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Adiponectin is a protein secreted by adipose cells that improves insulin sensitivity and possesses antiatherogenic properties. In this study, we investigated the relationship between adiponectin levels and ischemic stroke subtype.
Pediatric Neurology Volume 36, Issue 4, April 2007, Pages 253-257
This report describes the case of an 11-year-old girl with a prior history of epilepsy and multiple episodes of status epilepticus who presented with generalized convulsive status epilepticus and left hemiclonic seizures. Magnetic resonance imaging, including diffusion-weighted sequences and spectroscopy, and neuropathology at autopsy were consistent with excitotoxic neuronal injury to the hippocampus, cortex, thalamus, mammillary bodies, and cerebellum.
To determine if viral vectors carrying the gene for brain-derived neurotrophic factor
(BDNF) could be used to promote an axonal regenerative response in rubrospinal neurons after an acute cervical spinal cord injury.
Journal of Stroke and Cerebrovascular Diseases Volume 16, Issue 3, May-June 2007, Pages 91-102
Although stroke mortality has been decreasing in Japan, in 2000 it was still the third leading cause of death among Japanese of either sex. Elucidation of stroke mortality trends among age, calendar year, and birth cohorts should improve stroke prevention efforts.
Pediatric Neurology Volume 36, Issue 4, April 2007, Pages 274-276
We describe two siblings with neonatal hypocalcemic seizures whose mother took topiramate during both pregnancies. Apart from
hypocalcemia, the patients had no identifiable etiology for their seizures. Although biochemical data suggested that the hypocalcemia was caused by
hypoparathyroidism, no disorders typically associated with this condition were identified in the patients.
The involvement of matrix metalloproteinases (MMP) has been suggested in cellular mechanisms leading to
medulloblastoma, the most common malignant brain tumor in children. A significant association of the expression levels of MMP-9 with survival and M stage suggests that patients with medulloblastoma metastatic disease at diagnosis may benefit from the
anti-MMP therapy.
Nutrition Bulletin, Volume 32, Number 2, June 2007, pp. 145-153(9)
Stroke is a leading cause of death and adult disability in the Western world. Diet is an important consideration as there is evidence that around half of stroke patients are undernourished on admission to hospital and their nutritional status often declines during the hospital stay. Undernutrition is associated with both increased morbidity and mortality.
Journal of Stroke and Cerebrovascular Diseases Volume 16, Issue 3, May-June 2007, Pages 109-113
Acute spontaneous subdural hematomas of arterial origin without any traumatic history or vascular anomaly are rarely reported. Here, we report our series of 6 patients with acute spontaneous subdural
hematoma.
Hyperintense lesions are a common finding on neuroimaging and are associated not only with aging, medical illness, and some invasive medical procedures, but also with neurologic and psychiatric morbidity.
Journal of Stroke and Cerebrovascular Diseases Volume 16, Issue 3, May-June 2007, Pages 114-118
In animal models, brief periods of hypoxemia render the brain tolerant to subsequent ischemic insults. Sleep apnea leads to frequent episodes of nocturnal hypoxemia and may induce ischemic tolerance. Snoring and daytime sleepiness are cardinal symptoms of sleep apnea. We undertook this study to determine differences in stroke severity and early neurologic course in patients at risk for sleep apnea as determined by a sleep questionnaire.
Epilepsy is the most common symptom of cavernoma. Although microsurgery is the mainstay treatment for epileptogenic
cavernoma, this procedure may cause severe complications for some lesions. This report aimed to study if linear accelerator
(LINAC) radiosurgery was an alternative treatment modality for epileptogenic
cavernoma.
A large number of traditional Chinese patent medicine (TCPM) are widely used for ischemic stroke in China. The aim of this study was to systematically review the existing clinical evidence on TCPM for ischemic stroke.
The Food and Drug Administration has established requirements for protecting the public health by assuring the safety and effectiveness of a variety of medical products including drugs, devices, and biological products, and for promoting public health by expediting the approval of treatments that are safe and effective.
