| 05/10/2008
11:43 AM
Evolution of changes in the computed tomography scans of the brain of a patient with left middle cerebral artery infarction: a case report
Journal of Medical Case Reports 2008, 2:148
Stroke is a common and important condition in medicine. Effective early management of acute stroke can reduce morbidity and mortality.
05/10/2008
11:42 AM
Traumatic dissecting aneurysm at the vertebrobasilar junction in a 3-month-old infant: evaluation and treatment strategies
Journal of Neurosurgery Pediatrics May 2008 Volume 1, Number 5
Intracranial aneurysms in young infants are extremely rare, with few published reports on the etiology, evaluation, treatment strategies, and follow-up of this condition in this population. The authors report the case of a traumatic dissecting aneurysm at the vertebrobasilar junction (VBJ) in a 3-month-old infant caused by nonaccidental trauma.
05/10/2008
11:40 AM
Intraorbital and intracranial soft-tissue glomus tumor in an 8-year-old child
Journal of Neurosurgery Pediatrics May 2008 Volume 1, Number 5
Soft-tissue glomus tumors (or glomangiomas) are unrelated to neuroendocrine paragangliomas (glomus tympanicum, jugulare, and vagale). The authors present the first reported case of an orbital soft-tissue glomus tumor in a child.
05/10/2008
11:38 AM
Chromosome 6p22 Locus Associated with Clinically Aggressive Neuroblastoma
NEJM 10.1056/NEJMoa0708698
Neuroblastoma is a malignant condition of the developing sympathetic nervous system that most commonly affects young children and is often lethal. Its cause is not known.
05/10/2008
11:16 AM
Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial
Critical Care 2008, 12:R61
Severe traumatic brain injury (TBI) has been increasing with greater incidence of injuries from traffic or sporting accidents. Although there are a number of animal models of TBI using progesterone for head injury, the effects of progesterone on neurologic outcome of acute TBI patients remain unclear. The aim of the present clinical study was to assess the longer-term efficacy of progesterone on the improvement in neurologic outcome of patients with acute severe TBI.
05/10/2008
11:15 AM
Ten-year outcomes following traumatic brain injury: A population-based cohort
Brain Injury, Volume 22, Issue 6 June 2008 , pages 437 - 449
To quantify the 10 year health service use (HSU) and mortality outcomes for people with a traumatic brain injury (TBI).
05/10/2008
11:11 AM
Effects of rehabilitation on quality of life in patients with chronic stroke
Brain Injury, Volume 22, Issue 6 June 2008 , pages 451 - 456
To evaluate the effects of rehabilitation on disability and quality of life (QoL) in patients with chronic stroke.
05/10/2008
11:10 AM
Challenging behaviour profiles of people with acquired brain injury living in community settings
Brain Injury, Volume 22, Issue 6 June 2008 , pages 457 - 470
To determine the type and severity of challenging behaviours among a cohort of brain-injured persons referred to a community-based behaviour management service; and to determine whether different behaviour profiles were associated with aetiology of brain injury.
05/10/2008
11:09 AM
The serotonin transporter polymorphisms and major depression following traumatic brain injury
Brain Injury, Volume 22, Issue 6 June 2008 , pages 471 - 479
The purpose of this study was to examine the role of the serotonin transporter gene polymorphisms on the risk of major depression following traumatic brain injury (TBI).
05/10/2008
11:08 AM
Neuroanatomical correlates of malingered memory impairment: Event-related fMRI of deception on a recognition memory task
Brain Injury, Volume 22, Issue 6 June 2008 , pages 481 - 489
Event-related, functional magnetic resonance imaging (fMRI) data were acquired in healthy participants during purposefully malingered and normal recognition memory performances to evaluate the neural substrates of feigned memory impairment.
05/10/2008
11:07 AM
Predictors of performance on three developmentally sensitive neuropsychological tests in children with and without traumatic brain injury
Brain Injury, Volume 22, Issue 6 June 2008 , pages 491 - 500
To determine the effect of age and vocabulary as predictors of performance on neuropsychological tests in children with and without traumatic brain injury (TBI).
