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Medical Hypotheses Received 22 March 2009; accepted 18 April 2009. published online 25 May 2009
The clinical motor dysfunction in Parkinson´s disease (PD) is primarily linked to the depletion of dopamine in the striatum consecutive to the loss of the large dopaminergic neurons in the substantia
nigra.
A 64-year-old woman presented with a 6-month history of right-sided continuous headache, without autonomic symptoms and complete response to
indomethacin. Clinical examination and structural brain imaging were normal.
NeuroRehabilitation Volume 24, Number 3 / 2009 237-242
Introduction: Upright posture confers numerous medical and social benefits to a spinal cord injured (SCI) patient. Doing so is limited by symptoms of orthostatic hypotension. This is a common secondary impairment among tetraplegic sufferers.
To determine whether the immediate response to electrode implantation (micro lesion effect,
MLE) in the internal segment of the globus pallidus (GPi) predicts symptom improvement with deep brain stimulation (DBS) at 6 months in patients with Parkinson's disease (PD) or generalized
dystonia.
Although it has been suggested that high gravidity and parity increase the risk for coronary heart disease, their associations with stroke are unclear.
Prior work documented racial and ethnic disparities in incidence of stroke, stroke risk factors, and use of carotid
endarterectomy. Less is known about disparities in outcomes and appropriateness of carotid endarterectomy or reasons for such inequalities.
European Journal of Neurology Published Online: 22 May 2009
Some patients develop major neurological complications after carotid revascularization procedures, despite the lack of new infarcts or classical hyperperfusion syndrome.
Discovering potential cardiac sources of stroke is an important part of the urgent evaluation of the ischemic stroke patient as it often impacts treatment decisions that are essential for determining secondary stroke prevention strategies, yet the optimal approach to the cardiac workup of an ischemic stroke patient is not known.
The Third European Cooperative Acute Stroke Study (ECASS-3) demonstrated a benefit of treatment with intravenous tissue plasminogen activator
(tPA) for acute stroke in the 3- to 4.5-hour time-window.
Amyotrophic Lateral Sclerosis First Published on: 22 May 2009
Genetic variants may underlie sporadic amyotrophic lateral sclerosis (SALS), but in only a few percent of patients have causative mutations been found.
A deficit of the central executive of working memory is a frequent finding in patients with severe traumatic brain injury (TBI). The objective of the present study was to assess the efficacy of a rehabilitation programme of the central executive after severe TBI.
To compare the pre-injury subjective quality of life (SQOL) estimates of a representative sample of adults with TBI, using the Quality of Life Inventory
(QOLI) with the measure's generic US-based norms and identify a factor structure for the instrument within the local TBI population.
To examine self-reported post-concussion symptoms from 3-12 months post-injury in adults with traumatic brain injury (TBI) and to identify predictors of these symptoms.
Mild traumatic brain injury (mTBI) meta-analyses are sometimes cited as evidence that by 3 months post-injury the clinical effects are insignificant. In contrast to these conclusions are findings that long-term mTBI outcome can vary depending on (1) the mechanism of the injury, (2) which diagnostic criteria are employed, (3) which assessment tools utilized and (4) whether symptomatic groups are considered separately.
A previous study suggested that the routine use of drugs intended to improve attention and arousal, such as methylphenidate, tend to have a variable but not significant effect on sleep-wake cycles.
Traumatic brain injury is highly associated with the over-production of reactive oxygen species. The aim of this study was to investigate the putative neuroprotective effect of
montelukast, a cysteinyl-leukotriene receptor antagonist, in a rat model of traumatic brain injury (TBI).
This study examines the relationship between scores on the Western Neuro Sensory Stimulation Profile
(WNSSP) and therapeutic participation as it relates to rehabilitation readiness (RR) in adolescents with low response following severe traumatic brain injury (TBI).
To evaluate the benefits of the Brain Injury Family Intervention (BIFI) for families of persons with acquired brain injury and identify factors related to outcomes.
Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 1009-1017 (June 2009)
To explore events and describe phases for temporal coordination of the sit-to-walk
(STW) task, within a semistandardized set up, in subjects with stroke and matched controls.
Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 927-933 (June 2009)
To investigate voluntary step behavior of chronic stroke survivors during single- and dual-task conditions and compare the results to healthy age- and sex-matched controls.
Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 1061-1063 (June 2009)
To test the reproducibility of the ABILOCO questionnaire. To validate the patient self-reporting method and the third-party assessment of the stroke patients' locomotion ability by a treating physical therapist.
Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 1026-1029 (June 2009)
To determine the safety and feasibility of percutaneous radiologic gastrostomy
(PRG) tube placement in patients with amyotrophic lateral sclerosis
(ALS) with too low a vital capacity to be weaned off noninvasive positive pressure ventilation
(NPPV).
Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 939-946 (June 2009)
To describe frequency and magnitude of caregivers' emotional distress and life satisfaction using standardized assessment procedures; compare distress levels among spouses, parents, and other caregivers; and identify risk factors.
Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 956-965 (June 2009)
To compare reports of fatigue 12 months after minor trauma by participants with mild head injury
(MHI) with those with other injury, and identify injury and baseline predictors of fatigue.
Archives of Physical Medicine and Rehabilitation Volume 90, Issue 6, Pages 1030-1038 (June 2009)
To integrate and expand on previously published models of wheelchair service delivery, and provide a preliminary framework for developing more comprehensive, descriptive models of wheelchair service delivery for adults with spinal cord injury within the U.S. health care system.
Central European Journal of Medicine 1895-1058 (Print) 10.2478/s11536-009-0038-1
Brain abscesses represent organized foci of suppuration within the parenchyma. In this paper, we describe the case of a 3-month old girl with a large, complicated cerebral abscess.
Central European Journal of Medicine 1895-1058 (Print) 10.2478/s11536-009-0054-1
Parkinson's disease (PD) belongs to group of neurodegenerative diseases. PD diagnosis is clinical, based on these signs: tremor, rigidity,
bradykinesia, akinesia or hypokinesia.
Three neurodegenerative diseases affecting upper and/or lower motor neurons have been associated with loss of
ALS2/Alsin function: juvenile amyotrophic lateral sclerosis, primary lateral sclerosis and infantile-onset ascending hereditary spastic paralysis.
