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February 16-29 2008 Postings (Note: Some archived links may become inactive)

02/29/2008 01:12 PM

Proton versus photon radiotherapy for common pediatric brain tumors: Comparison of models of dose characteristics and their relationship to cognitive function

Pediatric Blood & Cancer Published Online: 27 Feb 2008

To determine whether proton radiotherapy has clinical advantages over photon radiotherapy, we modeled the dose characteristics of both to critical normal tissue volumes using data from patients with four types of childhood brain tumors.


02/29/2008 01:11 PM

Brain abscesses in Malawian children: value of CT scan

Annals of Tropical Paediatrics: International Child Health, Volume 28, Number 1, March 2008 , pp. 79-85(7)

The clinical presentation and management of brain abscess in three HIV-uninfected Malawian children are reported.


02/29/2008 01:10 PM

Electroencephalographic Cerebral Dysrhythmic Abnormalities in the Trinity of Nonepileptic General Population, Neuropsychiatric, and Neurobehavioral Disorders

J Neuropsychiatry Clin Neurosci 20:7-22, February 2008

Subclinical electroencephalographic epileptiform discharges in neurobehavioral disorders are not uncommon. The clinical significance and behavioral, diagnostic, and therapeutic implications of this EEG cerebral dysrhythmia have not been fully examined.


02/29/2008 01:08 PM

Content-Specific Delusions From Right Caudate Lacunar Stroke: Association with Prefrontal Hypometabolism

J Neuropsychiatry Clin Neurosci 20:62-67, February 2008

Patients with caudate lesions can present with content-specific delusions, possibly due to disruption of frontosubcortical circuits connecting the frontal lobes with the basal ganglia.


02/29/2008 01:07 PM

White Matter Brain Lesions in Midlife Familial Hypercholesterolemic Patients at 3-Tesla Magnetic Resonance Imaging

Acta Radiologica, Volume 49, Issue 2 2008 , pages 184 - 189

Patients with hypercholesterolemia of 60 years and older have an increased risk for white matter brain lesions and dementia.


02/29/2008 01:06 PM

Toll-Like Receptor 4 Is Involved in Subacute Stress-Induced Neuroinflammation and in the Worsening of Experimental Stroke

Stroke doi: 10.1161/STROKEAHA.107.498212

Psychological stress causes an inflammatory response in the brain and is able to exacerbate brain damage caused by experimental stroke. We previously reported that subacute immobilization stress in mice worsens stroke outcome through mechanisms that involve inflammatory mechanisms, such as accumulation of oxidative/nitrosative mediators and expression of inducible nitric oxide synthase and cyclooxygenase-2 in the brain.


02/29/2008 01:04 PM

Risk of Vertebrobasilar Stroke and Chiropractic Care: Results of a Population-Based Case-Control and Case-Crossover Study

Spine. 33(4S) Supplement:S176-S183, February 15, 2008

To investigate associations between chiropractic visits and vertebrobasilar artery (VBA) stroke and to contrast this with primary care physician (PCP) visits and VBA stroke.


02/29/2008 01:03 PM

Retinal Signs and Stroke. Revisiting the Link Between the Eye and Brain

Stroke doi: 10.1161/STROKEAHA.107.496091

The retinal and cerebral vasculature share similar anatomic, physiological, and embryological characteristics. We reviewed the literature, focusing particularly on recent population-based studies, to examine the relationship between retinal signs and stroke.


02/29/2008 01:02 PM

Mechanical Thromboembolectomy for Acute Ischemic Stroke. Comparison of the Catch Thromboectomy Device and the Merci Retriever In Vivo

Stroke doi: 10.1161/STROKEAHA.107.495614

The purpose of the study was to compare efficacy and potential complications of 2 commercially available devices for mechanical thromboembolectomy.


02/29/2008 01:01 PM

Is the Impact of Job Control on Stroke Independent From Socioeconomic Status?. A Large-Scale Study of the Swedish Working Population

Stroke doi: 10.1161/STROKEAHA.107.495523

The main purpose of this study was to test whether the impact of job control on stroke mortality is independent of socioeconomic factors.


02/29/2008 01:00 PM

Effects of Prophylactic Antibiotic Therapy With Mezlocillin Plus Sulbactam on the Incidence and Height of Fever After Severe Acute Ischemic Stroke. The Mannheim Infection in Stroke Study (MISS)

Stroke doi: 10.1161/STROKEAHA.107.49953

Fever after stroke is a strong predictor for a negative outcome with infections as the most common cause. The aim of this pilot study was to evaluate the effects of prophylactic antibiotic therapy on the incidence and height of fever after acute ischemic stroke.

02/29/2008 12:59 PM

Autopsy Prevalence of Intracranial Atherosclerosis in Patients With Fatal Stroke

Stroke doi: 10.1161 STROKEAHA.107.496513

The objective of this study was to determine the prevalence of intracranial plaques and stenoses and their causal role in patients with fatal stroke. Intracranial atherosclerosis is considered to be a rare condition with a severe prognosis. However, disease prevalence may be underestimated due to lack of appropriate diagnostic procedures.


02/29/2008 12:58 PM

Nondysphoric Depression Following Stroke

J Neuropsychiatry Clin Neurosci 20:52-61, February 2008

Right hemisphere damage may influence the presentation of depressive disorders ensuing after stroke by disrupting emotion processing mechanisms.


02/29/2008 12:57 PM

Validation of a Prognostic Subarachnoid Hemorrhage Grading Scale Derived Directly From the Glasgow Coma Scale

Stroke doi: 10.1161/STROKEAHA.107.498345

A new Glasgow Coma Scale-based scale has been developed to predict patient outcome in subarachnoid hemorrhage by calculating cut-off points by which 2 consecutive categories corresponded to a statistically significant different outcome.


02/29/2008 12:56 PM

Mechanical Thrombectomy for Acute Ischemic Stroke. Final Results of the Multi MERCI Trial

Stroke doi: 10.1161/STROKEAHA.107.497115

Endovascular mechanical thrombectomy may be used during acute ischemic stroke due to large vessel intracranial occlusion. First-generation MERCI devices achieved recanalization rates of 48% and, when coupled with intraarterial thrombolytic drugs, recanalization rates of 60% have been reported. Enhancements in embolectomy device design may improve recanalization rates.


02/29/2008 12:55 PM

Is Routine Retinal Examination Useful in Patients With Acute Ischemic Stroke?

Stroke doi: 10.1161/STROKEAHA.107.495648

Patients with ischemic stroke have a high prevalence of hypertension and diabetes, which are major risk factors for potentially blinding retinal diseases. We studied the prevalence of retinal diseases, and the need for an ophthalmology referral, among persons with acute ischemic stroke.


02/29/2008 12:54 PM

Early Seizures in Cerebral Vein and Dural Sinus Thrombosis. Risk Factors and Role of Antiepileptics

Stroke doi: 10.1161/STROKEAHA.107.487363

The risk of seizure early after the diagnosis of cerebral vein and dural sinus thrombosis (CVT) is not known, and the use of prophylactic antiepileptic (AED) medication in the acute phase of CVT is controversial.


02/28/2008 02:41 PM

Primary determinants of ischaemic stroke/brain abscess risks are independent of severity of pulmonary arteriovenous malformations in hereditary haemorrhagic telangiectasia

Thorax 2008;63:259-266

Brain abscesses and ischaemic strokes complicate pulmonary arteriovenous malformations (PAVMs). At risk individuals are poorly recognised. Stroke/abscess risk factors have not been defined.


02/28/2008 02:19 PM

Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide

BMC Cancer 2008, 8:58

Arsenic trioxide (As2O3) exhibits promising anticarcinogenic activity in acute promyelocytic leukemic patients and induces apoptosis in various tumor cells in vitro. Here, we investigated the effect of the natural alkaloid berberine on As2O3-mediated inhibition of cancer cell migration using rat and human glioma cell lines.


02/28/2008 02:17 PM

Predicting Outcome of Poor Grade Patients of Subarachnoid Haemorrhage Due to Anterior Communicating Artery Aneurysm

Journal of Neurological Sciences (Turkish) 2007, Volume 24, Number 4, Page(s) 287-295

This study deals with analyzing our protocol in managing patients of poor grade aneurysmal subarachnoid haemorrhage (aSAH) and in determining the factors that influenced outcome. The aim of our study is to find the outcome following aneurysmal subarachnoid haemorrhage in poor grade patients due to anterior communicating artery aneurysm and to find out if outcome could be predicted on basis of presentation.


02/28/2008 02:15 PM

Traumatic Posterior Fossa Epidural Hematomas and Their Complications

Journal of Neurological Sciences (Turkish) 2007, Volume 24, Number 4, Page(s) 280-286

Traumatic posterior fossa epidural hematomas (TPFEDH) occur infrequently however their mortality and morbidity are higher than supratentorial epidural hematomas. Signs and symptoms may be silent or nonspecific, even though they may show rapid progression and deterioration from consciousness to coma, thus they would cause fatal results. Recently, practice of computerized tomography (CT) has grown up and replaced the use of direct X-ray to detect calvarial fractures and other traumatic pathologies, therefore patients with posterior fossa trauma were diagnosed earlier.


02/28/2008 02:14 PM

Onset of Epilepsy In Menopause: Presentation of 5 Cases

Journal of Neurological Sciences (Turkish) 2007, Volume 24, Number 4, Page(s) 349-353

The distribution of epilepsy frequency is equal among women and men. However, menarche, pregnancy, menopause, hormone replacement therapy and use of oral contraceptives may affect the course of epilepsy in women. Few studies in literature have reported that the onset of epilepsy may first occur in menopause in women who have no previous history of epilepsy.


02/28/2008 02:13 PM

Vitamins and Stroke: The Homocysteine Hypothesis Still in Doubt.

Neurologist. 14(1):2-4, January 2008

During the last years, many epidemiologic studies have identified homocysteine as an independent risk factor for cardiovascular diseases like coronary events, stroke, and venous thromboembolism. Supplementation with oral folate and vitamins B6 and B12 (mainly folate) reduce plasma homocysteine levels to a significant degree.


02/28/2008 02:11 PM

Focal Cortical Resection for Complex Partial Status Epilepticus Due to a Paraneoplastic Encephalitis

Neurologist. 14(1):56-59, January 2008

We report a 57-year-old female who presented with epilepsia partialis continua and rapidly progressed to refractory complex partial status epilepticus (CPSE) with brain magnetic resonance imaging revealing a focal cortical lesion on T2 sequences corresponding to the seizure focus on ictal electroencephalographic recordings.