Hereditary spastic paraplegias (HSPs) are a group of neurodegenerative disorders characterized by progressive spasticity of the lower limbs. Here, we performed a genome-wide linkage analysis on a consanguineous family presenting an autosomal recessive form of HSP associated with mild mental retardation, brainstem
dysraphia, and clinically asymptomatic cerebellar atrophy.
We found spatially asymmetric allocation of attention in patients with traumatic brain injury
(TBI) without overt asymmetry on neurological examination. The possible effect of Methylphenidate in reducing this asymmetry is evaluated in the current research.
Few pediatric reports of thrombolysis exist. We sought to determine national rates of thrombolysis among pediatric ischemic stroke patients using a national database.
To assess the incidence of late post-traumatic epilepsy (PTE) in patients with very severe traumatic brain injury
(TBI) who either received or did not receive anti-epileptic prophylactic treatment.
To characterize different forms of intracranial artery dissections (IADs), and to test the assumption that IADs are frequently associated with subarachnoid hemorrhage
(SAH) and poor outcome, and that anticoagulant therapy is contraindicated in these patients.
The NeuroThera Effectiveness and Safety Trial-1 (NEST-1) study evaluated the safety and preliminary effectiveness of the NeuroThera Laser System in the ability to improve 90-day outcomes in ischemic stroke patients treated within 24 hours from stroke onset. The NeuroThera Laser System therapeutic approach involves use of infrared laser technology and has shown significant and sustained beneficial effects in animal models of ischemic stroke.
The aim of this statement is to present current and comprehensive recommendations for the diagnosis and treatment of acute spontaneous intracerebral hemorrhage.
A disruption of the extracellular matrix (ECM) of the intracranial arterial wall is a likely contributing factor in the pathogenesis of intracranial aneurysms. If this is a generalized process, patients with subarachnoid haemorrhage
(SAH) may have subtle signs of a general laxity of the connective tissue. We performed a pilot study to assess general laxity in SAH patients and to examine which tests for joint mobility can be best used in these patients.
Seizure Volume 16, Issue 4, June 2007, Pages 324-329
To analyze the validity and reliability of an epilepsy specific health related quality of life
(HRQL) instrument (QVCE-50), constructed for Brazilians. The QVCE-50 comprises the following domains: physical (9 items), psychological (18 items), social/familial (7 items), and cognitive/educational (16 items). Items were scored on a four point scale. Domains were equally weighted using percent scores. The questionnaire ends with a quality of life scale scored 0-10 and a space for free observations.
Psychiatry and Clinical Neurosciences, Volume 61, Number 3, June 2007, pp. 330-332(3)
Aggravation of seizures due to hyponatremia was investigated in five patients with epilepsy and
polydipsia-hyponatremia. They experienced marked increases in the frequency of their complex partial seizures with a decrease in the serum sodium level to 118-127-mEq/L.
A large number of patients experience ischemic stroke despite treatment with aspirin (acetylsalicylic acid,
ASA). It is not clear whether all of these patients with ischemic stroke respond normally to ASA or are hyporesponsive as assessed by inhibition of aggregation and thromboxane (TX) synthesis.
Topics in Stroke Rehabilitation Volume 14, Number 2 / Mar-Apr 2007
This descriptive study examined problems and successes that a sample of 73 adult caregivers new to the role expressed in the first year of caring for stroke survivors. Data were collected from May 2002 to December 2005.
The Journal of Pediatrics Volume 150, Issue 6, June 2007, Pages 592-596.e5
To assess interobserver reliability between 2 central readers of cranial ultrasound scanning (CUS) and accuracy of local, compared with central, interpretations.
According to previous studies, the quality of life is usually substantially altered in patients who have suffered a subarachnoid hemorrhage of an aneurysmal origin. Some studies have attempted to find out which factors predict the deterioration in quality of life. Our study will try to describe the quality of life of these patients and discover which variables may predict it in each of its dimensions.
Spontaneous intraventricular hemorrhage is an infrequent but severe complication of hemorrhagic stroke. The conventional treatment of intraventricular hemorrhage consists of ventricular drainage or surgical evacuation, but neither of them is encouraged. The objective of this article is to compare different surgical procedures in order to evaluate a method of minimally invasive treatment for intraventricular hemorrhage.