05/10/2008
11:04 AM
Evaluating an in-school injury prevention programme's effect on children's helmet wearing habits
Brain Injury, Volume 22, Issue 6 June 2008 , pages 501 - 507
To evaluate the effectiveness of the Bikes, Blades and Boards (BB&B) programme. It was hypothesized that children who participated in the BB&B programme would demonstrate greater knowledge of how to wear their helmets safely than a control group who did not participate in the programme and retain their skills when assessed 1 year later.
05/10/2008
11:03 AM
Health-related quality of life after stroke: what are we measuring?
International Journal of Rehabilitation Research. 31(2):111-117, June 2008
As there is no single, accepted definition of health-related quality of life (HRQOL), it is assumed to be a broad, multidimensional construct referring to those aspects of people's lives that reasonably relate to their health.
05/10/2008
11:03 AM
Effects of ideomotor apraxia on functional outcomes in patients with right hemiplegia
International Journal of Rehabilitation Research. 31(2):177-180, June 2008
The aim of this study was to investigate the effect of ideomotor apraxia on activities of daily living and to determine if the presence of apraxia interferes with rehabilitation.
05/08/2008
02:07 PM
Association between stroke lesions and sexual dysfunction in men
Nature Clinical Practice Urology (2008) 5, 234
Sexual dysfunction is a well-recognized problem in men with a history of stroke. Previous studies have assessed the association between sexual and erectile dysfunction in patients with cerebrovascular disease, but controversy persists over whether this link is organic or psychological.
05/08/2008
02:00 PM
Episomal amplification of MYCN in a case of medulloblastoma
Virchows Archiv, Volume 452, Number 5, May 2008 , pp. 491-497(7)
Gene amplification, in the form of double minutes (dmin) and/or homogeneously staining regions (hsr), is frequently associated with tumor development.
05/08/2008
01:59 PM
Surgery and radiotherapy: complementary tools in the management of benign intracranial tumors
Neurosurgical Focus May 2008 Volume 24, Number 5
Historically, radiation therapy has been used extensively in the treatment of malignant and aggressive intracranial tumors, and the importance of its role has been repeatedly verified by prolonged patient survival rates and increased tumor control.
05/08/2008
01:58 PM
Radiosurgery for hypothalamic hamartomas
Neurosurgical Focus May 2008 Volume 24, Number 5
Radiosurgery plays an important role in the treatment of refractory seizures induced by hypothalamic hamartomas (HHs). These lesions, deeply located and surrounded by a delicate vascular and neuronal network, are often associated with catastrophic epilepsy leading to progressive cognitive and behavioral deterioration.
05/08/2008
01:55 PM
Radiation therapy and CyberKnife radiosurgery in the management of craniopharyngiomas
Neurosurgical Focus May 2008 Volume 24, Number 5
Many benign intracranial tumors are amenable to radiotherapy treatment including meningiomas, schwannomas, pituitary tumors, and craniopharyngiomas. The authors present their experience in the treatment of craniopharyngiomas in 16 patients using frameless CyberKnife stereotactic radiosurgery (SRS).
05/08/2008
01:54 PM
Hitting a moving target: evolution of a treatment paradigm for atypical meningiomas amid changing diagnostic criteria
Neurosurgical Focus May 2008 Volume 24, Number 5
The World Health Organization (WHO) reclassified atypical meningiomas in 2000, creating a more clear and broadly accepted definition. In this paper, the authors evaluated the pathological and clinical transition period for atypical meningiomas according to the implementation of the new WHO grading system at their institution.
05/08/2008
01:53 PM
Evaluation of the role of Gamma Knife surgery in the treatment of craniopharyngiomas
Neurosurgical Focus May 2008 Volume 24, Number 5
The management of craniopharyngioma involves balancing adequate reduction in tumor volume and prevention of recurrence while minimizing damage to delicate surrounding structures. Because of the lesion's proximity to the optic chiasm and its relationship to the hypothalamic-pituitary axis, morbidity rates following treatment can be high.
05/08/2008
01:52 PM
Overexpression of Human S100B Exacerbates Brain Damage and Periinfarct Gliosis After Permanent Focal Ischemia
Stroke doi: 10.1161/STROKEAHA.107.503821
We have previously demonstrated that augmented and prolonged activation of astrocytes detrimentally influences both the subacute and chronic phases of cerebral ischemia. Furthermore, we have suggested that the astrocyte-derived protein S100B may be important in these pathogenic events. However, the causal relationship between S100B and exacerbation of brain damage in vivo remains to be elucidated.