02/28/2008 02:10 PM

Traumatic Brain Injury, Apolipoprotein E-[epsilon]4, and Cognition in Older Adults: A Two-Year Longitudinal Study

J Neuropsychiatry Clin Neurosci 20:68-73, February 2008

Patients with mild-to-moderate traumatic brain injury (TBI) (N=69) were compared with age-, gender-, and education-matched healthy control group subjects (N=79) on performance of neuropsychological tests at one and 2 years following injury, and informant-rated functional abilities.


02/28/2008 02:09 PM

Correlation Between Denial of Illness and Executive Function Following Stroke: A Pilot Study

J Neuropsychiatry Clin Neurosci 20:96-100, February 2008

Executive function and denial of illness were examined among 24 patients who received double-blind antidepressant treatment following stroke. Between end-of-treatment at 3 months and follow-up at 2 years, significant correlation was found between improvement in executive function and decrease in denial of illness.


02/28/2008 02:06 PM

Analysis of Cervical Injuries in Persons With Head Injuries

American Journal of Forensic Medicine & Pathology. 29(1):23-26, March 2008

To determine which clinical factors are useful for predicting concomitant injuries of the cervical spine and cervical spinal cord in persons with head injuries, we examined the nature and mechanisms of cervical injuries.


02/28/2008 02:04 PM

Desiccated vector mosquitoes used for the surveillance of Japanese encephalitis virus activity in endemic southern India

Tropical Medicine & International Health, Volume 13, Number 2, February 2008 , pp. 286-290(5)

To monitor Japanese encephalitis virus (JEV) activity in endemic areas of Tamil Nadu, southern India, desiccated vector mosquitoes were screened for JEV antigen using ELISA, from 1996.


02/28/2008 02:04 PM

Epidural Blood Patch for Severe Postoperative Intracranial Hypotension

Journal of Neurosurgical Anesthesiology. 20(1):49-52, January 2008

Brain sag is a rare but serious postoperative complication after craniotomy. It is a clinical entity that refers to severe cerebrospinal fluid hypovolemia causing acute neurologic decompensation and obtundation.


02/28/2008 02:02 PM

Risk of dementia associated with the ApoE 4 allele and falls causing head injury without explicit traumatic brain injury

Acta Neurologica Scandinavica doi:10.1111/j.1600-0404.2008.00994.x

Severe head injury (HI) and the apolipoprotein E (ApoE) 4 allele are risk factors for dementia. The corresponding effect of falls causing HI without explicit traumatic brain injury (TBI) in association with the ApoE 4 is not known.


02/28/2008 02:01 PM

Thrombolytic Toxicity: Blood Brain Barrier Disruption in Human Ischemic Stroke

Cerebrovasc Dis 2008;25:338-343

In experimental models of cerebral ischemia, thrombolytic drugs have been demonstrated to have a number of neurovascular toxic effects including blood brain barrier disruption.


02/28/2008 02:00 PM

Effect of Phospholipase C Blockade on Cerebral Vasospasm

Cerebrovasc Dis 2008;25:362-365

Delayed cerebral ischemia due to cerebral vasospasm remains a major cause of morbidity and mortality following subarachnoid hemorrhage.


02/28/2008 01:59 PM

Anxiety Symptoms in Spouses of Stroke Patients

Cerebrovasc Dis 2008;25:311-315

The aim of this longitudinal study was to investigate prevalence rates of anxiety symptoms in stroke patients' spouses and associated factors.


02/28/2008 01:58 PM

Prevention and Treatment of Perioperative Stroke

Neurologist. 14(1):30-36, January 2008

Perioperative stroke is an uncommon event associated with significant morbidity and mortality. Neurologists are often called to assess potential stroke risk factors to advice on prophylactic medical or surgical measures, which could decrease risk of this dreaded complication.


02/28/2008 01:57 PM

Imaging of the Intracranial Venous System

Neurologist. 14(1):12-22, January 2008

Evaluation of the intracranial venous system has historically been performed with conventional catheter-based digital subtraction angiography (DSA). The continued importance of DSA can not be overstated in light of its inherent option of endovascular intervention and thrombolysis for cerebral venous thrombosis.


02/28/2008 01:56 PM

Does Cervical Manipulative Therapy Cause Vertebral Artery Dissection and Stroke?

Neurologist. 14(1):66-73, January 2008

Does cervical manipulative therapy (CMT) cause vertebral arterial dissection (VAD) and subsequent ischemic stroke? What is the best estimate of the incidence of CMT associated with VAD and ischemic stroke?


02/28/2008 01:55 PM

Dengue Fever With Ischemic Stroke: A Case Report

Neurologist. 14(1):40-42, January 2008

We report a case of dengue fever with thrombocytopenia and ischemic stroke. Only supportive treatment was instituted. The neurologic deficits of the patient were initially progressive and then improved.


02/28/2008 01:51 PM

Telemedically Provided Stroke Expertise beyond Normal Working Hours

Cerebrovasc Dis 2008;25:332-337

State-of-the-art stroke management requires neurological expertise for the recognition of complex cerebrovascular syndromes or stroke-mimicking symptoms and initiation of proven acute therapies. Many community hospitals struggle to fulfill these premises particularly at evening/nighttimes or weekends. Telemedicine can improve that situation by offering rapid access to neurological expertise, but it has not been shown to what extent it is used beyond working times.


02/28/2008 01:50 PM

Aspirin Responsiveness in Acute Brain Ischaemia: Association with Stroke Severity and Clinical Outcome

Cerebrovasc Dis 2008;25:355-361

Platelets play a critical role in the pathogenesis of acute brain ischaemia. We studied the association between the degree of inhibition of platelet function by aspirin (ASA) and the severity and outcome of acute brain ischaemia.


02/28/2008 01:47 PM

Aphasia during the Acute Phase in Ischemic Stroke

Cerebrovasc Dis 2008;25:316-323

We investigated the incidence, clinical characteristics, outcome and factors associated with aphasia and early improvement in acute ischemic stroke.


02/28/2008 01:46 PM

Surgical management of traumatic intracranial pseudoaneurysms: A report of 12 cases

Neurology India Year : 2008 Volume : 56 Issue : 1 Page : 47-51


To investigate the characteristics and surgical treatment of traumatic intracranial pseudoaneurysms.


02/28/2008 01:45 PM

Subarachnoid hemosiderin deposition after subarachnoid hemorrhage on T2*-weighted MRI correlates with the location of disturbed cerebrospinal fluid flow on computed tomography cisternography

Neurology India Year : 2008 Volume : 56 Issue : 1 Page : 62-64

A 72-year-old male was admitted with subarachnoid hemorrhage associated with a ruptured cerebral aneurysm. The aneurysm was treated with clipping soon after radiological examination.


02/28/2008 01:41 PM

Simultaneous thalamic and cerebellar hypertensive hemorrhages

Neurology India Year : 2008 Volume : 56 Issue : 1 Page : 100-101

Hypertensive intracranial hemorrhages are generally located in defined sites and have a relatively typical pattern of extension. We report an unusual case where there were simultaneous spontaneous thalamic and cerebellar hemorrhages in a patient with known hypertension. Presence of two discrete and unconnected clots is rare in hypertensive bleeds and only isolated cases have been recorded in the literature.


02/28/2008 01:40 PM

Pattern of cerebellar perfusion on single photon emission computed tomography in subcortical hematoma: A clinical and computed tomography correlation

Neurology India Year : 2008 Volume : 56 Issue : 1 Page : 17-21

There is paucity of studies evaluating the role of asymmetry index (AI) on single photon emission computed tomography (SPECT) studies in patients with intracerebral hemorrhage (ICH). Aim: To evaluate cerebellar perfusion in ICH employing SPECT study and correlate with clinical and CT scan findings. Setting and Design: Tertiary care teaching hospital.


02/28/2008 01:38 PM

Osteoma of anterior cranial fossa complicated by intracranial mucocele with emphasis on its radiological diagnosis

Neurology India Year : 2008 Volume : 56 Issue : 1 Page : 79-80

We present a 43-year-old female patient who had recurrent headache for one year. An intracranial bony lesion surrounded by a cyst in the anterior cranial fossa was found on imaging. Postoperative histological examination confirmed the diagnosis of osteoma and mucocele.


02/28/2008 01:37 PM

MRI and MRA in spontaneous intracranial arterial dissection

Neurology India Year : 2008 Volume : 56 Issue : 1 Page : 102

A 19-year-old man, previously asymptomatic, presented with acute onset headache followed by right hemiplegia and global aphasia. A diffusion weighted MRI showed acute infarct of the left middle cerebral artery (MCA) territory.


02/28/2008 01:36 PM

Gamma knife radiosurgery for glomus jugulare tumors: Therapeutic advantages of minimalism in the skull base

Neurology India Year : 2008 Volume : 56 Issue : 1 Page : 57-61

Glomus jugulare (GJ) tumors are paragangliomas found in the region of the jugular foramen. Surgery with/without embolization and conventional radiotherapy has been the traditional management option.


02/28/2008 01:35 PM

Erythrocyte indicators of oxidative changes in patients with graded traumatic head injury

Neurology India Year : 2008 Volume : 56 Issue : 1 Page : 31-35

Acute oxidative stress following a traumatic head injury (HI) has been implicated in inducing severe secondary brain damage and influencing the clinical outcome of HI patients. Aims: This study was performed to evaluate and compare the oxidative changes in patients with varying severity of HI in the early posttraumatic period using erythrocyte indicators.


02/28/2008 01:33 PM

Endoscopic management of brain abscesses

Neurology India Year : 2008 Volume : 56 Issue : 1 Page : 13-16

Treatment of brain abscess is still a subject of controversy. Simple therapeutic approaches like twist drill/burr hole aspiration with or without insertion of a drain are also quite effective. There are reports of encouraging results following endoscopic treatment. We are reporting our results of endoscopic approach on 24 patients.


02/28/2008 01:32 PM

Drug compliance after stroke and myocardial infarction: Is complementary medicine an issue?

Neurology India Year : 2008 Volume : 56 Issue : 1 Page : 93

Though this study showed that there was a lower rate of compliance in patients with stroke, the authors do not satisfactorily explain this discrepancy.