To review current measurement approaches to activity and participation among wheeled mobility users and suggest key factors researchers should consider as they continue to develop and refine both the concept of participation and its measurement.
The aim of this paper is to highlight the contributions that complementary efficacy, effectiveness, and cost-effectiveness studies can make to assessing the outcomes of assistive technology interventions for enhancing mobility.
The Mobility Rehabilitation Engineering Research Center at the Georgia Institute of Technology held its State of the Science Conference to address challenges in studying the health, activity and participation of wheelchair users. The purpose of this project was to collect and report seating and wheeled mobility research priorities.
To bring together an interdisciplinary group of leaders in the field of seating and wheeled mobility to discuss and exchange information about the methodological challenges of studying health, activity and participation of wheelchair users. This article summarizes the discussions from the Wheeled Mobility breakout groups.
The Mobility Rehabilitation Engineering Research Center at the Georgia Institute of Technology held its State of the Science Conference to address challenges in studying the health, activity and participation of wheelchair users. This article summarizes the discussions of four seating and positioning research topics.
Using a correlational design, this study verifies the relationships between personal characteristics of individuals with TBI and their spouses and their level of psychological and marital adjustment.
Motivation has an important influence on neuropsychological test performances. This study examined effort on the Word Memory Test
(WMT) in groups with differing external incentives.
The rehabilitation of the traumatic brain injury (TBI) patient is especially challenging in non-western populations as the phenotypic indicators as well as the neurobehavioral assessments for the survivors of brain injury are limited.
The Wisconsin Card Sorting Test (WCST) has been demonstrated to have a relatively stable factor structure in traumatic brain injury
(TBI) samples. What is less clear is whether the scores derived from WCST factors are related to functional outcomes. The purpose of the current study was to replicate the WCST factor structure in a sample with severe
TBI, and to evaluate the relationship between the factor scores and outcome.
To investigate the use of a 'reminders' function on a mobile phone as a compensatory memory aid for five individuals with traumatic brain injury
(TBI).
Patients with Diffuse axonal injury (DAI) frequently exhibit cognitive disorders chronically. Radiologic recognition of DAI can help understand the clinical syndrome and to make treatment decisions. However, CT and conventional MRI are often normal or demonstrate lesions that are poorly related to the cognitive disorders. Recently, diffusion tensor imaging (DTI) fiber tractography has been shown to be useful in detecting various types of white matter damage.
The aim of the present study was to evaluate the association of contractures with an increase or reduction of non-spastic muscle overactivity due to severe cerebral damage.
There are only limited data regarding pituitary functions in the acute phase of traumatic brain injury
(TBI) and previous studies have been conducted in only small cohorts of subjects. Therefore we have investigated the pituitary functions in the early acute phase, within 24 hours of trauma, in 104 patients with
TBI. Additionally, the relationships between basal pituitary hormones, severity of the trauma and mortality due to trauma were also investigated.
Severe traumatic brain injury (TBI) is associated with a 30-70% mortality rate. Nevertheless, controversy has been raised concerning the prognostic value of biomarkers following severe
TBI. Therefore, our aim was to determine whether sFas or TNFa serum levels correlate with primary outcome following isolated severe
TBI.
The generation effect (GE) is a phenomenon in which material that is produced by an individual is learned and remembered better than information that is provided to that individual. The current study examined the potential benefits of self-generation on learning and memory in individuals with traumatic brain injury
(TBI).
The present study used the National Institute on Disability Rehabilitation and Research
(NIDRR) funded Traumatic Brain Injury Model Systems (TBIMS) database to examine the effect of gender on presentation of executive dysfunction following traumatic brain injury
(TBI) and variables that might impact the course and degree of recovery.
Reasons for prospective remembering and forgetting after traumatic brain injury
(TBI) were investigated using Ellis' (1996) five phases of prospective memory as a framework. Participants were 38 individuals with severe TBI and 34 controls. Participants self-rated their perceived reasons for prospective remembering and forgetting using section C of the Comprehensive Assessment of Prospective Memory
(CAPM).
