Community acquired bacteraemia with sepsis in adults admitted to the intensive care unit a prospective multicentre study
Critical Care 2007, 11(Suppl 4):P42
The main objectives of this study were to describe the epidemiology and microbiology of community-acquired bacteraemia (CAB) in patients with sepsis and to determine the associated crude mortality.
09/29/2007
11:42 AM
Paradoxical embolism, deep vein thrombosis pulmonary embolism in a patient with patent foramen ovale a case report
Journal of Medical Case Reports 2007, 1:104
Coexistence of pulmonary embolism and systemic arterial embolism suggest the diagnosis of paradoxical embolism which suggests the presence of intracardiac defects such as patent foramen ovale (PFO).
09/29/2007
11:41 AM
Human and Avian Influenza Viruses Target Different Cells in the Lower Respiratory Tract of Humans and Other Mammals
American Journal of Pathology. 2007;171:1215-1223
Viral attachment to the host cell is critical for tissue and species specificity of virus infections. Recently, pattern of viral attachment (PVA) in human respiratory tract was determined for highly pathogenic avian influenza virus of subtype H5N1. However, PVA of human influenza viruses and other avian influenza viruses in either humans or experimental animals is unknown.
09/29/2007
11:40 AM
Pleural effusion associated with rheumatoid arthritis what cell predominance to anticipate
Rheumatology International, Volume 27, Number 10, August 2007 , pp. 919-925(7)
Pleural involvement is the most frequent manifestation of rheumatoid arthritis (RA) in the chest. We report here two patients who presented with large exudative pleural effusions and subsequently developed sero-positive RA. In both cases, the differential cell count of the pleural effusion suggested empyema.
09/29/2007
11:38 AM
Combustion derived nanoparticles mechanisms of pulmonary toxicity
Clinical and Experimental Pharmacology and Physiology, Volume 34, Number 10, October 2007 , pp. 1044-1050(7)
The general term `nanoparticle' (NP) is used to define any particle less than 100 nm in at least one dimension and NPs are generally classified as natural, anthropogenic or engineered in origin. Anthropogenic, also referred to as `ultrafine' particles (UFPs), are predominately combustion derived and are characterized by having an equivalent spherical diameter less than 100 nm.
09/29/2007
11:38 AM
Effect of Race on Asthma Management and Outcomes in a Large Integrated Managed Care Organization
Arch Intern Med. 2007;167:1846-1852
Morbidity from asthma disproportionately affects black people. Whether this excess morbidity is fully explained by differences in asthma severity, access to care, or socioeconomic status (SES) is unknown.
09/29/2007
11:36 AM
Pulmonary Involvement in Behcet's Disease
Respiration (DOI: 10.1159/000101954)
Behcet's disease (BD) is a multisystem vasculitis and pulmonary involvement in BD is reported to indicate poor prognosis and high mortality.
09/29/2007
11:35 AM
Antioxidant Effect of Sulphurous Thermal Water on Human Neutrophil Bursts Chemiluminescence Evaluation
Respiration (DOI: 10.1159/000107976)
The activities of the HS (sulfhydryl or thiolic) group in the cysteine of glutathione or various low-weight soluble molecules (thiolic drugs), such as N-acethylcysteine, mesna, thiopronine and dithiotreitol or stepronine and erdosteine (prodrugs), include its antioxidant activity in the airways during the release of reactive oxygen or nitrogen species (ROS, RNS) by polymorphonuclear neutrophils (PMNs) activated in response to exogenous or endogenous stimuli.
09/29/2007
11:35 AM
An Unusual Cause of T Tube Obstruction 'Tricho-Tracheobezoar'
Respiration (DOI: 10.1159/000099616)
A T tube is an upper airway device well described in the literature which is used to maintain tracheal lumen patency. Although tube occlusion is a known complication, it can be minimized by certain precautions.
09/29/2007
11:33 AM
Acute Local Tolerability of Acidic Aqueous Vehicles Delivered via Respimat Soft Mist Inhaler in Hyperreactive Asthma Patients
Respiration
(DOI: 10.1159/000107739)
Acidic inhalers can be associated with increased adverse reactions. Objectives: This study aimed to determine the acute local tolerability of acidic aqueous placebo formulations delivered via Respimat® Soft Mist Inhaler
(SMI) and placebo chlorofluorocarbon metered dose inhaler (CFC-MDI).