02/28/2008 01:31 PM

Digital subtraction angiography laboratory with inbuilt CT (DynaCT): Application during intracranial anurysm embolization

Neurology India Year : 2008 Volume : 56 Issue : 1 Page : 90-91

It is known that early recognition and management that occur during a neuroendovascular procedure complications can improve clinical outcome.


02/28/2008 01:30 PM

Anesthesia management of awake craniotomy performed under asleep-awake-asleep technique using laryngeal mask airway: Report of two cases

Neurology India Year : 2008 Volume : 56 Issue : 1 Page : 65-67

Asleep-awake-asleep technique of anesthesia is used during awake craniotomy with or without securing airway. We assessed this technique using laryngeal mask airway (LMA) in two patients. Patients underwent awake craniotomy for epilepsy surgery and the removal of a frontotemporal glioma.


02/28/2008 01:28 PM

Acute progressive midbrain hemorrhage after topical ocular cyclopentolate administration

Neurology India Year : 2008 Volume : 56 Issue : 1 Page : 88-89

Cyclopentolate is a synthetic anti-cholinergic agent widely used in ophthalmology clinics. It can cause cardiovascular side-effects such as hypertension, ventricular arrhythmias and tachycardias.


02/26/2008 02:08 PM

Narrowing of the regions of allelic losses of chromosome 1p36 in meningioma tissues by an improved SSCP analysis

International Journal of Cancer Volume 122, Issue 8 , Pages 1820 - 1826

Mapping loss of heterozygosity (LOH) regions in the genomes of tumor tissues is a practical approach for identifying genes whose loss is related to tumorigenesis. Conventional LOH analyses using microsatellite or single nucleotide polymorphism (SNP) markers require the simultaneous examination of tumor- and matched normal-DNA. Here, we improved the previously developed SNP-based LOH assay using single strand conformation polymorphism (SSCP) analysis, so that LOH in tumor samples heavily contaminated with normal DNA can now be precisely estimated, even when matched normal DNA is not available.


02/26/2008 02:07 PM

Exercise Training for Cardiometabolic Adaptation After Stroke

Journal of Cardiopulmonary Rehabilitation & Prevention. 28(1):2-11, January/February 2008

Patients with stroke are severely deconditioned, leading to metabolic abnormalities that significantly increase risk for myocardial infarction and recurrent stroke. This review characterizes the nature of the metabolic decline, the underlying causes, and the potential for progressive aerobic exercise to address metabolic impairment following disabling stroke.


02/26/2008 02:06 PM

Nongenetic Cause of Epileptic Seizures in 2 Otherwise Healthy Chinese Families: Tetramine-Case Presentation and Literature Survey

Clinical Neuropharmacology. 31(1):57-61, January/February 2008

Tetramine, a banned rodenticide, is repeatedly reported to induce epileptic seizures in healthy people. Because both doctors and patients are often not aware of earlier tetramine contact, the occurrence of seizures is easily misdiagnosed as primary epilepsy.


02/26/2008 02:05 PM

Effects of Nebicapone on Levodopa Pharmacokinetics, Catechol-O-methyltransferase Activity, and Motor Fluctuations in Patients with Parkinson Disease

Clinical Neuropharmacology. 31(1):2-18, January/February 2008

To investigate the effects of nebicapone, a new catechol-O-methyltransferase (COMT) inhibitor, on levodopa pharmacokinetics, COMT activity, and motor fluctuations in Parkinson disease in comparison to placebo and entacapone.


02/26/2008 02:04 PM

Conversion From Dopamine Agonists to Cabergoline: An Open-Label Trial in 128 Patients With Advanced Parkinson Disease

Clinical Neuropharmacology. 31(1):19-24, January/February 2008

Cabergoline is an ergotic dopamine agonist with D2 receptor activity and a very long half-life. This pharmacological profile may result in clinically different effects. Small clinical trials indicate that overnight switching from 1 agonist to another can be performed safely.


02/26/2008 02:02 PM

The response to IV rt-PA in very old stroke patients

European Journal of Neurology, Volume 15, Number 3, March 2008 , pp. 253-256(4)

The use of rtPA in stroke patients aged >80-years remains controversial and it is debated whether there are sex-based differences in the response to rtPA.


02/26/2008 02:01 PM

In vivo detection of hepatitis C virus (HCV) RNA in the brain in a case of encephalitis: evidence for HCV neuroinvasion

European Journal of Neurology, Volume 15, Number 3, March 2008 , pp. 214-218(5)

We report here a 27-year-old woman who presented with encephalitis of unknown origin. Magnetic resonance imaging (MRI) of the brain revealed leukoencephalopathy, cerebrospinal fluid showed signs of inflammation.


02/26/2008 01:59 PM

Bilateral cerebral hemispheric infarction associated with sildenafil citrate (Viagra) use

European Journal of Neurology, Volume 15, Number 3, March 2008 , pp. 306-308(3)

Sildenafil citrate (Viagra) is one of the frequently prescribed drugs for men with erectile dysfunction.


02/26/2008 01:57 PM

Does motor subtype influence neurocognitive performance in Parkinson's disease without dementia?

European Journal of Neurology, Volume 15, Number 3, March 2008 , pp. 262-267(6)

The postural instability and gait difficulty (PIGD) motor subtype has been shown to represent a risk factor for development of dementia in Parkinson's disease. Whether this relationship extends to a more subtle cognitive dysfunction in patients is less clear.


02/26/2008 01:56 PM

Steroid-induced improvement of neurological signs in ataxia-telangiectasia patients

European Journal of Neurology, Volume 15, Number 3, March 2008 , pp. 223-228(6)

A recent clinical observation reported on a dramatic improvement of neurological symptoms following short-term betamethasone administration in a child affected with ataxia-teleangiectasia (A-T).


02/26/2008 01:53 PM

Bimodal administration of entacapone in Parkinson's disease patients improves motor control

European Journal of Neurology, Volume 15, Number 3, March 2008 , pp. 268-273(6)

CR levodopa, bimodal entacapone resulted in a significant improvement in the Unified Parkinson's Disease Rating Scale part III (motor).


02/26/2008 01:52 PM

Resveratrol and X rays affect gap junction intercellular communications in human glioblastoma cells

Molecular Carcinogenesis Published Online: 19 Feb 2008

Resveratrol (3,4,5-trihydroxystilbene) is a polyphenol synthesized by a wide variety of plant species in response to injury, UV irradiation and fungal attack. Many studies have revealed a variety of resveratrol intracellular targets whose modulation gives rise to overlapping responses leading to growth arrest and death. Many authors have reported different human cancer cell lines, treated with resveratrol at micromolar concentrations, arrested their proliferative cycle in the G1/S boundary or in the S phase and this cell cycle arrest was followed by apoptotic death.


02/26/2008 01:51 PM

The quality and adequacy of care received at home in the last 3 months of life by people who died following a stroke: a retrospective survey of surviving family and friends using the Views of Informal Carers Evaluation of Services questionnaire

Health & Social Care in the Community doi:10.1111/j.1365-2524.2007.00753.x

Stroke is the third leading cause of death in the UK. Despite this, little is known about the care needs of people who die from or following a stroke.


02/26/2008 01:50 PM

White matter lesions in migraine and right-to-left shunt: a conventional and diffusion MRI study

Cephalalgia doi:10.1111/j.1468-2982.2008.01544.x

Subjects with migraine with aura (MA) have a high prevalence of white matter lesions (WMLs) on magnetic resonance imaging (MRI). Moreover, right-to-left shunt (RILES), mainly due to patent foramen ovale, is frequently associated with MA.


02/26/2008 01:48 PM

Neisseria elongata endocarditis complicated by brain embolism and abscess

J Med Microbiol 57 (2008), 376-381

We report a case of Neisseria elongata endocarditis with thalamic septic embolization and subsequent brain abscess formation, which to the best of our knowledge has never been reported in the literature. The brain abscess completely resolved after a surgical repair of the infected mitral valve and an additional 4 weeks of antimicrobial therapy. Based on a review of all previous reports of N. elongata endocarditis, including ours, this will remind physicians that invasive N. elongata infections should be managed and followed up cautiously, as surgical intervention is often required.


02/26/2008 01:47 PM

Vagus Nerve Stimulation Therapy for Seizures

Journal of Neurosurgical Anesthesiology. 20(1):29-35, January 2008

Of the 3 million patients with seizures in North America approximately 70% have effective seizure control with medications. In the group refractory to medical treatment only a minority fit the criteria for surgical therapy. Vagus nerve stimulation therapy seems to be a suitable nonpharmacologic therapy for reducing seizure frequency in these cases.


02/26/2008 01:44 PM

Intracerebral abscess: A complication of severe cystic fibrosis lung disease

Journal of the Canadian Thoracic Society January/February 2008, Volume 15 Issue 1: 45-47

Intracerebral abscess is an uncommon complication of severe cystic fibrosis lung disease. The present report describes a case of fatal multiple intracerebral abscesses in a patient with a severely bronchiectatic, nonfunctioning right lung and chronic low-grade infection. The patient was previously turned down for pneumonectomy. Intracerebral abscess in cystic fibrosis and the potential role of pneumonectomy in the present patient are discussed.


02/26/2008 01:43 PM

Hospital Treatment of Patients With Ischemic Stroke or Transient Ischemic Attack Using the "Get With The Guidelines" Program

Arch Intern Med. 2008;168(4):411-417

Adherence to evidence-based interventions for hospitalized patients who have experienced a stroke is suboptimal. We examined the association of process improvement and Internet-based data collection and decision support with stroke care.


02/26/2008 01:42 PM

VISUAL FUNCTION AT BASELINE AND 1 MONTH IN ACUTE OPTIC NEURITIS: PREDICTORS OF VISUAL OUTCOME

Neurology.2008; 70: 728-729


02/26/2008 01:41 PM

Transmissible spongiform encephalopathy in the 21st century: Neuroscience for the clinical neurologist

Neurology.2008; 70: 713-722


02/26/2008 01:40 PM

Evaluation of the assessment and grading of medical students on a neurology clerkship

NEUROLOGY 2008;70:706-712

To describe a clinical encounter (Bedside Examination Exercise [BEE]) used for assessment and teaching in the Massachusetts General Hospital neurology clerkship; to compare results of the BEE with the Harvard Medical School Subjective Evaluation Form (SEF) and National Board of Medical Examiners Shelf examination (Shelf); and to develop a grading system that assesses multiple skills and reflects proficiency.


