| 04/19/2008
12:22 PM
Vein of Galen Aneurysmal Malformation With Deep Venous Communication and Subarachnoid Hemorrhage
Journal of Child Neurology, Vol. 23, No. 4, 441-446 (2008)
A previously healthy 2-year-old boy presented with the acute onset of left middle cerebral artery syndrome. Evaluation revealed subarachnoid hemorrhage and a vein of Galen aneurysmal malformation with angiographic reflux into the deep venous system.
04/19/2008
12:21 PM
The Roles of Oxidized Low-Density Lipoprotein and Interleukin-6 Levels in Acute Atherothrombotic and Lacunar Ischemic Stroke
Angiology, Vol. 59, No. 2, 224-229 (2008)
The role of circulating, oxidized low-density lipoprotein and interleukin-6 levels in acute ischemic stroke considering the primary-vessel disease was investigated.
04/19/2008
12:20 PM
Multiple Intracranial Tuberculomas Associated With Partial Status Epilepticus and Refractory Infantile Spasms
Journal of Child Neurology, Vol. 23, No. 4, 459-462 (2008)
We report the case of a 10 month-old girl presenting with multiple intracranial tuberculomas associated with partial status epilepticus and cerebrovascular accident in the left sylvian territory. She later developed paradoxical enlargement of the tuberculomas during antituberculous treatment and severe neurological sequelae with refractory infantile spasms.
04/19/2008
12:19 PM
Intracranial Hypertension in 2 Children With Marfan Syndrome
Journal of Child Neurology 2008, doi:10.1177/0883073808315341
Two unrelated children with Marfan syndrome presented with recurrent intracranial hypertension. Both children complained of headache, nausea, and vomiting and one of them had papilledema. Both had increased cerebrospinal fluid pressure, and their complaints disappeared after lumbar puncture. Although severe headache has been reported in Marfan syndrome due to intracranial hypotension, this is to our knowledge the first report of intracranial hypertension in Marfan patients.
04/19/2008
12:18 PM
Decompressive Hemicraniectomy in Children With Severe Ischemic Stroke and Life-Threatening Cerebral Edema
ournal of Child Neurology 2008, doi:10.1177/0883073808314960
Decompressive hemicraniectomy has been discussed as a treatment option that increases survival in adults with malignant stroke. This approach has not been studied extensively in children. From a prospective cohort, we identified 4 children who underwent decompressive hemicraniectomy for malignant infarctions with life-threatening cerebral edema within 72 hours of their stroke.
04/19/2008
12:17 PM
A Case of Pediatric Tumefactive Demyelinating Lesion Misdiagnosed and Treated as Glioblastoma
Journal of Child Neurology 2008, doi:10.1177/0883073808315419
Because of their clinical and neuroradiological features, tumefactive demyelinating lesions, or giant plaques, are easily mistaken for tumors, with a consequent risk of gross errors in the choice of treatment. This article reports a 10-year-old girl who underwent surgery for a left parietal lesion misinterpreted as a glioblastoma which subsequently proved to be a case of giant plaque.
04/19/2008
12:15 PM
Stroke in sickle cell disease patients: transcranial Doppler and magnetic resonance imaging
Hematologie. Volume 14, Number 1, 25-35
Sickle cell disease (SCD) is the most frequent cause of stroke occurrence during infancy and strokes are the most serious complication of SCD in children. Distal vasculopathy related to sludge explains 25% of strokes in SCD whereas proximal vasculopathy is responsible for 75% of strokes.
04/19/2008
12:14 PM
Sarpogrelate-Aspirin Comparative Clinical Study for Efficacy and Safety in Secondary Prevention of Cerebral Infarction (S-ACCESS) - A Randomized, Double-Blind, Aspirin-Controlled Trial
Stroke doi: 10.1161/STROKEAHA.107.505131
The antiplatelet agent sarpogrelate is a selective inhibitor of 5-hydroxytryptamine receptors. The purpose of this study was to compare the efficacy and safety of sarpogrelate with those of aspirin in Japanese ischemic stroke patients.
04/19/2008
12:13 PM
Fitness training for cardiorespiratory conditioning after traumatic brain injury
Cochrane Database of Systematic Reviews 2008 Issue 2
Cardiorespiratory deconditioning is a common sequelae after traumatic brain injury (TBI). Clinically, fitness training is implemented to address this impairment, however this intervention has not been subject to rigorous review.
