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J Neuropsychiatry Clin Neurosci 19:187-190, May 2007
The authors describe clinical, neuropsychological, and neuroimaging findings in a 70-year-old man with a cystic lesion in the midline cerebellum. He presented with pathological crying in parallel to a worsening of his ataxia. This report suggests a role for the cerebellum in the regulation of emotional expression.
Genetic factors for brain arteriovenous malformation are unexplored because of the low incidence of familial cases, albeit local and familial clustering. We used a combination of a linkage study and an association study to explore the genetic background.
European Journal of Neurology, Volume 14, Number 4, April 2007, pp. 428-434(7)
The objective of the present study was to examine the association between a polymorphism of the aldehyde dehydrogenase 2 (ALDH2) gene and lacunar infarcts of the brain.
The purpose of this study is to explore whether or not the levels of caspase-3 (Casp3), neuron-specific enolase
(NSE), and high-sensitivity C-reactive protein (hsCRP) were elevated in cerebrospinal fluid
(CSF) and serum of patients after aneurysmal subarachnoid hemorrhage
(SAH).
The role of athersclerosis in the difference between the pathogenesis of large-vessel disease
(LVD) and small-vessel disease (SVD) is a matter of debate. Common carotid artery
intima-media thickness (CCA IMT) is a marker of atherosclerosis. Our aim was to compare CCA IMT between SVD and LVD patients.
Seizure Volume 16, Issue 2 , March 2007, Pages 160-165
Myoclonic epilepsy is a common epileptic syndrome with high genetic contribution. We described a pedigree in which 10 individuals presented with a non-progressive, adult-onset myoclonic epilepsy.
Seizure Volume 16, Issue 3 , April 2007, Pages 195-203
To identify the clinical characteristics associated with poor psychosocial functioning among Spanish patients with epilepsy but no other neurological or psychiatric disorder.
Seizure Volume 16, Issue 3 , April 2007, Pages 248-253
In this study 30 patients with symptomatic epilepsy caused by cavernomas were investigated in a postoperative follow up study to assess predictors for postoperative outcome with respect to indications, time and approach of surgery.
Seizure Volume 16, Issue 3 , April 2007, Pages 254-260
To identify the prevalence, clinical characteristics and routine EEG features of the syndrome of eyelid myoclonia with absences
(EMA) using a retrospective case control study design.
Seizure Volume 16, Issue 3 , April 2007, Pages 276-282
Ictal transient opercular syndrome is rarely observed in benign epilepsy with
centro-temporal spikes in children, and even more rarely in epilepsia partialis continua and symptomatic focal status epilepticus in adults.
Little is known about the role of endothelial cells (ECs) in the pathogenesis of cerebral cavernous malformation because of the difficulties to obtain highly pure
ECs. Thus, this study attempted to establish a reliable procedure to isolate and culture ECs from human cerebral cavernous malformation lesions. The biological features and the angiogenic potential of the cultured ECs were also investigated.
We determined the relationship between secondary insults (hypoxia, hypotension, and hypothermia) occurring prior to or on admission to hospital and 6-month outcome after traumatic brain injury
(TBI).
European Journal of Neurology, Volume 14, Number 4, April 2007, pp. 424-427(4)
Pathogenesis of febrile seizures (FS), causing the most common of types of seizures in children, remains unknown. Genetic factors appear to play a pivotal role and FS can be inherited as a monogenic or genetically complex disorder.
Thrombolysis for acute ischemic stroke saves societal costs, but hospitals that practice acute stroke care appear to shoulder the burden of the cost, which exceeds reimbursement. With creation of the diagnosis-related group
(DRG) 559, the US Centers for Medicare and Medicaid Services pays hospitals approximately US $6000 more per case when thrombolysis is administered.
Brain aneurysms and vascular malformations can cause cerebral hemorrhages, with devastating consequences for the patients and their families. Since the development of microcatheters and materials used for endovascular
embolization, we have witnessed a rapid advancement in the technology and in the number or patients treated with this approach.
In the rural United States, patients with stroke are usually first evaluated locally by a nonneurologist physician
(NNP) before treatment is determined.
Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:501-507
Conventional MRI can provide critical information for care of patients with traumatic brain injury
(TBI), but MRI abnormalities rarely correlate to clinical severity and outcome. Previous magnetic resonance spectroscopy studies have reported clinically relevant brain metabolic changes in patients with
TBI. However, these changes were often assessed a few to several days after the trauma, with a consequent variation of the metabolic pattern due to temporal changes.
Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:508-511
To identify the proportion of patients in a large idiopathic normal pressure hydrocephalus
(INPH) cohort with large head circumference (HC) who presumably have congenital hydrocephalus that has not become clinically apparent until late in life.
Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:497-500
To compare the preoperative and postoperative health-related quality of life
(QOL) and psychological state of patients with asymptomatic unruptured intracranial aneurysms
(ICAs) who underwent elective surgery.
Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:454-456
In a study of 43 patients attending postgraduate neurology grand rounds, patients agreed that their history was described accurately (95%), they were relaxed (91%), the audience was not intimidating (84%), and that they had been well informed (70%); but only 62% found the meeting useful and 18% would have liked to have spoken more. Neurologists’ blinded ratings of their patients’ perceptions were concordant in 234 (91%) of 258 paired ratings.
Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:539-541
The pharmacological management of dysautonomia, otherwise known as autonomic storms, following acute neurological insults, is problematic and remains poorly researched. This paper presents six subjects with dysautonomia following extremely severe traumatic brain injury where gabapentin controlled paroxysmal autonomic changes and posturing in the early post-acute phase following limited success with conventional medication regimens.
We present the case of a patient with a symptomatic calcified chronic subdural haematoma
(CSDH), or a so-called "armoured-brain", who was admitted to our hospital with clinical signs of tentorial
herniation.
To evaluate the efficacy and safety of retigabine 600, 900, and 1,200 mg/day administered three times daily as adjunctive therapy in patients with partial-onset seizures.
Arachnoid cysts are intra-arachnoidal cerebrospinal fluid collections most frequently seen in the middle cranial
fossa. The optimal method of treatment for symptomatic arachnoid cysts remains controversial and includes cyst shunting, open craniotomy and endoscopic fenestration.
ABCA2 is a member of the adenosine triphosphate-binding cassette transporter superfamily and is proposed to exert critical functions in the transmembrane transport of endogenous lipids such as myelin.
American Journal of Neuroradiology 28:759-760, April 2007
Korsakoff-like amnestic syndromes have been rarely described following structural lesions of the central nervous system. In this report, we describe a case of acute
Korsakoff-like syndrome resulting from the combination of a left anteromedian thalamic infarct and a right hippocampal hemorrhage. We also review the literature relevant to the neuropathology and pathophysiology of Korsakoff syndrome and anterograde amnesia.
American Journal of Neuroradiology 28:622-627, April 2007
The role of blood-flow biomechanics on the size, morphology, and growth of cerebral aneurysms is poorly known. The purpose of this study was to evaluate
intra-aneurysmal hemodynamics before and after aneurysm growth.
American Journal of Neuroradiology 28:628-634, April 2007
3D time-of-flight MR angiography (3D TOF MRA) may be used as noninvasive alternative to digital subtraction angiography
(DSA) for the follow-up of patients with intracranial aneurysms treated with Guglielmi detachable coils
(GDCs).
Intracranial stenting has been used in the treatment of ischemic stroke caused by acute intracranial vessel occlusion after unsuccessful recanalization with the Merci retriever. We describe our early experience with this technique.
Journal of Head Trauma Rehabilitation. 22(2):75-84, March/April 2007
Traumatic brain injury is an important public health problem in the United States, especially for individuals from racial and ethnic minorities. The first part of this article provides a synthesis of findings and discussions of cultural issues in the rehabilitation, medical, and psychological scientific literature highlighting the needs and challenges of our diverse population of minority traumatic brain injury survivors in the United States.
Journal of Neurotrauma Feb 2007, Vol. 24, No. 2 : 421 -432
Following spinal cord injury (SCI), descending axons that carry motor commands from the brain to the spinal cord are injured or transected, producing chronic motor dysfunction and paralysis.
Subdural rhabdomyosarcoma is very rare, and even more unusual is the association between these sarcomas and chronic subdural
hematoma. In this report, we present a case of subdural rhabdomyosarcoma that developed in a chronic refractory subdural
hematoma.