Amyotrophic Lateral Sclerosis First Published on: 19 May 2009
Our objective was to assess the incidence of amyotrophic lateral sclerosis
(ALS), and its temporal variations, between 1997 and 2007. The study was based on data prospectively gathered by the referral ALS 'expert centre' of the Regional University Hospital of Limousin (710,792 inhabitants).
British Journal of Radiology 2009, doi:10.1259/bjr/90100265
The purpose of this study is to compare the effectiveness of relative cerebral blood volume, apparent diffusion coefficient and spectroscopic imaging in differentiating between cerebral abscesses and necrotic
tumours.
Disruption of the corticospinal tract at various locations in the brain has been shown to predict worse spontaneous motor recovery after stroke. However, the anatomic specificity of previous findings was limited by the categorical classification of infarct locations.
CT angiography (CTA) is receiving increased attention in intracerebral hemorrhage
(ICH) for its role in ruling out vascular abnormalities and potentially predicting ongoing bleeding. Its use is limited by the concern for contrast induced nephropathy
(CIN); however, the magnitude of this risk is not known.
The relative contributions of on-treatment low- and high-density lipoprotein cholesterol
(LDL-C, HDL-C), triglycerides, and blood pressure (BP) control on the risk of recurrent stroke or major cardiovascular events in patients with stroke is not well defined.
There is expanding literature to show that certain patients admitted during the weekend have worse outcomes than similar patients admitted during the week.
Early deterioration can occur after acute stroke for a variety of reasons. We describe a hemodynamic steal and associated neurological deterioration, the reversed Robin Hood syndrome
(RRHS). We aimed to investigate the frequency and factors associated with
RRHS.
Duchenne muscular dystrophy (DMD) is a lethal muscle disorder caused by mutations in the DMD gene for which no mutation-targeted therapy has been available thus far.
There are ~12,000 new cases per year in the United States of spinal cord injury (SCI) with life expectancies from 11 to 14 years (ventilator dependent) to 44 years (non-ventilator dependent).
Journal of Medical Systems 0148-5598 (Print) 10.1007/s10916-009-9290-9
In this paper, we propose a novel method using best basis wavelet functions and double thresholding that are well suited for detecting and localization of important epileptic events from noisy recorded seizure EEG signals.
To investigate the effect of a combination of botulinum toxin A (BTX-A) and rehabilitation on spasticity, pain and motor functioning in children with acquired brain injury
(ABI).
Australian Journal of Rural Health Volume 17 Issue 3, Pages 119 - 123
This review focuses on two factors that influence client access to care following head injury. These factors, namely the degree of rurality of a client's home town and the funding model to which they are allocated, are discussed in light of the results of the 'Head Injury Impact Project'.
Temperature measurement is important during routine neurocritical care especially as differences between brain and systemic temperatures have been observed.
The Lancet, Early Online Publication, 27 May 2009 doi:10.1016/S0140-6736(09)60941-7
Deep vein thrombosis (DVT) and pulmonary embolism are common after stroke. In small trials of patients undergoing surgery, graduated compression stockings (GCS) reduce the risk of
DVT.
Acta Neurologica Scandinavica Published Online: 26 May 2009
To explore diagnostic differences in periventricular white matter (PWM) and deep white matter
(DWM) diffusion patterns in patients diagnosed with Binswanger disease (BD) and in patients diagnosed with probable idiopathic normal pressure hydrocephalus
(INPH) using diffusion-weighted imaging (DWI).
Early goal-directed hemodynamic therapy is of particular importance for adequate cerebral circulation of patients with vasospasm after subarachnoid hemorrhage but is often precluded by the invasiveness of established cardiac output determination using a pulmonary artery catheter.
Perfusion-weighted MRI-based maps of cerebral blood flow (CBFMRI) are considered a good MRI measure of penumbral flow in acute ischemic stroke but are seldom used in clinical routine due to methodical issues.
Clinical trials for prevention of vasospasm after aneurysmal subarachnoid hemorrhage
(SAH) seldom have improved overall outcome; one reason may be inadequate sample size.
Restless leg syndrome (RLS) is a sensorimotor disorder. Clinical studies have implicated the dopaminergic system in
RLS, while others have suggested that it is associated with insufficient levels of brain iron.
Retinal lesions caused by eye diseases such as glaucoma and age-related macular degeneration can, over time, eliminate stimulation of parts of the visual cortex.
Mild cognitive impairment can represent a transitional state between normal ageing and Alzheimer's disease. Non-invasive diagnostic methods are needed to identify mild cognitive impairment individuals for early therapeutic interventions.
A previously asymptomatic 3-year-old boy presented with a large head, generalized seizures, and vision impairment for 7 months. Examination revealed macrocephaly (52 cm) and prominent scalp and facial veins.
It is well known that drugs that bring down the bad cholesterol in the blood
(statins) can reduce the risk of a second heart attack after a first heart attack occurs.
To determine whether statin therapy after hospital discharge affects ischemic stroke recurrence and long-term mortality in patients admitted for a first-ever occurrence of ischemic stroke.
We recently observed that 13% of 1,008 consecutive adults aged 15–49 years with first-ever ischemic stroke had one or more silent brain infarcts
(SBIs), and more than 5% presented with leukoaraiosis on CT or
MRI.
Cancer Research 69, 4502, May 15, 2009 doi: 10.1158/0008-5472.CAN-08-3884
Glioblastoma multiforme (GBM) are aggressive and uniformly fatal primary brain tumors characterized by their diffuse invasion of the normal-appearing parenchyma peripheral to the clinical imaging abnormality.
Journal of Psychopharmacology 2009, doi:10.1177/0269881109105721
Interactions between the 5-HT system and the dopaminergic system and cholinergic system may be important in determining cognitive function and motor function in Parkinson's disease (PD).
Cystic echinococcosis (CE) of the brain is an uncommon parasitic infestation. The World Health Organization (WHO) recently published a classification of hepatic CE based upon ultrasonographic findings.
Pharmacotherapy is commonly given to patients recovering from a stroke to prevent further complications (e.g. recurrent stroke, seizures) or enhance recovery.