Implicit learning is durable over time, robust under psychological stress and shows specificity of transfer; characteristics that may be beneficial in stroke rehabilitation. The purpose of this study was to investigate implicit sequence learning processes in unilateral stroke using an extended number of trial blocks in a serial reaction time task
(SRTT). Previous research, using a SRTT, has produced equivocal results that may be associated with the small number of trial blocks used. Seven adults, at least one year after stroke, and eight controls performed 54 blocks of a modified SRTT over two weeks.
Errorless training methods significantly improve learning in memory-impaired patients relative to errorful training procedures. However, the validity of this technique for acquiring linguistic information in aphasia has rarely been studied.
We investigated the presence of postural abnormalities in a consecutive sample of stroke patients, with either left or right brain damage, in relation to their perceived body position in space. The presence or absence of posture-related symptoms was judged by two trained therapists and subsequently analysed by hierarchical classes analysis
(HICLAS). The subject classes resulting from the HICLAS model were further validated with respect to posture-related measurements, such as centre of gravity position and head position, as well as measurements related to the postural body scheme, such as the perception of postural and visual verticality.
1997 saw the introduction of the Community Care (Direct Payments) Act in the UK. This piece of legislation introduced a mechanism that enabled local authorities to make cash payments to disabled people aged between 18 and 64 in lieu of directly provided services. The years since 1997 have seen the introduction of additional legislation resulting in direct payments now being an option for many more groups of people, including the carers of disabled children.
Topics in Stroke Rehabilitation Volume 14, Number 2 / Mar-Apr 2007
he purpose of this study was to describe household and community ambulatory activity profiles and their relationship to fatigue and cardiovascular fitness in a sample of men and women with chronic hemiparetic stroke.
Pediatric Neurology Volume 36, Issue 4, April 2007, Pages 231-235
The study objective was to assess the applicability and reliability of the semiological seizure classification in children with epilepsy in outpatient clinics. Ninety patients (age range, 2-16 years) who experienced clinical seizures during prolonged video-electroencephalogram (EEG) monitoring were evaluated. Semiological seizure classification was performed, first based on history obtained from parents of the patient during outpatient follow-up visits and then based on video EEG-monitoring.
Pediatric Neurology Volume 36, Issue 5, May 2007, Pages 312-317
Neuropsychologic test scores from a group of children with epilepsy were compared to the standardization sample of the
NEPSY: A Developmental Neuropsychological Assessment, a relatively new neuropsychologic testing instrument. Nineteen children with a confirmed diagnosis of epilepsy (11 boys, 8 girls), aged 3-12 years, participated. Attention/executive function, language,
sensorimotor, visuospatial, and learning/memory domain scores were examined, as well as individual subtest scores.
Pediatric Neurology Volume 36, Issue 5, May 2007, Pages 307-311
No comparative studies have addressed the oxidant and antioxidant states of blood and cerebrospinal fluid. To reveal this differential state, the study was designed to identify the seizure type with the worse prognosis by determining erythrocyte arginase and erythrocyte
catalase, plasma and cerebrospinal fluid malondialdehyde, and plasma and cerebrospinal fluid nitric oxide levels.
Fractional anisotropy (FA) is a powerful measure to study the integrity of the cerebral white matter in vivo. However, because clinical FA assessments are frequently based on single slice evaluations, intra- and interindividual comparisons are highly dependent on image alignment. We attempted to develop an observer-independent, fully automated technique for quantitative FA assessment.
Our goal is to provide an overview of the current evidence about components of the evaluation and treatment of adults with acute ischemic stroke. The intended audience is physicians and other emergency healthcare providers who treat patients within the first 48 hours after stroke. In addition, information for healthcare policy makers is included.
Symptomatic intracerebral hemorrhage (SICH) following thrombolytic therapy for acute ischemic stroke is associated with a high rate of morbidity and mortality. Knowledge of the risk factors associated with SICH following thrombolyitc therapy may provide insight into the pathophysiological mechanisms underlying the development of
SICH, lead to the development of treatments that reduce the risk of SICH and have implications for the design of future stroke trials.
The way in which patients with transient ischemic attack (TIA) are investigated and treated varies substantially worldwide. There are no data on the management and outcome of TIA patients admitted to a stroke unit.