04/19/2008
12:13 PM
Antiepileptic drugs for preventing seizures in people with brain tumors
Cochrane Database of Systematic Reviews 2008 Issue 2
Seizures can present at any time before or after diagnosis of a brain tumor. The risk of seizures varies by tumor type and its location in the brain. For a long time we believed that preventing seizures with antiepileptic drugs (seizure prophylaxis) was effective and necessary, but the supporting evidence was little and mixed. Such evidence was the basis for previous reviews to conclude that seizure prophylaxis was ineffective in people with brain tumors.
04/19/2008
12:11 PM
Adjuvant treatment of anaplastic oligodendrogliomas and oligoastrocytomas
Cochrane Database of Systematic Reviews 2008 Issue 2
AO and AOA are known to be chemosensitive tumors. However, the impact of adding chemotherapy to surgery and radiotherapy has not been studied. Also, the value of chromosome 1p and 19q deletions as prognostic and predictive markers is only beginning to be defined.
04/19/2008
12:10 PM
Identification of p18INK4c as a Tumor Suppressor Gene in Glioblastoma Multiforme
Cancer Research 68, 2564-2569, April 15, 2008
Genomic alterations leading to aberrant activation of cyclin/cyclin-dependent kinase (cdk) complexes drive the pathogenesis of many common human tumor types. In the case of glioblastoma multiforme (GBM), these alterations are most commonly due to homozygous deletion of p16INK4a and less commonly due to genomic amplifications of individual genes encoding cyclins or cdks.
04/19/2008
12:09 PM
Cyclin D1 and CDK4 Activity Contribute to the Undifferentiated Phenotype in Neuroblastoma
Cancer Research 68, 2599-2609, April 15, 2008
Genomic aberrations of Cyclin D1 (CCND1), CDK4, and CDK6 in neuroblastoma indicate that dysregulation of the G1 entry checkpoint is an important cell cycle aberration in this pediatric tumor.
04/19/2008
12:08 PM
Ubiquitin-Mediated Stress Response in the Spinal Cord After Transient Ischemia
Stroke doi: 10.1161/STROKEAHA.106.455832
Vulnerability of motor neurons in the spinal cord against ischemia is considered to play an important role in the development of delayed paraplegia after surgery of the thoracic aorta.
04/19/2008
12:08 PM
Outpatient Practice Patterns After Stroke Hospitalization Among Neurologists
Stroke doi: 10.1161/STROKEAHA.107.504860
Care after stroke hospitalization can provide several opportunities to optimize vascular risk reduction. However, not much is known about poststroke practice patterns among neurologists. Such knowledge may help direct specific efforts to improve the impact of practicing neurologists on clinical outcomes after stroke.
04/19/2008
12:07 PM
New Brain Lesions After Carotid Stenting Versus Carotid Endarterectomy. A Systematic Review of the Literature
Stroke doi: 10.1161/STROKEAHA.107.500603
Against the background of a relatively low rate of clinical events during carotid angioplasty and stenting (CAS) or carotid endarterectomy (CEA), diffusion-weighted imaging (DWI) is increasingly being used to compare the incidence of new ischemic lesions after both procedures.
04/19/2008
12:06 PM
MRI Findings in the Painful Poststroke Shoulder
Stroke doi: 10.1161/STROKEAHA.107.502187
We describe the structural abnormalities in the painful shoulder of stroke survivors and their relationships to clinical characteristics.
04/19/2008
12:05 PM
Importance of In-Hospital Initiation of Therapies and Therapeutic Inertia in Secondary Stroke Prevention. IMplementation of Prevention After a Cerebrovascular evenT (IMPACT) Study
Stroke doi: 10.1161/STROKEAHA.107.503094
Many patients do not receive prevention consistent with recommendations after stroke, but the relative importance of patient- and physician-related factors is uncertain.
04/19/2008
12:04 PM
Dual Antithrombotic Therapy Increases Severe Bleeding Events in Patients With Stroke and Cardiovascular Disease. A Prospective, Multicenter, Observational Study
Stroke doi: 10.1161/STROKEAHA.107.504993
We sought to determine the incidence and severity of bleeding events in patients with stroke and cardiovascular diseases who were taking oral antithrombotic agents in Japan, where the incidence of hemorrhagic stroke is higher than in Western countries.
04/19/2008
12:03 PM
An Uncommon Presentation of Stroke in a Child With Trisomy 21
Pediatric Emergency Care. 24(4):230-232, April 2008
A 3-year-old boy was presented to the emergency department with fever and refused to bear weight on his left leg. Evaluation leads to the eventual diagnosis of stroke secondary to moyamoya syndrome.