09/29/2007
11:32 AM
Pulmonary Radioaerosol Mucociliary Clearance in Diagnosis of Primary Ciliary Dyskinesia
Chest. 2007; 132:966-976
Methods relying on nasal ciliary motility for the diagnosis of primary ciliary dyskinesia (PCD) are often hampered by secondary ciliary dyskinesia. A functional test for pulmonary mucociliary clearance, which is not influenced by secondary nasal ciliary defects, would be a valuable tool in a PCD workup.
09/29/2007
11:31 AM
Titration Efficacy of Two Auto Adjustable Continuous Positive Airway Pressure Devices Using Different Flow Limitation Based Algorithms
Respiration (DOI: 10.1159/000103515)
Auto-adjustable continuous positive airway pressure devices are widely used in titration procedures to determine therapeutic pressure levels in obstructive sleep apnea patients. However, differences in operational characteristics may influence the effect on the apnea-hypopnea index (AHI).
09/29/2007
11:30 AM
Upper airway mechanics and post-hypoxic ventilatory decline during NREM sleep
Sleep and Breathing Volume 11, Number 3 / September, 2007 165-170
Termination of hypoxia results in a transient ventilatory decline referred to as post-hypoxic ventilatory decline (PHVD). We wished to determine whether PHVD is due to changes in ventilatory motor output or upper airway mechanics.
09/29/2007
11:24 AM
Inhaled mannitol changes the sputum properties in asthmatics with mucus hypersecretion
Respirology Volume 12 Issue 5 Page 683-691, September 2007
Most asthmatics with mucus hypersecretion have difficulty in clearing their secretions so that mucus plugs and airway obstruction are commonly present. Inhaled mannitol facilitates clearance of mucus. This study investigated the changes in the physical properties of sputum in response to mannitol in asthmatics with chronic cough and sputum production.
09/29/2007
11:23 AM
Improved lung function after thoracocentesis in patients with paradoxical movement of a hemidiaphragm secondary to a large pleural effusion
Respirology Volume 12 Issue 5 Page 719-723, September 2007
Previous studies have shown little or no improvement in pulmonary function and arterial blood oxygenation after therapeutic thoracocentesis. This study investigated changes in pulmonary function, arterial blood gases and dyspnoea after therapeutic thoracocentesis in patients with paradoxical movement (PM) of a hemidiaphragm due to pleural effusion.
09/29/2007
11:22 AM
The new ATS ERS guidelines for assessing the spirometric severity of restrictive lung disease differ from previous standards
Volume 12 Issue 5 Page 759-762, September 2007doi:10.1111/j.1440-1843.2007.01117.x
The ATS/ERS Task Force on Lung Function Testing recently proposed guidelines for the interpretation of pulmonary function tests and suggested that a reduction in FEV1 be used for categorizing both obstructive and restrictive abnormalities. This changes the severity stratification algorithm of restrictive patterns diagnosed by spirometry, that are currently categorized based on reduction in VC. This study examined the level of agreement between these two categorization schemes.
09/29/2007
11:21 AM
Effects of Continuous Positive Airway Pressure on Early Signs of Atherosclerosis in Obstructive Sleep Apnea
American Journal of Respiratory and Critical Care Medicine Vol 176. pp. 706-712, (2007)
Obstructive sleep apnea (OSA) is associated with adverse cardiovascular outcomes, including myocardial infarction and stroke. Atherosclerosis is a key mechanism for these cardiovascular events. Recent cross-sectional studies showed the presence of early signs of atherosclerosis in patients with OSA who were free of comorbidities.
09/29/2007
11:20 AM
Differential Diagnosis of Ground-Glass Opacity Nodules
Chest. 2007; 132:984-990
To differentiate among atypical adenomatous hyperplasia (AAH), bronchioloalveolar carcinoma (BAC), and adenocarcinoma showing ground-glass opacity (GGO) on CT scans, we conducted a study to determine the optimal parameter on CT number analysis using three-dimensional (3D) computerized quantification.
