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American Journal of Forensic Medicine & Pathology. 27(3):268-270, September 2006
We report a case of an adult man who was run over by a car, suffering severe head trauma. After 3 hours in the hospital, he experienced sudden and severe hemodynamic deterioration, dying immediately. The autopsy showed massive cerebral tissue pulmonary embolization (CTPE), confirmed by immunohistochemistry. Multiple fractures of the skull, tear of the transverse sinus, and brain laceration of the occipital lobe were present.
Urology Volume 68, Issue 2 , August 2006, Pages 406-409
Nocturnal enuresis has been associated with obstructive sleep-disordered breathing mostly in hospital-referred adults and children. To investigate whether primary nocturnal enuresis is significantly associated with habitual snoring in the general pediatric population irrespective of subjects’ age and sex, we studied children attending six randomly selected schools in a city in central Greece.
Respirology, Volume 11, Number 6, November 2006, pp. 715-722(8)
Pathological changes in severe acute respiratory syndrome (SARS) suggest that SARS sequelae are associated with dysregulation of cytokine and chemokine production. To improve understanding of the immuno-pathological processes involved in lung injury associated with SARS, the temporal changes in cytokine/chemokine profiles in the sera of SARS patients were compared with those of patients with community-acquired pneumonia (CAP), according to the degree of lung involvement.
PEDIATRICS Vol. 118 No. 4 October 2006, pp. 1409-1417
Prolonged mechanical ventilation is associated with lung injury in preterm infants. In these infants, weaning from synchronized intermittent mandatory ventilation may be delayed by their inability to cope with increased respiratory loads. The addition of pressure support to synchronized intermittent mandatory ventilation can offset these loads and may facilitate weaning.
Respirology, Volume 11, Number 6, November 2006, pp. 741-747(7)
Existence of an increased oxidative stress has been confirmed in patients with acute exacerbation of COPD. This study aims to examine the extent and time-course of antioxidant defence in patients with an acute exacerbation of COPD in comparison with stable patients.
Current Opinion in Pulmonary Medicine. 12(6):397-401, November 2006
Obstructive sleep apnea continues to be a significant public health problem. A variety of imaging modalities have been used recently to gain insight into the pathogenesis of this disease, as well as to identify therapeutic options.
Journal of Bronchology. 13(4):181-183, October 2006
Fine capillary network develops in the tracheo-bronchial tree and airway diseases cause several bronchial mucosal changes. A newly developed side-viewing high magnification bronchovideoscope (XBF-200HM3, Olympus Medical Systems Corp) was used in this study.
Disease Management & Health Outcomes, Volume 14, Number 4, 2006, pp. 223-233(11)
The worldwide asthma prevalence is estimated to be 150 million and is increasing in most developed countries. This review examines evidence for the burden of illness caused by nonadherence in asthma, reasons for nonadherence, and the effectiveness of interventions to improve adherence.
This study describes a high-frequency oscillatory ventilation (HFOV) protocol for term and near-term infants with acute respiratory failure (ARF) and reports results of its prospective application.
Journal of Bronchology. 13(4):191-193, October 2006
Respiratory tract involvement with amyloid is rare. We retrospectively reviewed the records of 10 patients with biopsy-proven pulmonary amyloidosis who were evaluated at our hospital between 1996 and 2003. All relevant information, such as clinical, historical, laboratory, radiographic, and histologic data were examined.
American Journal of Forensic Medicine & Pathology. 27(3):268-270, September 2006
We report a case of an adult man who was run over by a car, suffering severe head trauma. After 3 hours in the hospital, he experienced sudden and severe hemodynamic deterioration, dying immediately. The autopsy showed massive cerebral tissue pulmonary embolization (CTPE), confirmed by immunohistochemistry. Multiple fractures of the skull, tear of the transverse sinus, and brain laceration of the occipital lobe were present.
Urology Volume 68, Issue 2 , August 2006, Pages 406-409
Nocturnal enuresis has been associated with obstructive sleep-disordered breathing mostly in hospital-referred adults and children. To investigate whether primary nocturnal enuresis is significantly associated with habitual snoring in the general pediatric population irrespective of subjects’ age and sex, we studied children attending six randomly selected schools in a city in central Greece.