American Journal of Neuroradiology 28:603-607, April 2007
As an essential part of the National Cancer Institute (NCI)-funded Pediatric Brain Tumor Consortium
(PBTC), the Neuroimaging Center (NIC) is dedicated to infusing the study of pediatric brain tumors with imaging "best practice" by producing a correlative research plan that 1) resonates with novel therapeutic interventions being developed by the wider
PBTC, 2) ensures that every PBTC protocol incorporates an imaging "end point" among its objectives, 3) promotes the widespread implementation of standardized technical protocols for
neuroimaging, and 4) facilitates a quality assurance program that complies with the highest standards for image data transfer, diagnostic image quality, and data integrity. To accomplish these specific objectives, the NIC works with the various PBTC sites (10 in all, plus NCI/ National Institute of Neurological Diseases and Stroke representation) to ensure that the overarching mission of the consortium-to better understand tumor biology and develop new therapies for central nervous system tumors in children-is furthered by creating a uniform body of imaging techniques, technical protocols, and standards.
Journal of Trauma-Injury Infection & Critical Care. 62(4):951-963, April 2007
To determine the opinions of neurosurgeons regarding the care of the injured and to assess the impact of these attitudes on the care of the patients with brain injuries.
Brain infarction is one of the common causes of death and also a major cause of severe disability. To identify a
gene(s) susceptible to brain infarction, we performed a large-scale association study of Japanese patients with brain infarction, using 52608 gene-based single nucleotide polymorphism
(SNP) markers.
Complementary Therapies in Medicine Volume 15, Issue 1 , March 2007, Pages 46-53
Stroke is a leading cause of morbidity and mortality in many countries. Green tea is a simple and inexpensive beverage that is showing promise in the prevention of several diseases, including stroke. However, epidemiological studies examining the preventive effects of tea on stroke have generated inconsistent results.
Journal of Neurotrauma Feb 2007, Vol. 24, No. 2 : 329 -337
We studied the prognostic value of a wide range of conventional and novel prognostic factors on admission after traumatic brain injury
(TBI) using both univariate and multivariable analysis.
To report the presence of microscopic neoplasms of the testis in men with anti-Ma2-associated encephalitis (Ma2-encephalitis) and to discuss the clinical implications.
Contrast material enhancement for cross-sectional imaging has been used since the mid 1970s for computed tomography and the mid 1980s for magnetic resonance imaging. Knowledge of the patterns and mechanisms of contrast enhancement facilitate radiologic differential diagnosis.
Journal of Head Trauma Rehabilitation. 22(2):113-121, March/April 2007
To determine whether race/ethnicity and proficiency with the English language influence access to rehabilitation services, and ultimately outcome after traumatic brain injury
(TBI).
Diffuse arteriovenous malformations (AVM) have non-compact niduses, irregular margins, and intervening brain parenchyma. Deep perforating arteries often contribute to the ragged border of these diffuse AVMs.
Injury Extra Volume 38, Issue 5 , May 2007, Pages 175-178
On the 24th May 2003, the Aeromedical Retrieval Service Careflight
International, Australia was tasked to retrieve and transfer a patient from
Noumea, New Caledonia, in the Pacific Ocean, to a neurosurgical unit in Sydney, Australia.
Cerebral infarction would be expected to be associated with poor outcome after aneurysmal subarachnoid hemorrhage
(SAH), although there are few data on which to base this assumption. The goals of this study were to determine the impact of cerebral infarction on outcome and to examine predictors of infarction in these patients.
Although many patients show a satisfactory physical outcome after aneurysmal subarachnoid hemorrhage
(SAH), disabling cognitive dysfunction may still be present.
American Journal of Neuroradiology 28:750-758, April 2007
We investigated the association of multisection CT angiography (MSCTA) and perfusion CT (PCT) for the characterization of vasospasm secondary to aneurysmal subarachnoid hemorrhage.
Seizure Volume 16, Issue 2 , March 2007, Pages 185-189
Levetiracetam (LEV) is a novel antiepileptic drug (AED) that has recently obtained marketing authorisation for use in children. The purpose of this study was to assess the efficacy, tolerability and retention rate of LEV in children with refractory epilepsies.
Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2006-2013
In this prospective, double-blind, randomized, placebo-controlled study, we evaluated the hypothesis that oral alendronate administration would preserve BMD when administered soon after acute SCI.