09/29/2007
11:19 AM
Assessment Tools for Chronic Obstructive Pulmonary Disease
The Proceedings of the American Thoracic Society 4:507-511 (2007)
The change in FEV1 has been the traditional metric used to define the progression of chronic obstructive pulmonary disease in affected patients. Consequently, various treatments have "targeted" the accelerated decline in FEV1 in an attempt to modify or alter the disease process.
09/29/2007
11:18 AM
Salmeterol and cytokines modulate inositol-phosphate signalling in Human airway smooth muscle cells via regulation at the receptor locus
Respiratory Research 2007, 8:68
Airway hyper-responsiveness (AHR) is a key feature of asthma and a causal relationship between airway inflammation and AHR has been identified. The aim of the current study was to clarify the effect of proinflammatory cytokines and asthma medication on primary human airway smooth muscle (ASM) inositol phosphate (IPx) signalling and define the regulatory loci involved.
09/29/2007
11:07 AM
When should home mechanical ventilation be started in patients with different neuromuscular disorders
Respirology Volume 12 Issue 5 Page 749-753, September 2007
Current international consensus guidelines identify a number of indicators for the establishment of home mechanical ventilation (HMV) for patients with neuromuscular diseases but do not address the possible clinical differences between each of the underlying disorders. This study assessed the differences in the physiological parameters of patients with neuromuscular disease commenced on HMV for the treatment of symptomatic chronic hypercapnic respiratory failure.
09/27/2007
03:17 PM
Circadian rhythms and sleep related breathing disorders
Volume 8, Issue 6, Pages 681-687 (September 2007)
Recent studies have provided evidence that the human circadian timing system has an influence on respiration and respiratory control. Both sleep and circadian mechanisms combine to mediate the rise in lower airway resistance in nocturnal asthma. In rats, circadian rhythms in minute ventilation are present in both wakefulness and sleep, implying that circadian and sleep mechanisms also combine to influence the control of breathing.
09/27/2007
03:15 PM
Review of Acute Pulmonary Embolism in a General Hospital
Surgery Today Volume 37, Number 9 / September, 2007 740-744
Acute pulmonary embolism (APE) is a serious cardiovascular disease associated with high mortality rates. We analyzed the clinical characteristics, treatment, and outcome of patients with APE in a general hospital in Japan.
09/27/2007
03:13 PM
Nocturnal haemodialysis increases pharyngeal size in patients with sleep apnoea and end stage renal disease
Nephrology Dialysis Transplantation, doi:10.1093
Sleep apnoea is common in patients with end-stage renal disease (ESRD) and is improved by nocturnal haemodialysis (NHD). Recent findings from our laboratory indicate the development of ESRD is associated with pharyngeal narrowing. We hypothesized that NHD increases pharyngeal cross-sectional area and that this is associated with an improvement in sleep apnoea.
09/27/2007
03:11 PM
CT findings for blebs and bullae in children with spontaneous pneumothorax and comparison with findings in normal age matched controls
Pediatric Radiology Volume 37, Number 9 / September, 2007 879-884
Spontaneous pneumothorax (SPTX) is a relatively common condition. In patients with SPTX, CT has been advocated to identify blebs and bullae (BB) to help in management planning.
09/27/2007
03:10 PM
Exposure to Vehicular Pollution and Assessment of Respiratory Function in Urban Inhabitants
Lung Volume 185, Number 5 / September, 2007 263-270
Particulate matter less than PM10 and aromatic chemicals formed during incomplete combustion of organic matter are major environmental pollutants because of their toxic potential.
09/27/2007
03:09 PM
Emergency Department Management of Pediatric Asthma at a University Teaching Hospital
The Annals of Pharmacotherapy: Vol. 41, No. 10, pp. 1625-1631
Asthma is a major health problem and the most frequent cause of chronic illness and emergency department (ED) visits in children. Limited data examining the ED management of pediatric asthma within university teaching hospitals across the US exist.
