:17 AM

Folate Supplementation Limits the Aggressiveness of Glioma via the Remethylation of DNA Repeats Element and Genes Governing Apoptosis and Proliferation

Clinical Cancer Research 15, 3519, May 15, 2009. doi: 10.1158/1078-0432.CCR-08-2062

We have investigated whether the folate supplementation could be used to limit the aggressiveness of glioma through the DNA remethylation because (a) the cancer genome is characterized by a low level of DNA methylation (or 5-methylcytosine, 5 mC); and (b) folate is the main generator of S-adenosyl-methionine, the methyl donor molecule in the DNA methylation reaction catalyzed by the DNA methyltranferases.


05/21/2009 10:16 AM

Tube feeding and quality of life in children with severe neurologic impairment

Arch Dis Child. Published Online First: 12 May 2009. doi:10.1136/adc.2008.149542

To assess the QOL of neurologically impaired children before and after gastrostomy (G) and gastrojejunostomy (GJ) tube insertion.


05/21/2009 10:16 AM

Danshen extracts decrease blood c reactive protein and prevent ischemic stroke recurrence: a controlled pilot study

Phytotherapy Research Published Online: 15 May 2009

The efficacy of a danshen (Salvia miltiorrhiza) dripping pill (DDP) for secondary stroke prevention was evaluated in patients with ischemic cerebrovascular disease. The preparation also contained Panax notoginseng (sanqi) and Dryobalanops camphor.


05/21/2009 10:15 AM

The management of infants and children treated with aciclovir for suspected viral encephalitis

Arch Dis Child. Published Online First: 19 May 2009. doi:10.1136/adc.2008.144998

To investigate how infants and children with suspected viral encephalitis are currently managed in a UK tertiary children’s hospital.


05/21/2009 10:14 AM

A Survey of Complementary and Alternative Medicine (CAM) Awareness Among Neurosurgeons in Washington State

The Journal of Alternative and Complementary Medicine. May 2009, 15(5): 551-555. doi:10.1089/acm.2008.0427

Use of complementary and alternative medicine (CAM) by the U.S. population increased significantly in the past 2 decades. To maximize a patient's recovery from a neurosurgical procedure, it is critical that neurosurgeons be aware of the benefits and potential adverse complications of CAM therapies.


05/21/2009 10:13 AM

Changes in Aqueductal CSF Stroke Volume in Shunted Patients with Idiopathic Normal-Pressure Hydrocephalus

American Journal of Neuroradiology DOI 10.3174/ajnr.A1616

Aqueductal CSF stroke volume (ACSV) measured by phase-contrast MR imaging is a tool for selection of surgical patients with idiopathic normal-pressure hydrocephalus (iNPH).


05/21/2009 10:12 AM

Added Value and Diagnostic Performance of Intratumoral Susceptibility Signals in the Differential Diagnosis of Solitary Enhancing Brain Lesions: Preliminary Study

American Journal of Neuroradiology DOI 10.3174/ajnr.A1635

It has been reported that high-resolution susceptibility-weighted imaging (HR-SWI) is a promising tool for assessing brain tumor characterization noninvasively.


05/21/2009 10:11 AM

Consistency of response to sumatriptan/naproxen sodium in a placebo-controlled, crossover study

Cephalalgia Published Online: 12 Feb 2009

Two identical randomized, placebo-controlled, crossover studies were conducted to evaluate consistency of response to sumatriptan/naproxen sodium 85/500 mg (S/NS) over four attacks in adults with migraine.


05/21/2009 10:10 AM

Recurrent thunderclap headaches and multilobar intracerebral haemorrhages: two cases of reversible cerebral vasoconstriction syndrome (RCVS)

Cephalalgia Published Online: 11 Feb 2009

We describe two patients with thunderclap headaches due to reversible cerebral vasoconstriction syndrome (RCVS).


05/21/2009 10:09 AM

Implicit representation and explicit detection of features in patients with hemispatial neglect

Brain, doi:10.1093/brain/awp109

Despite profound inattention to the side of space opposite a brain lesion in patients with unilateral neglect, priming studies demonstrate that undetected stimuli are capable of influencing subsequent behaviour.


05/21/2009 10:06 AM

Causal role of prefrontal cortex in the threshold for access to consciousness

Brain, doi:10.1093/brain/awp111

What neural mechanisms support our conscious perception of briefly presented stimuli? Some theories of conscious access postulate a key role of top-down amplification loops involving prefrontal cortex (PFC).


05/21/2009 10:05 AM

Blood-Brain Barrier Disruption and Intra-Arterial Methotrexate-Based Therapy for Newly Diagnosed Primary CNS Lymphoma: A Multi-Institutional Experience

Journal of Clinical Oncology, 10.1200/JCO.2008.19.3789

Primary CNS lymphoma (PCNSL) is confined to the CNS and/or the eyes at presentation and is usually initially treated with intravenous methotrexate-based chemotherapy and whole-brain radiotherapy (WBRT). However, the intact blood-brain barrier (BBB) can limit diffusion of methotrexate into brain and tumor. With BBB disruption (BBBD), enhanced drug delivery to the tumor can be achieved.