The authors report the case of a 69-year-old woman suffering from paroxysmal hemicrania (PH), intolerant to indomethacin and resistant to multiple therapies, in which sphenopalatine endoscopic ganglion block
(SPG) dramatically modified the clinical outcome.
We showed reduced motor intracortical inhibition (ICI) and paradoxical increase of intracortical facilitation
(ICF) to 1 Hz repetitive transcranial magnetic stimulation
(rTMS) in patients affected by migraine with aura (MA).
Locomotor activity and spinal reflexes (SRs) show common features in different mammals, including humans. Here we report the time-course of the development of locomotor activity and SRs after a complete spinal cord injury in humans.
Acta Neurologica Scandinavica Published Online: 21 May 2009
In Parkinson's disease (PD), there is entanglement of disease-inherent and treatment-induced sleep abnormalities. So far, there has been no study specifically investigating the influence of diurnal dopaminergic medication (DM) on nocturnal slow wave sleep
(SWS).
The mechanisms underlying motor recovery after stroke are not fully understood. Several studies used functional MRI longitudinally to relate brain activity changes with performance gains of the upper limb after therapy, but research into training-induced recovery of lower limb function has been relatively neglected thus far.
Mirror pattern of cerebral artery atherosclerosis in patients with ischaemic stroke Published Online: 22 May 2009
Although it has been suggested that bilateral symmetry of atherosclerosis can be found in paired arteries, including external carotid arteries and femoral arteries, it has remained unknown in intracranial arteries. We determined whether bilateral symmetry (a mirror pattern) of atherosclerosis presents in the entire cerebral arterial system.
European Journal of Neurology Published Online: 22 May 2009
This study aims to examine the risk of adverse pregnancy outcomes [low birthweight
(LBW), preterm birth, cesarean sections (CS) and babies born small for gestational age
(SGA)] in pregnant women with myasthenia gravis (MG), using a 3-year population-based database, taking characteristics of infant and mother into consideration.
Child's Nervous System 0256-7040 (Print) 10.1007/s00381-009-0901-z
A penetrating head injury belongs to the most severe traumatic brain injuries, in which communication can arise between the intracranial cavity and surrounding environment.
European Journal of Neurology Published Online: 22 May 2009
Dementia remains an exclusion criterion in diagnosing multiple system atrophy
(MSA). This study aimed to determine the cognitive changes and brain atrophy patterns in the Parkinsonian
(MSA-P) and cerebellar (MSA-C) variants of MSA.
Child's Nervous System 0256-7040 (Print) 10.1007/s00381-009-0900-0
The ependymomas are relatively not a common tumor. However, most clinicians agree that the radical removal of the tumor is the most important prognostic factor.
Child's Nervous System 0256-7040 (Print) 10.1007/s00381-009-0910-y
Cerebrospinal fluid (CSF) overdrainage in hydrocephalus is well recognized. Overshunting following
cysto-peritoneal (CP) drainage in patients with arachnoid cysts (AC) is rarely documented.
The high risk of recurrence and comorbidity after a stroke associated with atrial fibrillation (AF) justifies an aggressive diagnostic approach so that anticoagulant treatment can be initiated.
Determining cognitive dysfunctioning (CDF) after stroke is an important issue because it influences choices for management in terms of return to previous activities.
Although open-angle glaucoma (OAG) is associated with some of the risk factors of stroke development, there is still no published study addressing whether OAG increases the risk of stroke development. We investigated the risk of stroke development after a diagnosis of
OAG.
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a marker of unstable atherosclerotic plaque, and is predictive of both primary and secondary stroke in population-based studies.
Psycholinguistic models of short-term retention suggest that performance at verbal short-term memory
(STM) tasks relies on the activation of phonological, lexical, and semantic representations, the relative impact of each depending on task variables.
Spinal Cord advance online publication 26 May 2009; doi: 10.1038/sc.2009.44
To validate the prognostic value of the acute phase sacral sparing measurements with regard to chronic phase-independent ambulation in patients with traumatic spinal cord injury (SCI).
Journal of Head Trauma Rehabilitation: May/June 2009 - Volume 24 - Issue 3 - p 155-165
To summarize the current literature regarding the significant prevalence and potential consequences of sleep disturbance following traumatic brain injury (TBI), particularly mild TBI.
Journal of Head Trauma Rehabilitation: May/June 2009 - Volume 24 - Issue 3 - p 178-186
To determine the prevalence and risk factors of asymptomatic lower-limb deep venous thrombosis
(DVT) among Asians in inpatient rehabilitation after traumatic brain injury (TBI).
Journal of Head Trauma Rehabilitation: May/June 2009 - Volume 24 - Issue 3 - p 195-212
Return to work after traumatic brain injury (TBI) is an important outcome but frequently problematic to achieve. Vocational rehabilitation is commonly recommended as a means of facilitating return to work after TBI.
Our guest Dr. Neera kapoor presents an overview of
Neuro-Optometry and visual impairment after a brain injury. Selecting a
Neuro-Optometrist, assessment, the eye examination and treatment options are discussed.
Am J Psychiatry Published May 15, 2009 doi: 10.1176/appi.ajp.2009.08101604
The authors examine the relationship of the two signature injuries experienced by military personnel serving in Afghanistan and Iraq: posttraumatic stress disorder
(PTSD) and mild traumatic brain injury (mild TBI).
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 2009, 17:23doi:10.1186/1757-7241-17-23
Continuous monitoring of central venous oxygen saturation (ScvO2) has been proposed as a prognostic indicator in several pathological conditions, including cardiac diseases, sepsis, trauma.
The purpose of this study was to determine whether the superficial temporal artery as a surrogate arterial input function, compared with the anterior cerebral artery as the arterial input function, generates accurate perfusion CT maps with significant correlates for cerebral blood flow, cerebral blood volume, and mean transit time.
Relative maturation of peripheral and central regions of the neonatal brainstem was studied using brainstem auditory evoked responses in 174 healthy preterm infants (gestational age 30-36 wk). From 30- to 42-wk postconceptional age
(PCA), I-III and III-V intervals shortened with increasing age.