05/08/2008
01:50 PM
Double-Blind Randomized Treatment of Poststroke Depression Using Nefiracetam
J Neuropsychiatry Clin Neurosci 20:178-184, May 2008
In preliminary trials, nefiracetam, a gamma aminobutyric compound, enhanced blood flow and improved mood following stroke. Within 3 months following stroke with major depression, 159 patients were enrolled in a double-blind trial of nefiracetam or placebo.
05/08/2008
01:49 PM
Not All Stroke Units Are the Same. A Comparison of Physical Activity Patterns in Melbourne, Australia, and Trondheim, Norway
Stroke doi: 10.1161/STROKEAHA.107.507160
Very early mobilization may be one of the most important factors contributing to the favorable outcome observed from a stroke unit in Trondheim, Norway. The aims of this study were to (1) describe and compare the pattern of physical activity of patients with stroke managed in a stroke unit with specified mobilization protocols (Trondheim) and those without in Melbourne, Australia; and (2) identify differences in activity according to stroke severity between the 2 sites.
05/08/2008
01:48 PM
Mapping Cerebrovascular Reactivity Using Blood Oxygen Level-Dependent MRI in Patients With Arterial Steno-occlusive Disease. Comparison With Arterial Spin Labeling MRI
Stroke doi: 10.1161/STROKEAHA.107.506709
Blood oxygen level-dependent MRI (BOLD MRI) of hypercapnia-induced changes in cerebral blood flow is an emerging technique for mapping cerebrovascular reactivity (CVR). BOLD MRI signal reflects cerebral blood flow, but also depends on cerebral blood volume, cerebral metabolic rate, arterial oxygenation, and hematocrit.
05/08/2008
01:47 PM
Pten Haploinsufficiency Accelerates Formation of High-Grade Astrocytomas
Cancer Research 68, 3286-3294, May 1, 2008
We previously reported that central nervous system (CNS) inactivation of Nf1 and p53 tumor suppressor genes in mice results in the development of low-grade to high-grade progressive astrocytomas. When the tumors achieve high grade, they are frequently accompanied by Akt activation, reminiscent of the frequent association of PTEN mutations in human high-grade glioma.
05/08/2008
01:45 PM
Correlation of Carotid Atheromatous Plaque Inflammation Using USPIO-Enhanced MR Imaging With Degree of Luminal Stenosis
Stroke doi: 10.1161/STROKEAHA.107.504753
Inflammation is a recognized risk factor for the vulnerable atherosclerotic plaque. The study explores the relationship between the degree of Magnetic Resonance
(MR)–defined inflammation using Ultra Small Super-Paramagnetic Iron Oxide
(USPIO) particles and the severity of luminal stenosis in asymptomatic carotid plaques.
05/08/2008
01:44 PM
Selective Reduction of Blood Flow to White Matter During Hypercapnia Corresponds With Leukoaraiosis
Stroke doi: 10.1161/STROKEAHA.107.501692
Age-related white matter disease (leukoaraiosis) clusters in bands in the centrum semiovale, about the occipital and frontal horns of the lateral ventricles, in the corpus callosum, and internal capsule.
05/08/2008
01:44 PM
Right-to-Left Shunt in CADASIL Patients. Prevalence and Correlation With Clinical and MRI Findings
Stroke doi: 10.1161/STROKEAHA.107.506311
A high prevalence of right-to-left shunt (RLS) was described in a family of patients with CADASIL, a rare cerebral arteriopathy attributable to Notch3 gene mutations. The aim of this study was to determine the prevalence of RLS in patients with CADASIL and possible relation to clinical phenotype and cerebral MRI lesion load.
05/08/2008
01:43 PM
Reperfusion Half-Life. A Novel Pharmacodynamic Measure of Thrombolytic Activity
Stroke doi: 10.1161/STROKEAHA.107.510818
We hypothesized that the probability of reperfusion can be modeled by an exponential decay (ie, half-life) function and that this reperfusion half-life is decreased by thrombolytic treatment.