05/21/2009 10:04 AM

Homocysteine and cognitive impairment in Parkinson's disease: A biochemical, neuroimaging, and genetic study

Movement Disorders Published Online: 18 May 2009

The role of the plasma level of homocysteine (Hcy), as a primary outcome, and the effect of silent cerebrovascular lesions and genetic variants related to Hcy metabolism, as secondary outcomes, in the cognitive decline and dementia in Parkinson's disease (PD) were studied.


05/21/2009 10:03 AM

Increased baroreflex sensitivity and heart rate variability in migraine patients

Acta Neurologica Scandinavica Published Online: 19 May 2009

We investigated whether spontaneous baroreflex sensitivity and heart rate variability (HRV) are different in migraine patients compared to healthy controls.


05/21/2009 10:02 AM

Renal Function Predicts Survival in Patients with Acute Ischemic Stroke

Cerebrovasc Dis 2009;28:88-94

Among patients with acute ischemic stroke, impaired kidney function has been shown to increase the mortality risk, but the shape of this relationship has not been evaluated in detail.


05/21/2009 10:01 AM

Incidence and Risk Factors of Intracranial Atherosclerotic Stroke: The Northern Manhattan Stroke Study

Cerebrovasc Dis 2009;28:65-71

To assess the prevalence of risk factors as determinants of intracranial atherosclerosis (IATH)-related stroke in a multi-ethnic community-based cohort.


05/21/2009 10:01 AM

Diffusion-Weighted Imaging Showing 'Pearls' Predicts Large-Vessel Disease as Stroke Etiology

Cerebrovasc Dis 2009;28:49-54

The patterns on diffusion-weighted (DWI) MRI may be predictive of stroke etiology. In this retrospective study, we assessed whether DWI bright lesions termed 'pearls' predicted the presence of large-vessel arterial stenosis as the etiology of stroke.


05/21/2009 10:00 AM

Extent of Intra-Arterial Calcification on Head CT Is Predictive of the Degree of Intracranial Atherosclerosis on Digital Subtraction Angiography

Cerebrovasc Dis 2009;28:45-48

Intracranial intra-arterial calcifications (ICAC) are a common finding on head CT examinations, but their significance is not known.


05/21/2009 09:55 AM

Usage of support services in primary lateral sclerosis

Amyotrophic Lateral Sclerosis, Volume 10, Issue 3 June 2009 , pages 185 - 187

Patients with amyotrophic lateral sclerosis (ALS) rely on a variety of support services during the course of their illness. Patients with primary lateral sclerosis (PLS) have a slower progression of disease and different clinical spectrum.


05/21/2009 09:55 AM

Problem solving skills predict quality of life and psychological morbidity in ALS caregivers

Amyotrophic Lateral Sclerosis, Volume 10, Issue 3 June 2009 , pages 147 - 153

Amyotrophic lateral sclerosis (ALS) often is associated with a particularly intensive caregiving experience, and the well-being of caregivers impacts that of patients.


05/21/2009 09:54 AM

Percutaneous nocturnal oximetry in amyotrophic lateral sclerosis: Periodic desaturation

Amyotrophic Lateral Sclerosis, Volume 10, Issue 3 June 2009 , pages 154 - 161

Percutaneous nocturnal oximetry (PNO) is useful to screen respiratory function in amyotrophic lateral sclerosis (ALS). PNO recordings of some patients disclose a periodical pattern of O2 desaturation (PP), whose significance is unknown.


05/21/2009 09:53 AM

Longitudinal assessment of grey matter contraction in amyotrophic lateral sclerosis: A tensor based morphometry study

Amyotrophic Lateral Sclerosis, Volume 10, Issue 3 June 2009 , pages 168 - 174

Our objective was to investigate grey matter (GM) contraction in patients with amyotrophic lateral sclerosis (ALS) using tensor based morphometry (TBM). Using a 1.5 Tesla scanner, T1-weighted MRI scans were obtained at baseline and at follow-up (mean interval, 9 months) from 16 ALS and 10 controls. Standard TBM procedures in Statistical Parametric Mapping (SPM2) were used for image processing and statistical analyses.


05/21/2009 09:52 AM

IPLEX and the Telephone Game: The difficulty in separating myth from reality on the internet

Amyotrophic Lateral Sclerosis, Volume 10, Issue 3 June 2009 , pages 182 - 184


05/21/2009 09:51 AM

Identification of candidate genes for sporadic amyotrophic lateral sclerosis by array comparative genomic hybridization

Amyotrophic Lateral Sclerosis, Volume 10, Issue 3 June 2009 , pages 162 - 167

Amyotrophic lateral sclerosis (ALS) is a devastating disorder of the central nervous system that leads to progressive loss of upper and lower motor neurons.