Emerging Infectious Diseases Volume 15, Number 6-June 2009
Dispatch
Bats have been increasingly recognized as an important source of zoonotic viruses responsible for some of the recent major disease outbreaks, including
Hendra, Nipah, severe acute respiratory syndrome-associated, and Ebola viruses.
Acta Neurologica Scandinavica Published Online: 20 May 2009
To assess the impact of childhood epilepsy on parental quality of life (QOL) and psychological health, and to investigate possible correlations between parental QOL and background variables as well as parental anxiety and depression.
Acta Neurologica Scandinavica Published Online: 20 May 2009
Over a 3-year period, we have performed 312 tests in 197 shunted patients. The data have been analyzed retrospectively to: (1) investigate the parameters describing CSF dynamics that correlate with shunt under-drainage and (2) estimate accuracy of this method.
Journal of Cerebral Blood Flow & Metabolism advance online publication 20 May 2009;
doi: 10.1038/jcbfm.2009.68
The well-vascularized nature of gliomas has generated a lot of interest in antiangiogenic therapies. However, the potential of vascular disrupting agents
(VDAs) against gliomas has not been investigated extensively.
Recently, two randomized controlled phase II studies showed that acute initiation of statin treatment directly after aneurysmal subarachnoid hemorrhage
(SAH) decreases the incidence of radiologic vasospasm and clinical signs of delayed cerebral ischemia
(DCI), and even reduces mortality.
Adequate reliability and valid factor structure are prerequisites for appropriate use of a measure in a population. Although the Repeatable Battery for Assessment of Neuropsychological Status
(RBANS) has been used to examine cognition in Parkinson's disease (PD), its reliability and factor structure have not been examined in this population.
As no comprehensive assessment instrument for impulse control disorders (ICDs) in Parkinson's disease (PD) exists, the aim of this study was to design and assess the psychometric properties of a self-administered screening questionnaire for ICDs and other compulsive behaviors in PD.
The outcomes after stroke vary considerably between countries, yet the extent of the variation after intracerebral hemorrhage
(ICH) remains unknown. This study examines differences in outcomes after ICH in a recent multinational trial, and explores the effect of differences in patient severity and case management for the variations observed.
Neurology Published online before print April 27, 2009, doi:10.1212/WNL.0b013e3181a6b325
To reassess the evidence for management issues related to the care of women with epilepsy
(WWE) during pregnancy, including preconceptional folic acid use, prenatal vitamin K use, risk of hemorrhagic disease of the newborn, clinical implications of placental and breast milk transfer of antiepileptic drugs
(AEDs), risks of breastfeeding, and change in AED levels during pregnancy.
NeuroRehabilitation Volume 24, Number 3 / 2009 219-223
To investigate whether the application of glycerin poultice to the flexor digitorum profundus in the middle phalanx of the little finger
(GFML) improves motor disturbance in Parkinson Disease (PD).
NeuroRehabilitation Volume 24, Number 3 / 2009 225-229
Patients with neurological conditions may be affected by spasticity. The Modified Modified Ashworth Scale
(MMAS) is a clinical tool used to measure spasticity.
NeuroRehabilitation Volume 24, Number 3 / 2009 237-242
Upright posture confers numerous medical and social benefits to a spinal cord injured (SCI) patient. Doing so is limited by symptoms of orthostatic hypotension. This is a common secondary impairment among tetraplegic sufferers.
NeuroRehabilitation Volume 24, Number 3 / 2009 231-236
The purpose of this paper was to examine the reliability and validity (concurrent and construct) of a newly developed online Chinese version of the Rivermead Behavioral Memory Test
(OL-RBMT) and its equivalence with the face-to-face version
(FTF-RBMT).
NeuroRehabilitation Volume 24, Number 3 / 2009 255-266
Current descriptions of the language problems following traumatic brain injury (TBI) generally emphasize evaluating discourse production and explaining the observed outcomes in terms of disruptions to executive processes.
NeuroRehabilitation Volume 24, Number 3 / 2009 291-297
We investigated a long-term exercise-induced neuroplasticity and spatial memory recovery in 15 rats in a treadmill as follows: normal control rats (NC), streptozotocin
(STZ)-induced diabetic control rats (DC), and STZ-induced diabetic rats exercising in a treadmill (DE).
NeuroRehabilitation Volume 24, Number 3 / 2009 267-271
In the healthy volunteers, the third ventricle was enlarging after reaching the sitting position. The median diameter was 2.35 mm in the lying and 2.9 mm in the sitting position (p > 0.05).
NeuroRehabilitation Volume 24, Number 3 / 2009 279-283
The corticospinal tract (CST) is the most important motor pathway in the human brain, therefore, the accurate estimation of the CST state following brain injury would enable us to predict the motor outcome or enable accurate surgical planning.
Topics in Spinal Cord Injury Rehabilitation Volume 14, Number 4 / Spring 2009 - Advancing the Frontier: Research and Clinical Care in Canada 23-33
Advanced electrophysiological recording techniques can assess sensory function from individual spinal segments and track the potential risks or benefits of a therapeutic intervention.
Topics in Spinal Cord Injury Rehabilitation Volume 14, Number 4 / Spring 2009 - Advancing the Frontier: Research and Clinical Care in Canada 62-68
A brain-machine interface (BMI) can generate control commands using signals from the brain. These devices have great potential to assist individuals with severe mobility impairments.
Topics in Spinal Cord Injury Rehabilitation Volume 14, Number 4 / Spring 2009 - Advancing the Frontier: Research and Clinical Care in Canada 122-132
The purpose of this study was to increase physical activity in individuals with spinal cord injury (SCI) through regular participation in a home exercise program.
Topics in Spinal Cord Injury RehabilitationVolume 14, Number 4 / Spring 2009 - Advancing the Frontier: Research and Clinical Care in Canada 69-87
This article presents the qualitative results of a 2-year mixed methodology study (quantitative and qualitative) examining the personal impact of being a support provider (SP) to a person living in the community with a spinal cord injury (SCI).
Topics in Spinal Cord Injury Rehabilitation Volume 14, Number 4 / Spring 2009 - Advancing the Frontier: Research and Clinical Care in Canada 1-22
Low hip and knee region bone mineral density (BMD) after spinal cord injury (SCI) results in an increased risk of lower extremity fragility fractures or sublesional osteoporosis (SLOP).
