| 03/10/2008
12:54 PM
Evidence on magnetic resonance imaging of Brown-Sequard spinal cord injury suffered indirectly from a gunshot wound
Journal of Neurosurgery March 2008 Volume 8, Number 3
The authors describe a rare case of Brown-Sequard syndrome as a result of indirect, concussive trauma to the spinal cord from a gunshot wound (GSW) and present the magnetic resonance (MR) imaging evidence obtained in this interesting case.
03/10/2008
12:52 PM
MRI-Based Correction for Partial-Volume Effect Improves Detectability of Intractable Epileptogenic Foci on 123I-Iomazenil Brain SPECT Images
Journal of Nuclear Medicine Vol. 49 No. 3 383-389
123I-Iomazenil brain SPECT has been used for the detection of epileptogenic foci, especially when surgical intervention is considered. Although epileptogenic foci exhibit a decrease in 123I-iomazenil accumulation, normal cerebral cortices often exhibit similar findings because of thin cortical ribbons, gray matter atrophy, or pathologic brain structures.
03/08/2008
11:37 AM
Stroke Health and Risk Education (SHARE) Pilot Project. Feasibility and Need for Church-Based Stroke Health Promotion in a Bi-Ethnic Community
Stroke doi: 10.1161/STROKEAHA.107.503557
We performed a pilot project to assess the need for and feasibility of a church-based stroke risk reduction intervention in a predominantly Mexican American community.
03/08/2008
11:36 AM
Staged Escalation Therapy in Acute Basilar Artery Occlusion. Intravenous Thrombolysis and On-Demand Consecutive Endovascular Mechanical Thrombectomy: Preliminary Experience in 16 Patients
Stroke doi: 10.1161/STROKEAHA.107.505123
The prognosis of acute basilar artery occlusion (BAO) is poor if early recanalization is not achieved. Recanalization strategies include intravenous thrombolysis (IVT) and intra-arterial thrombolysis, as well as endovascular mechanical thrombectomy (EMT). The combination of IVT with consecutive on-demand EMT may allow for early treatment initiation with high recanalization rates but has never been systematically tested in patients with BAO.
03/08/2008
11:35 AM
Predictors and Outcomes of Intraprocedural Rupture in Patients Treated for Ruptured Intracranial Aneurysms. The CARAT Study
Stroke doi: 10.1161/STROKEAHA.107.504670
Intraprocedural rupture (IPR) is a well known complication of intracranial aneurysm treatment. Risks and predictors of IPR and its impact on outcome have not been clearly established.
03/08/2008
11:34 AM
Intra-arterial Thrombolysis of Acute Iatrogenic Intracranial Arterial Occlusion Attributable to Neuroendovascular Procedures or Coronary Angiography
Stroke doi: 10.1161/STROKEAHA.107.506279
For selected stroke patients, intra-arterial thrombolysis (IAT) has been shown to be an effective treatment option. However, knowledge of safety and efficacy of IAT in patients with acute stroke as a complication of arterial catheter interventions is limited.
03/08/2008
11:33 AM
Cigarette Smoking and Risk of Stroke in the Chinese Adult Population
Stroke doi: 10.1161/STROKEAHA.107.505305
We studied the relationship between cigarette smoking and stroke incidence and mortality in the Chinese adult population.
03/08/2008
11:31 AM
Cerebrospinal Fluid Tenascin-C Increases Preceding the Development of Chronic Shunt-Dependent Hydrocephalus After Subarachnoid Hemorrhage
Stroke doi: 10.1161/STROKEAHA.107.505735
The possible cause of chronic hydrocephalus after subarachnoid hemorrhage (SAH) has been reported to be meningeal fibrosis. We examined whether the induction of tenascin-C (TN-C), an extracellular matrix glycoprotein known to promote tissue fibrosis, was associated with chronic hydrocephalus after SAH.
03/08/2008
11:31 AM
Tissue factor/FVIIa activates Bcl-2 and prevents doxorubicin-induced apoptosis in neuroblastoma cells
BMC Cancer 2008, 8:69
Tissue factor (TF) is a transmembrane protein that acts as a receptor for activated coagulation factor VII (FVIIa), initiating the coagulation cascade. Recent studies demonstrate that expression of tumor-derived TF also mediates intracellular signaling relevant to tumor growth and apoptosis. Our present study investigates the possible mechanism by which the interaction between TF and FVIIa regulates chemotherapy resistance in neuroblastoma cell lines.