09/27/2007
03:07 PM
Hypoxia induced pulmonary hypertension Different impact of iloprost, sildenafil, and nitric oxide
Respiratory Medicine, Volume 101, Issue 10, Pages 2125-2132
Chronic alveolar hypoxia induces pulmonary hypertension, evident from elevated pulmonary artery pressure (PAP), pulmonary vascular resistance, right ventricular hypertrophy (RVH), and increased muscularization of the pulmonary vasculature. Additionally, the vasoconstrictor response to acute hypoxia (HPV) may be reduced in the remodeled vasculature.
09/27/2007
03:06 PM
Drug Induced Pneumonitis Associated with Imatinib Mesylate in a Patient with Idiopathic Pulmonary Fibrosis
Respiration (DOI: 10.1159/000091272)
A 74-year-old man with idiopathic pulmonary fibrosis (IPF) developed severe dyspnea on exertion after the readministration of imatinib mesylate for chronic myeloid leukemia.
09/27/2007
03:05 PM
Bronchiolitis Obliterans A Rare Chronic Pulmonary Complication Associated with Stevens Johnson Syndrome
Pediatric Dermatology, Volume 24, Number 4, July/August 2007 , pp. E22-E25(1)
Pulmonary manifestations are well recognized during the acute phase of Stevens-Johnson syndrome but persistent pulmonary sequela is rarely reported. We report two boys with bronchiolitis obliterans following the acute phase of Stevens-Johnson syndrome and discuss the clinical picture and treatment of persistent pulmonary complications with reference to earlier reports.
09/27/2007
03:03 PM
B2 ADRENOCEPTOR POLYMORPHISMS AND OBSTRUCTIVE AIRWAY DISEASES IMPORTANT ISSUES OF STUDY DESIGN
inical and Experimental Pharmacology and Physiology, Volume 34, Number 10, October 2007 , pp. 1029-1036(8)
Asthma and chronic obstructive pulmonary disease (COPD) are chronic airway diseases characterized by airflow obstruction. The B2-adrenoceptor mediates bronchodilatation in response to exogenous and endogenous B-adrenoceptor agonists.
09/27/2007
03:02 PM
Sleep Disordered Breathing and Chronic Opioid Therapy
Pain Medicine doi:10.1111/j.1526-4637.2007.00343.x
To assess the relation between medications prescribed for chronic pain and sleep apnea.
09/27/2007
03:01 PM
Clinical and Radiological Grading of Superior Vena Cava Obstruction
Respiration (DOI: 10.1159/000108921)
Superior vena cava obstruction (SVCO) is commonly caused by neoplastic venous compression and presents with typical symptoms and signs. Its clinical severity presumably depends on the degree of obstruction and the adequacy of venous collateral formation.
09/27/2007
03:00 PM
Boussignac Continuous Positive Airway Pressure for Weaning with Tracheostomy Tubes
Respiration (DOI: 10.1159/000106551)
In patients who are weaned with a tracheostomy tube (TT), continuous positive airway pressure (CPAP) is frequently used. Dedicated CPAP systems or ventilators with bulky tubing are usually applied. However, CPAP can also be effective without a ventilator by the disposable Boussignac CPAP (BCPAP) system that is normally used with face masks.
09/27/2007
02:58 PM
Simulated driving in obstructive sleep apnoea hypopnoea effects of oral appliances and continuous positive airway pressure
Sleep and Breathing Volume 11, Number 3 / September, 2007 129-138
Impaired simulated driving performance has been demonstrated in obstructive sleep apnoea-hypopnoea syndrome (OSAHS) patients. Although continuous positive airway pressure (CPAP) generally improves simulated driving performance, the effects of oral-appliance (OA) therapy are unknown.
09/27/2007
02:57 PM
Safety of ramelteon in individuals with mild to moderate obstructive sleep apnea
Sleep and Breathing Volume 11, Number 3 / September, 2007 159-164
Ramelteon is a selective MT1/MT2-receptor agonist indicated for insomnia treatment. Because it has no depressant effects on the nervous system, it is not expected to affect the control of breathing. The potential effects of ramelteon on apneic and hypopneic events and arterial oxygen saturation (SaO2) in individuals with obstructive sleep apnea were assessed.