Journal of Head Trauma Rehabilitation. 22(1):56-64, January/February 2007
Despite significant advances in the understanding of pediatric traumatic brain injury
(TBI)-related sequelae, members of the medical community working with adult survivors often do not appreciate the impact of "latent" effects of these injuries.
Critical Care Medicine. 35(4):1027-1031, April 2007
Survival of patients with severe traumatic brain injury may be improved by minimizing secondary brain injury. We aimed to identify potentially modifiable contributors to secondary brain injury that may persist and adversely affect patient outcome.
Seizure Volume 16, Issue 2 , March 2007, Pages 95-98
Data are limited on seizure recurrence after antiepileptic drug (AED) discontinuation in operated seizure-free patients. We reviewed seizure outcome in patients who came off AEDs after being seizure-free for 2 years following temporal lobe surgery in our center.
The purpose of this study was to evaluate seizure outcome in children with intractable secondary generalized epilepsy without a resectable focus who underwent complete corpus callosotomy and compare these results to those of anterior two-third
callosotomy.
To evaluate whether the presence of leukoaraiosis or multiple lacunes is associated with symptomatic intracerebral hemorrhage
(ICH) and 90-day outcome after thrombolytic treatment with tissue plasminogen activator
(tPA).
Early CT signs of cerebral ischemia are subtle. Little is known of which factors influence the detection of infarct signs. We compared neuroradiologists’ scan readings with those of other specialists involved in the care of stroke patients.
To determine the evolution of NNPs' familiarity and attitudes about using recombinant tissue plasminogen activator
(rtPA) since this therapy has been approved.
To evaluate the efficacy and safety of retigabine 600, 900, and 1,200 mg/day administered three times daily as adjunctive therapy in patients with partial-onset seizures.
A number of techniques are being investigated to accomplish bladder control recovery in paralyzed patients using the
neurostimulation, but currently, all techniques are based on the dorsal implantation of the electrodes using a
laminectomy.
The issue of whether nitric oxide (NO) production is beneficial or deleterious on ischemic injuries of the central nervous system still remains doubtful.
In glioma of World Health Organization (WHO) grade II (low-grade glioma), the natural course of a particular patient is not predictable and the treatment strategy is controversial. We determined prognostic factors in adult patients with untreated,
nonenhancing, supratentorial low-grade glioma with special regard to PET using the amino acid O-(2-18F-fluoroethyl)-L-tyrosine (18F-FET) and
MRI.
The Journal of Obstetrics and Gynaecology Research, Volume 33, Number 2, April 2007, pp. 195-198(4)
We report the case of a 25-year-old Malay woman, admitted for preterm delivery at 35 weeks' gestation. Vaginal swab did not isolate any organism. She delivered a baby girl who developed respiratory distress syndrome, requiring ventilation.
Brainstem tumors comprise 10-20% of all pediatric central nervous system tumors. The management of these tumors has evolved dramatically in the past century. Once considered uniformly fatal, it is now known that brainstem tumors have distinguishing characteristics and do not behave identically.
The objective was to assess the stroke risk and prevalence of the cardiovascular risk factors and to analyze their relationship with the specific stroke rates of mortality in each of the autonomic communities of Spain.
Basilar artery occlusion (BAO) is a stroke subtype with poor prognosis, but recanalizing therapies have been reported to be effective. We investigated whether initial admission to telemedically linked general hospitals with subsequent stroke-center transfer is related to poorer outcome than direct admission to stroke centers.
Journal of Neurotrauma Feb 2007, Vol. 24, No. 2 : 281 -286
We aimed to describe and quantify the relationship between cause of injury and final outcome following traumatic brain injury
(TBI). Individual patient data (N = 8708) from eight therapeutic Phase III randomized clinical trials in moderate or severe
TBI, and three TBI surveys were used to investigate the relationship between cause of injury and outcome, as assessed by the Glasgow Outcome Scale
(GOS) at 6 months.
Archives of Physical Medicine and Rehabilitation Volume 88, Issue 3 , March 2007, Pages 302-308
To assess the psychometric properties of the National Institutes of Health Stroke Scale
(NIHSS) in people with either left or right acute hemisphere stroke for the purpose of improving the scale’s sensitivity in detecting neurologic impairment.