04/19/2008
12:02 PM
VENTRICULOPERITONEAL SHUNTING AFTER ANEURYSMAL SUBARACHNOID HEMORRHAGE: ANALYSIS OF THE INDICATIONS, COMPLICATIONS, AND OUTCOME WITH A FOCUS ON PATIENTS WITH BORDERLINE VENTRICULOMEGALY
Neurosurgery. 62(3):618-627, March 2008
The goals of this study were to investigate the risk factors, indications, complications, and outcome for patients with ventriculoperitoneal shunts (VPSs) after subarachnoid hemorrhage and to define a subgroup eligible for future prospective studies designed to clarify indications for placement of a VPS.
04/19/2008
12:02 PM
TUBERCULUM SELLAE MENINGIOMAS: HIGH ROUTE OR LOW ROUTE? A SERIES OF 51 CONSECUTIVE CASES
Neurosurgery. 62(3):556-563, March 2008
Tuberculum sellae meningiomas represent 5 to 10% of all intracranial meningiomas. Such lesions are classically removed through a variety of well-standardized transcranial approaches. The extended endonasal transsphenoidal route, under either microscopic or endoscopic visualization, has only recently been proposed as a viable surgical technique for the management of such tumors.
04/19/2008
12:01 PM
THE IMPACT OF BALLOON ANGIOPLASTY ON THE EVOLUTION OF VASOSPASM-RELATED INFARCTION AFTER ANEURYSMAL SUBARACHNOID HEMORRHAGE
Neurosurgery. 62(3):610-617, March 2008
Vasospasm of the cerebral vessels remains a major source for morbidity and mortality after aneurysmal subarachnoid hemorrhage. The purpose of this study was to evaluate the frequency of infarction after transluminal balloon angioplasty (TBA) in patients with severe subarachnoid hemorrhage-related vasospasm.
04/19/2008
12:00 PM
SURVIVAL WITH GOOD OUTCOME AFTER TRAVERSING BRAINSTEM INJURY: CASE REPORT
Neurosurgery. 62(3):E749, March 2008
A penetrating injury to the brainstem is usually a fatal injury. The number of cases in which the brainstem is traversed during the injury and the patient survives is exceedingly small.
04/19/2008
11:59 AM
RISK FACTORS FOR HEMORRHAGIC PRESENTATION IN PATIENTS WITH DURAL ARTERIOVENOUS FISTULAE
Neurosurgery. 62(3):628-635, March 2008
Intracranial dural arteriovenous fistulae (DAVFs) can present as disabling intracranial hemorrhage. The aim of this study was to investigate the independent effects of specific demographic and clinical variables on hemorrhagic presentation in patients with DAVFs.
04/19/2008
11:58 AM
RADIATION-INDUCED MENINGIOMA CONCEALED BY SHUNT VALVE ARTIFACT: CASE REPORT
Neurosurgery. 62(3):E743-E744, March 2008
Ventricular shunting is a common neurosurgical procedure. Metal-containing shunt components can cause artifacts on magnetic resonance imaging (MRI), obscuring visualization of the surrounding tissue. We present the case of a radiation-induced meningioma growing around a ventricular catheter that was not noted at an early stage as a result of artifact from an overlying shunt.
04/19/2008
11:57 AM
MORPHOLOGICAL DIFFERENCES BETWEEN RUPTURED AND UNRUPTURED CASES IN MIDDLE CEREBRAL ARTERY ANEURYSMS
Neurosurgery. 62(3):602-609, March 2008
To elucidate the morphological differences between ruptured and unruptured aneurysms, three-dimensional digital subtraction angiography was performed in 44 cases (20 unruptured, 24 ruptured) of middle cerebral artery aneurysm.
04/19/2008
11:56 AM
EXTENT OF RESECTION AND SURVIVAL IN GLIOBLASTOMA MULTIFORME: IDENTIFICATION OF AND ADJUSTMENT FOR BIAS
Neurosurgery. 62(3):564-576, March 2008
The influence of the degree of resection on survival in patients with glioblastoma multiforme is still under discussion. The highly controlled 5-aminolevulinic acid study provided a unique platform for addressing this question as a result of the high frequency of "complete" resections, as revealed by postoperative magnetic resonance imaging scans achieved by fluorescence-guided resection and homogeneous patient characteristics.