09/27/2007
02:56 PM
Pulmonary Hypertension and Thyroid Disease
Chest. 2007; 132:793-797
The association between thyroid dysfunction and pulmonary hypertension (PH) has not been well characterized.
09/27/2007
02:55 PM
Interstitial Lung Disease in Systemic Sclerosis
Lung Volume 185, Number 4 / August, 2007 211-220
We reviewed the literature concerning pathogenesis, clinical features, diagnosis and treatment of interstitial lung disease (ILD) in patients with systemic sclerosis (SSc). ILD is detectable in approximately 70% of patients at autopsy. Nonspecific interstitial pneumonia (NSIP) is the most common pathologic finding.
09/27/2007
02:54 PM
Heterogeneity in Combined Pulmonary Fibrosis and Emphysema
Respiration (DOI: 10.1159/000107048)
Combined pulmonary fibrosis and emphysema (CPFE) is a unique disorder described in several case series of upper lobe emphysema associated with lower lobe fibrosis. Patients with this entity have relatively preserved lung volumes and spirometry but marked reductions in diffusing capacity on pulmonary function testing.
09/27/2007
02:52 PM
Association between asthma asthma symptoms and C reactive protein in US adults Data from the national health and nutrition examination survey 1999-2002
Respirology Volume 12 Issue 5 Page 675-682, September 2007
CRP is elevated in several inflammatory diseases; however, little is known about its association with asthma.
09/27/2007
02:19 PM
The Nonpharmacologic Treatment of Chronic Obstructive Pulmonary Disease
The Proceedings of the American Thoracic Society 4:549-553 (2007)
The optimal care of patients with chronic obstructive pulmonary disease generally requires combining pharmacologic and nonpharmacologic therapies. The latter include smoking cessation, the encouragement of physical activity and exercise, influenza and pneumonia vaccinations, education on adherence to medical therapy, collaborative self-management strategies, such as a plan to manage exacerbations, and advance directives.
09/27/2007
02:18 PM
Systemic Effects of Chronic Obstructive Pulmonary Disease
The Proceedings of the American Thoracic Society 4:522-525 (2007)
Chronic obstructive pulmonary disease (COPD) is associated with pulmonary and systemic inflammation. The latter is likely to contribute significantly to the pathobiology of numerous extrapulmonary effects of the disease-the so-called systemic effects of COPD.
09/27/2007
02:13 PM
Haemodialysis patients with sleep apnoea syndrome experience increased central adiposity and altered muscular composition and functionality
Nephrology Dialysis Transplantation, doi:10.1093
Sleep apnoea frequently affects patients with end-stage renal disease. However, it is still unclear whether or to what extent sleep disorders may affect functional capacity and quality of life in haemodialysis patients. We tested the hypothesis that apneic dialysis patients due to the lack of restorative sleep will have a further reduced functional capacity and further compromised quality of life compared to their non-apneic counterparts.
09/27/2007
02:12 PM
Apnea Patients at Higher Risk for Cardiovascular Disease
Emergency Medicine News:Volume 29(7)July 2007p 12
Researchers have found that patients with obstructive sleep apnea have higher levels of apoptotic cells from the endothelium of their blood vessels circulating in their bloodstream than people who do not have obstructive sleep apnea, which may explain why those with apnea are at higher risk for cardiovascular disease. The findings appear in the June 1 issue of the American Journal of Respiratory and Critical Care Medicine.
09/27/2007
02:11 PM
The characteristics of complementary and alternative medicine use by parents of asthmatic children in Southern Israel
Acta Paediatrica doi:10.1111/j.1651-2227.2007.00513.x
The aim of this study was to estimate the rate and describe the characteristics of complementary and alternative medicine (CAM) use by children with asthma in a paediatric primary care clinic in southern Israel.
09/27/2007
02:10 PM
Neonatal characteristics and risk of atopic asthma in schoolchildren results from a large prospective birth cohort study
Acta Paediatrica doi:10.1111/j.1651-2227.2007.00449.x
Asthma is among the most common chronic diseases in childhood and steadily increasing in prevalence. Identification of risk predictors for a hospitalization for atopic asthma in childhood may help design prevention programmes and improve our understanding of disease pathobiology.