02/26/2008 01:37 PM

Configuration of intracranial arteries and development of aneurysms

NEUROLOGY 2008;70:700-705

The reasons for development of intracranial aneurysms are unknown; hemodynamic factors may play an important role in this process. We performed a cohort study to further elicit the role of intracranial arterial geometry.


02/23/2008 01:14 PM

Gliomatosis cerebri presenting as rapidly progressive dementia and parkinsonism in an elderly woman: a case report

Journal of Medical Case Reports 2008, 2:53

Dementia is one of the most important neurological disorders in the elderly. Dementia of tumoral origin is rare and parkinsonism of neoplastic origin is unusual.


02/23/2008 01:12 PM

Psychiatric Disorders in Children and Adolescents Who Have Epilepsy

Pediatrics in Review. 2008;29:e9-e14

Epilepsy occurs in approximately 1% of the population. It is the third most common neurologic disorder in the United States after Alzheimer disease and stroke. The prevalence of epilepsy is equal to the combined prevalence of cerebral palsy, multiple sclerosis, and Parkinson disease. Epilepsy is the most common childhood neurologic disorder, affecting 0.5% to 1.0% of children younger than age 16 years. (1) More than 326,000 children younger than age 15 years have epilepsy, and approximately 90,000 have seizures that are not controlled completely by treatment. Epilepsy often occurs in conjunction with other conditions, including autism spectrum disorder, cerebral palsy, Down syndrome, and intellectual disability.


02/23/2008 01:11 PM

Histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin suppresses the malignant phenotype of neuroblastoma cells

International Journal of Cancer Volume 122, Issue 8 , Pages 1891 - 1900

The survival rate of children with advanced neuroblastoma (NB) is dismal despite intensive multimodal therapy. The limited efficacy and the frequent and serious side effects of currently used therapeutic regimens necessitate the development of new, less toxic treatment strategies.


02/23/2008 01:10 PM

Determinants and Associations of Homocysteine and Prothrombotic Risk Factors in Kuwaiti Patients with Cerebrovascular Accident

Med Princ Pract 2008;17:136-142

The objective ofthis study was to evaluate the determinants and associations of some prothrombotic risk factors in patients with cerebrovascular accidents (CVAs).


02/23/2008 01:08 PM

Prevalence and incidence of Parkinson’s disease in The Faroe Islands

Acta Neurologica Scandinavica doi:10.1111/j.1600-0404.2007.00991.x

A study in The Faroe Islands in 1995 suggested a high prevalence of idiopathic Parkinson’s disease (IPD) and total parkinsonism of 187.6 and 233.4 per 100,000 inhabitants respectively.


02/23/2008 01:06 PM

Vasomotion in Multiple Spontaneous Cervical Artery Dissections

Stroke doi: 10.1161/STROKEAHA.107.497362

The etiology of spontaneous cervical artery dissection (sCAD) is still unknown, even though an underlying arteriopathy impairing vasomotion has often been suspected.


02/23/2008 01:05 PM

Solid Cerebral Microemboli and Cerebrovascular Symptoms in Patients With Prosthetic Heart Valves

Stroke doi: 10.1161/STROKEAHA.107.493031

Although cerebral microemboli are often detected by transcranial Doppler ultrasonography in mechanical heart valve patients, the clinical significance of such microemboli is unclear.


02/23/2008 01:04 PM

Predictors of Emotional Distress After Stroke

Stroke doi: 10.1161/STROKEAHA.107.498279

The aim of this prospective longitudinal study was to identify factors relating to emotional distress in the first 6 months after stroke in a sample including patients with aphasia.


02/23/2008 01:03 PM

Grading Carotid Intrastent Restenosis. A 6-Year Follow-Up Study

Stroke doi: 10.1161/STROKEAHA.107.497487

accuracy of carotid ultrasound has not been well established in predicting intrastent restenosis (ISR) after carotid artery stenting (CAS).


02/23/2008 01:02 PM

Gender Differences in Stroke Examined in a 10-Year Cohort of Patients Admitted to a Canadian Teaching Hospital

Stroke doi: 10.1161/STROKEAHA.107.495143

Studies suggest that women with stroke are investigated less aggressively and receive tissue plasminogen activator less frequently than men.


02/23/2008 01:01 PM

Blocking of Platelets or Intrinsic Coagulation Pathway-Driven Thrombosis Does Not Prevent Cerebral Infarctions Induced by Photothrombosis

Stroke doi: 10.1161/STROKEAHA.107.496448

Models of photochemically-induced thrombosis are widely used in cerebrovascular research. Photothrombotic brain infarctions can be induced by systemic application of photosensitizing dyes followed by focal illumination of the cerebral cortex.


02/23/2008 01:00 PM

Walking Speed and Risk of Incident Ischemic Stroke Among Postmenopausal Women

Stroke doi: 10.1161/STROKEAHA.107.500850

Walking speed is a simple, reliable, and valid measure of functional status that has been shown to be strongly correlated with age-related outcomes and may be an indicator of subclinical cerebrovascular disease. However, few studies have investigated the association of walking speed with risk of incident ischemic stroke.


02/23/2008 12:59 PM

Vascular and Nonvascular Mimics of the CT Angiography "Spot Sign" in Patients With Secondary Intracerebral Hemorrhage

Stroke doi: 10.1161/STROKEAHA.107.499442

The newly-described computed tomography angiography (CTA) Spot Sign is present in about one third of patients with acute primary intracerebral hemorrhage (PICH) and predicts hematoma expansion.


02/23/2008 12:58 PM

Spatial Distribution of White-Matter Hyperintensities in Alzheimer Disease, Cerebral Amyloid Angiopathy, and Healthy Aging

Stroke doi: 10.1161/STROKEAHA.107.497438

White-matter hyperintensities (WMHs) detected by magnetic resonance imaging are thought to represent the effects of cerebral small-vessel disease and neurodegenerative changes.


02/23/2008 12:57 PM

Interexaminer Difference in Infarct Volume Measurements on MRI. A Source of Variance in Stroke Research

Stroke doi: 10.1161/STROKEAHA.107.502104

The measurement of ischemic lesion volume on diffusion- (DWI) and perfusion-weighted MRI (PWI) is examiner dependent. We sought to quantify the variance imposed by measurement error in DWI and PWI lesion volume measurements in ischemic stroke.


02/23/2008 12:56 PM

How Accurate Is CT Angiography in Evaluating Intracranial Atherosclerotic Disease?

Stroke doi: 10.1161/STROKEAHA.107.502906

Digital subtraction angiography (DSA) is regarded as the gold standard in assessing degree of stenosis in intracranial vessels. However, it is invasive and can only be carried out at specialized centers. We sought to compare CT angiography (CTA) to DSA for detection and measurement of stenosis in large intracranial arteries.


02/23/2008 12:53 PM

Association Between Serum Ferritin Level and Perihematoma Edema Volume in Patients With Spontaneous Intracerebral Hemorrhage

Stroke doi: 10.1161/STROKEAHA.107.501213

Preclinical evidence indicates that iron plays a key role in mediating neuronal injury and edema formation after intracerebral hemorrhage (ICH). However, the clinical role of iron in patients with ICH has not been well studied. We undertook this exploratory study to investigate the association of serum ferritin, as an indicator of body iron load, with perihematoma edema after ICH.


02/23/2008 12:52 PM

Corrigendum to "Modeling and simulation of intravenous levetiracetam pharmacokinetic profiles in children to evaluate dose adaptation rules" [Epilepsy Research 76 (2-3) (2007) 140-147]

Epilepsy Research Volume 78, Issue 2, Page 246 (February 2008)


02/23/2008 12:51 PM

Commentary on the usefulness of a morning routine EEG recording in patients with juvenile myoclonic epilepsy

Epilepsy Research Volume 78, Issue 2, Pages 244-245 (February 2008)


02/23/2008 12:50 PM

Ictal SPECT in Sturge-Weber syndrome

Epilepsy Research Volume 78, Issue 2, Pages 240-243 (February 2008)

We report on a patient with right-sided Sturge-Weber syndrome (SWS), in whom earlier functional hemispherectomy failed. Subtraction of ictal and interictal single-photon-emission-computed-tomography (SPECT) superimposed on individual MRI showed a right fronto-orbital hyperperfusion, with a left-sided EEG seizure pattern.


02/23/2008 12:49 PM

Effects of subdural application of lidocaine in patients with focal epilepsy

Epilepsy Research Volume 78, Issue 2, Pages 235-239 (February 2008)

Antiepileptic drug (AED) delivery directly into the neocortex has recently been shown to be able to both prevent and terminate focal seizures in rats. The present clinical experiment aimed to test the local effects of lidocaine delivered onto the pia mater adjacent to epileptogenic zones in human patients.


02/23/2008 12:48 PM

Strain and age affect electroconvulsive seizure testing in rats

Epilepsy Research Volume 78, Issue 2, Pages 232-234 (February 2008)

Electroconvulsive seizure thresholds were compared between adolescent and mature Sprague-Dawley, Wistar, and Fischer rats. All strains had similar hindbrain or forebrain seizure thresholds as adolescents.


02/23/2008 12:48 PM

Neonatal onset of hot water reflex seizures in monozygotic twins subsequently manifesting episodes of alternating hemiplegia

Epilepsy Research Volume 78, Issue 2, Pages 225-231 (February 2008)

We report on monozygotic twins with neonatal onset of daily reflex seizures triggered by hot water. Video record during the hot water bathing showed clinical signs consistent with a reflex seizure.


02/23/2008 12:47 PM

Epileptic spasms in older pediatric patients: MEG and ictal high-frequency oscillations suggest focal-onset seizures in a subset of epileptic spasms

Epilepsy Research Volume 78, Issue 2, Pages 216-224 (February 2008)

To elucidate the pathophysiology of intractable epileptic spasms in older children by describing the interictal magnetoencephalography spike sources (MEGSSs), intracranial EEG ictal-onset zones (IOZs) and their ictal high-frequency oscillations (HFOs) and surgical outcomes.