04/19/2008
11:55 AM
DISTAL ANTERIOR CEREBRAL ARTERY ANEURYSMS: TREATMENT AND OUTCOME ANALYSIS OF 501 PATIENTS
Neurosurgery. 62(3):590-601, March 2008
This study presents the combined experience of two Finnish neurosurgical centers in the treatment of 501 consecutive patients with distal anterior cerebral artery (DACA) aneurysms. Our aim was to compare treatment outcomes of these lesions with intracranial aneurysms in general and to identify factors predicting the outcome.
04/19/2008
11:54 AM
COSTANZO VAROLIO (CONSTANTIUS VAROLIUS 1543-1575) AND THE PONS VAROLLI
Neurosurgery. 62(3):734-737, March 2008
COSTANZO VAROLIO (CONSTANTIUS Varolius) (1543-1575) was born in Bologna and died in Rome. This professor of anatomy and papal physician was the first to examine the brain from its base up, in contrast with previous dissections of this organ performed from the top down.
04/17/2008
02:21 PM
Vertebral Artery Dissection and Posterior Stroke in a Child
Journal of Child Neurology 2008, doi:10.1177/0883073807313038
04/17/2008
02:20 PM
Using Magnetic Resonance Imaging to Predict New Learning Outcome at 5 Years After Childhood Traumatic Brain Injury
Journal of Child Neurology 2008, doi:10.1177/0883073807309773
04/17/2008
02:19 PM
Stroke in sickle cell disease
Sang Thrombose Vaisseaux. Volume 20, Number 2, 77-81, février 2008
Sickle cell disease (SCD) is due to a mutation (GAG to GTG) of the gene of the {beta}-globin chain resulting in a hemoglobinopathy SS. Stroke is a severe complication of SCD in term of mobidity and mortality and 75% of the neurologic events are ischemic. Stroke is a common complication of SCD with a lifetime risk of 25-40% and a peak of incidence before 8 years old.
04/17/2008
02:18 PM
Neurophysiological assessment of the electrostimulation procedures used in stroke patients during rehabilitation
Int J Artif Organs 2008; 31: 76 - 86
The aim of this study was to evaluate the effectiveness of the associated electrotherapeutical and kinesiotherapeutical treatment in patients after ischemic stroke (N=24), mainly by means of neurophysiological tests.
04/17/2008
02:17 PM
Neonatal Seizures: Relation of Ictal Video-Electroencephalography (EEG) Findings With Neurodevelopmental Outcome
Journal of Child Neurology, Vol. 23, No. 4, 394-398 (2008)
Neonatal electroencephalographic background activity has been found to be a predictive factor of the neurodevelopmental outcome. The aim of our study was to identify if the electrical ictal findings present on the first electroencephalography (EEG) recording are related to the outcome of newborns with neonatal seizures.
04/17/2008
02:17 PM
Migrating Focal Seizures in Infancy: Analysis of the Electroclinical Patterns in 17 Patients
Journal of Child Neurology 2008, doi:10.1177/0883073807309771
04/17/2008
02:16 PM
Levetiracetam Versus Carbamazepine Monotherapy for Partial Epilepsy in Children Less Than 16 Years of Age
Journal of Child Neurology 2008, doi:10.1177/0883073807309784
04/17/2008
02:15 PM
GLUT1 Deficiency Without Epilepsy: Yet Another Case
Journal of Child Neurology 2008, doi:10.1177/0883073808314896
04/17/2008
02:14 PM
A Prospective Study of Quality of Life in Adults With Newly Diagnosed High-Grade Gliomas: Comparison of Patient and Caregiver Ratings of Quality of Life
American Journal of Clinical Oncology. 31(2):163-168, April 2008
To examine whether a caregiver can provide reliable proxy quality of life (QOL) ratings of their adult significant other with a newly diagnosed high-grade glioma.
04/17/2008
02:13 PM
Evaluation of Feeding Intolerance in Patients with Pentobarbital-Induced Coma
The Annals of Pharmacotherapy: Vol. 42, No. 4, pp. 516-522
There is considerable debate regarding the appropriateness of feeding patients by the enteral route in conjunction with pentobarbital coma therapy.
04/17/2008
02:12 PM
Choreoathetosis After Herpes Simplex Encephalitis With Basal Ganglia Involvement on MRI
PEDIATRICS Vol. 121 No. 4 April 2008, pp. e1003-e1007
Children with herpes simplex virus encephalitis have a relapse in ~25% of cases, which rarely may present as a movement disorder, most often choreoathetosis. The anatomic basis for herpes simplex virus encephalitis-associated movement disorders has been poorly understood, because neuroimaging, to date, has not been able to show the direct involvement of the areas of the brain that typically govern such movements.