05/08/2008
01:42 PM
Reduction in the Recurrence of Stroke by Eicosapentaenoic Acid for Hypercholesterolemic Patients. Subanalysis of the JELIS Trial
Stroke doi: 10.1161/STROKEAHA.107.509455
The JELIS trial examined the preventive effect of eicosapentaenoic acid (EPA) against coronary artery diseases. Hypercholesterolemic patients received statin only (no EPA group: n=9319) or statin with EPA (EPA group: n=9326) for around 5 years. EPA significantly suppressed the incidence of coronary events in previous analysis. Herein, we investigated the effects of EPA on the primary and secondary prevention of stroke.
05/08/2008
01:41 PM
Pulse Pressure and Mean Arterial Pressure in Relation to Ischemic Stroke Among Patients With Uncontrolled Hypertension in Rural Areas of China
Stroke doi: 10.1161/STROKEAHA.107.510677
Information has been sparse on the comparison of pulse pressure (PP) and mean arterial pressure (MAP) in relation to ischemic stroke among patients with uncontrolled hypertension. The present study examined the relation among PP, MAP, and ischemic stroke in uncontrolled hypertensive subjects in China.
05/08/2008
01:40 PM
Nascent Aneurysm Formation at the Basilar Terminus Induced by Hemodynamics
Stroke doi: 10.1161/STROKEAHA.107.509422
Hemodynamic insults at arterial bifurcations are hypothesized to play a key role in intracranial aneurysm formation. This study investigates aneurysm-initiating vascular responses at the rabbit basilar terminus subsequent to common carotid artery ligation.
05/08/2008
01:39 PM
Impact of Comorbidities on Ischemic Stroke Outcomes in Women
Stroke doi: 10.1161/STROKEAHA.107.509281
We assessed the association of prestroke comorbidities with long-term stroke outcomes among women with ischemic stroke.
05/08/2008
01:38 PM
Hyperdense Internal Carotid Artery Sign. A CT Sign of Acute Ischemia
Stroke doi: 10.1161/STROKEAHA.107.505230
The hyperdense middle cerebral artery sign (HMCAS) is a well-established marker of early ischemia on noncontrast computed tomography of the brain (NCCT). Recently the MCA dot sign has been described and proposed to indicate thrombosis of the M2 or M3 middle cerebral artery branches.
05/08/2008
01:37 PM
Endothelial Progenitor Cell Research in Stroke. A Potential Shift in Pathophysiological and Therapeutical Concepts
Stroke doi: 10.1161/STROKEAHA.107.507251
Stroke is the leading cause of disability in the Western world; however, few therapies are at hand to decrease this burden.
05/08/2008
01:36 PM
Depression as a Risk Factor for the Incidence of First-Ever Stroke in 85-Year-Olds
Stroke doi: 10.1161/STROKEAHA.107.490797
Depression may increase the risk for stroke. Few studies have examined whether depression increases the risk for stroke in the very old and among the demented. We examined the relation between depression in 85-year-olds and the 3-year incidence of first-ever stroke.
05/08/2008
01:35 PM
Radiation-induced meningioma
Neurosurgical Focus May 2008 Volume 24, Number 5
The long-term or delayed side effects of irradiation on neural tissue are now known to include the induction of new central nervous system neoplasms. However, during the first half of the 20th century, human neural tissue was generally considered relatively resistant to the carcinogenic and other ill effects of ionizing radiation.
05/08/2008
01:34 PM
The principles of skull base radiosurgery
Neurosurgical Focus May 2008 Volume 24, Number 5
Stereotactic radiosurgery is commonly used for selected patients with benign cranial base tumors. The goal of radiosurgery is cessation of tumor growth and preservation of neurological function. Over the last 2 decades, the technique of radiosurgery has evolved due to improved imaging, better radiosurgical devices and software, and the continued analysis of results.
05/08/2008
01:33 PM
Autonomic Neural Control of the Cerebral Vasculature. Acute Hypotension
Stroke doi: 10.1161/STROKEAHA.107.510008
The effect of antihypertensive drugs on autonomic neural control of the cerebral circulation remains unclear. This study was designed to compare middle cerebral artery mean blood velocity responses to acute hypotension with and without {alpha}1-adrenoreceptor blockade (Prazosin) in young, healthy humans.
05/08/2008
01:31 PM
Toxicity from chemoradiotherapy in older patients with glioblastoma multiforme
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-008-9593-6
Elderly patients have glioblastomas (GBM) that are aggressive and poorly responsive to treatment. They are also prone to the side effects of treatment of GBM. Methods To shed light on the treatment of elderly patients with GBM, we reviewed the treatment toxicities and survival of patients 65 years of age or older who were treated with chemoradiotherapy, which is the new standard of care for GBM in younger patients.