03/08/2008
11:30 AM
Extracranial carotid artery pseudoaneurysm presenting with embolic stroke in a pediatric patient
Journal of Neurosurgery Pediatrics March 2008 Volume 1, Number 3
Extracranial carotid artery (CA) aneurysms are rare in the pediatric population and are usually the result of connective tissue disorders, traumatic dissection, or infection. The authors present the case of a large calcified internal carotid artery pseudoaneurysm of obscure origins presenting with embolic stroke in a child.
03/08/2008
11:27 AM
Adverse facial edema associated with off-label use of recombinant human bone morphogenetic protein-2 in cranial reconstruction for craniosynostosis
Journal of Neurosurgery Pediatrics March 2008 Volume 1, Number 3
The authors present a case of scalp and facial edema following craniofacial reconstruction for metopic craniosynostosis in which recombinant human bone morphogenetic protein–2 (rhBMP-2) was used to treat cranial defects related to the frontoorbital reconstruction.
03/08/2008
11:26 AM
Unrecognized Myocardial Infarction in Relation to Risk of Dementia and Cerebral Small Vessel Disease
Stroke doi: 10.1161/STROKEAHA.107.501106
Men, but not women, with unrecognized myocardial infarction (MI) have an increased risk of cardiac events and stroke compared with those without MI or with recognized MI. We investigated whether unrecognized MI is also a risk factor for dementia and cerebral small vessel disease (white matter lesions and brain infarction) in 2 population-based cohort studies.
03/08/2008
11:26 AM
The Metabolic Syndrome Predicts Incident Stroke. A 14-Year Follow-Up Study in Elderly People in Finland
Stroke doi: 10.1161/STROKEAHA.107.499830
Limited information is available on the role of the metabolic syndrome (MetS) to predict stroke. We investigated the relationship of the MetS and its single components, defined by 6 different criteria, with stroke in a prospective population-based study.
03/08/2008
11:25 AM
Remodeling the Brain. Plastic Structural Brain Changes Produced by Different Motor Therapies After Stroke
Stroke doi: 10.1161/STROKEAHA.107.502229
Studies on adult stroke patients have demonstrated functional changes in cortical excitability, metabolic rate, or blood flow after motor therapy, measures that can fluctuate rapidly over time.
03/08/2008
11:24 AM
Rapid Morphologic Plasticity of Peri-Infarct Dendritic Spines After Focal Ischemic Stroke
Stroke doi: 10.1161/STROKEAHA.107.498238
Focal stroke is associated with cell death, abnormal synaptic activity, and neurologic impairments. Given that many of these neuropathologic processes can be attributed to events that occur shortly after injury, it is necessary to understand how stroke affects the structure of neurons in surviving peri-infarct regions, particularly at the level of the dendritic spines, which transmit normal and potentially abnormal and injurious synaptic signaling. Recently, we described ischemia-induced changes in the structure of layer 1 dendritic tufts of transgenic mice expressing YFP in layer 5 cortical neurons.
03/08/2008
11:23 AM
Progression of White Matter Hyperintensities and Incidence of New Lacunes Over a 3-Year Period. The Leukoaraiosis and Disability Study
Stroke doi: 10.1161/STROKEAHA.107.498535
We studied the natural course of white matter hyperintensities (WMH) and lacunes, the main MRI representatives of small vessel disease, over time and evaluated possible predictors for their development.
03/08/2008
11:22 AM
Progression of Symptomatic Intracranial Large Artery Atherosclerosis Is Associated With a Proinflammatory State and Impaired Fibrinolysis
Stroke doi: 10.1161/STROKEAHA.107.498600
The molecular pathways involved in the progression of intracranial large artery atherosclerosis (ILA) are largely unknown. Our objective was to prospectively study the relationship between circulating levels of inflammatory markers and fibrinolysis inhibitors, and the risk of progression of symptomatic ILA.