04/17/2008
02:11 PM
Aerobic Capacity and Growth Hormone Deficiency after Traumatic Brain Injury
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2008-0368
Growth hormone (GH) deficiency occurs in approximately 20% of all individuals who suffer from a moderate to severe traumatic brain injury.
04/17/2008
02:11 PM
Epileptic Spasms: A Variety of Etiologies and Associated Syndromes
Journal of Child Neurology, Vol. 23, No. 4, 407-414 (2008)
Epileptic spasms have been described as a paroxysmal epileptic seizure type that consists of a series of motor movements, involving sudden flexion or extension predominantly of axial and/or proximal limb muscles, occurring with a noticeable periodicity, outside the age of infantile spasms, but have otherwise not been well characterized or described.
04/17/2008
02:10 PM
Social Networks and Incident Stroke Among Women With Suspected Myocardial Ischemia
Psychosomatic Medicine 70:282-287 (2008)
To describe the prospective relationship between social networks and nonfatal stroke events in a sample of women with suspected myocardial ischemia. Social networks are an independent predictor of all-cause and cardiovascular mortality, but their relationship with stroke events in at-risk populations is largely unknown.
04/17/2008
02:09 PM
Folate, Vitamin B6, Vitamin B12, and Methionine Intakes and Risk of Stroke Subtypes in Male Smokers
American Journal of Epidemiology 2008 167(8):954-961
The associations of dietary folate, vitamin B6, vitamin B12, and methionine intakes with risk of stroke subtypes were examined among 26,556 male Finnish smokers, aged 50-69 years, enrolled in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Dietary intake was assessed at baseline by using a validated food frequency questionnaire.
04/17/2008
02:08 PM
Evidence-Based Versus Reported Epilepsy Management Practices
Journal of Child Neurology 2008, doi:10.1177/0883073807309785
04/17/2008
02:07 PM
Translational research in glioblastoma multiforme: molecular criteria for patient selection
Future Oncology, Volume 4, Number 2, April 2008 , pp. 219-228(10)
In spite of the dismal outcome of glioblastoma multiforme (GBM), we are in a position to provide a ray of hope to patients and families. Methylation of MGMT in tumor occurs in approximately a third of patients and predicts meaningful response and survival to adjuvant radiotherapy plus temozolomide.
04/17/2008
02:06 PM
Refining Frontotemporal Dementia With Parkinsonism Linked to Chromosome 17
Arch Neurol. 2008;65(4):460-464
Frontotemporal dementia with parkinsonism (FTDP) is a major neurodegenerative syndrome, particularly for those with symptoms beginning before age 65 years. A spectrum of degenerative disorders can present as sporadic or familial FTDP.
04/17/2008
02:05 PM
Timing of Neonatal Seizures and Intrapartum Obstetrical Factors
Journal of Child Neurology 2008, doi:10.1177/0883073807313049
04/17/2008
02:04 PM
Quantifying Pediatric Neuro-oncology Risk Factors: Development of the Neurological Predictor Scale
Journal of Child Neurology, Vol. 23, No. 4, 455-458 (2008)
Pediatric neuro-oncology researchers face methodological challenges associated with quantifying the influence of tumor and treatment-related risk factors on child outcomes. The Neurological Predictor Scale was developed to serve as a cumulative index of a child's exposure to risk factors.
04/17/2008
02:03 PM
Psychosis With Frontal Lobe Epilepsy Responds to Carbamazepine
Journal of Child Neurology, Vol. 23, No. 4, 431-434 (2008)
Frontal lobe epilepsy is an unusual form of complex partial seizures associated with behavioral changes including fear, agitation, kicking, and screaming. The seizures are often missed or mistaken for psychiatric problems or sleep disorders.
04/17/2008
02:03 PM
Is continuous insulin treatment safe in aneurysmal subarachnoid hemorrhage?
Vascular Health and Risk Management Issue: ON-LINE EARLY
To investigate the long-term effect of continuous insulin infusion for glucose control on cerebral metabolism in aneurysmal subarachnoid hemorrhage (SAH) patients.