Pediatric Neurology Volume 36, Issue 5, May 2007, Pages 281-292
The ketogenic diet is a valuable therapeutic approach for epilepsy, one in which most clinical experience has been with children. Although the mechanism by which the diet protects against seizures is unknown, there is evidence that it causes effects on intermediary metabolism that influence the dynamics of the major inhibitory and excitatory neurotransmitter systems in brain.
The Lausanne Stroke Registry includes, from 1979, all patients admitted to the department of Neurology of the Lausanne University Hospital with the diagnosis of first clinical stroke. Using the Lausanne Stroke Registry, we aimed to determine trends in risk factors, causes, localization and inhospital mortality over 25 years in hospitalized stroke patients.
Pediatric Neurology Volume 36, Issue 4, April 2007, Pages 236-243
A variety of developmental brain anomalies have been described in individuals with fetal hydrocephalus, regardless of etiology. Examples include callosal
dysgenesis, periventricular gray matter heterotopia, hippocampal and white matter
hypoplasia, and cortical polygyration.
Early recovery after intravenous thrombolysis can be observed in stroke; however, the utility of measuring clinical improvement to assess artery status has not been established. We sought to determine the accuracy of serial National Institutes of Health Stroke Scale
(NIHSS) scores to detect complete early recanalization of the middle cerebral artery.
Seizure Volume 16, Issue 4, June 2007, Pages 356-364
The National Centre for Epilepsy in Norway admits patients with refractory epilepsy from the whole country. The purpose of this study was to investigate how antiepileptic drugs
(AEDs) are used at the centre and compare it with the total consumption in the country and international guidelines regarding clinical use of
AEDs.
Pediatric Neurology Volume 36, Issue 4, April 2007, Pages 217-226
Traumatic brain injury is a common cause of death and disability in children; early neuroimaging has assumed an increasingly important role in evaluating the extent and severity of injury.
To evaluate the predictive impact of chromosome 1p/19q deletions on the response and outcome of progressive low-grade gliomas
(LGG) treated with up-front temozolomide (TMZ) chemotherapy.
Transcranial Doppler sonography (TCD) has been used widely for long-term monitoring of cerebral blood flow without adverse reports. However, attention has not been adequately paid to the fact that an increase in the time period of TCD insonation causes brain temperature to rise due to ultrasound absorption by tissue and the skull.
Early risk of stroke after a transient ischaemic attack (TIA) can be reliably predicted with risk scores based on clinical features of the patient and the event, but it is unclear how these features correlate with findings on brain imaging and few studies have investigated this in the subacute phase.
To evaluate the predictive impact of chromosome 1p/19q deletions on the response and outcome of progressive low-grade gliomas
(LGG) treated with up-front temozolomide (TMZ) chemotherapy.
Journal of Trauma-Injury Infection & Critical Care. 62(5):1250-1258, May 2007
The optimal timing for noncranial surgery after multisystem injury is not known. Early surgery may lead to decreased pulmonary complications and length of stay, but also predispose to secondary brain injury if decreased cerebral perfusion occurs
intraoperatively. Previous work has not consistently evaluated neuropsychological or functional outcome. We sought to determine whether 6-month neuropsychological and functional outcome was associated with timing of noncranial surgery after traumatic brain injury.
Evaluation of knees of tetraplegic patients who have been walking for several months with the aid of a system that involves neuromuscular stimulation, treadmill and a harness support device.
Pediatric Neurology Volume 36, Issue 4, April 2007, Pages 268-270
Neurologic complications of cardiac catheterization are usually embolic events resulting in stroke or seizures of vascular origin. Contrast-induced seizures have been rarely described in children.
Pediatric Neurology Volume 36, Issue 5, May 2007, Pages 293-300
We aimed to define the dose of pirfenidone in children and adolescents with neurofibromatosis 1 and plexiform neurofibromas that is pharmacokinetically comparable to the active adult dose. Pirfenidone was administered orally on a continuous dosing schedule.
Pediatric Neurology Volume 36, Issue 5, May 2007, Pages 330-333
Positron emission tomography can be used to evaluate brain function following perinatal hypoxia. This case report demonstrates transient hypermetabolism in the basal ganglia detected by glucose metabolism positron emission tomography study in a newborn who suffered hypoxic-ischemic encephalopathy and developed dystonic cerebral palsy later.