05/08/2008
01:29 PM
Selective cancer-germline gene expression in pediatric brain tumors
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-008-9577-6
Cancer-germline genes (CGGs) code for immunogenic antigens that are present in various human tumors and can be targeted by immunotherapy. Their expression has been studied in a wide range of human tumors in adults.
05/08/2008
01:27 PM
Multifocal glioblastoma multiforme with synchronous spontaneous hemorrhage: case report
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-008-9582-9
We report a 65 year old man who presented with left hemiparesis, and was found to have multiple, discrete, peripherally enhancing, hemorrhagic intra-axial masses in the right hemisphere of the brain.
05/08/2008
01:26 PM
Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-008-9579-4
The prognosis of glioblastomas is still extremely poor and the discovery of novel molecular therapeutic targets can be important to optimize treatment strategies. Gene expression analyses comparing normal and neoplastic tissues have been used to identify genes associated with tumorigenesis and potential therapeutic targets.
05/08/2008
01:24 PM
Expression of cell adhesion proteins and proteins related to angiogenesis and fatty acid metabolism in benign, atypical, and anaplastic meningiomas
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-008-9588-3
Most meningiomas are benign tumours of arachnoidal origin, although a small number have high proliferative rates and invasive properties which complicate complete surgical resection and are associated with increased recurrence rates.
05/08/2008
01:23 PM
Cryptococcal meningitis in patients with glioma: a report of two cases
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-008-9581-x
We describe two patients with high-grade glioma undergoing treatment with corticosteroids and chemotherapy who presented with cryptococcal meningitis and sepsis.
05/08/2008
01:22 PM
Cerebellar anaplastic astrocytoma in a teenager with Ollier Disease
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-008-9583-8
Ollier Disease is a sporadic skeletal disorder with a predisposition to oncogenesis. It is estimated at around 1/100,000.
05/08/2008
01:20 PM
Brain metastases in breast cancer: clinical and pathologic characteristics associated with improvements in survival
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-008-9578-5
As breast cancer patients live longer with control of systemic disease, survival after the diagnosis of brain metastases (BM) also appears to be improving.
05/08/2008
01:19 PM
Blockage of the STAT3 signaling pathway with a decoy oligonucleotide suppresses growth of human malignant glioma cells
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-008-9590-9
Gliomas are the most common type of primary tumor in the human central nervous system. STAT3, a signal transducer and activator of transcription 3, is over expressed in gliomas. Its involvement in tumorgenesis can be attributed to its ability to induce cell proliferation and inhibit apoptosis.
05/08/2008
01:18 PM
BEHAB/brevican requires ADAMTS-mediated proteolytic cleavage to promote glioma invasion
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-008-9575-8
Malignant gliomas are the most common and deadly primary brain tumors, due to their infiltrative invasion of the normal neural tissue that makes them virtually impossible to completely eliminate.
05/08/2008
01:17 PM
An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-008-9591-8
The human glioma cell lines, U87 and T98G, were evaluated for their ability to survive and form colonies in an acidic environment of pHext 6.0. In contrast to U87, which showed an 80-90% survival rate, only 40% of T98G cells survived 6 days at pHext 6.0 and lost their colony forming ability when returned to a normocidic environment.
05/08/2008
01:15 PM
Activities of DNA-PK and Ku86, but not Ku70, may predict sensitivity to cisplatin in human gliomas
Journal of Neuro-Oncology 0167-594X (Print) 10.1007/s11060-008-9592-7
This study was designed to investigate the relationship between activities of DNA-dependent protein kinase (DNA-PK), its subunits Ku86/Ku70, and sensitivities to cisplatin in human glioma samples.
05/08/2008
01:14 PM
Prognostic Value of 18F-Fluoroethyl-L-Tyrosine PET and MRI in Small Nonspecific Incidental Brain Lesions
Journal of Nuclear Medicine Vol. 49 No. 5 730-737
Nonspecific incidental brain lesions (NILs) are being detected more frequently because of an increasing number of screening or research MRI scans of the brain, and their natural course is uncertain.