C-reactive protein (CRP) is used as an indicator of inflammatory processes. However, its expression is unspecific and will increase after surgery. Without normative data on its regular course after craniotomy, postoperative infection can barely be detected or excluded.
Treatment of posterior circulation aneurysms poses a great technical challenge for the practicing neurosurgeon. The advent of endovascular techniques has made such treatment more feasible. We report our experience with the endovascular management of ruptured and unruptured posterior circulation aneurysms during the past 10 years.
Acute basilar artery occlusion portends high risk of stroke and death. Thrombolysis or endovascular therapy has been limited to patients who present within hours of symptom onset. Without
recanalization, acute basilar artery occlusion almost always results in death or severe disability.
Child's Nervous System, Volume 23, Number 4, April 2007, pp. 421-425(5)
Prenatal diagnosis of myelomeningocele (MMC) has permitted a better planning for optimum management of the disease. More recently, it has allowed for a possible intrauterine repair of the spinal defect.
Child's Nervous System, Volume 23, Number 4, April 2007, pp. 431-435(5)
We established a routine protocol for concussion evaluation in athletes for nonmedical personnel. The evaluation, management guidelines, and return-to-play recommendations were summarized with a memorable mnemonic on a convenient handheld card.
Stereotyped motor behaviors, known as "punding," originally described among amphetamine abusers have only recently been reported in Parkinson disease associated with both
pro-(eg, levodopa) or anti-(eg, quetiapine) dopaminergic therapy. We describe a non–Parkinson disease case of nonpharmacologically induced punding as a complication of a brain stem cardiovascular accident.
To enable self-reporting of functional outcome in quality registers, the corresponding questions have to be easy to interpret. In scientific research, the modified Rankin Scale
(mRS) is a standard assessment method.
Vascular disorders that increase risk for stroke may be accompanied by decrements in cognitive functioning and by stroke symptoms in the absence of diagnosed stroke or transient ischemic attack. This study evaluates relationships among cognitive status, stroke symptom reports, and cardiovascular and behavioral factors.
Journal of Trauma-Injury Infection & Critical Care. 62(3):647-656, March 2007
Fluid therapy and/or acute lung injury may increase intra-abdominal pressure
(IAP) and intrathoracic pressure, thereby increasing intracranial pressure
(ICP) after traumatic brain injury (TBI). Further fluid administration to support cerebral perfusion or increasing ventilatory support to treat acute lung injury further increases
ICP.
Seizure Volume 16, Issue 2 , March 2007, Pages 173-184
Quality of life is impaired in patients with epilepsy and can be improved by effective therapy. Randomised clinical trials have shown that lamotrigine treatment is associated with improved quality of life.
European Journal of Neurology, Volume 14, Number 4, April 2007, pp. 387-390(4)
Five young children developed slowly progressive hemiparesis as the initial manifestation of Rasmussen encephalitis (RE). Three have remained seizure free over an observational period of 1.3-1.9-years. In the remaining two patients, seizures occurred after 0.5 and 0.6-years respectively. We suggest that RE might be presently underdiagnosed and should be suspected in cases of new onset
hemiparesis.
Journal of Neurotrauma Mar 2007, Vol. 24, No. 3 : 435 -445
To test if observed vs. expected mortality differs by age among traumatic brain injury
(TBI) cases, a population-based, historical cohort study was conducted in Olmsted County, Minnesota.
Headache: The Journal of Head and Face Pain, Volume 47, Number 3, March 2007, pp. 438-441(4)
We describe a 47-year-old woman with a 3-year history of a continuum mild-moderate right-side headache, with exacerbations, associated with stabbing volleys of pain on right orbit-temporal region (10/10) and right eye ptosis and lacrimation with conjunctival injection.
Clinical Journal of Sport Medicine. 17(1):31-37, January 2007
Following the Second International Conference on Concussion in Sport in 2005, a summary agreement statement was published that introduced new terminology for sport-related concussions. This new classification system is binary
(ie, "simple" versus "complex" concussions). Athletes who are slow to recover
(ie, >10 days) are classified as having complex concussions.
Mental practice (MP) of a particular motor skill has repeatedly been shown to activate the same musculature and neural areas as physical practice of the skill. Pilot study results suggest that a rehabilitation program incorporating MP of valued motor skills in chronic stroke patients provides sufficient repetitive practice to increase affected arm use and function.