Topics in Spinal Cord Injury Rehabilitation Volume 14, Number 4 / Spring 2009 - Advancing the Frontier: Research and Clinical Care in Canada 34-46
To refine the Graded and Redefined Assessment of Strength, Sensibility and Prehension
(GRASSP) as a measure of upper limb impairment following cervical SCI.
The Lancet, Volume 373, Issue 9677, Pages 1780 - 1788, 23 May 2009
Amputations in people with type 2 diabetes mellitus substantially impair their quality of life and impose high costs on health-care systems. Our aim was to assess the effect of fenofibrate on amputation events in a large cohort of patients with type 2 diabetes.
This paper sets out the results of a Spanish study of the experience and meaning of work among disabled women of two generations, with three types of disability (physical, visual and hearing).
In this historical-geographical approach to the Belgian Maritime Hospital Roger de Grimberghe space is introduced as a conceptual tool to deconstruct the notion of the child at risk. The starting point for the creation of the maritime hospitals lay in the immediate relationship between the idea of improving children's welfare with healthy sea air and concern about declining public health at the end of the nineteenth century, together with a need for the moral reclamation of the nation.
Contemporary sociology has made sense of bodily difference by mobilising a number of tropes. 'Wounded' (or vulnerable), 'monstrous' and 'abject' stand out by virtue of their ubiquity though they do not exhaust the repertoire.
Eighty-one cases of neurologic disease, including encephalitis, meningitis, stroke, and peripheral neuropathy, that were associated with parvovirus B19 infection were reviewed.
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-009-9915-3
Follicular thyroid cancer rarely manifests itself as a distant metastatic lesion. We report a case of a 61-year-old woman presented with a solid mass located in the left
temporo-occipital region.
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-009-9906-4
Skull metastases can occur with nearly all types of tumor. They frequently are asymptomatic, causing local swelling, which is usually painless and rarely leads to neurological dysfunction.
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-009-9914-4
Current treatments for Glioblastoma multiforme (GBM) involve surgery, radiotherapy, and cytotoxic chemotherapy; however, these treatments are not effective and there is an urgent need for better treatments.
The patients of this prospective study were analysed for headache as a sequela of surgery for acoustic neuroma (AN). Thirty-two per cent (30/95) of patients complained about a persisting headache syndrome with a severity of at least 6/10 on the nominal analogue scale 6 months after surgery.
The aim of this pilot study was to investigate the effects of levetiracetam monotherapy on seizure control, quality of life and neurocognitive performance in patients with brain tumor-related epilepsy.
Brain arteriovenous malformations (BAVMs) are an important cause of intracerebral hemorrhage
(ICH) in young adults. Biological predictors of future ICH risk are lacking, and controversy exists over previous studies of natural history risk among predominantly ruptured BAVM cohorts.
Antiplatelet medication use and reduced platelet activity may be associated with mortality after intracerebral hemorrhage
(ICH). We tested the hypothesis that reduced platelet activity is associated with early ICH clot growth and worse outcomes.
Predictive models of outcome after ischemic stroke have incorporated acute diffusion-weighted MRI
(DWI) information with mixed results. We hypothesized that serial measurements of DWI infarct volume would be predictive of functional outcome after ischemic stroke.
We examined the associations between lifestyle factors and the risk of amyotrophic lateral sclerosis
(ALS) using a case-control study in Aichi Prefecture, Japan.
Clinical Cancer Research 15, 3617, May 15, 2009. Published Online First May 5, 2009;
doi: 10.1158/1078-0432.CCR-08-3071
Enzastaurin is a selective inhibitor of protein kinase C {beta}. Prior phase I studies did not show increased drug exposures with escalating once daily administration. Limits from gastrointestinal absorption may be overcome by twice daily dosing, potentially improving antitumor effects.
Clinical Cancer Research 15, 3519, May 15, 2009. doi: 10.1158/1078-0432.CCR-08-2062
We have investigated whether the folate supplementation could be used to limit the aggressiveness of glioma through the DNA remethylation because (a) the cancer genome is characterized by a low level of DNA methylation (or 5-methylcytosine, 5
mC); and (b) folate is the main generator of S-adenosyl-methionine, the methyl donor molecule in the DNA methylation reaction catalyzed by the DNA
methyltranferases.
Phytotherapy Research Published Online: 15 May 2009
The efficacy of a danshen (Salvia miltiorrhiza) dripping pill (DDP) for secondary stroke prevention was evaluated in patients with ischemic cerebrovascular disease. The preparation also contained Panax notoginseng
(sanqi) and Dryobalanops camphor.
The Journal of Alternative and Complementary Medicine. May 2009, 15(5): 551-555. doi:10.1089/acm.2008.0427
Use of complementary and alternative medicine (CAM) by the U.S. population increased significantly in the past 2 decades. To maximize a patient's recovery from a neurosurgical procedure, it is critical that neurosurgeons be aware of the benefits and potential adverse complications of CAM therapies.
American Journal of Neuroradiology DOI 10.3174/ajnr.A1616
Aqueductal CSF stroke volume (ACSV) measured by phase-contrast MR imaging is a tool for selection of surgical patients with idiopathic normal-pressure hydrocephalus
(iNPH).
American Journal of Neuroradiology DOI 10.3174/ajnr.A1635
It has been reported that high-resolution susceptibility-weighted imaging (HR-SWI) is a promising tool for assessing brain tumor characterization
noninvasively.
Two identical randomized, placebo-controlled, crossover studies were conducted to evaluate consistency of response to
sumatriptan/naproxen sodium 85/500 mg (S/NS) over four attacks in adults with migraine.
Despite profound inattention to the side of space opposite a brain lesion in patients with unilateral neglect, priming studies demonstrate that undetected stimuli are capable of influencing subsequent
behaviour.
What neural mechanisms support our conscious perception of briefly presented stimuli? Some theories of conscious access postulate a key role of top-down amplification loops involving prefrontal cortex
(PFC).