Acta Neurologica Scandinavica, Volume 115, Number 6, June 2007, pp. 425-428(4)
Cortical laminar necrosis (CLN) is a metabolic injury pattern usually observed after cerebral hypoxia, hypoglycemia, or ischemia. We report serial magnetic resonance imaging findings in a patient with complex partial status epilepticus (SE) developing a band-like, T1-hyperintense lesion consistent with CLN along the surface of the left hippocampus without concurrent other causes of
CLN.
Acta Neurologica Scandinavica, Volume 115, Number 6, June 2007, pp. 398-402(5)
To study the prevalence of post-concussion symptoms (PCS) 5-7 years after mild head injury
(MHI) and to investigate whether patients suffer from more symptoms than the normal population.
To prospectively assess the feasibility of standardized presurgical functional magnetic resonance
(MR) imaging for localizing the Broca and Wernicke areas and for lateralizing language function.
To prospectively evaluate whether quantitative and qualitative magnetic resonance
(MR) imaging assessments after spinal cord injury (SCI) correlate with patient neurologic status and are predictive of outcome at long-term follow-up.
Pediatric Neurology Volume 36, Issue 5, May 2007, Pages 318-323
Hospitalizations due to breakthrough seizures were studied in children with newly diagnosed epilepsy to evaluate (1) risk factors associated with such admissions, in particular the withholding of medication and subtherapeutic dose of anticonvulsants, and (2) the impact of the unscheduled hospitalization on subsequent seizure outcome.
Pediatric Neurology Volume 36, Issue 4, April 2007, Pages 227-230
Although levetiracetam has shown efficacy in children with epilepsy, when used as adjunctive therapy, limited data are available regarding its use as
monotherapy. The objective of this study is to evaluate the efficacy and tolerability of levetiracetam monotherapy in a cohort of pediatric patients with epilepsy.
Journal of Head Trauma Rehabilitation. 22(3):192-197, May/June 2007
Mild traumatic brain injury (mTBI) without frank neurological disturbance has been linked to persistent physical, cognitive, and affective disturbances in some cases. The cognitive sequelae of this syndrome represent the most frequently studied symptoms, yet the legacy of such injuries on communicative functions remains largely undetermined.
Journal of Head Trauma Rehabilitation. 22(3):184-191, May/June 2007
To examine the patterns of swallowing resolution and outcomes of traumatic brain injury
(TBI) patients in an acute care setting and document the risk factors or predictors of resolution of swallowing function.
Journal of Head Trauma Rehabilitation. 22(3):198-205, May/June 2007
To examine the efficacy of Brain Injury Partners: Advocacy Skills for Parents, an interactive multimedia intervention that provides training in educational advocacy skills for parents of children with traumatic brain injury
(TBI).
Journal of Head Trauma Rehabilitation. 22(3):141-155, May/June 2007
To determine to what extent magnetic resonance imaging (MRI), single photon emission computed tomography
(SPECT), and magnetoencephalography (MEG) can provide objective evidence of brain injury in adult patients with persistent (>1 year) postconcussive symptoms following mild blunt head trauma.
Journal of Head Trauma Rehabilitation. 22(3):167-176, May/June 2007
To demonstrate the feasibility of a skills-based substance abuse prevention counseling program in a community setting for adults who sustained traumatic brain injury.
Sepsis-associated encephalopathy (SAE) is a poorly understood and underdiagnosed neurological complication of sepsis. Several conditions commonly associated with sepsis (hepatic or renal dysfunction, electrolyte abnormalities, acid-base disturbances, glycemia disturbances, hypotension, hypoxemia, sedation, body temperature disturbances, and neuroendocrine dysfunction) make SAE evaluation difficult.
British Journal of Clinical Pharmacology, Volume 63, Number 6, June 2007, pp. 689-697(9)
To investigate the prescribing epidemiology, in UK primary care, of newer antiepileptic drugs
(AEDs) compared with conventional AEDs and to identify AEDs for further research in response to the European Medicines Agency report on epilepsy.