05/08/2008
01:07 PM
Metabolic Imaging of Cerebral Gliomas: Spatial Correlation of Changes in O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Proton Magnetic Resonance Spectroscopic Imaging
Journal of Nuclear Medicine Vol. 49 No. 5 721-729
The aim of this study was to determine the spatial correlation of O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) uptake and the concentrations of choline (Cho), creatine (Cr), and total N-acetylaspartate (tNAA) determined with proton magnetic resonance spectroscopic imaging (1H MRSI) in cerebral gliomas for the multimodal evaluation of metabolic changes.
05/08/2008
01:06 PM
Use of preoperative functional MRI to predict verbal memory decline after temporal lobe epilepsy surgery
Epilepsia doi:10.1111/j.1528-1167.2008.01625.x
Verbal memory decline is a frequent complication of left anterior temporal lobectomy (L-ATL). The goal of this study was to determine whether preoperative language mapping using functional magnetic resonance imaging (fMRI) is useful for predicting which patients are likely to experience verbal memory decline after L-ATL.
05/08/2008
01:05 PM
The FLEP scale in diagnosing nocturnal frontal lobe epilepsy, NREM and REM parasomnias: Data from a tertiary sleep and epilepsy unit
Epilepsia doi:10.1111/j.1528-1167.2008.01602.x
To test the usefulness of the FLEP scale in diagnosing nocturnal frontal lobe epilepsy (NFLE), arousal parasomnias, and REM sleep behavior disorder (RBD).
05/08/2008
01:04 PM
Spread of ictal activity in focal epilepsy
Epilepsia doi:10.1111/j.1528-1167.2008.01627.x
Latencies between seizure onset, propagation of ictal activity, and initial clinical symptoms and signs are critically important for the successful implementation of detection-based intervention systems in the treatment of epilepsy.
05/08/2008
01:03 PM
Simultaneous EEG-fMRI in drug-naive children with newly diagnosed absence epilepsy
Epilepsia doi:10.1111/j.1528-1167.2008.01626.x
In patients with idiopathic generalized epilepsy (IGE), blood oxygen level dependent (BOLD) EEG during functional MRI (EEG-fMRI) has been successfully used to link changes in regional neuronal activity to the occurrence of generalized spike-and-wave (GSW) discharges.
05/08/2008
01:02 PM
Seizure remission and relapse in adults with intractable epilepsy: A cohort study
Epilepsia doi:10.1111/j.1528-1167.2008.01601.x
To investigate the cumulative probabilities of ≥12 month seizure remission and seizure relapse following remission, and to test the associations of clinical characteristics with these two study end points in a prevalence cohort of intractable adult epilepsy patients during medical management.
05/08/2008
01:01 PM
Reproductive hormonal changes and catamenial pattern in adolescent females with epilepsy
Epilepsia doi:10.1111/j.1528-1167.2008.01622.x
We aimed to evaluate the effect of epilepsy on the reproductive hormones levels among female patients, and to investigate the frequency of catamenial pattern of seizures.
05/08/2008
01:00 PM
Neural basis of photo/chromatic sensitivity in adolescence
Epilepsia doi:10.1111/j.1528-1167.2008.01605.x
To determine a psychophysiological basis for age visual sensitivity to chromatic and achromatic stimuli.
05/08/2008
12:59 PM
Local spatial effect of 50 Hz cortical stimulation in humans
Epilepsia doi:10.1111/j.1528-1167.2008.01628.x
Cortical stimulation to abort seizures is under human investigation. Ideal electrode placement and stimulating parameters are unknown with poor understanding of tissue volume affected by stimulation or duration and nature of its effect on cortical activity. To help characterize this effect, we analyzed electrocorticography (ECoG) recorded adjacent to stimulated contacts during and after bipolar stimulation in patients undergoing functional cortical mapping with subdural electrodes.
05/08/2008
12:59 PM
Language lateralization in temporal lobe epilepsy using functional MRI and probabilistic tractography
Epilepsia doi:10.1111/j.1528-1167.2008.01607.x
Language functional magnetic resonance imaging (fMRI) is used to noninvasively assess hemispheric language specialization as part of the presurgical work-up in temporal lobe epilepsy (TLE). White matter asymmetries on diffusion tensor imaging (DTI) may be related to language specialization as shown in controls and TLE.