09/27/2007
02:09 PM
National registry diagnoses agree with medical records on hospitalized asthmatic children
Acta Paediatrica Volume 96 Issue 10 Page 1470-1473, October 2007
The present study was performed to explore the validity of discharge diagnoses on asthma in the Danish National Patient Registry compared with medical records.
09/27/2007
02:07 PM
Four cases of congenital airway obstruction optimising perinatal management
Acta Paediatrica Volume 96 Issue 10 Page 1542-1545, October 2007
Congenital anomalies causing airway obstruction in the newborn are potentially fatal. However if an effective airway can be maintained the long-term prognosis is often excellent. We present four cases of airway obstruction, three of which were diagnosed antenatally.
09/27/2007
02:07 PM
Influenza vaccine for children and adults with bronchiectasis
Cochrane Database of Systematic Reviews 2007 Issue 3
Bronchiectasis is a major cause of respiratory morbidity especially in developing countries. In affluent countries, bronchiectasis is increasingly recognised in certain subsections of communities (e.g. Aboriginal communities) as well as a coexistent disease/comorbidity and disease modifier in respiratory diseases such as COPD (reported rates of 29-50% in adults).
09/27/2007
02:04 PM
Effect of inhaled corticosteroid on pulmonary injury and inflammatory mediator production after cardiopulmonary bypass in children
Pediatric Critical Care Medicine. 8(5):465-469, September 2007
To determine whether inhaled steroid administration after cardiopulmonary bypass will attenuate pulmonary inflammation and improve lung compliance and oxygenation.
09/27/2007
02:03 PM
The Immunopathogenesis of Chronic Obstructive Pulmonary Disease
The Proceedings of the American Thoracic Society 4:512-521 (2007)
Chronic obstructive pulmonary disease (COPD) progression is characterized by accumulation of inflammatory mucous exudates in the lumens of small airways, and thickening of their walls, which become infiltrated by innate and adaptive inflammatory immune cells.
09/27/2007
02:02 PM
Airway infection in stable lung transplant patients is associated with decreased intracellular T helper type 1 pro inflammatory cytokines in bronchoalveolar lavage T cell subsets
Transplant Infectious Disease doi:10.1111/j.1399-3062.2007.00236.x
Current immunosuppression protocols to prevent lung transplant rejection reduce pro-inflammatory and T-helper type 1 (Th1) cytokines. However, Th1 T-cell pro-inflammatory cytokine production is important in host defense against bacterial infection in the lungs.
09/27/2007
02:01 PM
Asthma and airways collapse in two heritable disorders of connective tissue
Annals of the Rheumatic Diseases 2007;66:1369-1373
This study investigated the clinical impression that there was an increased prevalence of respiratory disorders in both the Hypermobility Syndrome (HMS)/Benign Joint Hypermobility Syndrome (BJHS) and Ehlers-Danlos Syndrome (EDS), compared with the normal population.
09/27/2007
02:00 PM
Time course of platelet aggregation during thrombolytic treatment of massive pulmonary embolism
Blood Coagulation & Fibrinolysis. 18(7):661-667, October 2007
We studied changes in platelet aggregation and fibrinogen levels during thrombolysis with massive or submassive pulmonary embolism.
09/27/2007
01:59 PM
Value of ischemia modified albumin in the diagnosis of pulmonary embolism
The American Journal of Emergency Medicine, Volume 25, Issue 7, Pages 770-773
Pulmonary embolism (PE) is a common condition, but the diagnostic strategy for the evaluation of suspected PE is somewhat controversial. Despite the use of various biochemical markers (such as D-dimer and C-reactive protein) and various probability calculation algorithms based on clinical findings for that purpose, there is still a need for more specific and practical markers in PE diagnosis. The aim of this study was to investigate the diagnostic value of ischemia-modified albumin (IMA) levels in the diagnosis of PE.