Respirology, Volume 11, Number 6, November 2006, pp. 715-722(8)
Pathological changes in severe acute respiratory syndrome (SARS) suggest that SARS sequelae are associated with dysregulation of cytokine and chemokine production. To improve understanding of the immuno-pathological processes involved in lung injury associated with SARS, the temporal changes in cytokine/chemokine profiles in the sera of SARS patients were compared with those of patients with community-acquired pneumonia (CAP), according to the degree of lung involvement.
PEDIATRICS Vol. 118 No. 4 October 2006, pp. 1409-1417
Prolonged mechanical ventilation is associated with lung injury in preterm infants. In these infants, weaning from synchronized intermittent mandatory ventilation may be delayed by their inability to cope with increased respiratory loads. The addition of pressure support to synchronized intermittent mandatory ventilation can offset these loads and may facilitate weaning.
Respirology, Volume 11, Number 6, November 2006, pp. 741-747(7)
Existence of an increased oxidative stress has been confirmed in patients with acute exacerbation of COPD. This study aims to examine the extent and time-course of antioxidant defence in patients with an acute exacerbation of COPD in comparison with stable patients.
Current Opinion in Pulmonary Medicine. 12(6):397-401, November 2006
Obstructive sleep apnea continues to be a significant public health problem. A variety of imaging modalities have been used recently to gain insight into the pathogenesis of this disease, as well as to identify therapeutic options.
Journal of Bronchology. 13(4):181-183, October 2006
Fine capillary network develops in the tracheo-bronchial tree and airway diseases cause several bronchial mucosal changes. A newly developed side-viewing high magnification bronchovideoscope (XBF-200HM3, Olympus Medical Systems Corp) was used in this study.
Disease Management & Health Outcomes, Volume 14, Number 4, 2006, pp. 223-233(11)
The worldwide asthma prevalence is estimated to be 150 million and is increasing in most developed countries. This review examines evidence for the burden of illness caused by nonadherence in asthma, reasons for nonadherence, and the effectiveness of interventions to improve adherence.
This study describes a high-frequency oscillatory ventilation (HFOV) protocol for term and near-term infants with acute respiratory failure (ARF) and reports results of its prospective application.
Journal of Bronchology. 13(4):191-193, October 2006
Respiratory tract involvement with amyloid is rare. We retrospectively reviewed the records of 10 patients with biopsy-proven pulmonary amyloidosis who were evaluated at our hospital between 1996 and 2003. All relevant information, such as clinical, historical, laboratory, radiographic, and histologic data were examined.
American Journal of Respiratory Cell and Molecular Biology. Vol. 35, pp. 513-518, 2006
Substantial evidence implicates common respiratory viral infections in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD). Children who experience recurrent virally induced wheezing episodes during infancy are at greater risk for developing asthma. In addition, respiratory viral infections are a major trigger for acute exacerbations of both asthma and COPD.
European Journal of Pediatrics Volume 165, Number 12 / December, 2006 845-849
Acute lower respiratory infection due to adenovirus is an important cause of chronic lung disease (CLD) in infants. The objectives of this paper is to describe growth in the height and weight of children with post-viral chronic lung disease (PVCLD) and to relate it with associated variables (invasive mechanical ventilation, chronic hypercapnia, oxygen therapy at home and steroid treatment).
Current Opinion in Cardiology. 21(6):561-568, November 2006
Pulmonary arterial hypertension (PAH) has been a disease with limited treatment options and poor prognosis. This article reviews the recent advances that took place in the medical management of PAH.
Cardiology in Review. 14(6):312-318, November/December 2006
Pulmonary arterial hypertension (PAH) is a progressive disorder with a poor prognosis. It is characterized by sustained elevation of pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR). It is defined hemodynamically by a mean PAP over 25 mm Hg, a pulmonary arterial wedge pressure of 15 mm Hg or less (which excludes left sided lesions), and a PVR of 3 or more Wood units (240 dyn.sec.cm-5).
We investigated health-related quality of life (HRQoL) and persistent symptoms of post-traumatic stress disorder (PTSD) in long-term survivors of acute respiratory distress syndrome (ARDS). We wished to evaluate the influence of PTSD on HRQoL and to investigate the influence of perceived social support during intensive care unit (ICU) treatment on both PTSD symptoms and HRQoL.