03/08/2008
11:22 AM
Genetic Variation in Soluble Epoxide Hydrolase (EPHX2) Is Associated With an Increased Risk of Ischemic Stroke in White Europeans
Stroke doi: 10.1161/STROKEAHA.107.502179
Genetic variation in the EPHX2 gene region has been reported to influence susceptibility to ischemic stroke in blacks. We assessed the role of this gene region in white Europeans and performed analyses with regard to stroke subtypes.
03/08/2008
11:21 AM
Genetic Variation in Members of the Leukotriene Biosynthesis Pathway Confer an Increased Risk of Ischemic Stroke. A Replication Study in Two Independent Populations
Stroke doi: 10.1161/STROKEAHA.107.491969
The recent finding that genetic variants in 5-lipoxygenase activating protein and leukotriene A4 hydrolase may confer an increased risk of ischemic stroke has implicated the leukotriene family as potential mediators of cardiovascular disease. Using a case control replication methodology, all members of the leukotriene synthesis pathway and their receptors were examined for genetic variants, which may act as risk factors for all ischemic stroke and stroke subtypes.
03/08/2008
11:20 AM
Dual-Modality Monitoring of Targeted Intraarterial Delivery of Mesenchymal Stem Cells After Transient Ischemia
Stroke doi: 10.1161/STROKEAHA.107.502047
In animal models of stroke, functional improvement has been obtained after stem cell transplantation. Successful therapy depends largely on achieving a robust and targeted cell engraftment, with intraarterial (IA) injection being a potentially attractive route of administration.
03/08/2008
11:19 AM
Cigarette Smoking, Systolic Blood Pressure, and Cardiovascular Diseases in the Asia-Pacific Region
Stroke doi: 10.1161/STROKEAHA.107.496752
Smoking and increased levels of blood pressure (BP) substantially increase the risk of cardiovascular diseases (CVD). If these 2 risk factors have a synergistic impact on cardiovascular events, lowering BP and quitting smoking will contribute more to reducing CVD than would be expected from ignoring their interaction.
03/08/2008
11:16 AM
Aspirin Plus Dipyridamole Versus Aspirin for Prevention of Vascular Events After Stroke or TIA. A Meta-Analysis
Stroke doi: 10.1161/STROKEAHA.107.496281
This meta-analysis systematically reviewed randomized controlled trials comparing aspirin plus dipyridamole with aspirin alone in patients with stroke and TIA to determine the efficacy of these agents in preventing recurrent cerebral and systemic vascular events.
03/08/2008
11:15 AM
A Whole-Genome Scan for Stroke or Myocardial Infarction in Family Blood Pressure Program Families
Stroke doi: 10.1161/STROKEAHA.107.490433
Atherothrombotic diseases, including stroke and myocardial infarction, share a common pathogenesis. Chromosomal regions have been linked to atherothrombotic diseases in family studies, and association studies have identified candidate gene polymorphisms that affect the risk of stroke and/or myocardial infarction. Using data from the Family Blood Pressure Program, we tested for chromosomal regions linked to the composite phenotype of stroke or myocardial infarction in a large set of hypertensive families.
03/08/2008
11:14 AM
Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making
Current Opinion in Critical Care. 14(2):135-141, April 2008
Emerging data suggest that biomarkers of brain injury have potential utility as diagnostic, prognostic, and therapeutic adjuncts in the setting of traumatic and ischemic brain injury. Two approaches are being used, namely, assessing markers of structural damage and quantifying mediators of the cellular, biochemical, or molecular cascades in secondary injury or repair. Novel proteomic, multiplex, and lipidomic methods are also being applied.
03/08/2008
11:13 AM
Trends in Usage of Alternative Antiplatelet Therapy After Stroke and Transient Ischemic Attack
Stroke doi: 10.1161/STROKEAHA.107.496729
The effects of alternative antiplatelet agents such as clopidogrel and dipyridamole have been studied in clinical trials and heavily marketed. Because public data on their usage are limited, we examined trends in their prescription after stroke and transient ischemic attack to assess the impact of marketing and trial results.
03/08/2008
11:12 AM
Misclassified Tissue Volumes in Alzheimer Disease Patients With White Matter Hyperintensities. Importance of Lesion Segmentation Procedures for Volumetric Analysis
Stroke doi: 10.1161/STROKEAHA.107.498196
MRI-based quantification of gray and white matter volume is common in studies involving elderly patient populations. The aim of the present study was to describe the effects of not accounting for subcortical white matter hyperintensities (WMH) on tissue volumes in Alzheimer Disease patients with varying degrees of WMH (mild: n=19, moderate: n=22, severe: n=18).