Journal of Clinical Oncology, 10.1200/JCO.2008.19.3789
Primary CNS lymphoma (PCNSL) is confined to the CNS and/or the eyes at presentation and is usually initially treated with intravenous
methotrexate-based chemotherapy and whole-brain radiotherapy (WBRT). However, the intact blood-brain barrier (BBB) can limit diffusion of methotrexate into brain and tumor. With BBB disruption
(BBBD), enhanced drug delivery to the tumor can be achieved.
The role of the plasma level of homocysteine (Hcy), as a primary outcome, and the effect of silent cerebrovascular lesions and genetic variants related to Hcy metabolism, as secondary outcomes, in the cognitive decline and dementia in Parkinson's disease (PD) were studied.
Acta Neurologica Scandinavica Published Online: 19 May 2009
We investigated whether spontaneous baroreflex sensitivity and heart rate variability
(HRV) are different in migraine patients compared to healthy controls.
Among patients with acute ischemic stroke, impaired kidney function has been shown to increase the mortality risk, but the shape of this relationship has not been evaluated in detail.
To assess the prevalence of risk factors as determinants of intracranial atherosclerosis
(IATH)-related stroke in a multi-ethnic community-based cohort.
The patterns on diffusion-weighted (DWI) MRI may be predictive of stroke etiology. In this retrospective study, we assessed whether DWI bright lesions termed 'pearls' predicted the presence of large-vessel arterial stenosis as the etiology of stroke.
Patients with amyotrophic lateral sclerosis (ALS) rely on a variety of support services during the course of their illness. Patients with primary lateral sclerosis
(PLS) have a slower progression of disease and different clinical spectrum.
Amyotrophic lateral sclerosis (ALS) often is associated with a particularly intensive caregiving experience, and the well-being of caregivers impacts that of patients.
Percutaneous nocturnal oximetry (PNO) is useful to screen respiratory function in amyotrophic lateral sclerosis
(ALS). PNO recordings of some patients disclose a periodical pattern of O2 desaturation (PP), whose significance is unknown.
Our objective was to investigate grey matter (GM) contraction in patients with amyotrophic lateral sclerosis
(ALS) using tensor based morphometry (TBM). Using a 1.5 Tesla scanner, T1-weighted MRI scans were obtained at baseline and at follow-up (mean interval, 9 months) from 16 ALS and 10 controls. Standard TBM procedures in Statistical Parametric Mapping (SPM2) were used for image processing and statistical analyses.
Amyotrophic lateral sclerosis (ALS) is a devastating disorder of the central nervous system that leads to progressive loss of upper and lower motor neurons.
Our objective was to assess the regulation of the hypoxia response of angiogenic and inflammatory factors from 76 cerebrospinal fluids
(CSF) of sporadic amyotrophic lateral sclerosis (ALS) patients with different respiratory status.
Amyotrophic lateral sclerosis (ALS) is increasingly recognized to be a multisystem disorder which includes both clinical and neuropathological features of a frontotemporal lobar degeneration
(FTLD).
Hashimoto encephalopathy is a potentially fatal condition associated with a presentation of
myoclonus, altered conscious state, strokelike episodes, rapid cognitive decline, and neuropsychiatric symptoms. Both congenital hypothyroidism and acquired hypothyroidism are common in patients with Down syndrome.
Amyotrophic Lateral Sclerosis First Published on: 15 May 2009
Granulocyte-colony stimulating factor (G-CSF) is used to mobilize CD34+ haematopoietic stem cells from the bone marrow to the peripheral blood. We proposed to use cell subsets induced by
G-CSF to slow down disease progression in patients with amyotrophic lateral sclerosis
(ALS).
Acta Neurologica Belgica 2009, N 1 (Vol. 109/1) p.32-37
Genistein (4",5,7-trihydroxyisoflavone) is the most abundant isoflavone found in the soybean that exhibits an anti-inflammatory effect. The present study was designed to examine the effects of genistein on expression levels of
hemolysate-induced proinflammatory and adhesion molecules in SD rat brain microvascular endothelial cells
(BMECs).
Acta Neurologica Belgica 2009, N 1 (Vol. 109/1) p.18-23
There are currently no data on the relationship between admission pulse pressure (PP) level and short term clinical outcome among acute stroke patients in the Chinese population.
Segal and McLaurin first described giant serpentine aneurysms, based on their distinct angiographic features, in 1977. These lesions are - 25 mm, partially thrombosed aneurysms with a patent, serpiginous vascular channel that courses through the aneurysm.
Amyotrophic Lateral Sclerosis First Published on: 28 January 2009
Our objectives were to 1) increase awareness of total laryngectomy (TL) as a treatment for complications of bulbar weakness in patients with amyotrophic lateral sclerosis
(ALS) and outline specific surgical indications; 2) educate physicians about the surgical procedure,
peri-operative course and benefits from having a TL; and 3) retrospectively review the clinical course of Mayo Clinic - Florida patients with ALS who had a TL.
The optimal therapy for prevention of recurrent stroke or transient ischemic attack in patients with cryptogenic stroke and patent foramen ovale has not been defined.
We improved standard treatment approaches by systematically addressing cognitive and behavioral change in association with frontal and temporal dysfunction in
ALS. We evaluated the profile of inchange 198 ALS patients with a 20-minute screen exam.
Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5
Bioresorbable implant systems have been used in neurosurgery for the rigid fixation of cranial and facial bones. A relatively recent advancement has been the fixation of these implants using an ultrasonic device.
Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5
Arteriovenous malformations (AVMs) within the spinal canal and in the paraspinal region are unusual. Spinal cord and dural AVMs or arteriovenous fistulas have been the subject of numerous reports, but paraspinal malformations causing venous congestion or hemorrhage in the spinal canal are rare and present special diagnosis and management challenges.
Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5
The authors present the case of a peripheral aneurysmal lesion that developed in a newborn baby and was successfully treated by endovascular parent artery occlusion.
Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5
The intracranial pulse pressure is often increased when neuropathology is present, particularly in cases of increased intracranial pressure
(ICP) such as occurs in hydrocephalus.
The authors performed a comprehensive review of the literature to evaluate current information regarding the genetics,
pathophysiology, and behavior of AVMs.