Stroke patients often report that primary care physicians (PCPs) are their first medical contact after onset of symptoms. We studied PCP attitudes and current practice in early management of suspected stroke patients.
To determine the relative contributions of psychological (mood and anxiety), social, and seizure-related variables to quality of life
(QOL) scores in epilepsy.
ALTHOUGH THE STUDY of the human brain is a rapidly developing and expanding science, we must take pause to examine the historical and evolutionary events that helped shape the brain of Homo sapiens. From an examination of the human lineage to a discussion of evolutionary principles, we describe the basic principles and theories behind the evolution of the human brain.
This is the first report of the rupture of a giant aneurysm in a patient who sustained a remote angiographically negative subarachnoid hemorrhage
(SAH).
Astroblastomas are rare glial neoplasms that usually occur in young adults and have a predilection for the cerebral hemispheres. Patients typically present with signs of increased intracranial pressure and seizures. Imaging studies reveal circumscribed, contrast-enhancing tumors that contain both cystic and solid components with variable peritumoral edema. Hemorrhage, which suggested the presence of a vascular lesion in this patient, has not been previously described as a feature of this neoplasm.
Journal of Trauma-Injury Infection & Critical Care. 62(3):657-663, March 2007
Postconcussion symptoms (PCS) (such as dizziness, headache, irritability, fatigue, and impaired memory) are common in patients who sustain a mild traumatic brain injury
(mTBI). However, few studies have systematically investigated the association between PCS and clinical outcomes in mTBI patients. Therefore, the present study attempted to examine PCS during the disease course and to determine whether PCS adversely affect outcome.
Guidelines for the clinical management of patients with atrial fibrillation suggest that treatment strategies for prescribing oral anticoagulant therapy should implicate change at age 60, 65 and 75 years. We examined if there is any threshold concerning risk of stroke by age.
Both transcranial Doppler (TCD) and spiral computed tomography angiography (CTA) are used for noninvasive vascular assessment tools in acute stroke. We aimed to evaluate the diagnostic accuracy of TCD against CTA in patients with acute cerebral ischemia.
Subdural rhabdomyosarcoma is very rare, and even more unusual is the association between these sarcomas and chronic subdural
hematoma. In this report, we present a case of subdural rhabdomyosarcoma that developed in a chronic refractory subdural
hematoma.
Intracranial stenting has been used in the treatment of ischemic stroke caused by acute intracranial vessel occlusion after unsuccessful recanalization with the Merci retriever. We describe our early experience with this technique.
Hypodensities on computed tomographic (CT) brain scans are thought to take at least 6 hours to become apparent after blunt head trauma. This finding, in conjunction with the later evolution of the
hypodensities, is used in timing the injury in children with suspected non-accidental brain injury, in whom the history may be inaccurate. The purpose of this study is to report the occurrence of diffuse cerebral parenchymal hypodensities on CT scans performed within 5 hours of a well-defined accidental head injury.
The purpose of this study is to explore whether or not the levels of caspase-3 (Casp3), neuron-specific enolase
(NSE), and high-sensitivity C-reactive protein (hsCRP) were elevated in cerebrospinal fluid
(CSF) and serum of patients after aneurysmal subarachnoid hemorrhage
(SAH).
Cerebral infarction would be expected to be associated with poor outcome after aneurysmal subarachnoid hemorrhage
(SAH), although there are few data on which to base this assumption. The goals of this study were to determine the impact of cerebral infarction on outcome and to examine predictors of infarction in these patients.
Diffuse arteriovenous malformations (AVM) have non-compact niduses, irregular margins, and intervening brain parenchyma. Deep perforating arteries often contribute to the ragged border of these diffuse AVMs. We hypothesized that diffuseness and deep perforator supply increase the difficulties and risks associated with microsurgical AVM resection.
C-reactive protein (CRP) is used as an indicator of inflammatory processes. However, its expression is unspecific and will increase after surgery. Without normative data on its regular course after craniotomy, postoperative infection can barely be detected or excluded.
Magnetic resonance imaging (MRI)-guided focused ultrasound is a novel technique that was developed to enable precise, image-guided targeting and destruction of tumors by
thermocoagulation.
To determine the relative contributions of psychological (mood and anxiety), social, and seizure-related variables to quality of life
(QOL) scores in epilepsy.