05/21/2009 09:50 AM

CSF profiles of angiogenic and inflammatory factors depend on the respiratory status of ALS patients

Amyotrophic Lateral Sclerosis, Volume 10, Issue 3 June 2009 , pages 175 - 181

Our objective was to assess the regulation of the hypoxia response of angiogenic and inflammatory factors from 76 cerebrospinal fluids (CSF) of sporadic amyotrophic lateral sclerosis (ALS) patients with different respiratory status.


05/21/2009 09:49 AM

Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis, Volume 10, Issue 3 June 2009 , pages 131 - 146

Amyotrophic lateral sclerosis (ALS) is increasingly recognized to be a multisystem disorder which includes both clinical and neuropathological features of a frontotemporal lobar degeneration (FTLD).


05/21/2009 09:48 AM

ALSUntangled (ALSU): A Scientific Approach to Off-Label Treatment Options for People with ALS Using Tweets and Twitters

Amyotrophic Lateral Sclerosis, Volume 10, Issue 3 June 2009 , pages 129 - 130


05/19/2009 07:58 AM

Respiratory Problems in Parkinson Disease

Clinical Pulmonary Medicine: May 2009 - Volume 16 - Issue 3 - pp 139-143

Parkinson disease (PD), also known as paralysis agitans, is a common neurodegenerative disorder.


05/19/2009 07:58 AM

Hashimoto Encephalopathy and Down Syndrome

Arch Neurol. 2009;66(5):663-666

Hashimoto encephalopathy is a potentially fatal condition associated with a presentation of myoclonus, altered conscious state, strokelike episodes, rapid cognitive decline, and neuropsychiatric symptoms. Both congenital hypothyroidism and acquired hypothyroidism are common in patients with Down syndrome.


05/19/2009 07:56 AM

Recombinant human granulocyte-colony stimulating factor administration for treating amyotrophic lateral sclerosis: A pilot study

Amyotrophic Lateral Sclerosis First Published on: 15 May 2009

Granulocyte-colony stimulating factor (G-CSF) is used to mobilize CD34+ haematopoietic stem cells from the bone marrow to the peripheral blood. We proposed to use cell subsets induced by G-CSF to slow down disease progression in patients with amyotrophic lateral sclerosis (ALS).


05/19/2009 07:55 AM

Genistein, a soybean isoflavone, reduces the production of pro-inflammatory and adhesion molecules induced by hemolysate in brain microvascular endothelial cells

Acta Neurologica Belgica 2009, N 1 (Vol. 109/1) p.32-37

Genistein (4",5,7-trihydroxyisoflavone) is the most abundant isoflavone found in the soybean that exhibits an anti-inflammatory effect. The present study was designed to examine the effects of genistein on expression levels of hemolysate-induced proinflammatory and adhesion molecules in SD rat brain microvascular endothelial cells (BMECs).


05/19/2009 07:54 AM

Relationship between admission pulse pressure and clinical outcome during hospitalization among acute stroke patients

Acta Neurologica Belgica 2009, N 1 (Vol. 109/1) p.18-23

There are currently no data on the relationship between admission pulse pressure (PP) level and short term clinical outcome among acute stroke patients in the Chinese population.


05/19/2009 07:53 AM

Clinical features and outcomes in spontaneous intracranial hypotension: a survey of 90 consecutive patients

Neurological Sciences Volume 30, Supplement 1 / May, 2009 11-13

Spontaneous intracranial hypotension (SIH) is a rare disabling condition whose main clinical manifestation is orthostatic headache.


05/19/2009 07:52 AM

Giant serpentine aneurysms

Neurosurgical Focus May 2009 Volume 26, Number 5

Segal and McLaurin first described giant serpentine aneurysms, based on their distinct angiographic features, in 1977. These lesions are - 25 mm, partially thrombosed aneurysms with a patent, serpiginous vascular channel that courses through the aneurysm.


05/19/2009 07:51 AM

Total laryngectomy in patients with advanced bulbar symptoms of amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis First Published on: 28 January 2009

Our objectives were to 1) increase awareness of total laryngectomy (TL) as a treatment for complications of bulbar weakness in patients with amyotrophic lateral sclerosis (ALS) and outline specific surgical indications; 2) educate physicians about the surgical procedure, peri-operative course and benefits from having a TL; and 3) retrospectively review the clinical course of Mayo Clinic - Florida patients with ALS who had a TL.


05/19/2009 07:50 AM

Percutaneous Device Closure of Patent Foramen Ovale for Secondary Stroke Prevention. A Call for Completion of Randomized Clinical Trials, A Science Advisory From the American Heart Association/American Stroke Association and the American College of Cardiology Foundation

Circulation doi: 10.1161/CIRCULATIONAHA.109.192272

The optimal therapy for prevention of recurrent stroke or transient ischemic attack in patients with cryptogenic stroke and patent foramen ovale has not been defined.