04/17/2008
02:02 PM
Behavioral Disorders in Children With Idiopathic Intracranial Hypertension
Journal of Child Neurology, Vol. 23, No. 4, 447-450 (2008)
The purpose of this research was to evaluate the association between idiopathic intracranial hypertension and behavior, attention, and learning abilities in children. Parents of school-age children with idiopathic intracranial hypertension were asked to fill out a questionnaire and to rank the child's behavioral patterns before and after the diagnosis and treatment of the disease.
04/17/2008
02:01 PM
Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis
Int J Med Sci 2008; 5:92-99
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. Previous proteomic evidence revealed that the content of certain peptide fragments including Vgf-derived peptide aa 398-411 (Vgf398-411) of the precursor Vgf protein in the cerebral spinal fluid (CSF) correctly identified patients with ALS from normal and disease controls.
04/17/2008
01:59 PM
Cortical processing of residual ano-rectal sensation in patients with spinal cord injury: an fMRI study
Neurogastroenterology and Motility, Volume 20, Number 5, May 2008 , pp. 488-497(10)
Eleven paraplegic patients with complete traumatic spinal cord injuries (SCI) [according to American Spinal Injury Association (ASIA) criteria] at different levels (Th3-L3) were investigated during non-painful stimulation of the distal rectum and anal canal, using event related functional magnetic resonance imaging.
04/17/2008
01:58 PM
Quantitative Estimation of Permeability Surface-Area Product in Astroglial Brain Tumors Using Perfusion CT and Correlation with Histopathologic Grade
American Journal of Neuroradiology 29:694-700, April 2008
Glioma angiogenesis and its different hemodynamic features, which can be evaluated by using perfusion CT (PCT) imaging of the brain, have been correlated with the grade and the aggressiveness of gliomas.
04/17/2008
01:58 PM
Increased Cochlear Fluid-Attenuated Inversion Recovery Signal in Patients with Vestibular Schwannoma
American Journal of Neuroradiology 29:720-723, April 2008
Elevated protein levels have been reported in perilymph of patients with vestibular schwannoma. Fluid-attenuated inversion recovery (FLAIR) imaging is sensitive to high protein contents in fluids.
04/17/2008
01:57 PM
Diagnostic Accuracy and Interobserver Variability of Pulsed Arterial Spin Labeling for Glioma Grading
cta Radiologica, Volume 49, Issue 4 2008 , pages 450 - 457
Although pulsed arterial spin labeling (PASL) enables the reliable qualitative grading of brain tumors, its use in quantification for glioma grading may be hampered by the limited interobserver variability associated with low spatial resolution.
04/17/2008
01:56 PM
Towards a non-invasive interictal application of hypothermia for treating seizures: a feasibility and pilot study
Acta Neurologica Scandinavica doi:10.1111/j.1600-0404.2008.01008.x
To evaluate the feasibility and safety of head-neck cooling in conscious normal volunteers (10) and patients with medically refractory epilepsy (5) without causing shivering.
04/17/2008
01:55 PM
Silver syndrome variant of hereditary spastic paraplegia. A locus to 4p and allelism with SPG4
Neurology 2008, doi:10.1212/01.wnl.0000294330.27058.61
To perform a clinical and genetic study of two large Italian families (RM-36 and RM-51) showing the cardinal clinical features of Silver syndrome (SS), a rare dominantly inherited form of hereditary spastic paraplegia (HSP) complicated by amyotrophy of the small hand muscles.
04/17/2008
01:54 PM
Clinical Diagnosis of Ventriculoperitoneal Shunt Failure Among Children With Hydrocephalus
Pediatric Emergency Care. 24(4):201-210, April 2008
To define the significance of various symptoms and signs in the diagnosis of ventriculoperitoneal shunt failure and infection.
04/17/2008
01:53 PM
Rapid Eye Movement Sleep Disturbances in Huntington Disease
Arch Neurol. 2008;65(4):482-488
Sleep disorders including insomnia, movements during sleep, and daytime sleepiness are common but poorly studied in Huntington disease (HD).
04/17/2008
01:53 PM
Patients Homozygous and Heterozygous for SNCA Duplication in a Family With Parkinsonism and Dementia
Arch Neurol. 2008;65(4):514-519
Multiplication of the {alpha}-synuclein gene (SNCA) (OMIM 163890) has been identified as a causative mutation in hereditary Parkinson disease or dementia with Lewy bodies.
04/17/2008
01:52 PM
Disruption of Sodium Bicarbonate Transporter SLC4A10 in a Patient With Complex Partial Epilepsy and Mental Retardation
Arch Neurol. 2008;65(4):550-553
To determine gene(s) disrupted in a patient with partial frontal lobe epilepsy and cognitive impairment with concomitant de novo balanced chromosomal translocation t(2;13)(q24;q31).