03/08/2008
11:11 AM
Metabolic Syndrome Is Associated With Silent Ischemic Brain Lesions
Stroke doi: 10.1161/STROKEAHA.107.508630
Metabolic syndrome (MetS) is a recognized risk factor for stroke, but it is unclear whether MetS is also related to subclinical ischemic lesions. We examined the association of MetS with the prevalence of silent brain infarction, periventricular hyperintensity, and subcortical white matter lesions in healthy adults.
03/08/2008
11:10 AM
Clinical and Tissue Response to Intravenous Thrombolysis in Tandem Internal Carotid Artery/Middle Cerebral Artery Occlusion. An MRI Study
Stroke doi: 10.1161/STROKEAHA.107.50495
The benefit of intravenous thrombolysis in tandem internal carotid artery (ICA)/middle cerebral artery (MCA) occlusion remains unclear. We studied clinical and imaging outcome of intravenous thrombolysis in MRI-selected patients with tandem ICA/MCA occlusion as compared to isolated MCA occlusion.
03/08/2008
11:07 AM
Benchmarks and Determinants of Adherence to Stroke Performance Measures
Stroke doi: 10.1161/STROKEAHA.107.496570
Develop achievable benchmarks for 9 stroke performance measures (PM) and to identify organizational factors associated with adherence.
03/08/2008
11:06 AM
Applications and Advantages of Power Motion-Mode Doppler in Acute Posterior Circulation Cerebral Ischemia
Stroke doi: 10.1161/STROKEAHA.107.499392
Evaluation of posterior circulation with single-gate transcranial Doppler (TCD) is technically challenging and yields lower accuracy parameters in comparison to anterior circulation vessels. Transcranial power motion-mode Doppler (PMD-TCD), in addition to spectral information, simultaneously displays in real-time flow signal intensity and direction over 6 cm of intracranial space. We aimed to evaluate the diagnostic accuracy of PMD-TCD against angiography in detection of acute posterior circulation stenoocclusive disease.
03/06/2008
02:16 PM
Susceptibility weighted imaging in holohemispheric venous angioma with cerebral hemiatrophy
Neurology India Year : 2008 Volume : 56 Issue : 1 Page : 103-104
A 13-year-old boy presented with history of recurrent episodes of right focal seizures since first year of life. The neurological examination was within normal limits. Routine laboratory and hematological workup was also normal. The seizures were well controlled on anti-epileptic medication.
03/06/2008
02:14 PM
MRI and MRA in spontaneous intracranial arterial dissection
Neurology India Year : 2008 Volume : 56 Issue : 1 Page : 101
A 19-year-old man, previously asymptomatic, presented with acute onset headache followed by right hemiplegia and global aphasia.
03/06/2008
02:12 PM
Neurodevelopmental outcome in prenatally diagnosed isolated agenesis of the corpus callosum
Acta Paediatrica doi:10.1111/j.1651-2227.2008.00688.x
To evaluate long-term neurodevelopmental outcomes in children with prenatally diagnosed, isolated agenesis of the corpus callosum (ACC).
03/06/2008
02:11 PM
Cerebellar Mutism
Journal of Neurosurgery Pediatrics March 2008 Volume 1, Number 3
Cerebellar mutism syndrome (CMS) is a unique postoperative syndrome typically arising 1 to 2 days after resection of a midline posterior fossa tumor; it consists of diminished speech progressing to mutism, emotional lability, hypotonia, and ataxia. Most descriptions have been limited to small institutional series using a retrospective chart review methodology.
03/06/2008
02:10 PM
Preparing for a motor perturbation: Early implication of primary motor and somatosensory cortices
Human Brain Mapping Published Online: 2 Jan 2008
Although preparation of voluntary movement has been extensively studied, very few human neuroimaging studies have examined preparation of an intentional reaction to a motor perturbation.