05/19/2009 07:49 AM

Penn State screen exam for the detection of frontal and temporal dysfunction syndromes: Application to ALS

Amyotrophic Lateral Sclerosis, Volume 10, Issue 2 April 2009 , pages 107 - 112

We improved standard treatment approaches by systematically addressing cognitive and behavioral change in association with frontal and temporal dysfunction in ALS. We evaluated the profile of inchange 198 ALS patients with a 20-minute screen exam.


05/19/2009 07:48 AM

Ultrasound-aided fixation of a biodegradable cranial fixation system: uses in pediatric neurosurgery

Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5

Bioresorbable implant systems have been used in neurosurgery for the rigid fixation of cranial and facial bones. A relatively recent advancement has been the fixation of these implants using an ultrasonic device.


05/19/2009 07:47 AM

Paraspinal arteriovenous malformations in children

Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5

Arteriovenous malformations (AVMs) within the spinal canal and in the paraspinal region are unusual. Spinal cord and dural AVMs or arteriovenous fistulas have been the subject of numerous reports, but paraspinal malformations causing venous congestion or hemorrhage in the spinal canal are rare and present special diagnosis and management challenges.


05/19/2009 07:46 AM

Acute subdural hematoma secondary to distal middle cerebral artery aneurysm rupture in a newborn infant

Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5

The authors present the case of a peripheral aneurysmal lesion that developed in a newborn baby and was successfully treated by endovascular parent artery occlusion.


05/19/2009 07:45 AM

Resonant and notch behavior in intracranial pressure dynamics

Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5

The intracranial pulse pressure is often increased when neuropathology is present, particularly in cases of increased intracranial pressure (ICP) such as occurs in hydrocephalus.


05/19/2009 07:44 AM

Coxsackie B meningoencephalitis in a patient with acquired immunodeficiency syndrome and a multiple sclerosis-like illness

Journal of Neurovirology First Published on: 14 May 2009

Both Coxsackie infection and multiple sclerosis (MS) are rare in human immunodeficiency virus (HIV) infection.


05/19/2009 07:43 AM

Cerebral arteriovenous malformations. Part 1: cellular and molecular biology

Neurosurgical Focus May 2009 Volume 26, Number 5

The authors performed a comprehensive review of the literature to evaluate current information regarding the genetics, pathophysiology, and behavior of AVMs.


05/19/2009 07:42 AM

Cerebral arteriovenous malformations. Part 2: physiology

Neurosurgical Focus May 2009 Volume 26, Number 5

The scientific understanding of the nature of arteriovenous malformations (AVMs) in the brain is evolving. It is clear from current work that AVMs can undergo a variety of phenomena, including growth, remodeling, and/or regression-and the responsible processes are both molecular and physiological.


05/19/2009 07:41 AM

A rare case of hemangioma of infancy presenting as intraspinal hemorrhage

Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5

Hemangiomas of infancy (HOIs) are among the most common benign tumors of childhood and classically appear as a vascular stain or small vascular papule at birth.


05/19/2009 07:40 AM

Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection

Journal of Neurovirology First Published on: 14 May 2009

Circulating levels of specific matrix metalloproteinases (MMPs; 1 and 7) were evaluated as correlates of brain injury in eight individuals in advanced human immunodeficiency virus (HIV) infection.


05/19/2009 07:39 AM

Intratentorial osteochondrolipoma in a 9-year-old boy

Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5

Intracranial osteolipomas and chondromas are rare benign tumors. Forty-five chondromas, mostly supratentorial, have been reported in the literature since 1981, with origins most commonly in the sellar regions.


05/19/2009 07:38 AM

Assessment of arcuate fasciculus with diffusion-tensor tractography may predict the prognosis of aphasia in patients with left middle cerebral artery infarcts

Neuroradiology 0028-3940 (Print) 10.1007/s00234-009-0534-7

It is often clinically difficult to assess the severity of aphasia in the earliest stage of cerebral infarction. A method enabling objective assessment of verbal function is needed for this purpose.


05/19/2009 07:36 AM

Medulloblastomas: a correlative study of MIB-1 proliferation index along with expression of c-Myc, ERBB2, and anti-apoptotic proteins along with histological typing and clinical outcome

Child's Nervous System 0256-7040 (Print) 10.1007/s00381-009-0884-9

Medulloblastoma (MB) is the most common pediatric brain tumor. It is however rare in adults


05/19/2009 07:35 AM

Is gabapentin an effective treatment choice for hemicrania continua?

The Journal of Headache and Pain 1129-2369 (Print) 10.1007/s10194-009-0126-2

The objective of this study is to examine the efficacy of gabapentin for the treatment of hemicrania continua (HC) in cases where patients had difficulty tolerating indomethacin due to adverse effects.