09/27/2007
01:58 PM
A teaching hospital's experience applying the Pneumonia Severity Index and antibiotic guidelines in the management of community acquired pneumonia
Respirology Volume 12 Issue 5 Page 754-758, September 2007
The Pneumonia Severity Index (PSI) was developed to predict mortality in community-acquired pneumonia (CAP). It has been prospectively validated to identify patients who are at low risk of death and thereby aid in the selection of patients for outpatient management. This study assessed the compliance of medical staff at a university teaching hospital with the use of the PSI and the PSI-based local antibiotic guidelines in admitted patients.
09/27/2007
01:56 PM
Diffuse idiopathic skeletal hyperostosis as a cause of acute respiratory distress in early postoperative period of total knee arthroplasty
Archives of Orthopaedic and Trauma Surgery Volume 127, Number 7 / September, 2007 553-555
Diffuse idiopathic skeletal hyperostosis (DISH) is a common disorder among the elderly. The diagnosis is made on radiological findings and most of the cases are asymptomatic. In the cases with spinal involvement, bridging ossification of the anterior longitudinal ligament is a common finding.
09/27/2007
01:54 PM
Short Term Cigarette Smoke Exposure Predisposes the Lung to Secondary Injury
Lung Volume 185, Number 4 / August, 2007 227-233
Brief exposure to cigarette smoke is not generally associated with pulmonary injury and may adversely affect the lung only if underlying disease is present. To test this hypothesis, our laboratory performed a series of experiments involving exposure of hamsters to second-hand cigarette smoke (2 h/day for 5 days), either immediately before or after induction of acute pulmonary injury by intratracheal administration of amiodarone.
09/27/2007
01:53 PM
Transmission of Lung Sounds through Light Clothing
Respiration (DOI: 10.1159/000098404)
Doctors are exhorted to always place the stethoscope directly on the skin and never to auscultate through clothing. Nevertheless, casual observation reveals that doctors and even pulmonologists often violate this principle.
09/27/2007
01:52 PM
Transition From IV Epoprostenol to Subcutaneous Treprostinil in Pulmonary Arterial Hypertension
Chest. 2007; 132:757-763
We determined the relative efficacy of subcutaneous (SC) treprostinil in stable World Health Organization class II and III patients transitioned from IV epoprostenol.
09/27/2007
01:51 PM
Elevated Levels of B D Glucan in Bronchoalveolar Lavage Fluid in Patients with Farmer's Lung in Miyazaki, Japan
Respiration (DOI: 10.1159/000098406)
Farmers may be often exposed to -D-glucan in moldy hay, since straw for feed can be stored throughout the year.
09/27/2007
01:50 PM
Mixed Expired and End Tidal CO2 Distinguish Between Ventilation and Perfusion Defects During Exercise Testing in Patients With Lung and Heart Diseases
Chest. 2007; 132:977-983
Mismatching of ventilation to perfusion is found in patients with COPD, left ventricular failure (LVF), and pulmonary vascular diseases. Such mismatching may be due to ventilation or perfusion defects or both.
09/27/2007
01:49 PM
Comparison of Automatic and Continuous Positive Airway Pressure in a Night by Night Analysis A Randomized, Crossover Study
Respiration (DOI: 10.1159/000097767)
Long-term compliance is suboptimal in the treatment of the obstructive sleep apnea syndrome (OSAS).
09/27/2007
01:48 PM
Absence of Human Herpesvirus 8 DNA Sequences in Lung Biopsies from Israeli Patients with Pulmonary Arterial Hypertension
Respiration (DOI: 10.1159/000097495)
Pulmonary hypertension is a severe pulmonary vascular disease leading to rapid deterioration and death. Histological and clinical evidence suggests that smooth muscle proliferation is part of the pathogenesis of the disease.
09/27/2007
01:47 PM
Central Venous Blood Oxygen Saturation Monitoring in Patients With Chronic Pulmonary Arterial Hypertension Treated With Continuous IV Epoprostenol
Chest. 2007; 132:786-792
IV epoprostenol is a highly effective therapy for pulmonary arterial hypertension (PAH). However, monitoring the efficacy and adjusting the dose of epoprostenol often requires serial invasive hemodynamic measurements.