04/17/2008
01:51 PM
Cryptogenic Epileptic Syndromes Related to SCN1A
Arch Neurol. 2008;65(4):489-494
Sodium channel alpha 1 subunit gene, SCN1A, is the gene encoding the neuronal voltage-gated sodium channel {alpha} 1 subunit (Nav1.1) and is mutated in different forms of epilepsy. Mutations in this gene were observed in more than 70% of patients with severe myoclonic epilepsy of infancy (SMEI) and were also found in different types of infantile epileptic encephalopathy.
04/17/2008
01:50 PM
Training of Reaching in Stroke Survivors With Severe and Chronic Upper Limb Paresis Using a Novel Nonrobotic Device. A Randomized Clinical Trial
Stroke doi: 10.1161/STROKEAHA.107.498485
Severe upper limb paresis is a major contributor to disability after stroke. This study investigated the efficacy of a new nonrobotic training device, the Sensorimotor Active Rehabilitation Training (SMART) Arm, that was used with or without electromyography-triggered electrical stimulation of triceps brachii to augment elbow extension, permitting stroke survivors with severe paresis to practice a constrained reaching task.
04/17/2008
01:49 PM
Fas System Activation in Perihematomal Areas After Spontaneous Intracerebral Hemorrhage
Stroke doi: 10.1161/STROKEAHA.107.500876
Apoptosis has been implicated as the prominent form of cell death in the brain perihematomal region in animal models and in autopsy or postsurgical human studies. Both the Fas system and caspase activation play a central role in apoptotic pathways. The aims of this study were to investigate soluble Fas (s-Fas) plasma levels after acute intracerebral hemorrhage (ICH), to determine its influence on clinical and radiologic features, and to assess Fas receptor and Fas ligand (Fas-L) protein expression in human ICH brain tissue.
04/17/2008
01:49 PM
Effects of Neuroglobin Overexpression on Acute Brain Injury and Long-Term Outcomes After Focal Cerebral Ischemia
Stroke doi: 10.1161/STROKEAHA.107.506022
Emerging data suggest that neuroglobin (Ngb) may protect against hypoxic/ischemic neuronal insults. However, the underlying mechanisms in vivo and implications for long-term outcomes are still not well understood.
04/17/2008
01:48 PM
DP-b99, a Membrane-Activated Metal Ion Chelator, as Neuroprotective Therapy in Ischemic Stroke
Stroke doi: 10.1161/STROKEAHA.107.506378
DP-b99 is a chelator of zinc and calcium ions that acts selectively within cell membranes and has neuroprotective properties in animal models of stroke. We present the results of a multicenter, double-blind, placebo-controlled, randomized trial to assess the safety and potential protective effects of DP-b99 in acute ischemic stroke.
04/17/2008
01:47 PM
Critical Cap Thickness and Rupture in Symptomatic Carotid Plaques. The Oxford Plaque Study
Stroke doi: 10.1161/STROKEAHA.107.507988
Advances in carotid plaque imaging could allow quantification of fibrous cap thickness in vivo. While a cap thickness <65 µm is the accepted definition of rupture-prone plaque in the coronary circulation, the threshold value for carotid plaques is unknown.
04/17/2008
01:46 PM
Characterization of Cortical Microvascularization in Adult Moyamoya Disease
Stroke doi: 10.1161/STROKEAHA.107.501759
Increased cortical microvascularization has been proposed to be a Moyamoya disease (MMD)-specific characteristic. It was the aim of our study to characterize the anatomic pattern and microhemodynamics of cortical microvascularization in MMD.
04/17/2008
01:46 PM
Assessment of Intracranial Collateral Flow by Using Dynamic Arterial Spin Labeling MRA and Transcranial Color-Coded Duplex Ultrasound
Stroke doi: 10.1161/STROKEAHA.107.503482
To evaluate the potential of a new dynamic MRA sequence (DynAngio) based on arterial spin labeling for the assessment of intracranial collateral flow.
04/17/2008
01:45 PM
Acute Stroke Imaging Research Roadmap
Stroke doi: 10.1161/STROKEAHA.107.512319
The recent "Advanced Neuroimaging for Acute Stroke Treatment" meeting on September 7 and 8, 2007 in Washington DC, brought together stroke neurologists, neuroradiologists, emergency physicians, neuroimaging research scientists, members of the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), industry representatives, and members of the US Food and Drug Administration (FDA) to discuss the role of advanced neuroimaging in acute stroke treatment.