05/19/2009 07:34 AM

Unruptured intracranial aneurysms and the assessment of rupture risk based on anatomical and morphological factors: sifting through the sands of data

Neurosurgical Focus May 2009 Volume 26, Number 5

Aneurysmal subarachnoid hemorrhage continues to have high rates of morbidity and mortality for patients despite optimal medical and surgical management. Due to the fact that aneurysmal rupture can be such a catastrophic event, preventive treatment is desirable for high-risk lesions.


05/19/2009 07:34 AM

The evolution of cerebral revascularization surgery

Neurosurgical Focus May 2009 Volume 26, Number 5

Among the relatively few surgeons to be awarded the Nobel Prize was Alexis Carrel, a French surgeon and pioneer in revascularization surgery at the turn of the 20th century.


05/19/2009 07:33 AM

Embryopathogenetic surgicoanatomical classification of dysraphism and surgical outcome of spinal lipoma: a nationwide multicenter cooperative study in Japan

Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5

The natural history of asymptomatic spinal lipoma in infancy remains unclear, and the indication for the prophylactic untethering operation is still debatable.


05/19/2009 07:32 AM

Gait freezing in Parkinson's disease and the stride length sequence effect interaction

Brain, doi:10.1093/brain/awp053

Freezing of gait (FOG) has been identified as one of the main contributors to gait disturbances in Parkinson's disease.


05/19/2009 07:32 AM

Two consecutive pregnancies in early and late stage of amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis First Published on: 28 January 2009

There are few reports on pregnancies in sporadic and familial amyotrophic lateral sclerosis (ALS). We report on a young woman with sporadic ALS who gave birth twice during the course of her disease.


05/19/2009 07:30 AM

Alterations in the cerebral venous circulation as a cause of headache

Neurological Sciences Volume 30, Supplement 1 / May, 2009 7-10

The alterations of the cerebral venous circulation are a rare but clinically important cause of headache. Although any process involving the cerebral veins or sinuses may cause headache, the most frequent and important are cerebral venous thrombosis and idiopathic intracranial hypertension.


05/19/2009 07:29 AM

Intracranial growing teratoma syndrome mimicking tumor relapse: a diagnostic dilemma

Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5

It is important to differentiate growing teratoma syndrome (GTS) from tumor recurrence in the setting of an enlarging residual mass present after treatment of intracranial germ cell tumors (GCTs).


05/19/2009 07:28 AM

Bias in request for medical care and impact on outcome during office and non-office hours in stroke patients

European Journal of Neurology Published Online: 14 May 2009

We compared characteristics and treatment success of ischaemic stroke patients admitted during daytime on working days (office hours) with patients admitted on weekend or nighttime (non-office hours) to test if differences in presentation or restraints of medical care during non-office hours determine outcome in stroke patients.


05/19/2009 07:28 AM

Graft selection in cerebral revascularization

Neurosurgical Focus May 2009 Volume 26, Number 5

Cerebral revascularization constitutes an important treatment modality in the management of complex aneurysms, carotid occlusion, tumor, and moyamoya disease.


05/19/2009 07:27 AM

Endogenous tenascin-C enhances glioblastoma invasion with reactive change of surrounding brain tissue

Cancer Science Published Online: 20 Apr 2009

Tenascin-C is an extracellular matrix glycoprotein implicated in embryogenesis, wound healing and tumor progression. We previously revealed that tenascin-C expression is correlated with the prognosis of patients with glioblastoma.


05/19/2009 07:26 AM

Recurrent acute dystonic reaction and oculogyric crisis despite withdrawal of dopamine receptor blocking drugs

Movement Disorders Published Online: 1 May 2009

Adverse events of dopamine-blocking agents include acute dystonic reactions and oculogyric crises (OGCs). OGCs may be recurrent on maintenance of or re-exposure to the drug.


05/19/2009 07:25 AM

Utilization of antiepileptic drugs during pregnancy: Comparative patterns in 38 countries based on data from the EURAP registry

Epilepsia Published Online: 12 May 2009

We assessed the utilization of antiepileptic drugs (AEDs), 1999-2005, in 4,798 prospective epilepsy pregnancies from 38 countries participating in EURAP, an international AED and pregnancy registry.


05/19/2009 07:23 AM

Cross-sectional and longitudinal studies of three-dimensional stereotactic surface projection SPECT analysis in Parkinson's disease

Movement Disorders Published Online: 13 May 2009

Although dementia is increasingly recognized as a common feature in Parkinson's disease (PD), its pathological substrate remains unknown. We conducted cross-sectional and longitudinal brain perfusion SPECT analyses to explore changes during the course of developing dementia in PD.


05/19/2009 07:22 AM

Imbalance of neural cell adhesion molecule and polysialyltransferase alleles causes defective brain connectivity

Brain, doi:10.1093/brain/awp117

The neural cell adhesion molecule (NCAM) and its post-translational modification polysialic acid (polySia) are broadly implicated in neural development.