02/23/2008 12:46 PM

Limbic event-related potentials to words and pictures in the presurgical evaluation of temporal lobe epilepsy

Epilepsy Research Volume 78, Issue 2, Pages 207-215 (February 2008)

We recorded limbic event-related potentials (ERPs) with intrahippocampal depth electrodes in a more demanding verbal and an easier pictorial continuous recognition task in patients undergoing presurgical evaluations of their medical refractory mesial temporal lobe epilepsies (MTLE).


02/23/2008 12:45 PM

Difference in age of onset of psychosis between epilepsy and schizophrenia

Epilepsy Research Volume 78, Issue 2, Pages 201-206 (February 2008)

To clarify the nature of psychosis development in epilepsy patients, we studied differences in age of onset of psychosis between epilepsy patients with psychosis (epilepsy-psychosis) and schizophrenia patients.


02/23/2008 12:44 PM

Postoperative auras and the risk of recurrent seizures

Epilepsy Research Volume 78, Issue 2, Pages 195-200 (February 2008)

Little is known about the prognostic significance of persistent auras following temporal lobe surgery in determining the recurrence of complex partial seizures (CPS) or generalized tonic-clonic seizures (GTCS).


02/23/2008 12:43 PM

Effects of the ketogenic diet on neurogenesis after kainic acid-induced seizures in mice

Epilepsy Research Volume 78, Issue 2, Pages 186-194 (February 2008)

The ketogenic diet (KD) remains a therapy in search of explanation although it is an established treatment of intractable epilepsy. Recent studies suggest that the KD may be both anticonvulsant and antiepileptogenic.


02/23/2008 12:42 PM

Changes of cortical epileptic afterdischarges after status epilepticus in immature rats

Epilepsy Research Volume 78, Issue 2, Pages 178-185 (February 2008)

Status epilepticus (SE) in developing rats leads to neuronal degeneration in many brain structures including neocortex but the functional consequences of cortical damage were studied only exceptionally.


02/23/2008 12:41 PM

Increased oxidative stress in epileptic children treated with valproic acid

Epilepsy Research Volume 78, Issue 2, Pages 171-177 (February 2008)

To determine influence of Valproic Acid (VPA) treatment on oxidative status in non-obese and overweight epileptic children.


02/23/2008 12:40 PM

Lateralization of hippocampal activation differs between left and right temporal lobe epilepsy patients and correlates with postsurgical verbal learning decrement

Epilepsy Research Volume 78, Issue 2, Pages 161-170 (February 2008)

We addressed the question whether lateralization of memory-related medial temporal lobe (MTL) activity in medial temporal lobe epilepsy (MTLE) patients is determined by pathology or sex, differentiating between two MTL subregions implicated in visuospatial memory as regions-of-interest (ROI) – the hippocampus (Hc) and the parahippocampal place area (PPA).


02/23/2008 12:40 PM

Value of routine screening for bone demineralization in an urban population of patients with epilepsy

Epilepsy Research Volume 78, Issue 2, Pages 155-160 (February 2008)

Reduced bone mineral density (BMD) is increasingly recognized in patients receiving antiepileptic drug therapy. The precise prevalence is not known due to variability across populations studied. We set out to characterize the prevalence of abnormal BMD in an urban population of patients with epilepsy with the intent to determine the value of routine BMD screening.


02/23/2008 12:39 PM

Organic and inorganic calcium antagonists inhibit veratridine-induced epileptiform activity in CA3 neurons of the guinea pig

Epilepsy Research Volume 78, Issue 2, Pages 147-154 (February 2008)

Veratridine is believed to cause epileptiform discharges via its effects on sodium channels. We addressed the question whether calcium currents, known to contribute to the generation of paroxysmal depolarization shifts (PDS) in most models of epilepsies, also contribute to veratridine-induced epileptiform activity.


02/23/2008 12:37 PM

Relative influences of adjunctive topiramate and adjunctive lamotrigine on scanning and the effective field of view

Epilepsy Research Volume 78, Issue 2, Pages 140-146 (February 2008)

A subsample of 67 adult patients with partial seizures participating in a randomized, double-blind study comparing the cognitive effects of adjunctive lamotrigine (LTG) and adjunctive topiramate (TPM) was administered Performance On-Line (POL) in addition to a battery of neuropsychological tests at baseline, week 8 and week 16 of treatment.


02/23/2008 12:36 PM

Antiepileptic drugs and brain maturation: Fetal exposure to lamotrigine generates cortical malformations in rats

Epilepsy Research Volume 78, Issue 2, Pages 131-139 (February 2008)

Intake of antiepileptic drugs (AEDs) during pregnancy can provoke severe and subtle fetal malformations associated with deleterious sequelae, reflecting the need for experimental investigations on the comparative teratogenic potential of these agents.


02/23/2008 12:35 PM

Increased striatal serotonin synthesis following cortical resection in children with intractable epilepsy

Epilepsy Research Volume 78, Issue 2, Pages 124-130 (February 2008)

Serotonin is a major regulator of structural brain plasticity, which may occur following cortical resection in humans. In this study we used positron emission tomography (PET) with alpha[11C]methyl-l-tryptophan (AMT) to evaluate serotonergic alterations in subcortical structures following cortical resection in children with intractable epilepsy.


02/23/2008 12:34 PM

Deep brain stimulation of the anterior nucleus of the thalamus: Effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus

Epilepsy Research Volume 78, Issue 2, Pages 117-123 (February 2008)

Electrical stimulation of the anterior nucleus of the thalamus appears to be effective against seizures in animals and humans. As the optimal stimulation settings remain elusive, we studied the effects of different stimulation parameters against pilocarpine induced seizures and status epilepticus (SE).


02/23/2008 12:33 PM

Pathology and pathophysiology of the amygdala in epileptogenesis and epilepsy

Epilepsy Research Volume 78, Issue 2, Pages 102-116 (February 2008)

Acute brain insults, such as traumatic brain injury, status epilepticus, or stroke are common etiologies for the development of epilepsy, including temporal lobe epilepsy (TLE), which is often refractory to drug therapy.


02/23/2008 12:32 PM

Saccadic eye movements and anti-epileptic drugs

Epilepsy Research Volume 78, Issue 2, Pages 93-101 (February 2008)

Saccadic eye movements can be used to evaluate different aspects of brain function, and in this article we are concerned with possible applications in relation to anti-epileptic drug treatment.


02/23/2008 12:31 PM

The protective effect of risk factors against stroke severity

Journal of the Neurological Sciences Volume 267, Issue 1, Pages 187-188 (15 April 2008)


02/23/2008 12:30 PM

Antioxidant use in Friedreich ataxia

Journal of the Neurological Sciences Volume 267, Issue 1, Pages 174-176 (15 April 2008)

Many antioxidants have been suggested as potential treatments for Friedreich ataxia, but have not been tested in clinical trials.


02/23/2008 12:26 PM

Atrial fibrillation as an independent predictor for no early recanalization after IV-t-PA in acute ischemic stroke

Journal of the Neurological Sciences Volume 267, Issue 1, Pages 57-61 (15 April 2008)

Intravenous administration of tissue plasminogen activator (t-PA) dissolves the clot and can improve clinical outcome in patients with acute ischemic stroke. However, lack of early recanalization frequently does not result in good outcome.


02/23/2008 12:25 PM

Traumatic brain injury in Finland 1991-2005: A nationwide register study of hospitalized and fatal TBI

Brain Injury, Volume 22, Issue 3 2008 , pages 205 - 214

To examine the epidemiology of traumatic brain injury (TBI) in Finland in 1991-2005.


02/23/2008 12:24 PM

Health-related quality of life and psychosocial consequences after mild traumatic brain injury in children and adolescents

Brain Injury, Volume 22, Issue 3 2008 , pages 215 - 221

Little is known about the course of health-related quality of life (HRQOL) and functional outcome parameters in children and adolescents with TBI. In addition, a neuropsychological screening instrument would be useful for routine clinical care.


02/23/2008 12:23 PM

The presence and impact of traumatic brain injury among clients in treatment for co-occurring mental illness and substance abuse

Brain Injury, Volume 22, Issue 3 2008 , pages 223 - 231

To compare diagnostic and treatment-related differences between persons participating in treatment for dually diagnosed substance use disorders and severe mental illness who have or do not have a history of traumatic brain injury (TBI).


02/23/2008 12:22 PM

Risk factors for depressive symptoms after mild-to-moderate traumatic brain injury

Brain Injury, Volume 22, Issue 3 2008 , pages 233 - 241

To determine the extent to which pre-injury psychosocial factors, injury-related variables and post-injury litigation, perceived stress, fatigue, pain and information processing speed contributed to depressive symptoms after traumatic brain injury (TBI).


02/23/2008 12:21 PM

Semantic memory organization during the early stage of recovery from traumatic brain injury

Brain Injury, Volume 22, Issue 3 2008 , pages 243 - 253

This study used an object definitions test to examine semantic memory and the organization of semantic knowledge during the early stage of recovery from traumatic brain injury (TBI).


02/23/2008 12:20 PM

Cognitive and functional outcomes of terror victims who suffered from traumatic brain injury

Brain Injury, Volume 22, Issue 3 2008 , pages 255 - 263

To describe the outcomes of terror victims suffered from traumatic brain injury (TBI).


02/23/2008 12:19 PM

Deficits in complex visual information processing after mild TBI: Electrophysiological markers and vocational outcome prognosis

Brain Injury, Volume 22, Issue 3 2008 , pages 265 - 274

To evaluate low-level to complex information processing using visual electrophysiology and to examine the latter's prognostic value in regards to vocational outcome in persons having sustained a mild traumatic brain injury (mTBI).


02/23/2008 12:18 PM

Spry2-mediated inhibition of the Ras/ERK pathway through interaction with Src kinase following cerebral ischemia

Brain Injury, Volume 22, Issue 3 2008 , pages 275 - 281

Global ischemia reportedly results in intense ERK activation followed by its inactivation and mild reactivation. This study examined the molecular mechanisms underlying inhibition of the ERK pathway following cerebral ischemia in the rat hippocampus.


02/23/2008 12:12 PM

A case study of amnesia: Exploring a paradigm for new semantic learning and generalization

Brain Injury, Volume 22, Issue 3 2008 , pages 283 - 292

The purpose of this study was to explore and extend previous findings that training with variant items improves generalization performance on novel semantic sentences in an individual with amnesia.