The scientific understanding of the nature of arteriovenous malformations (AVMs) in the brain is evolving. It is clear from current work that AVMs can undergo a variety of phenomena, including growth, remodeling, and/or regression-and the responsible processes are both molecular and physiological.
Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5
Hemangiomas of infancy (HOIs) are among the most common benign tumors of childhood and classically appear as a vascular stain or small vascular papule at birth.
Journal of Neurovirology First Published on: 14 May 2009
Circulating levels of specific matrix metalloproteinases (MMPs; 1 and 7) were evaluated as correlates of brain injury in eight individuals in advanced human immunodeficiency virus (HIV) infection.
Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5
Intracranial osteolipomas and chondromas are rare benign tumors. Forty-five
chondromas, mostly supratentorial, have been reported in the literature since 1981, with origins most commonly in the sellar regions.
It is often clinically difficult to assess the severity of aphasia in the earliest stage of cerebral infarction. A method enabling objective assessment of verbal function is needed for this purpose.
The Journal of Headache and Pain 1129-2369 (Print) 10.1007/s10194-009-0126-2
The objective of this study is to examine the efficacy of gabapentin for the treatment of hemicrania continua (HC) in cases where patients had difficulty tolerating indomethacin due to adverse effects.
Aneurysmal subarachnoid hemorrhage continues to have high rates of morbidity and mortality for patients despite optimal medical and surgical management. Due to the fact that aneurysmal rupture can be such a catastrophic event, preventive treatment is desirable for high-risk lesions.
Among the relatively few surgeons to be awarded the Nobel Prize was Alexis Carrel, a French surgeon and pioneer in revascularization surgery at the turn of the 20th century.
Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5
The natural history of asymptomatic spinal lipoma in infancy remains unclear, and the indication for the prophylactic untethering operation is still debatable.
Amyotrophic Lateral Sclerosis First Published on: 28 January 2009
There are few reports on pregnancies in sporadic and familial amyotrophic lateral sclerosis
(ALS). We report on a young woman with sporadic ALS who gave birth twice during the course of her disease.
Neurological Sciences Volume 30, Supplement 1 / May, 2009 7-10
The alterations of the cerebral venous circulation are a rare but clinically important cause of headache. Although any process involving the cerebral veins or sinuses may cause headache, the most frequent and important are cerebral venous thrombosis and idiopathic intracranial hypertension.
Journal of Neurosurgery: Pediatrics May 2009 Volume 3, Number 5
It is important to differentiate growing teratoma syndrome (GTS) from tumor recurrence in the setting of an enlarging residual mass present after treatment of intracranial germ cell tumors
(GCTs).
European Journal of Neurology Published Online: 14 May 2009
We compared characteristics and treatment success of ischaemic stroke patients admitted during daytime on working days (office hours) with patients admitted on weekend or nighttime (non-office hours) to test if differences in presentation or restraints of medical care during non-office hours determine outcome in stroke patients.
Cerebral revascularization constitutes an important treatment modality in the management of complex aneurysms, carotid occlusion, tumor, and moyamoya disease.
Tenascin-C is an extracellular matrix glycoprotein implicated in embryogenesis, wound healing and tumor progression. We previously revealed that
tenascin-C expression is correlated with the prognosis of patients with
glioblastoma.
Adverse events of dopamine-blocking agents include acute dystonic reactions and oculogyric crises
(OGCs). OGCs may be recurrent on maintenance of or re-exposure to the drug.
We assessed the utilization of antiepileptic drugs (AEDs), 1999-2005, in 4,798 prospective epilepsy pregnancies from 38 countries participating in
EURAP, an international AED and pregnancy registry.
Although dementia is increasingly recognized as a common feature in Parkinson's disease (PD), its pathological substrate remains unknown. We conducted cross-sectional and longitudinal brain perfusion SPECT analyses to explore changes during the course of developing dementia in PD.
The neural cell adhesion molecule (NCAM) and its post-translational modification polysialic acid
(polySia) are broadly implicated in neural development.
White matter lesions (WMLs) have been shown to be associated with the risk of stroke in previous studies but little is known about the prediction of other vascular events.
Among patients with a patent foramen ovale (PFO) and a prior cryptogenic ischemic stroke or
TIA, the absolute and relative risk of recurrent events is unclear.
This scientific statement is intended for use by physicians and allied health personnel caring for patients with transient ischemic attacks. Formal evidence review included a structured literature search of Medline from 1990 to June 2007 and data synthesis employing evidence tables, meta-analyses, and pooled analysis of individual patient-level data.
Expert Review of Anticancer Therapy May 2009, Vol. 9, No. 5, Pages 597-612
In addition to stem cells providing a better understanding about the biology and origins of
gliomas, new therapeutic approaches have been developed based on the use of stem cells as delivery vehicles.
Amyotrophic Lateral Sclerosis First Published on: 18 May 2009
Respiratory function tests (RFTs) are commonly used as a measure of progression in
ALS. This study assessed the ability of various RFTs to predict survival in ALS patients. Subjects with ALS had one or more measurements of seated and supine
FVC, maximal inspiratory pressure (MIP) and maximal expiratory pressure
(MEP).
Central European Journal of Medicine 1895-1058 (Print) 10.2478/s11536-009-0049-y
There is no consensus regarding the time of antiepileptic drug withdrawal and the relevant risk factors for seizure relapse. In this study, we aimed to determine the seizure relapse rates and the associated risk factors for seizure relapse in childhood epilepsy.
Central European Journal of Medicine 1895-1058 (Print) 10.2478/s11536-009-0040-7
The aim of this study was to evaluate vitamin B12 and folate levels, thyroid functions, sex hormones and bone mineral density in idiopathic epileptic patients taking oxcarbazepine as
monotherapy.
Conventional magnetic resonance (MR) imaging has a number of limitations in the diagnosis of the most common intracranial brain tumors, including tumor specification and the detection of tumoral infiltration in regions of peritumoral edema.
Charcot-Marie-Tooth disease type 1A (CMT1A) is caused by a 1.4 Mb duplication on chromosome 17p11.2, which contains the peripheral myelin protein-22 (PMP22) gene.