03/06/2008
02:08 PM
Investigation of white matter pathology in ALS and PLS using tract-based spatial statistics
Human Brain Mapping Published Online: 2 Jan 2008
We aimed to investigate differences in fractional anisotropy (FA) between primary lateral sclerosis (PLS) and amyotrophic lateral sclerosis (ALS) and the relationship between FA and disease progression using tract-based spatial statistics (TBSS).
03/06/2008
02:06 PM
Encoding touch and the orbitofrontal cortex
Human Brain Mapping Published Online: 2 Jan 2008
Lesion studies on nonhuman primates utilizing recognition memory tests have shown that the orbitofrontal cortex is critical for the encoding of novel information, and anatomical studies have shown that the orbitofrontal cortex forms part of a mnemonic circuit that connects limbic medial temporal areas with higher-order lateral frontal cortical regions.
03/06/2008
02:05 PM
Cerebrospinal Fluid Leakage in Intracranial Hypotension Syndrome: Usefulness of Indirect Findings in Radionuclide Cisternography for Detection and Treatment Monitoring
Clinical Nuclear Medicine. 33(3):181-185, March 2008
To evaluate indirect findings of cerebrospinal fluid (CSF) leakage on radionuclide cisternography and their changes after treatment.
03/06/2008
02:04 PM
Risk of intraoperative ischemia due to temporary vessel occlusion during standard extracranial-intracranial arterial bypass surgery
Journal of Neurosurgery March 2008 Volume 108, Number 3
Standard extracranial-intracranial (EC-IC) arterial bypass surgery represents a well-recognized procedure in which the aim is to augment distal cerebral circulation. The creation of the bypass requires temporary occlusion of the recipient vessel. Thus, there exists controversy about the risk of standard EC-IC arterial bypass surgery causing ischemic complications due to temporary vessel occlusion.
03/06/2008
02:03 PM
Long-term seizure outcome after mesial temporal lobe epilepsy surgery: corticalamygdalohippocampectomy versus selective amygdalohippocampectomy
Journal of Neurosurgery March 2008 Volume 108, Number 3
Resection strategies for the treatment of temporal lobe epilepsy (TLE) are a matter of discussion, and little information is available. The aim of this study was to compare seizure outcomes at the 5-year follow-up in patients with medically refractory unilateral mesial TLE (MTLE) due to hippocampal sclerosis (HS) who were treated using a cortical amygdalohippocampectomy (CorAH) or a selective AH (SelAH).
03/06/2008
02:02 PM
Long-term outcome following radical temporal bone resection for lateral skull base malignancies: a neurosurgical perspective
Journal of Neurosurgery March 2008 Volume 108, Number 3
Primary temporal bone malignancy is a rare form of tumor for which the therapeutic strategy remains controversial. In this study, the authors reviewed their experience with radical temporal bone resection (TBR) of such lesions and analyzed the long-term results to provide treatment recommendations.
03/06/2008
02:01 PM
Intracranial aneurysms treated with Guglielmi detachable coils: long-term imaging follow-up with contrast-enhanced magnetic resonance angiography
Journal of Neurosurgery March 2008 Volume 108, Number 3
The aim of this study was to assess the long-term results of intracranial aneurysms treated with Guglielmi detachable coils (GDCs) with the aid of contrast-enhanced magnetic resonance (MR) angiography.
03/06/2008
02:00 PM
Intraarterial abciximab for treatment of thromboembolism during coil embolization of intracranial aneurysms: outcome and fatal hemorrhagic complications
Journal of Neurosurgery March 2008 Volume 108, Number 3
Experience with intraarterial abciximab for the treatment of thromboembolism during endovascular coil embolization is limited. The authors report the outcome of intraarterial abciximab use, with an emphasis on fatal hemorrhagic complications.
03/06/2008
02:00 PM
Inhibitory effect of gap junction blockers on cerebral vasospasm
Journal of Neurosurgery March 2008 Volume 108, Number 3
The gap junction is important in the propagation of dilation/constriction signals along vessels for coordinated behavior in control of vascular tone. The authors hypothesized that gap junctions might play a role in cerebral vasospasm following subarachnoid hemorrhage (SAH).
03/06/2008
01:59 PM
Influence of cocaine on ruptured intracranial aneurysms: a case control study of poor prognostic indicators
Journal of Neurosurgery March 2008 Volume 108, Number 3
The purpose of this study was to determine whether cocaine use is a significant prognostic factor for outcome measures such as Hunt and Hess grade and Glasgow Outcome Scale (GOS) score among patients presenting with ruptured intracranial aneurysms (IAs).