05/19/2009 07:21 AM

Cerebral White Matter Lesions Are Associated With the Risk of Stroke But Not With Other Vascular Events. The 3-City Dijon Study

Stroke doi: 10.1161/STROKEAHA.109.548222

White matter lesions (WMLs) have been shown to be associated with the risk of stroke in previous studies but little is known about the prediction of other vascular events.


05/19/2009 07:20 AM

Recurrent cerebral ischemia in medically treated patent foramen ovale. A meta-analysis

Neurology 2009, doi:10.1212/WNL.0b013e3181aa2a19

Among patients with a patent foramen ovale (PFO) and a prior cryptogenic ischemic stroke or TIA, the absolute and relative risk of recurrent events is unclear.


05/19/2009 07:19 AM

Definition and Evaluation of Transient Ischemic Attack. A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association Stroke Council; Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Nursing; and the Interdisciplinary Council on Peripheral Vascular Disease

Stroke doi: 10.1161/STROKEAHA.108.192218

This scientific statement is intended for use by physicians and allied health personnel caring for patients with transient ischemic attacks. Formal evidence review included a structured literature search of Medline from 1990 to June 2007 and data synthesis employing evidence tables, meta-analyses, and pooled analysis of individual patient-level data.


05/19/2009 07:17 AM

Applications of neural and mesenchymal stem cells in the treatment of gliomas

Expert Review of Anticancer Therapy May 2009, Vol. 9, No. 5, Pages 597-612

In addition to stem cells providing a better understanding about the biology and origins of gliomas, new therapeutic approaches have been developed based on the use of stem cells as delivery vehicles.


05/19/2009 07:15 AM

Use of respiratory function tests to predict survival in amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis First Published on: 18 May 2009

Respiratory function tests (RFTs) are commonly used as a measure of progression in ALS. This study assessed the ability of various RFTs to predict survival in ALS patients. Subjects with ALS had one or more measurements of seated and supine FVC, maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP).


05/19/2009 07:14 AM

Determination of risk factors associated with seizure relapse after antiepileptic drug withdrawal

Central European Journal of Medicine 1895-1058 (Print) 10.2478/s11536-009-0049-y

There is no consensus regarding the time of antiepileptic drug withdrawal and the relevant risk factors for seizure relapse. In this study, we aimed to determine the seizure relapse rates and the associated risk factors for seizure relapse in childhood epilepsy.


05/19/2009 07:13 AM

The effects of oxcarbazepine treatment on vitamin B12 and folate levels, thyroid functions, sex hormones, and bone mineral density in epileptic patients

Central European Journal of Medicine 1895-1058 (Print) 10.2478/s11536-009-0040-7

The aim of this study was to evaluate vitamin B12 and folate levels, thyroid functions, sex hormones and bone mineral density in idiopathic epileptic patients taking oxcarbazepine as monotherapy.


05/19/2009 07:11 AM

Quantitative Apparent Diffusion Coefficients in the Characterization of Brain Tumors and Associated Peritumoral Edema

Acta Radiologica First Published on: 15 May 2009

Conventional magnetic resonance (MR) imaging has a number of limitations in the diagnosis of the most common intracranial brain tumors, including tumor specification and the detection of tumoral infiltration in regions of peritumoral edema.


05/19/2009 07:10 AM

PMP22 expression in dermal nerve myelin from patients with CMT1A

Brain, doi:10.1093/brain/awp113

Charcot-Marie-Tooth disease type 1A (CMT1A) is caused by a 1.4 Mb duplication on chromosome 17p11.2, which contains the peripheral myelin protein-22 (PMP22) gene.


05/19/2009 07:08 AM

Trk Receptor Expression and Inhibition in Neuroblastomas

Clinical Cancer Research 15, 3244, May 15, 2009

Neuroblastoma, the most common and deadly solid tumor in children, exhibits heterogeneous clinical behavior, from spontaneous regression to relentless progression. Current evidence suggests that the TRK family of neurotrophin receptors plays a critical role in these diverse behaviors.


05/19/2009 07:07 AM

White matter tract injury and cognitive impairment in human immunodeficiency virus-infected individuals

Journal of Neurovirology, Volume 15, Issue 2 April 2009 , pages 187 - 195

Approximately half of those infected with the human immunodeficiency virus (HIV) exhibit cognitive impairment, which has been related to cerebral white matter damage. Despite the effectiveness of antiretroviral treatment, cognitive impairment remains common even in individuals with undetectable viral loads.


05/19/2009 07:06 AM

Treatment options for recurrent glioblastoma: pitfalls and future trends

Expert Review of Anticancer Therapy May 2009, Vol. 9, No. 5, Pages 613-619

Standard treatment with temozolomide and radiotherapy for patients with newly diagnosed glioblastoma has increased the median overall survival and, more importantly, the 2-year survival rate of patients.