Neuroblastoma, the most common and deadly solid tumor in children, exhibits heterogeneous clinical behavior, from spontaneous regression to relentless progression. Current evidence suggests that the TRK family of neurotrophin receptors plays a critical role in these diverse behaviors.
Journal of Neurovirology, Volume 15, Issue 2 April 2009 , pages 187 - 195
Approximately half of those infected with the human immunodeficiency virus (HIV) exhibit cognitive impairment, which has been related to cerebral white matter damage. Despite the effectiveness of antiretroviral treatment, cognitive impairment remains common even in individuals with undetectable viral loads.
Expert Review of Anticancer Therapy May 2009, Vol. 9, No. 5, Pages 613-619
Standard treatment with temozolomide and radiotherapy for patients with newly diagnosed glioblastoma has increased the median overall survival and, more importantly, the 2-year survival rate of patients.
Neurocritical Care 1541-6933 (Print) 10.1007/s12028-009-9227-7
The initial noncontrast computed tomography (CT) study of the head after an aneurysmal subarachnoid hemorrhage
(SAH) is used to predict the risk of developing vasospasm.
Epilepsia Special Issue: Epilepsy Syndromes in Development Published Online: 4 May 2009
Hypothalamic hamartoma (HH) is the pathologic hallmark of a spectrum of epileptic conditions, ranging from a mild form of epilepsy, whose seizures are an urge to laugh without cognitive defects, to the fully developed syndrome of early onset gelastic seizures (GS) associated with precocious puberty and the evolution to a catastrophic epilepsy syndrome.
Seizure manifesting motor arrest, that is, negative motor seizure (NMS), is a rare epileptic condition in which only inability to conduct voluntary movements or praxis is produced, although consciousness is preserved. The negative motor area
(NMA) seems to be responsible, but its generator mechanism has not yet been clarified.
Lesion-negative refractory partial epilepsy is a major challenge in the assessment of patients for potential surgery. Finding a potential epileptogenic lesion simplifies assessment and is associated with good outcome.
Gait dysfunction is an early problem identified by patients with Parkinson's disease (PD). Alterations in gait may result in an increase in the energy cost of walking (i.e., walking economy).
The clinical heterogeneity of progressive supranuclear palsy (PSP), which is classified as classic Richardson's syndrome (RS) and
PSP-Parkinsonism (PSP-P), has been previously discussed. We retrospectively analyzed 22 consecutive Japanese patients with pathologically proven PSP to investigate the clinicopathological heterogeneity.
Patent foramen ovale (PFO) is significantly associated with cryptogenic stroke (CS). However, even in patients with CS, a PFO can be an incidental finding. We sought to estimate the probability that a PFO in a patient with CS is incidental.
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-009-9916-2
Glioblastoma is the most common and aggressive form of primary brain tumor. The prognosis for patients diagnosed with glioblastoma is poor, with a median survival of 12-14 months and a 5-year survival rate of <5%.
Whether recurrent epileptic seizures induce brain damage is debated. Disease progression in epilepsy has been evaluated only in a few community-based studies involving patients with seizures well controlled by medication.
Lacunar stroke is common, but the etiology of the small vessel abnormality is unknown. Retinal vessels share ontogeny, size, and physiologic characteristics with cerebral small vessels, and retinopathy is associated with stroke.
In healthy subjects, preparation to move is accompanied by motor cortical
disinhibition. Poor control of intracortical inhibitory function in the primary motor cortex (M1) might contribute to persistent abnormal motor behavior in the paretic hand after chronic stroke.
The need for biological markers of Alzheimer disease (AD) is constantly increasing. Proton magnetic resonance spectroscopy (1H-MRS) studies have provided consistent evidence for a reduction of the neuronal marker
N-acetylaspartate (NAA) in patients with AD.
Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 57-68
Future development in neurorehabilitation depends upon bringing together the endeavors of basic science and clinical practice. The Bobath concept is widely utilized in rehabilitation following stroke and other neurological conditions.
Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 44-56
There is a revolution underway in stroke rehabilitation. International comparative studies coupled with an impressive evidence base have provided a platform from which an ideal system for stroke rehabilitation can be envisioned.
Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 27-33
A Consensus Conference on Stroke in 1988 concluded that rehabilitation for stroke in the United Kingdom was poorly
organised, was not based on evidence, and was associated with poor outcomes compared with similar health care systems.
Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 11-19
Stroke rehabilitation in Canada continues to function under models and practices that have changed little in the last four decades and struggles to implement new evidence-based or best practices.
Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 1-10
In this article, we explain the stroke rehabilitation infrastructure including consumer
organisations, research networks, data collection systems, and registries. This represents a complex but fledgling set of organisations showing great promise for coordination of care and research.
Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 34-43
In this article, we consider (1) the role of Medicare in shaping US inpatient rehabilitation facility
(IRF) stroke rehabilitation, (2) admission criteria for IRF care in the United States and medical management while in
IRF, (3) the organization and delivery of IRF-level nursing and therapy, (4)
post-IRF rehabilitation choices, (5) monitoring of rehabilitation outcomes, and (6) the implications of a multisite stroke outcome study for stroke rehabilitation practice.
Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 20-26
Our understanding of the components of stroke rehabilitation critical to patients' outcomes is limited. Comparing practices and outcomes across countries may give clues to how to improve rehabilitation services.
Topics in Stroke Rehabilitation Volume 16, Number 1 / Jan-Feb 2009 - An International Perspective of Stroke Rehabilitation 80-91
To identify the percentage of persons with stroke resuming therapy within 4 weeks of inpatient rehabilitation discharge, to compare the characteristics of those who did and did not resume therapy, and to determine the predictors of resuming physical (PT), occupational (OT), and speech (ST) therapy.
Spinal Cord advance online publication 19 May 2009; doi: 10.1038/sc.2009.50
To report on the respiratory and kinematic changes associated with body weight supported treadmill training
(BWSTT) in an individual with an incomplete cervical spinal cord injury (SCI).
Recently, evidence has emerged for a radial orientation bias in early visual cortex. These results predict that in early visual cortex a tangential bias should be present for motion direction.
Glutamate is critically involved in the regulation of cognitive functions in humans. There is, however, sparse evidence regarding how blocking glutamate action at the receptor site during a cognitive task affects brain activation.