03/06/2008
01:58 PM
High-dose intraarterial verapamil in the treatment of cerebral vasospasm after aneurysmal subarachnoid hemorrhage
Journal of Neurosurgery March 2008 Volume 108, Number 3
Because oral calcium channel blockers appear to reduce the severity of cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH), interest in their application intraarterially has emerged for cases in which noninvasive means of alleviating vasospasm are unsuccessful. Studies to date have been limited to the administration of low intraarterial doses because of concerns about hemodynamic stability and changes in intracranial pressure. These doses, although effective in cases of milder vasospasm, were inadequate in severe cases.
03/06/2008
01:56 PM
Automated end-to-side anastomosis to the middle cerebral artery: a feasibility study
Journal of Neurosurgery March 2008 Volume 108, Number 3
The treatment of complex cerebrovascular or skull base pathological conditions necessitates a microsurgical blood flow preservation or augmentative revascularization procedure as either an adjunctive safety measure or a definitive treatment. The brain is susceptible to ischemia, and procedure-related risks can be minimized by the reduction of occlusion time or the use of a nonocclusive technique. The authors therefore analyzed the feasibility of an automatic device (C-Port xA, Cardica) designed for constructing an end-to-side anastomosis with or without flow interruption for a middle cerebral artery (MCA) bypass in a human cadaveric model and in an in vivo craniotomy simulation model.
03/06/2008
01:55 PM
A complex cavernous sinus dural arteriovenous fistula secondary to covered stent placement for a traumatic carotid artery-cavernous sinus fistula
Case report
Journal of Neurosurgery March 2008 Volume 108, Number 3
The authors present the case of a patient with a direct carotid artery–cavernous sinus fistula caused by head trauma in whom a self-expanding covered stent was successfully used to obliterate the fistula. However, at the 9-month follow-up an angiogram revealed a complex caroticocavernous fistula that was completely obliterated with Onyx 18
transarterially.
03/06/2008
01:54 PM
Primary Treatment of Ruptured Blood Blister-Like Aneurysms with Stent-Assisted Coil Embolization: Report of Two Cases
Acta Radiologica, Volume 49, Issue 2 2008 , pages 180 - 183
Blood blister-like aneurysms (BBAs) are among the most hazardous cerebrovascular aneurysms to treat; microsurgical treatment of these small, wide-necked, and exceptionally fragile aneurysms place patients at significant risk of morbidity or mortality.
03/06/2008
01:53 PM
Brief Report: Sleep Disturbances following Mild Traumatic Brain Injury in Childhood
Journal of Pediatric Psychology 2008 33(3):242-247
To examine objective and subjective reports of sleep disturbance in school-aged children who had sustained mild traumatic brain injury (TBI) at least 6 months prior to the study.
03/06/2008
01:52 PM
Unexplained seizures, confusion or hallucinations: think Hashimoto encephalopathy
Acta Paediatrica doi:10.1111/j.1651-2227.2008.00686.x
Hashimoto encephalopathy (HE) is a serious but treatable condition that is probably underdiagnosed. We summarize and review all published cases to delineate the disease and to alert paediatricians so that they recognize the disease in children.
03/06/2008
01:51 PM
Cost-effectiveness of temozolomide for the treatment of newly diagnosed glioblastoma multiforme
Cancer Published Online: 22 Jan 2008
The study aimed to compare the cost-effectiveness of concomitant and adjuvant temozolomide (TMZ) for the treatment of newly diagnosed glioblastoma multiforme versus initial radiotherapy alone from a public health care perspective.
03/06/2008
01:49 PM
Cortical dysfunction in patients with Huntington's disease during working memory performance
Human Brain Mapping Published Online: 2 Jan 2008
Previous functional neuroimaging studies on executive function suggested multiple functionally aberrant cortical regions in patients with Huntington's disease (HD). However, little is known about the neural mechanisms of working memory (WM) function in this patient population.
03/06/2008
01:48 PM
N-myc is a novel regulator of PI3K-mediated VEGF expression in neuroblastoma
Oncogene 18 February 2008
Angiogenesis in neuroblastoma (NB) correlates with increased expression of vascular endothelial growth factor (VEGF) and a worse clinical outcome.