09/27/2007
01:46 PM
Bronchoscopic Myths and Legends Bronchoscopy in the Treatment of Lobar Atelectasis
Clinical Pulmonary Medicine. 14(5):302-305, September 2007
Atelectasis occurs frequently in the medical and surgical patient. Complications of prolonged atelectasis include worsening hypoxemia, respiratory failure, and pneumonia. Flexible bronchoscopy along with chest physiotherapy has been advocated for the prompt resolution of atelectasis. However, it is unclear whether one treatment is superior. We reviewed the existing literature to determine whether flexible fiberoptic bronchoscopy is superior to chest physiotherapy for the initial treatment of atelectasis.
09/27/2007
01:45 PM
Incidence Rate and Factors Related to Post Bronchoalveolar Lavage Fever in Children
Respiration (DOI: 10.1159/000107737)
Post-bronchoscopy and bronchoalveolar lavage (BAL) fever in children has been described by several authors.
09/27/2007
01:44 PM
Evaluation of Persistent Pulmonary Hypertension After Acute Pulmonary Embolism
Chest. 2007; 132:780-785
Better knowledge of the evolution of persistent pulmonary hypertension after acute pulmonary embolism (PE) is required to optimize the indication and timing of pulmonary endarterectomy (PEA).
09/27/2007
01:43 PM
Correlation between High Resolution Computed Tomography Findings and Lung Function in Pulmonary Langerhans Cell Histiocytosis
Respiration (DOI: 10.1159/000106843)
Pulmonary Langerhans cell histiocytosis (PLCH) is an uncommon interstitial lung disease which can lead to serious respiratory failure. The correlation between high-resolution computed tomography (HRCT) findings and lung function have not been studied in depth.
09/27/2007
01:42 PM
Acute Exacerbations of Idiopathic Pulmonary Fibrosis
American Journal of Respiratory and Critical Care Medicine Vol 176. pp. 636-643, (2007)
The natural history of idiopathic pulmonary fibrosis (IPF) has been characterized as a steady, predictable decline in lung function over time. Recent evidence suggests that some patients may experience a more precipitous course, with periods of relative stability followed by acute deteriorations in respiratory status. Many of these acute deteriorations are of unknown etiology and have been termed acute exacerbations of IPF.
09/27/2007
01:41 PM
Idiopathic Organizing Pneumonia A Relapsing Disease
Respiration (DOI: 10.1159/000103240)
Although organizing pneumonia (OP) is a common pathological finding, studies including a substantial number of patients with idiopathic forms from a unique center and a long follow-up are rare.
09/27/2007
01:40 PM
Pharmacologic Interventions in Chronic Obstructive Pulmonary Disease
The Proceedings of the American Thoracic Society 4:526-534 (2007)
Chronic obstructive pulmonary disease (COPD) is a treatable disease characterized by progressive airflow limitation. Prevention of disease progression, improvement of symptoms, exercise tolerance, health status, and decrease in exacerbations and in mortality are the main goals of the management of COPD. Bronchodilators play a pivotal role in the treatment of symptomatic patients with COPD.
09/27/2007
01:39 PM
CPAP adherence and partial upper airway obstruction during sleep
Sleep and Breathing Volume 11, Number 3 / September, 2007 171-176
Nasal continuous positive airway pressure (CPAP) is the treatment of choice in severe obstructive sleep-disordered breathing (SDB). Partial obstruction is usually considered as mild SDB with poor CPAP adherence. In a retrospective study, we investigated the occurrence of partial obstruction in 233 age and BMI-matched male-female pairs and its impact on CPAP adherence after one year using static-charge-sensitive bed.
09/27/2007
01:37 PM
Salmeterol plus fluticasone propionate versus fluticasone propionate plus montelukast: a randomised controlled trial investigating the effects on airway inflammation in asthma
Respiratory Research 2007, 8:67
Few studies have compared treatment strategies in patients with asthma poorly controlled on low dose inhaled corticosteroids, and little is known about the effects of different treatments on airway inflammation. In this double-blind, placebo-controlled, parallel group study, we compared the effects of salmeterol plus fluticasone propionate (FP) (SeretideTM; SFC) and FP plus montelukast (FP/M) on sputum inflammatory markers, airway responsiveness, lung function, and symptoms in adult asthmatics.
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