Epileptic Disorders. Volume 9, Number 1, 51-6, March 2007
Three patients with neurosyphilis are reported. The first and third patients presented with convulsive status epilepticus and the second with non-convulsive status after penicillin administration. In all cerebrospinal fluid and the serum Venereal Disease Research Laboratory Test
(VDRL) and Treponema Pallidum hemagglutination (TPHA) or fluorescent treponemal antibody absorption test
(FTA-ABS) were positive, but HIV serology was negative.
Epileptic Disorders. Volume 9, Number 1, 98-103, March 2007
West Nile virus (WNV) has re-emerged with a much wider geographic distribution and a higher incidence than ever. In spite of some recent reports on the neurological manifestations and EEG changes caused by WNV encephalitis, there are few data on the incidence of seizures, status epilepticus or post-encephalitic epilepsy.
Epileptic Disorders. Volume 9, Number 1, 1-10, March 2007
Depression in epilepsy may be managed more effectively if the relationship to the ictus is better understood. 4) Other factors such as stressful life events, related or unrelated to epilepsy, may contribute to the depressive symptoms.
To assess the diagnostic accuracy of flow cytometric immunophenotyping in comparison with classic cytomorphology for diagnosing CNS localizations of hematologic malignancies, and to evaluate the implications of CSF pleocytosis and protein content in this context.
American Journal of Neuroradiology 28:830-834, May 2007
A recent trial shows an 8.3 per 100-patient-years' ischemic stroke rate in the territory of the intracranial stenotic artery, despite aspirin treatment. Our aim was to prospectively study the feasibility and outcome of a new intracranial balloon-expandable Apollo stent for symptomatic atherosclerotic intracranial stenosis (SAIS).
British Journal of Clinical Pharmacology, Volume 63, Number 6, June 2007, pp. 640-647(8)
To determine whether a particular anticonvulsant is more effective or safer than another or placebo in patients with status
epilepticus, and to summarize the available evidence from randomized controlled trials, and to highlight areas for future research in status
epilepticus.
Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:593-599
Previous studies have shown an inverse gradient in socioeconomic status for disability after stroke. However, no distinction has been made between the period in the stroke rehabilitation unit
(SRU) and the period after discharge. The purpose of this study was to examine the impact of education and equivalent income on motor and functional recovery for both periods.
Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:581-586
Secondary degeneration of the pyramidal tract distal to the primary lesion after a stroke has been detected by some studies using diffusion tensor imaging (DTI) but its potential clinical significance and the degeneration of the fibre tract proximal to the primary lesion have received little attention.
Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:587-592
The integrity of motor pathways and functional connectivity patterns are important in assessing plastic changes related to successful recovery, to obtain prognostic information and to monitor future therapeutic strategies of stroke patients.
Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:605-609
To compare long term (10 years) seizure outcome, psychosocial outcome and use of antiepileptic drugs
(AED) with the 2 year follow-up in adults after resective epilepsy surgery.
Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:620-623
Arachnoid cysts (AC) can cause a wide spectrum of clinical symptoms. Only a limited number of studies have investigated intracranial pressure in patients with AC. We wished to investigate the relationship between intracystic pressure, preoperative complaints and postoperative symptom relief in adult patients operated on for a unilateral temporal AC.
Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:555-564
The objective of this review was to evaluate whether systematic visual training leads to (1) a restitution of the visual field (restoration), (2) an increase in the visual search field size or an improvement in scanning strategies (compensation) and (3) a transfer of training-related improvements in activities of daily living such as reading.
Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:644-646
A range of neuropathological and psychosocial factors have been implicated in the aetiology and maintenance of post-concussional syndrome (PCS), with a growing consensus in the literature that this is a complex, multifactorial condition. The role of patients’ perceptions in PCS has not been examined to date.
Frontotemporal Lobar Degeneration (FTLD) thus recently renamed, refers to a spectrum of heterogeneous conditions. This same heterogeneity of presentation represents the major methodological limit for the correct evaluation of clinical designation and brain functional correlates. At present, no study has investigated clinical clusters due to specific cognitive and behavioural disturbances beyond current clinical criteria.