03/06/2008
01:47 PM
Surgical strategies and seizure control in pediatric patients with dysembryoplastic neuroepithelial tumors: a single-institution experience
Journal of Neurosurgery Pediatrics March 2008 Volume 1, Number 3
Dysembryoplastic neuroepithelial tumors (DNTs) are commonly associated with medically resistant epilepsy that usually starts in childhood. Presurgical workup and surgical strategies remain controversial. The authors present a study of long-term seizure outcome after noninvasive presurgical investigations and different surgical strategies were used in a series of pediatric patients.
03/06/2008
01:45 PM
Prediction of prognosis in children with medulloblastoma by using immunohistochemical analysis and tissue microarray
Journal of Neurosurgery Pediatrics March 2008 Volume 1, Number 3
Medulloblastoma is the most common malignant neuroepithelial tumor found in children. Several reports have described efforts to identify the prognostic significance of various patterns of pathological and immunohistochemical features in medulloblastoma, but the published data appear to be controversial. The authors therefore attempted to demonstrate these prognostic factors convincingly in a retrospective study performed in patients with medulloblastoma.
03/06/2008
01:45 PM
p21Waf1/Cip1 Expression by Curcumin in U-87MG Human Glioma Cells: Role of Early Growth Response-1 Expression
Cancer Research 68, 1369-1377, March 1, 2008
Curcumin, a natural compound, is a well-known chemopreventive agent with potent anticarcinogenic activity in a wide variety of tumor cells.
03/06/2008
01:43 PM
Oncolytic Herpes Simplex Virus Type-1 Therapy in a Highly Infiltrative Animal Model of Human Glioblastoma
Clinical Cancer Research 14, 1571-1580, March 1, 2008
We have examined the spread and antitumor efficacy of an oncolytic herpes simplex virus-1-based vector (G207) in glioblastoma biopsy spheroids in vitro and in vivo after local delivery to corresponding intracranial xenografts. Spheroids from three patients were infected with increasing doses of G207 and transgene expression was quantified.
03/06/2008
01:42 PM
Optimal hemoglobin concentration in patients with subarachnoid hemorrhage, acute ischemic stroke and traumatic brain injury
Current Opinion in Critical Care. 14(2):156-162, April 2008
The review outlines recent clinical and experimental studies regarding the effects of red blood-cell transfusion on clinical outcome in neurocritical patients, including patients with subarachnoid hemorrhage, acute ischemic stroke and traumatic brain injury. Optimal hemoglobin transfusion trigger and the role of other transfusion indicators for neurocritical patients are discussed.
03/06/2008
01:41 PM
Adrenal insufficiency following traumatic brain injury in adults
Current Opinion in Critical Care. 14(2):163-166, April 2008
Hypoadrenalism occurs in approximately 25% of patients soon after traumatic brain injury. Neurosurgeons or critical care physicians should be prepared to diagnose and treat this and other related hormonal deficiencies.
03/06/2008
01:40 PM
Assessing Quality of Life in ALS
Journal of Clinical Neuromuscular Disease. 9(2):318-325, December 2007
The issue of quality of life is important for the patient with amyotrophic lateral sclerosis (ALS) and his or her family. Although initial thoughts frequently are that quality of life will be poor, there are strong data to support a relatively good quality of life despite the inexorable decline in strength and loss of function with disease progression.
03/06/2008
01:39 PM
Reduced serum level of THDOC, an anticonvulsant steroid, in women with perimenstrual catamenial epilepsy
Epilepsia doi:10.1111/j.1528-1167.2008.01555.x
Seizure exacerbation in catamenial epilepsy (CE) is associated with the decrease in progesterone secretion and increase in estradiol secretion during the premenstrual period.
03/06/2008
01:35 PM
The diagnostic value of oral lacerations and incontinence during convulsive "seizures"
Epilepsia doi:10.1111/j.1528-1167.2008.01554.x
Oral lacerations and urinary incontinence have long been considered useful clinical features for the diagnosis of epileptic seizures; however, both are also reported in patients with psychogenic nonepileptic seizures (PNES).
|
What
is RSS?