05/08/2008
12:58 PM
Gene expression analysis in absence epilepsy using a monozygotic twin design
Epilepsia doi:10.1111/j.1528-1167.2008.01630.x
To identify genes involved in idiopathic absence epilepsies by analyzing gene expression using a monozygotic (MZ) twin design.
05/08/2008
12:57 PM
Epileptic encephalopathy with continuous spikes and waves during sleep in children with shunted hydrocephalus: A study of nine cases
Epilepsia doi:10.1111/j.1528-1167.2008.01608.x
We present a series of nine patients with early-onset hydrocephalus who had seizures and continuous spikes and waves during slow sleep (CSWS) associated with neurocognitive and motor deterioration.
05/08/2008
12:56 PM
Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients
Epilepsia doi:10.1111/j.1528-1167.2008.01603.x
Temporal lobe epilepsy (TLE) is associated with smaller hippocampal volume and with elevated extracellular (EC) glutamate levels. We investigated the relationship between the hippocampal volume and glutamate in refractory TLE patients.
05/08/2008
12:55 PM
Clinical differences between patients with nonepileptic seizures who report antecedent sexual abuse and those who do not
Epilepsia doi:10.1111/j.1528-1167.2008.01611.x
To investigate clinical differences between patients with psychogenic nonepileptic seizures (PNES) who report antecedent sexual abuse, and patients who do not.
05/08/2008
12:54 PM
Attention impairment in rolandic epilepsy: Systematic review
Epilepsia doi:10.1111/j.1528-1167.2008.01610.x
Conflicting evidence about impairment of attention systems and the absence of a working model of attention has contributed to lack of clarity about comorbidity of attention problems in rolandic epilepsy (RE). Impairments in distributed attention systems may inform a disease model for RE, as well as direct interventions.
05/08/2008
12:53 PM
Anticonvulsant profile and teratogenicity of 3,3-dimethylbutanoylurea: A potential for a second generation drug to valproic acid
Epilepsia doi:10.1111/j.1528-1167.2008.01624.x
The purpose of this study was to evaluate the anticonvulsant activity and teratogenic potential of branched aliphatic acylureas represented by isovaleroylurea (IVU), pivaloylurea (PVU) and 3,3-dimethylbutanoylurea (DBU), as potential second-generation drugs to valproic acid (VPA).
05/08/2008
12:52 PM
Adaptive visual memory reorganization in right medial temporal lobe epilepsy
Epilepsia doi:10.1111/j.1528-1167.2008.01629.x
We investigated functional reorganization mechanisms of the human medial temporal lobe (MTL) for episodic memory, in patients suffering from medial temporal lobe epilepsy (MTLE) with hippocampal sclerosis (HS).
05/08/2008
12:52 PM
A case-control evaluation of the ketogenic diet versus ACTH for new-onset infantile spasms
Epilepsia doi:10.1111/j.1528-1167.2008.01606.x
ACTH is currently the standard first-line therapy for new-onset infantile spasms, but it has significant side effects. We hypothesized the ketogenic diet (KD), previously reported as beneficial for intractable infantile spasms, would have similar efficacy, but better tolerability than ACTH when used first-line.
05/08/2008
12:50 PM
Therapeutic effect of a T helper cell supported CTL response induced by a survivin peptide vaccine against murine cerebral glioma
Cancer Immunology, Immunotherapy 0340-7004 (Print) 10.1007/s00262-008-0510-9
Survivin is a tumor-associated antigen (TAA) that has significant potential for use as a cancer vaccine target. To identify survivin epitopes that might serve as targets for CTL-mediated, anti-tumor responses, we evaluated a series of survivin peptides with predicted binding to mouse H2-Kb and human HLA-A*0201 antigens in peptide-loaded dendritic cell (DC) vaccines. H2-Kb-positive, C57BL/6 mice were vaccinated using syngeneic, peptide-loaded DC2.4 cells.
05/08/2008
12:50 PM
Guidelines for Management of Ischaemic Stroke and Transient Ischaemic Attack 2008
Cerebrovasc Dis 2008;25:457-507
This article represents the update of the European Stroke Initiative Recommendations for Stroke Management. These guidelines cover both ischaemic stroke and transient ischaemic attacks, which are now considered to be a single entity.