To describe the physiologic and behavioral characteristics of circadian rhythm sleep disorders
(CRSDs) following minor traumatic brain injury (mTBI) in patients complaining of insomnia.
To estimate changes in rates of cerebral infarction and intracerebral hemorrhage, comorbidity profile, and case fatality rates in Quebec over 15 years.
To assess the immunomodulatory effects of the purine nucleoside inosine on
macrophage/microglia activation at and near the lesion site and in white matter areas remote from the injury epicenter.
To study hemodynamic responses to CAH in humans following spinal cord injuries of various levels, and examine the effect of spinal cord integrity on the cold pressor response.
To determine the prevalence of fatigue in an outpatient spinal cord injury population and to examine the clinical variables contributing to that fatigue.
To assess the efficacy of posterior spinal shortening for paraparetic patients following vertebral collapse owing to osteoporosis, especially on instrumentation loosening.
To describe the clinical presentation and course of patients with magnetic resonance imaging
(MRI) features of subacute progressive ascending myelopathy (SPAM). A rare complication of spinal cord injury.
Seizure Volume 16, Issue 3 , April 2007, Pages 211-217
We investigated the coping styles and their correlation to psycho-social functioning in two groups of patients, the first group with drug-resistant epilepsy and the second with well-controlled epilepsy.
Geriatrics and Gerontology International, Volume 7, Number 1, March 2007, pp. 1-14(14)
Vascular dementia is the second largest cause of dementia in the elderly. There is no effective treatment for cerebral infarction, which is one of the common causes of vascular dementia. In rodent experimental models, gene therapies using growth factors such as brain-derived neurotrophic factor, fibroblast growth factor-2, hepatocyte growth factor, glial cell-line derived neurotrophic factor or vascular endothelial growth factor had beneficial effects on
neuroprotection, neurogenesis and/or angiogenesis.
Seizure Volume 16, Issue 3 , April 2007, Pages 266-270
Epidemiologic data indicate that electroconvulsive therapy (ECT) does not precipitate epilepsy. However, when an ECT patient develops this condition, one is faced with the question as to whether ECT caused it and whether ECT can be safely continued.
Seizure Volume 16, Issue 2 , March 2007, Pages 142-146
Whereas the relationship between epilepsy and anxiety has received much attention, less is known about the relationship between death anxiety and this disorder.
Annals of Emergency Medicine Volume 49, Issue 4 , April 2007, Pages 391-402.e2
Laboratory evidence indicates that progesterone has potent neuroprotective effects. We conducted a pilot clinical trial to assess the safety and potential benefit of administering progesterone to patients with acute traumatic brain injury.
Journal of Neurosurgical Anesthesiology. 19(1):10-17, January 2007
The purpose of this meta-analysis was to assess the efficacy of prophylactic administration of 5-HT3 receptor antagonists for postoperative nausea and vomiting in neurosurgical patients at 24 and 48+ hours. After a systematic search, 7 published randomized placebo controlled trials involving 448 craniotomy patients (222 treatment, 226 control) were included in the meta-analysis.
Radiosurgery is increasingly used to manage malignant melanoma brain metastases. We reviewed our series of patients who underwent radiosurgery for melanoma brain metastases to assess clinical outcomes and identify prognostic factors for survival and cerebral disease control.
Seizure Volume 16, Issue 3 , April 2007, Pages 271-275
To assess the efficacy, tolerability and safety of Levetiracetam (LEV) therapy, we identified 21 (15 male; 6 female) patients with a history of benign epilepsy with centrotemporal spikes
(BECTS), with and without secondarily generalization in children and adolescents aged between 5.0 and 12.1 years.
Patients with a perimesencephalic nonaneurysmal subarachnoid hemorrhage are not at risk for rebleeding in the initial years after the hemorrhage. Nevertheless, uncertainty remains on the long-term prognosis after perimesencephalic hemorrhage, and former patients are often considered high-risk cases for health insurance or are denied life insurance.
In the early stage of stroke, the occurrence of neurologic and medical complications is associated with clinical deterioration. Previous studies were focused on the first week after stroke onset. The aim of this study was to evaluate the impact of complications on clinical outcome in patients with stroke in the early subacute stage.
Subarachnoid hemorrhage (SAH) can be devastating, yet its initial presentation may be limited to common symptoms and subtle signs, potentially leading to misdiagnosis.