02/23/2008 12:11 PM

Simulation-based executive cognitive assessment and rehabilitation after traumatic frontal lobe injury: A case report

Disability & Rehabilitation, Volume 30, Issue 6 2008 , pages 468 - 478

To investigate whether identifying specific deficits after brain injury can lead to a more focused and potentially effective cognitive rehabilitation technology.


02/23/2008 11:38 AM

A subjective measure of environmental facilitators and barriers to participation for people with mobility limitations

Disability & Rehabilitation, Volume 30, Issue 6 2008 , pages 434 - 457

The aim of this paper is to describe the development and psychometric properties of a self-report survey of environmental facilitators and barriers to participation by people with mobility impairments.


02/21/2008 02:36 PM

Reoperation for sella haematoma after pituitary surgery

Clinical Endocrinology, Volume 68, Number 3, March 2008 , pp. 413-415(3)

though occasionally discussed as a general complication in large pituitary series, the incidence of reoperation for postoperative sella haematoma is unclear. We retrospectively reviewed a large pituitary surgical series to determine the incidence and associated factors of this complication.


02/21/2008 02:39 PM

Are Brain Volumes based on Magnetic Resonance Imaging Mediators of the Associations of Cumulative Lead Dose with Cognitive Function?

American Journal of Epidemiology 2008 167(4):429-437

The authors used cross-sectional data (2001-2003) to consider the pathway through which past occupational lead exposure impacts cognitive function. They were motivated by studies linking cumulative lead dose with brain volumes, volumes with cognitive function, and lead dose with cognitive function


02/21/2008 02:38 PM

The olfactory vector hypothesis of neurodegenerative disease: Is it viable?

Annals of Neurology Volume 63, Issue 1 , Pages 7 - 15

Environmental agents, including viruses, prions, and toxins, have been implicated in the cause of a number of neurodegenerative diseases, most notably Alzheimer's and Parkinson's diseases.


02/21/2008 02:36 PM

Reoperation for sella haematoma after pituitary surgery

Clinical Endocrinology, Volume 68, Number 3, March 2008 , pp. 413-415(3)

though occasionally discussed as a general complication in large pituitary series, the incidence of reoperation for postoperative sella haematoma is unclear. We retrospectively reviewed a large pituitary surgical series to determine the incidence and associated factors of this complication.


02/21/2008 02:35 PM

Memory enhancement induced by hypothalamic/fornix deep brain stimulation

Annals of Neurology Volume 63, Issue 1 , Pages 119 - 123

Bilateral hypothalamic deep brain stimulation was performed to treat a patient with morbid obesity. We observed, quite unexpectedly, that stimulation evoked detailed autobiographical memories.


02/21/2008 02:33 PM

Targeting the Phosphoinositide 3-Kinase Isoform p110{delta} Impairs Growth and Survival in Neuroblastoma Cells

Clinical Cancer Research 14, 1172-1181, February 15, 2008

The phosphoinositide 3-kinase (PI3K)/Akt pathway is frequently activated in human cancer and plays a crucial role in neuroblastoma biology. We were interested in gaining further insight into the potential of targeting PI3K/Akt signaling as a novel antiproliferative approach in neuroblastoma.


02/21/2008 02:32 PM

BAC array CGH distinguishes mutually exclusive alterations that define clinicogenetic subtypes of gliomas

International Journal of Cancer Volume 122, Issue 8 , Pages 1778 - 1786

The pathological classification of gliomas constitutes a critical step of the clinical management of patients, yet it is frequently challenging. To assess the relationship between genetic abnormalities and clinicopathological characteristics, we have performed a genetic and clinical analysis of a series of gliomas.


02/21/2008 02:31 PM

Mesial temporal lobe epilepsy: Clinical and neuropathologic findings of familial and sporadic forms

Epilepsia doi:10.1111/j.1528-1167.2008.01551.x

To evaluate the clinical and hippocampal histological features of patients with mesial temporal lobe epilepsy (MTLE) in both familial (FMTLE) and sporadic (SMTLE) forms.


02/21/2008 02:30 PM

Homozygous W748S mutation in the POLG1 gene in patients with juvenile-onset Alpers syndrome and status epilepticus

Epilepsia doi:10.1111/j.1528-1167.2008.01544.x

Polymerase gamma (POLG) is the sole enzyme in the replication of mitochondrial DNA (mtDNA). Numerous mutations in the POLG1 gene have been detected recently in patients with various phenotypes including a classic infantile-onset Alpers-Huttenlocher syndrome (AHS). Here we studied the molecular etiology of juvenile-onset AHS manifesting with status epilepticus and liver disease in three teenagers.


02/21/2008 02:28 PM

Balanced translocation in a patient with severe myoclonic epilepsy of infancy disrupts the sodium channel gene SCN1A

Epilepsia doi:10.1111/j.1528-1167.2008.01550.x

In a patient with severe myoclonic epilepsy of infancy (SMEI), we identified a de novo balanced translocation, t(2;5)(q24.3,q34).


02/21/2008 02:28 PM

Dural arteriovenous fistula causing primary intraventricular haemorrhage

British Journal of Radiology (2008) 81, e44-e47

Primary intraventricular haemorrhage is a rare presentation of a dural arteriovenous fistula. We describe the case of a 52-year-old woman with a past history of idiopathic intracranial hypertension who presented with sudden-onset severe headache.


02/21/2008 02:27 PM

A case of schizencephaly presenting with unilateral cryptophthalmos

British Journal of Radiology (2008) 81, e40-e43

We describe an unusual case of schizencephaly associated with unilateral orbital meningoencephalocele, anophthalmos, orbital soft mass, cryptophthalmos and partial agenesis of corpus callosum, along with ectopic kidney and thumb anomaly.


02/21/2008 02:25 PM

Phase I Clinical Trial of Cilengitide in Children With Refractory Brain Tumors: Pediatric Brain Tumor Consortium Study PBTC-012

Journal of Clinical Oncology, Vol 26, No 6 (February 20), 2008: pp. 919-924

A phase I trial of the antiangiogenesis agent cilengitide (EMD 121974), an alpha v beta 3,5 integrin antagonist, was performed to estimate the maximum-tolerated dose (MTD) and describe dose-limiting toxicities (DLTs) and the incidence and severity of other toxicities when administered to children with refractory brain tumors.


02/21/2008 02:23 PM

Multi-institutional phase II study of temozolomide administered twice daily in the treatment of recurrent high-grade gliomas

Cancer Volume 112, Issue 5 , Pages 1139 - 1146

The prognosis for patients with recurrent high-grade gliomas is poor and treatment options are limited. Current chemotherapeutic regimens can improve clinical outcomes, but extend survival by only a few months. Temozolomide is a methylating agent that is typically administered once daily. Because preclinical studies suggested that a twice-daily dosing schedule might be more effective, the safety and efficacy of twice-daily dosing of temozolomide were studied in patients with recurrent gliomas at their first, second, or third recurrence.


02/21/2008 02:22 PM

A simple procedure to improve FMRIb Software Library Brain Extraction Tool performance

British Journal of Radiology (2008) 81, 250-251

The Oxford FMRIb Software Library (FSL) Brain Extraction Tool (BET) is a widely used algorithm for removing extracranial tissues from MR images. Although BET is effective and simple to operate, it often fails to exclude fully all non-brain tissues unless the centre of gravity of the brain is specified to the programme.


02/21/2008 02:19 PM

Can Proton MR Spectroscopic and Perfusion Imaging Differentiate Between Neoplastic and Nonneoplastic Brain Lesions in Adults?

American Journal of Neuroradiology 29:366-372, February 2008

Noninvasive diagnosis of brain lesions is important for the correct choice of treatment. Our aims were to investigate whether 1) proton MR spectroscopic imaging (1H-MRSI) can aid in differentiating between tumors and nonneoplastic brain lesions, and 2) perfusion MR imaging can improve the classification.


02/19/2008 03:14 PM

Long-term follow-up of idiopathic intracranial hypertension

NEUROLOGY 2008;70:634-640

To evaluate recurrent or delayed worsening of papilledema and visual function in patients with idiopathic intracranial hypertension (IIH) followed for more than 10 years.


02/19/2008 03:13 PM

Functions and involvement in neurologic disease

Neurology.2008; 70: 648-652


02/19/2008 03:12 PM

Hypothalamic hamartomas and hedgehogs: Not a laughing matter

Neurology.2008; 70: 588-589


02/19/2008 03:12 PM

ROSTRAL MIDBRAIN INFARCTION PRODUCING ISOLATED LATEROPULSION

Neurology.2008; 70: 655-656


02/19/2008 03:11 PM

SOMATIC MUTATIONS IN GLI3 CAN CAUSE HYPOTHALAMIC HAMARTOMA AND GELASTIC SEIZURES

Neurology.2008; 70: 653-655


02/19/2008 03:08 PM

Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures

NEUROLOGY 2008;70:607-616

Currently, there are no published randomized controlled trials evaluating the efficacy and safety of adjunctive antiepileptic therapy in idiopathic generalized epilepsy with myoclonic seizures.


02/19/2008 03:07 PM

HOSPITAL VOLUME AND STROKE OUTCOME: DOES IT MATTER?

Neurology.2008; 70: 657


02/19/2008 03:07 PM

Genetic markers predictive of chemosensitivity and outcome in gliomatosis cerebri

NEUROLOGY 2008;70:590-595

Up-front temozolomide (TMZ) has been recently proposed as a treatment for gliomatosis cerebri (GC), but no predictive or prognostic markers have been identified so far.


02/19/2008 03:06 PM

Endovascular treatment of idiopathic intracranial hypertension Clinical and radiologic outcome of 10 consecutive patients

NEUROLOGY 2008;70:641-647

Optic nerve sheath fenestration and ventricular shunting are the classic methods when medical treatment has failed. Idiopathic intracranial hypertension is caused by venous sinus obstruction in an unknown percentage of cases. Recently, endoluminal venous sinus stenting was proposed as an alternative treatment.


02/19/2008 01:14 PM

Retinoic acid reduces human neuroblastoma cell migration and invasiveness: effects on DCX, LIS1, neurofilaments-68 and vimentin expression

BMC Cancer 2008, 8:30

Neuroblastoma is a severe pediatric tumor, histologically characterised by a variety of cellular phenotypes. One of the pharmacological approaches to neuroblastoma is the treatment with retinoic acid. The mechanism of action of retinoic acid is still unclear, and the development of resistance to this differentiating agent is a great therapy problem.