05/19/2009 07:05 AM

Cerebral oedema in episodic ataxia

Acta Neurologica Belgica 2009, N 1 (Vol. 109/1) p.38-39

We report a patient with episodic ataxia (presumably of type 2) who developed cerebral oedema secondary to a common infection (presumably viral).


05/19/2009 07:03 AM

Timing of Computed Tomography and Prediction of Vasospasm after Aneurysmal Subarachnoid Hemorrhage

Neurocritical Care 1541-6933 (Print) 10.1007/s12028-009-9227-7

The initial noncontrast computed tomography (CT) study of the head after an aneurysmal subarachnoid hemorrhage (SAH) is used to predict the risk of developing vasospasm.


05/19/2009 07:02 AM

The syndrome gelastic seizures-hypothalamic hamartoma: Severe, potentially reversible encephalopathy

Epilepsia Special Issue: Epilepsy Syndromes in Development Published Online: 4 May 2009

Hypothalamic hamartoma (HH) is the pathologic hallmark of a spectrum of epileptic conditions, ranging from a mild form of epilepsy, whose seizures are an urge to laugh without cognitive defects, to the fully developed syndrome of early onset gelastic seizures (GS) associated with precocious puberty and the evolution to a catastrophic epilepsy syndrome.


05/19/2009 07:01 AM

Negative motor seizure arising from the negative motor area: Is it ictal apraxia?

Epilepsia Published Online: 12 May 2009

Seizure manifesting motor arrest, that is, negative motor seizure (NMS), is a rare epileptic condition in which only inability to conduct voluntary movements or praxis is produced, although consciousness is preserved. The negative motor area (NMA) seems to be responsible, but its generator mechanism has not yet been clarified.


05/19/2009 07:00 AM

Parahippocampal epilepsy with subtle dysplasia: A cause of "imaging negative" partial epilepsy

Epilepsia Published Online: 12 May 2009

Lesion-negative refractory partial epilepsy is a major challenge in the assessment of patients for potential surgery. Finding a potential epileptogenic lesion simplifies assessment and is associated with good outcome.


05/19/2009 06:58 AM

Walking economy in people with Parkinson's disease

Movement Disorders Published Online: 13 May 2009

Gait dysfunction is an early problem identified by patients with Parkinson's disease (PD). Alterations in gait may result in an increase in the energy cost of walking (i.e., walking economy).


05/19/2009 06:57 AM

Cerebellar involvement in progressive supranuclear palsy: A clinicopathological study

Movement Disorders Published Online: 1 May 2009

The clinical heterogeneity of progressive supranuclear palsy (PSP), which is classified as classic Richardson's syndrome (RS) and PSP-Parkinsonism (PSP-P), has been previously discussed. We retrospectively analyzed 22 consecutive Japanese patients with pathologically proven PSP to investigate the clinicopathological heterogeneity.


05/19/2009 06:55 AM

Patent Foramen Ovale in Cryptogenic Stroke. Incidental or Pathogenic?

Stroke doi: 10.1161/STROKEAHA.109.547828

Patent foramen ovale (PFO) is significantly associated with cryptogenic stroke (CS). However, even in patients with CS, a PFO can be an incidental finding. We sought to estimate the probability that a PFO in a patient with CS is incidental.


05/19/2009 06:54 AM

Differentiation of SWO-38 glioma cells induced by CDA-2 is mediated by peroxisome proliferator-activated receptor y

Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-009-9900-x

Glioma remains one of the most lethal human tumors in spite of the progress in radiotherapy, chemotherapy, and surgical techniques.


05/19/2009 06:50 AM

Improving the prognosis for patients with glioblastoma: the rationale for targeting Src

Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-009-9916-2

Glioblastoma is the most common and aggressive form of primary brain tumor. The prognosis for patients diagnosed with glioblastoma is poor, with a median survival of 12-14 months and a 5-year survival rate of <5%.


05/19/2009 06:49 AM

Temporal lobe epilepsy is a progressive neurologic disorder: Time means neurons!

Neurology.2009; 72: 1718-1719


05/19/2009 06:48 AM

Oligodendrocytes: Susceptibility to injury and involvement in neurologic disease Benarroch

Neurology.2009; 72: 1779-1785


05/19/2009 06:47 AM

Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy

NEUROLOGY 2009;72:1747-1754

Whether recurrent epileptic seizures induce brain damage is debated. Disease progression in epilepsy has been evaluated only in a few community-based studies involving patients with seizures well controlled by medication.


05/19/2009 06:47 AM

IMPROVEMENT OF TICS AFTER SUBTHALAMIC NUCLEUS DEEP BRAIN STIMULATION

Neurology.2009; 72: 1787-1789


05/19/2009 06:46 AM

Differences in retinal vessels support a distinct vasculopathy causing lacunar stroke

NEUROLOGY 2009;72:1773-1778

Lacunar stroke is common, but the etiology of the small vessel abnormality is unknown. Retinal vessels share ontogeny, size, and physiologic characteristics with cerebral small vessels, and retinopathy is associated with stroke.