The objective of this study was to determine whether children who sought care for a head injury were at greater risk of having a subsequent head injury within the following 6 and 12 months compared with children who sought care for an injury other than to the head.
Oxidative stress plays a role in atherosclerosis. Human paraoxonase (PON) gene products exhibit antioxidant properties. We studied the significance of the Q192R and M55L polymorphisms of the PON1 gene and the C311S polymorphism of the PON2 gene in different etiologies of ischemic stroke.
Quality of life (QoL) is reduced for stroke patients and coping strategies have been suggested as determinants of
QoL. Thus far the relationship between coping and QoL has only been examined in small-scale cross-sectional designs. Therefore, the current study set out to examine this relationship in a longitudinal setting.
The abuse of stimulant drugs is increasing in the western United States. Although numerous case reports and animal studies suggest a link with stroke, epidemiologic studies have yielded conflicting results.
Ultrasound examinations for foetal brain abnormalities have been a part of the routine antenatal screening programme in the UK for many years. In utero brain magnetic resonance imaging
(MRI) is now being used increasingly successfully to clarify abnormal ultrasound findings, often resulting in a change of diagnosis or treatment plan.
American Journal of Neuroradiology 28:479-485, March 2007
Diffusion and magnetization transfer (MT) techniques have been applied to the investigation with MR of epilepsy and have revealed changes in patients with or without abnormalities on MR imaging. We hypothesized that also in the coeliac disease (CD), epilepsy and cerebral calcifications (CEC) syndrome diffusion and MT techniques could reveal brain abnormalities undetected by MR imaging and tentatively correlated to epilepsy.
Clinical Orthopaedics & Related Research. 456:98-102, March 2007
Most studies investigating articular cartilage changes use global parameters and neglect the large topological variation in the response of cartilage to immobilization and remobilization.
Journal of Neurosurgical Anesthesiology. 19(1):25-30, January 2007
The use of deep hypothermic circulatory arrest (DHCA), using groin cannulation with the chest closed
(CCDHCA), has improved the surgical treatment of large and giant cerebral aneurysms. Twelve consecutive ASA I-II patients (10 women and 2 men), with a mean age of 35 years (range 14 to 55 y) underwent DHCA for clipping or trapping of their aneurysm (giant, n=10; large, n=2; 42% posterior circulation), under balanced general anesthesia. Intraoperative standard monitors were completed with jugular oxygen saturation, pulmonary artery, pulmonary artery occlusion, central venous pressures, electroencephalography, evoked potentials, and cerebral
(subdural), and core temperature.
Journal of Neurosurgical Anesthesiology. 19(1):31-37, January 2007
Epinephrine-containing lidocaine solution is commonly infiltrated on the scalp before craniotomy. But the hemodynamic changes caused by epinephrine-containing lidocaine solution have been less intensely studied.
The American Journal of Medicine Volume 120, Issue 1 , January 2007, Pages 47-53
To evaluate trend in mortality in stroke associated with atrial fibrillation, we examined mortality trend after stroke with atrial fibrillation by calendar year period (1980-1984, 1985-1989, 1990-1994, 1995-1999, and 2000-2002).
To determine patterns of nystagmus in oculopalatal tremor (OPT, also designated oculopalatal
myoclonus) and correlate them with MRI changes in the inferior olivary nuclei (ION). Mixed
torsional-vertical pendular nystagmus (PN) in OPT has been considered to signify unilateral brainstem damage and symmetric vertical nystagmus considered to indicate bilateral disease.
Cerebrospinal fluid (CSF) leaks result from a communication between the subarachnoid space and the upper aerodigestive tract. Because of the risk of complications such as meningitis, brain abscess, and
pneumocephalus, all persistent CSF leaks should be repaired.
To retrospectively evaluate the cerebrovascular complications from elective stent placement for symptomatic intracranial stenosis and to explore preliminarily which factors are associated with complications.
Although cognitive impairment early after stroke is a powerful predictor of long-term functional dependence and dementia, little is known about the characteristics and determinants of cognitive dysfunction in acute stroke.
A limited series of patients with aneurysm were reviewed retrospectively to analyze strategies for integrating microsurgical and endovascular techniques in the management of complex, surgically intractable aneurysms.
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