05/08/2008
12:49 PM
The human ventromedial frontal lobe is critical for learning from negative feedback
Brain 2008 131(5):1323-1331
Are positive and negative feedback weighed in a common balance in the brain, or do they influence behaviour through distinct neural mechanisms? Recent neuroeconomic studies in both human and non-human primates indicate that the ventromedial frontal lobe carries information about both losses and gains, suggesting that this region may encode value across the continuum from absolute negative to absolute positive outcomes.
05/08/2008
12:48 PM
Priming the motor system enhances the effects of upper limb therapy in chronic stroke
Brain 2008 131(5):1381-1390
After stroke, the function of primary motor cortex (M1) between the hemispheres may become unbalanced. Techniques that promote a re-balancing of M1 excitability may prime the brain to be more responsive to rehabilitation therapies and lead to improved functional outcomes.
05/08/2008
12:47 PM
Phenotypical characteristics of idiopathic infantile nystagmus with and without mutations in FRMD7
Brain 2008 131(5):1259-1267
Idiopathic infantile nystagmus (IIN) consists of involuntary oscillations of the eyes. The familial form is most commonly X-linked. We recently found mutations in a novel gene FRMD7 (Xq26.2), which provided an opportunity to investigate a genetically defined and homogeneous group of patients with nystagmus.
05/08/2008
12:46 PM
Metabolic correlates of subthalamic nucleus activity in Parkinson's disease
Brain 2008 131(5):1373-1380
Overactivity of subthalamic nucleus (STN) neurons is a consistent feature of Parkinson's disease (PD) and is a target of therapy for this disorder. However, the relationship of STN firing rate to regional brain function is not known.
05/08/2008
12:45 PM
Disconnecting force from money: effects of basal ganglia damage on incentive motivation
Brain 2008 131(5):1303-1310
Bilateral basal ganglia lesions have been reported to induce a particular form of apathy, termed auto-activation deficit (AAD), principally defined as a loss of self-driven behaviour that is reversible with external stimulation.
05/08/2008
12:44 PM
Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making
Brain 2008 131(5):1311-1322
The ventromedial prefrontal cortex (vmPFC) and insular cortex are implicated in distributed neural circuitry that supports emotional decision-making. Previous studies of patients with vmPFC lesions have focused primarily on decision-making under uncertainty, when outcome probabilities are ambiguous (e.g. the Iowa Gambling Task).
05/08/2008
12:43 PM
Cognitive sequencing impairment in patients with focal or atrophic cerebellar damage
Brain 2008 131(5):1332-1343
Although cognitive impairment after cerebellar damage has been widely reported, the mechanisms of cerebro-cerebellar interactions are still a matter of debate.
05/08/2008
12:43 PM
Cognitive deficits and striato-frontal dopamine release in Parkinson's disease
Brain 2008 131(5):1294-1302
Idiopathic Parkinson's disease (PD) is often accompanied by a pattern of executive deficits similar to those found in patients with frontal lobe lesions.
05/08/2008
12:42 PM
Cerebellar growth and behavioural & neuropsychological outcome in preterm adolescents
Brain 2008 131(5):1344-1351
Adolescence is a time of social and cognitive development associated with changes in brain structure and function. These developmental changes may show an altered path in individuals born before 33
weeks' gestation (very preterm; VPT).
05/08/2008
12:41 PM
Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions
Brain 2008 131(5):1282-1293
Frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U) is the most common neuropathology associated with the clinical syndrome of frontotemporal dementia (FTD).
05/08/2008
12:40 PM
Association between therapy outcome and right-hemispheric activation in chronic aphasia
Brain 2008 131(5):1391-1401
The role of the right hemisphere for language processing and successful therapeutic interventions in aphasic patients is a matter of debate.
05/08/2008
12:39 PM
Recommendations and treatment strategies for the management of acute ischemic stroke
Expert Opinion on Pharmacotherapy, Volume 9, Number 7, May 2008 , pp. 1071-1085(15)
Stroke is one of the leading causes of mortality and disability worldwide. From the establishment of the penumbra concept, ischemic stroke has been recognized as a dynamic process and two main therapeutic strategies have been designed: one that tries to reopen the occluded artery and the second aims to protect the penumbra brain tissue until the physiologic mechanisms-or the treatment-stop the ischemia.
05/08/2008
12:38 PM
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