04/17/2008
01:44 PM
Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome
Neurology 2008, doi:10.1212/01.wnl.0000303813.95800.0d
Lennox-Gastaut syndrome is a catastrophic pediatric epilepsy syndrome characterized by multiple types of treatment-resistant seizures and high rates of seizure-related injury. Current available treatments are inadequate, leaving patients with few treatment options and opportunities.
04/17/2008
01:43 PM
Results from a phase I safety trial of hAADC gene therapy for Parkinson disea
Neurology 2008, doi:10.1212/01.wnl.0000312381.29287.ff
In a primate model of Parkinson disease (PD), intrastriatal infusion of an adeno-associated viral (AAV) vector containing the human aromatic L-amino acid decarboxylase (hAADC) gene results in robust gene expression.
04/17/2008
01:42 PM
Total cholesterol and the risk of Parkinson disease
Neurology 2008, doi:10.1212/01.wnl.0000312511.62699.a8
To examine the association between serum total cholesterol at baseline and the risk of Parkinson disease (PD).
04/17/2008
01:39 PM
Long-term efficacy of gamma knife radiosurgery in mesial temporal lobe epilepsy
Neurology 2008, doi:10.1212/01.wnl.0000294326.05118.d8
Gamma knife (GK) radiosurgery has been proposed as an alternative to classic microsurgery in mesial temporal lobe epilepsy (MTLE). Short-term follow-up studies have reported encouraging results, but long-term efficacy is not known.
04/17/2008
01:38 PM
Therapy-based rehabilitation services for patients living at home more than one year after stroke
Cochrane Database of Systematic Reviews 2008 Issue 2
Current practice of rehabilitation intervention mainly concentrates on the first six months of stroke. At present, there is no agreed consensus about the benefits of such a service more than one year after stroke.
04/17/2008
01:37 PM
Therapeutic exercise for people with amyotrophic lateral sclerosis or motor neuron diseas
Cochrane Database of Systematic Reviews 2008 Issue 2
Despite the high incidence of muscle weakness in individuals with amyotrophic lateral sclerosis (ALS) or motor neuron disease (MND), the effects of exercise in this population are not well understood.
04/17/2008
01:36 PM
Effects of Action Observation on Physical Training After Stroke
Stroke doi: 10.1161/STROKEAHA.107.508184
In healthy humans, observation of another individual performing a motor training task (action observation [AO]) facilitates, in the observer, the effects of physical training (PT) on motor memory formation. It is not known whether this facilitatory process, of potential value for neurorehabilitation, occurs after stroke.
04/17/2008
01:34 PM
Case 12-2008 - A Newborn Infant with Intermittent Apnea and Seizures
NEJM Volume 358:1713-1723 April 17, 2008 Number 16
A 1-day-old female infant was admitted to the neonatal intensive care unit of this hospital because of intermittent apnea and cyanosis. The day before admission, the patient was born at another hospital at 41 weeks 4 days' gestation to a 33-year-old primigravid mother. After 44 hours of labor, during which the amniotic membranes were artificially ruptured (17 hours before delivery) and the mother's temperature rose to 38.0°C, with a white-cell count of 26,700 per cubic millimeter, a cesarean section was performed because of failure of labor to progress.
04/17/2008
01:34 PM
APOE epsilon4 lowers age at onset and is a high risk factor for Alzheimer's disease; a case-control study from central Norway
BMC Neurology 2008, 8:9
The objective of this study was to analyze factors influencing the risk and timing of Alzheimer's disease (AD) in central Norway. The APOE epsilon4 allele is the only consistently identified risk factor for late onset Alzheimer's disease (LOAD). We have described the allele frequencies of the apolipoprotein E gene (APOE) in a large population of patients with AD compared to the frequencies in a cognitively-normal control group, and estimated the effect of the APOE epsilon4 allele on the risk and the age at onset of AD in this population.
04/17/2008
01:32 PM
Shape (But Not Volume) Changes in the Thalami in Parkinson Disease
BMC Neurology 2008, 8:8
Recent pathological studies have suggested that thalamic degeneration may represent a site of non-dopaminergic degeneration in Parkinson's Disease (PD). Our objective was to determine if changes in the thalami could be non-invasively detected in structural MRI images obtained from subjects with Parkinson disease (PD), compared to age-matched controls.
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