02/19/2008 01:11 PM

Isolated Spinal Cord Injury Following Suicidal Stab Wound In The Anterior Neck: An Unusual Case

The Internet Journal of Emergency and Intensive Care Medicine. 2008. Volume 11 Number 1

Penetrating trauma injuries in the neck constitute 5-10% of the patients presenting in emergency 1 , 2 . The mode of injury is mostly homicidal or accidental, but and rarely suicidal. The usual cause of mortality in such cases is airway obstruction or laceration of great vessels in the neck 3 . We report an unusual and interesting case of spinal cord transaction due to a suicidal stab wound in the anterior neck caused by a blunt kitchen knife. However, all vital structures including great vessels and aero-digestive tract were surprisingly spared by the stab injury.


02/19/2008 01:08 PM

A decade of Japanese encephalitis surveillance in Sarawak, Malaysia: 1997-2006

Tropical Medicine & International Health, Volume 13, Number 1, January 2008 , pp. 52-55(4)

Japanese encephalitis virus (JEV) is an important encephalitis virus in Asia, but there are few data on Malaysia. A hospital-based surveillance system for Japanese encephalitis (JE) has been in operation in Sarawak, Malaysia, for the last 10-years.


02/19/2008 01:05 PM

The timing of MRI determines the presence or absence of diffuse pachymeningeal enhancement in patients with spontaneous intracranial hypotension

Cephalalgia doi:10.1111/j.1468-2982.2007.01498.x

The timing and clinical relevance of diffuse pachymeningeal enhancement (DPE) in the magnetic resonance imaging (MRI) examination of patients with spontaneous intracranial hypotension (SIH) remain undetermined.


02/19/2008 01:04 PM

Risk for symptomatic intracerebral hemorrhage after thrombolysis assessed by diffusion-weighted magnetic resonance

Annals of Neurology Volume 63, Issue 1 , Pages 52 - 60

The risk for symptomatic intracerebral hemorrhage (sICH) associated with thrombolytic treatment has not been evaluated in large studies using diffusion-weighted imaging (DWI). Here, we investigated the relation between pretreatment DWI lesion size and the risk for sICH after thrombolysis.


02/19/2008 01:03 PM

Pain intensity, pain interference and characteristics of spinal cord injury

Spinal Cord 19 February 2008

To examine if the intensity of pain in persons with spinal cord injury (SCI) varied as a function of pain site, and to identify the patient and SCI characteristics associated with pain location, pain intensity and pain interference in a sample of persons with SCI.


02/19/2008 01:02 PM

Intramedullary melanotic schwannoma of the conus medullaris: a case report

Spinal Cord 19 February 2008

A case of a very rare type of schwannoma is reported. It is the sixth reported case of intramedullary melanotic schwannoma and the only one localized in the conus.


02/19/2008 01:00 PM

A longitudinal study of skeletal muscle following spinal cord injury and locomotor training

Spinal Cord 19 February 2008

Experimental rat model of spinal cord contusion injury (contusion SCI).


02/19/2008 12:59 PM

Social behavior following traumatic brain injury and its association with emotion recognition, understanding of intentions, and cognitive flexibility

Journal of the International Neuropsychological Society (2008), 14: 318-326

Although the adverse consequences of changes in social behavior following traumatic brain injury (TBI) are well documented, relatively little is known about possible underlying neuropsychological deficits.


02/19/2008 12:58 PM

Inability to empathize following traumatic brain injury

Journal of the International Neuropsychological Society (2008), 14: 289-296

This study examines: (a) the impact of traumatic brain injury (TBI) on emotional empathy, (b) the relationship between emotional empathy and neuropsychological ability, and (c) the influence of low emotional empathy on measures of affect.


02/19/2008 12:57 PM

Functional outcome 10 years after traumatic brain injury: Its relationship with demographic, injury severity, and cognitive and emotional status

Journal of the International Neuropsychological Society (2008), 14: 233-242

Previous investigations of long-term outcome following traumatic brain injury (TBI) have yielded mixed results regarding the predictive power of injury severity and demographic factors.


02/16/2008 12:09 PM

Effects of transcutaneous electrical stimulation combined with locomotion-like movement in the treatment of post-stroke gait disorder - a single-case study

Disability & Rehabilitation, Volume 30, Issue 5 2008 , pages 411 - 416

This study was designed to examine the effects of electrical stimulation combined with locomotion-like movement (ES/LM) for improving gait disorder in a stroke patient.


02/16/2008 12:08 PM

Assessment of aspiration risk in acute ischaemic stroke-evaluation of the simple swallowing provocation test

Journal of Neurology, Neurosurgery, and Psychiatry 2008;79:312-314

Aspiration is a common complication in acute stroke patients and is strongly associated with a poor outcome. Due to an insufficient sensitivity and specificity of clinical bedside tests, further refinements are needed to improve the accuracy of clinical aspiration screening in acute stroke.


02/16/2008 12:08 PM

Antigliadin antibodies in Cuban patients with spinocerebellar ataxia type 2

Journal of Neurology, Neurosurgery, and Psychiatry 2008;79:315-317

To evaluate the significance of antigliadin antibodies (AGA) levels for spinocerebellar ataxia type 2.


02/16/2008 12:07 PM

The mirror world of motor inhibition - the alien hand syndrome in chronic stroke

Journal of Neurology, Neurosurgery, and Psychiatry 2008;79:246-252

Alien hand syndrome (AHS) is rare, but important due to its disabling impact on everyday life. The determining characteristic of AHS is intermanual conflict, a type of inhibitory motor behaviour that occurs against willed action.


02/16/2008 12:06 PM

Subarachnoid haemorrhage in Sweden 1987-2002 - regional incidence and case fatality rates

Journal of Neurology, Neurosurgery, and Psychiatry 2008;79:294-299

Incidence estimates of subarachnoid haemorrhage (SAH) in Sweden vary, which may be caused by regional variations. Reliable estimates of age-specific case fatality rates are lacking.


02/16/2008 12:05 PM

Residual haptic sensation following stroke using ipsilateral stimulation

Journal of Neurology, Neurosurgery, and Psychiatry 2008;79:266-270

In 1987, Weiskrantz and Zhang described a stroke patient with severe somatosensory loss who, nevertheless, demonstrated impressive residual sensory performance when required to touch the affected limb with her ipsilesional hand (self touch; ST).


02/16/2008 12:03 PM

Predictors of survival after haemorrhagic stroke in a multi-ethnic population - the South London Stroke Register (SLSR)

Journal of Neurology, Neurosurgery, and Psychiatry 2008;79:260-265

To identify the predictors of long-term survival after haemorrhagic stroke.


02/16/2008 12:01 PM

Mild traumatic brain injury does not predict acute postconcussion syndrome

Journal of Neurology, Neurosurgery, and Psychiatry 2008;79:300-306

The aetiology of postconcussion syndrome (PCS) following mild traumatic brain injury (mTBI) remains controversial. Identifying acute PCS (within the first 14 days after injury) may optimise initial recovery and rehabilitation, identify those at risk and increase understanding of PCS.


02/16/2008 12:00 PM

Microembolic signals at 48 hours after stroke onset contribute to new ischaemia within a week

Journal of Neurology, Neurosurgery, and Psychiatry 2008;79:253-259

We investigated whether new ischaemic lesions (NIL) on follow-up diffusion weighted magnetic resonance imaging (DWI) are associated with microembolic signals (MES) within 24 h or at 48 h after stroke onset.


02/16/2008 11:59 AM

Albendazole therapy for single small enhancing CT lesions (SSECTL) in the brain in epilepsy

Journal of Neurology, Neurosurgery, and Psychiatry 2008;79:272-275

To evaluate the response to albendazole treatment in patients who had SSECTL and new onset seizures treated with antiepileptic drugs (AED) in a prospective clinical trial.


02/16/2008 11:58 AM

Stroke and pregnancy

Journal of Neurology, Neurosurgery, and Psychiatry 2008;79:240-245

Pregnancy-related stroke is, fortunately, a rare event. However, when it occurs, there may be implications for management of the patient and delivery of the child.


02/16/2008 11:57 AM

Mild traumatic brain injury and postconcussion syndrome - the importance of base rates in diagnosis and clinical formulation

Journal of Neurology, Neurosurgery, and Psychiatry 2008

The paper by Meares and colleagues1 in this issue of J Neurol Neurosurg Psychiatry concerns the implications of defining a syndrome by symptoms that have a high base rate of occurrence in the general population or in other syndromes.


02/16/2008 11:55 AM

What do people with acquired brain injury think about respite care and other support services

International Journal of Rehabilitation Research. 31(1):3-11, March 2008

Little is known about the need for continuing support services, such as respite for persons with acquired brain injury (ABI). This study focuses on the views of people with ABI on respite and support services.


02/16/2008 11:54 AM

Outcomes of a skiing program on level and stability of self-esteem and physical self in adults with spinal cord injury

International Journal of Rehabilitation Research. 31(1):59-64, March 2008

This study explored the intraindividual level and variability of global self-esteem and physical self-worth in adults with spinal cord injury over three consecutive periods, 4 weeks at home, 1 week in an adapted skiing program, and 4 weeks at home.


02/16/2008 11:52 AM

Body composition after stroke

International Journal of Rehabilitation Research. 31(1):93-96, March 2008

The aim of this study was to compare the body composition, including lean tissue mass, fat tissue mass, and bone mineral content, of the paretic leg with that of the nonaffected leg in patients with stroke and to evaluate the effects of time since stroke, spasticity, and motor recovery on the body composition specifically within the first year after stroke.


02/16/2008 11:51 AM

Hypomyelination and Congenital Cataract - Neuroimaging Features of a Novel Inherited White Matter Disorder

American Journal of Neuroradiology 29:301-305, February 2008

Hypomyelination and congenital cataract (HCC) is an autosomal recessive white matter disease caused by deficiency of hyccin, a membrane protein implicated in both central and peripheral myelination.


02/16/2008 11:51 AM

Fenestrations of the Anterior Communicating Artery - Incidence on 3D Angiography and Relationship to Aneurysms

American Journal of Neuroradiology 29:296-298, February 2008

Demonstration of fenestrations of the anterior communicating artery (AcomA) with conventional digital subtraction angiography is very uncommon.