05/19/2009 06:45 AM

Deficient intracortical inhibition (SICI) during movement preparation after chronic stroke

NEUROLOGY 2009;72:1766-1772

In healthy subjects, preparation to move is accompanied by motor cortical disinhibition. Poor control of intracortical inhibitory function in the primary motor cortex (M1) might contribute to persistent abnormal motor behavior in the paretic hand after chronic stroke.


05/19/2009 06:44 AM

A multicenter 1H-MRS study of the medial temporal lobe in AD and MCI

NEUROLOGY 2009;72:1735-1740

The need for biological markers of Alzheimer disease (AD) is constantly increasing. Proton magnetic resonance spectroscopy (1H-MRS) studies have provided consistent evidence for a reduction of the neuronal marker N-acetylaspartate (NAA) in patients with AD.


05/19/2009 06:44 AM

The Bobath Concept in Contemporary Clinical Practice

Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 57-68

Future development in neurorehabilitation depends upon bringing together the endeavors of basic science and clinical practice. The Bobath concept is widely utilized in rehabilitation following stroke and other neurological conditions.


05/19/2009 06:43 AM

Stroke Rehabilitation: An International Perspective

Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 44-56

There is a revolution underway in stroke rehabilitation. International comparative studies coupled with an impressive evidence base have provided a platform from which an ideal system for stroke rehabilitation can be envisioned.


05/19/2009 06:42 AM

Stroke Rehabilitation in the United Kingdom

Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 27-33

A Consensus Conference on Stroke in 1988 concluded that rehabilitation for stroke in the United Kingdom was poorly organised, was not based on evidence, and was associated with poor outcomes compared with similar health care systems.


05/19/2009 06:41 AM

Stroke Rehabilitation in Canada: A Work in Progress

Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 11-19

Stroke rehabilitation in Canada continues to function under models and practices that have changed little in the last four decades and struggles to implement new evidence-based or best practices.


05/19/2009 06:40 AM

Stroke Rehab Down Under: Can Rupert Murdoch, Crocodile Dundee, and an Aboriginal Elder Expect the Same Services and Care?

Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 1-10

In this article, we explain the stroke rehabilitation infrastructure including consumer organisations, research networks, data collection systems, and registries. This represents a complex but fledgling set of organisations showing great promise for coordination of care and research.


05/19/2009 06:39 AM

Rhythmic Auditory-Motor Entrainment Improves Hemiparetic Arm Kinematics During Reaching Movements: A Pilot Study

Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 69-79

Recovery of skilled upper limb movement remains a critical focus of rehabilitation in individuals post stroke


05/19/2009 06:38 AM

Hospital-Based Stroke Rehabilitation in the United States

Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 34-43

In this article, we consider (1) the role of Medicare in shaping US inpatient rehabilitation facility (IRF) stroke rehabilitation, (2) admission criteria for IRF care in the United States and medical management while in IRF, (3) the organization and delivery of IRF-level nursing and therapy, (4) post-IRF rehabilitation choices, (5) monitoring of rehabilitation outcomes, and (6) the implications of a multisite stroke outcome study for stroke rehabilitation practice.


05/19/2009 06:37 AM

European Comparison of Stroke Rehabilitation

Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 20-26

Our understanding of the components of stroke rehabilitation critical to patients' outcomes is limited. Comparing practices and outcomes across countries may give clues to how to improve rehabilitation services.


05/19/2009 06:36 AM

Predictors of Resuming Therapy Within Four Weeks After Discharge from Inpatient Rehabilitation

Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 80-91

To identify the percentage of persons with stroke resuming therapy within 4 weeks of inpatient rehabilitation discharge, to compare the characteristics of those who did and did not resume therapy, and to determine the predictors of resuming physical (PT), occupational (OT), and speech (ST) therapy.


05/19/2009 06:35 AM

Locomotor-respiratory synchronization after body weight supported treadmill training in incomplete tetraplegia: a case report

Spinal Cord advance online publication 19 May 2009; doi: 10.1038/sc.2009.50

To report on the respiratory and kinematic changes associated with body weight supported treadmill training (BWSTT) in an individual with an incomplete cervical spinal cord injury (SCI).


05/16/2009 10:53 AM

Directional anisotropy of motion responses in retinotopic cortex

Human Brain Mapping Published Online: 15 May 2009

Recently, evidence has emerged for a radial orientation bias in early visual cortex. These results predict that in early visual cortex a tangential bias should be present for motion direction.


05/16/2009 10:52 AM

The effects of the glutamate antagonist memantine on brain activation to an auditory perception task

Human Brain Mapping Published Online: 15 May 2009

Glutamate is critically involved in the regulation of cognitive functions in humans. There is, however, sparse evidence regarding how blocking glutamate action at the receptor site during a cognitive task affects brain activation.


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