Journal of Pediatric Hematology/Oncology. 29(5):298-300, May 2007
We present a 7-month-old male infant with stage I Wilms tumor who unexpectedly died from a catastrophic intracerebral hemorrhage, 4 months after completion of chemotherapy and complete surgical resection of the tumor. The precise etiology underlying the fatal event remains unclear as postmortem was refused, but we postulate spontaneous hemorrhage from an underlying cerebral vascular malformation as the most likely cause, which led to the child's unfortunate demise.
Journal of Paediatrics and Child Health, Volume 43, Number 5, May 2007, pp. 409-410(2)
We present a case of neonatal seizures and encephalopathy with peripheral neuropathy. Long bone radiographs demonstrated sclerotic changes. Elevated serum lead concentrations were later found in both the child and mother, resulting in the diagnosis of neonatal encephalopathy secondary to prenatal lead exposure.
The vast majority of spinal cord lesions cause neurogenic bladder disorders. Detrusor hyperreflexia presents a major risk factor for renal damage in these patients. We evaluated the long-term results of patients with spinal cord injury treated at our institution.
The influence that previous clinical expressions of systemic atherosclerosis may have on evolution and early mortality in patients with acute ischemic stroke is not known.
Current Opinion in Pediatrics. 19(3):258-264, June 2007
Clinicians frequently but at times indiscriminately perform computed tomography scans for children with minor blunt head trauma resulting in potentially harmful radiation exposure. Recent guidelines recognize the limited but increasing data available to make strong recommendations regarding appropriate neuroimaging decisions. Investigators have derived and validated clinical prediction models to accurately identify patients with substantial traumatic brain injury, though no clear definitive rule exists. Children younger than 2 years appear to have a higher risk of intracranial injury following minor head trauma.
Past studies consistently show an inverse relationship between physicians' surgical procedures/diagnoses volume and cost. There is little information available on this aspect of stroke care. We used nationwide population-based data to explore the association between physician case volume and costs per discharge for patients with stroke.
Therapeutic Apheresis and Dialysis, Volume 11, Number 3, June 2007, pp. 171-176(6)
To evaluate the therapeutic effects of the HELP system (heparin-induced extracorporeal low-density
lipoprotein-apolipoprotein(a)-fibrinogen precipitation) in patients with acute ischemic stroke and probe into its possible mechanism, 10 patients with acute ischemic stroke were included in this study and received the HELP therapy in addition to low molecular weight
dextran, salvia miltiorrhiza and aspirin.
Congenital plasminogen deficiency is an infrequent disorder, which usually becomes symptomatic as ligneous conjunctivitis. However, pseudomembranous lesions in the mucosa of the pharynx, tracheobronchial tree, and the peritoneum may likewise occur.
Aneurysmal subarachnoid hemorrhage (aSAH) stands out from other subtypes of stroke because of the high early mortality and the risk of complications. Serum glial fibrillary acidic protein
(s-GFAP) concentrations are increased after stroke. The aim of this study was to investigate whether
s-GFAP could be used as a marker of brain damage and outcome after
aSAH.
The aim of this study was to investigate the association between atrial fibrillation (AF), stroke, dementia, and their correlation with brain pathology in subjects aged 85 years or older.
Magnetic Resonance Imaging Volume 25, Issue 3, April 2007, Pages 303-310
There is increasing interest in obtaining quantitative imaging parameters to aid in the assessment of tumor responses to treatment. In this study, the feasibility of performing integrated diffusion, perfusion and permeability magnetic resonance imaging
(MRI) for characterizing responses to dexamethasone in intracranial tumors was assessed.
Journal of Clinical Neuroscience Volume 14, Issue 4, April 2007, Pages 344-348
Gastric paresis in traumatic brain injury (TBI) hinders the effectiveness of enteral support in this patient group. In this study we have investigated the effect of metoclopramide on gastric emptying in TBI patients.
Journal of Clinical Neuroscience Volume 14, Issue 4, April 2007, Pages 317-321
Decompressive hemicraniectomy as an appropriate treatment for malignant middle cerebral artery (MCA) infarction is still a controversial issue. This study aimed to determine the survival rate and functional outcome, and factors associated with these, in patients with malignant MCA infarction. From January 2000 to December 2003, 60 patients with malignant MCA infarction were treated in our hospital.
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