02/16/2008 11:49 AM

Continuous Intra-Arterial Infusion of Nimodipine During Embolization of Cerebral Aneurysms Associated With Vasospasm

American Journal of Neuroradiology 29:291-295, February 2008

Despite rigorous efforts, cerebral vasospasm remains an important cause of morbidity and mortality in patients who survive their initial subarachnoid hemorrhage.


02/16/2008 11:48 AM

Attention mediates radiation's impact on daily living skills in children treated for brain tumors

Pediatric Blood & Cancer

Radiotherapy is associated with an increased survival rate in children with brain tumors, but also with cognitive decline. This study examined the time-dependent effects of radiation treatment on adaptive functioning in children with brain tumors. The potentially mediating effects of attention span (Trial 1 of the Rey Auditory Verbal Learning Test [RAVLT]) assessed within 7 years of diagnosis were explored.


02/16/2008 11:46 AM

Craniovertebral Stabilization

Neurosurgical Focus February 2008 Volume 1, Number 2

Atlantoaxial and occipitocervical instability in children have traditionally been treated with posterior bone and wire fusion and external halo orthoses. Recently, successful outcomes have been achieved using rigid internal fixation, particularly C1-2 transarticular screws. The authors describe flow diagrams created to help clinicians determine which method of internal fixation to use in complex anatomical circumstances when bilateral transarticular screw placement is not possible.


02/16/2008 11:44 AM

Microcystic Meningioma - Importance of Obvious Hypointensity on T1-Weighted Magnetic Resonance Images

Journal of Computer Assisted Tomography. 32(1):130-134, January/February 2008

To investigate the sensitivity and specificity of various magnetic resonance imaging findings for microcystic meningioma.


02/16/2008 11:44 AM

Poststroke Cerebral Peduncular Atrophy Correlates with a Measure of Corticospinal Tract Injury in the Cerebral Hemisphere

American Journal of Neuroradiology 29:354-358, February 2008

Methods have not been well developed and tested to predict the extent of remote degeneration in the central nervous system that follows cerebral infarction. We hypothesized that the extent of infarction overlap with the cerebral hemispheric course of the corticospinal tract (CST) on structural MR imaging predicts the extent of ipsilateral cerebral peduncular atrophy in patients with chronic stroke.


02/16/2008 11:43 AM

Occlusion Length Is a Crucial Determinant of Efficiency and Complication Rate in Thrombectomy for Acute Ischemic Stroke

American Journal of Neuroradiology 29:247-252, February 2008

Although mechanical thrombectomy (MT) has an encouragingly high recanalization rate in treating stroke, it is associated with severe complications of which the underlying factors have yet to be identified.


02/16/2008 11:42 AM

Neurologic Complications of Arteriovenous Malformation Embolization Using Liquid Embolic Agents

American Journal of Neuroradiology 29:242-246, February 2008

Embolization of arteriovenous malformations (AVMs) is commonly used to achieve nidal volume reduction before microsurgical resection or stereotactic radiosurgery.


02/16/2008 11:40 AM

Monitoring Serial Change in the Lumen and Outer Wall of Vertebrobasilar Aneurysms

American Journal of Neuroradiology 29:259-264, February 2008

Estimation of the stability of fusiform aneurysms of the basilar artery requires precise monitoring of the luminal and outer wall volumes. In this report we describe the use of MR imaging and 3D postprocessing methods to study the evolution of those aneurysms.


02/16/2008 11:39 AM

In Vivo Demonstration of Neuroinflammatory Molecule Expression in Brain Abscess with Diffusion Tensor Imaging

American Journal of Neuroradiology 29:326-332, February 2008

Neuroinflammatory molecules, including tumor necrosis factor-{alpha}, interleukin1-alpha, lymphocyte function associated molecule-1, and intercellular cell adhesion molecule-1 contribute to the development of brain abscess.


02/16/2008 11:38 AM

Endovascular Treatment of Intracranial Dural Arteriovenous Fistulas with Cortical Venous Drainage - New Management Using Onyx

American Journal of Neuroradiology 29:235-241, February 2008

DAVFs (dural arteriovenous fistulas) represent one of the most dangerous types of intracranial AV shunts. Most of them are cured by arterial or venous embolization, but surgery/radiosurgery can be required in case of failure.


02/16/2008 11:37 AM

Impact of Arterial Reocclusion and Distal Fragmentation during Thrombolysis among Patients with Acute Ischemic Stroke

American Journal of Neuroradiology 29:253-258, February 2008

Arterial reocclusion and distal embolization are known complications of ischemic stroke intervention, impacting treatment strategies and device design. We sought to determine their rates of occurrence and effects on long-term outcomes during endovascular treatment of patients with acute ischemic stroke.


02/16/2008 11:36 AM

Clinical and Brain MR Imaging Features Focusing on the Brain Stem and Cerebellum in Patients with Myoclonic Epilepsy with Ragged-Red Fibers due to Mitochondrial A8344G Mutation

American Journal of Neuroradiology 29:392-395, February 2008

We report 3 patients with myoclonic epilepsy with ragged-red fibers (MERRF) diagnosed by mitochondrial A8344G mutation. Cerebellar ataxia was the first symptom in all patients.


02/16/2008 11:33 AM

Freehand dynamic endoscopic resection of an epidermoid tumor of the cerebellopontine angle - technical case report

Neurosurgery. 61(5) Operative Neurosurgery Supplement 2:E239-E240, November 2007

In the last 10 years, experience with endoscopic transsphenoidal surgery for the treatment of sellar and perisellar lesions has highlighted advantages brought about by the endoscope for less-invasive procedures.


02/16/2008 11:32 AM

Predicting Grade of Cerebral Glioma Using Vascular-Space Occupancy MR Imaging

American Journal of Neuroradiology 29:373-378, February 2008

MR imaging can measure tissue perfusion and the integrity of the blood-brain barrier. We hypothesize that a combined measure of cerebral blood volume and vascular permeability using vascular-space occupancy (VASO) MR imaging, a recently developed imaging technique, is of diagnostic value for predicting tumor grade.


02/16/2008 11:27 AM

Endovascular Therapy of Symptomatic Intracranial Stenosis in Patients With Impaired Regional Cerebral Blood Flow or Failure of Medical Therapy

American Journal of Neuroradiology 29:273-280, February 2008

Symptomatic intracranial stenoses have a high risk for a recurrent stroke if treated medically. Although angioplasty and stent placement are proposed treatment options, data on longer-term outcome are limited.


02/16/2008 11:25 AM

Comparison of Optimized and Standard Diffusion-Weighted Imaging at 1 5T for the Detection of Acute Lesions in Patients with Transient Ischemic Attack

American Journal of Neuroradiology 29:363-365, February 2008

The high rate of normal diffusion-weighted imaging (DWI) in patients with transient ischemic attack (TIA) raises the question as to its sensitivity for detecting small ischemic lesions.


02/16/2008 11:24 AM

Thirty-year follow-up after extracranial-intracranial bypass surgery

Neurosurcial Focus February 2008 Volume 24, Number 2

The conventional wisdom resulting from the international, multicenter, trial of extracranial-intracranial bypass surgery is that this procedure offers no benefit. Because of the complex and unique circumstances of some, clinical experience and judgment must sometimes overrule some statistical conclusions.


02/16/2008 11:23 AM

The superficial temporal artery trunk as a donor vessel in cerebral revascularization - benefits and pitfalls

Neurosurgical Focus February 2008 Volume 24, Number 2

The superficial temporal artery (STA) is the mainstay of donor vessels for extracranial–intracranial bypass in cerebral revascularization. However, the typically used STA anterior or posterior branch is not always adequate in its flow-carrying capacity. In this report the authors describe the use of the STA trunk at the level of the zygoma as an alternative donor and highlight the benefits and pitfalls of this revascularization option.


02/16/2008 11:21 AM

Surgical treatment of blood blister-like aneurysms of the supraclinoid internal carotid artery with extracranial-intracranial bypass and trapping

Neurosurgical Focus February 2008 Volume 24, Number 2

Blood blister-like aneurysms (BBAs) arise from the supraclinoid internal carotid artery (ICA) at non-branching sites. These aneurysms are challenging to treat primarily with either surgical clip placement or endovascular therapy. The authors describe a series of 4 patients who presented with high-grade subarachnoid hemorrhage (SAH) due to a BBA, which was treated with an extracranial-intracranial (EC-IC) bypass followed by trapping of the aneurysm.


02/16/2008 11:20 AM

Cerebral bypass surgery for skull base lesions - technical notes incorporating lessons learned over two decades

Neurosurgical Focus February 2008 Volume 24, Number 2 February 2008

Despite advancements in endovascular neurosurgery, there remains an important role for cerebral bypass surgery in the treatment of skull base lesions. The authors describe their replacement cerebral bypass surgery techniques incorporating lessons learned over 2 decades.


02/16/2008 11:08 AM

Lower blood pressure and risk of recurrent stroke in patients with chronic kidney disease - PROGRESS trial

Kidney International 13 February 2008

Recent epidemiological studies have shown a J-shaped association between the risk of stroke and systolic blood pressure (SBP) levels in people with chronic kidney disease (CKD).


02/16/2008 11:07 AM

Clinical proteomics in neurodegenerative disorders

Acta Neurologica Scandinavica doi:10.1111/j.1600-0404.2007.00985.x

Neurodegenerative disorders are characterized by neuronal impairment that eventually leads to neuronal death. In spite of the brain’s known capacity for regeneration, lost neurons are difficult to replace.


02/16/2008 11:05 AM

Alternative vascular graft for extracranial-intracranial bypass surgery: descending branch of the lateral circumflex femoral artery

Neurosurgical Focus February 2008 Volume 24, Number 2

Arterial bypass is an important method of treating intracranial disease requiring sacrifice of the parent vessel. The conduits for extracranial-intracranial (EC-IC) bypass surgery include the superficial temporal artery, occipital artery, superior thyroid artery, radial artery, and saphenous vein (long or short). In an aging population with an increased prevalence of vascular disease, conduits for EC-IC bypass may be in short supply in some patients. Herein, the authors describe a case in which the descending branch of the lateral circumflex femoral artery (DLCFA) was utilized as a high-flow conduit for an EC-IC bypass.


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