Sleep Medicine Volume 7, Issue 6 , September 2006, Pages 498-507
Obstructive sleep apnea–hypopnea (OSAH) is associated with sleep fragmentation and nocturnal hypoxemia. In clinical samples, patients with OSAH frequently are found to have deficits in neuropsychological function. However, the nature and severity of these abnormalities in non-clinical populations is less well defined.
To investigate the effects of segmental allergen challenge on the concentration of soluble CD86 (sCD86) in BAL fluids in patients with allergic asthma.
Current Opinion in Pulmonary Medicine. 12(6):409-413, November 2006
The purpose of this review is to discuss the nature of adherence to continuous positive airway pressure (CPAP), identify measurement modalities, consider factors that have been identified in the literature associated with nonadherence and present interventions that may promote use.
Accurate characterization of asthma severity is difficult due to the variability of symptoms. Hyperpolarized helium-3 MRI (H3HeMR) is a new technique in which the airspaces are visualized, depicting regions with airflow obstruction as "ventilation defects."
In a prospective observational study of 1038 adult admissions to a 31-bed medical/surgical intensive care unit (ICU), acute respiratory failure (ARF, defined as a Pao2/Fio2 ratio 200 mm Hg and the need for respiratory support) occurred in 182 (58%) of the 313 admissions with an ICU stay of more than 48 h. Initial ARF (onset within 48 h of ICU admission) occurred in 133 (42%) patients, and delayed onset ARF (onset >48 h after ICU admission) in 49 (16%).
We evaluated the rate of complications experienced by children who undergo adenotonsillectomy for obstructive sleep apnea syndrome (OSAS), the safety of a standard anesthetic protocol for these children, and preoperative predictors of complications.
Journal of Infection Volume 53, Issue 4 , October 2006, Pages 248-254
Respiratory viruses are a common trigger for exacerbations of chronic obstructive pulmonary disease (COPD). Human metapneumovirus (hMPV) is a paramyxovirus associated with respiratory tract infections and wheezing. Our aim was to determine whether hMPV was associated with exacerbations of COPD.
Pediatric Allergy and Immunology, Volume 17, Number 7, November 2006, pp. 508-513(6)
Although allergic asthma and allergic rhinitis have recently been considered to be a single disease, many questions remain unanswered. Why do some atopic patients develop asthma symptoms and others develop allergic rhinitis symptoms? Which factors play a role in the development of different allergic phenotypes? We hypothesized that angiotensin-converting enzyme (ACE) gene polymorphism might play a role in the development of asthma phenotypes in children with allergic rhinitis.
Antenatal carnitine administration has been shown to induce fetal lung maturity by increasing pulmonary surfactant in animal and human studies. The aim of this study was to investigate serum free carnitine (FC) levels in preterm infants with respiratory distress syndrome (RDS) and controls during the first week of postnatal life.
Journal of Infection Volume 53, Issue 4 , October 2006, Pages e181-e183
Among patients with cutaneous T-cell lymphoma (CTCL), sepsis and pulmonary infections are the first cause of death. We report on a patient with CTCL who, after more than 10 years of aggressive antineoplastic treatments, showed extensive pulmonary infiltrations on staging CT scan.
Respiratory Medicine Volume 100, Issue 10 , October 2006, Pages 1716-1723
To explore the experiences of chronic obstructive pulmonary disease (COPD) patients invited to join a pulmonary rehabilitation (PR) programme. PR has been shown to be an effective non-pharmacological intervention; however uptake and completion of programmes is frequently low.
Respiratory Medicine Volume 100, Issue 10 , October 2006, Pages 1688-1705
Patients with asthma have exaggerated bronchoconstriction of their airways in response to certain indirect (e.g. cold air, allergens, dust, exercise) or direct (e.g. inhaled
methacholine) stimuli. This ‘hyper-reactivity’ usually co-exists with airway inflammation, although the pathophysiological mechanisms underlying these changes are not fully understood.
The diagnosis of ventilator-associated pneumonia relies on protected specimen brush (PSB), BAL, and plugged telescoping catheter (PTC) procedures. In the particular setting of nosocomial pneumonia (NP) occurring in non-mechanically ventilated patients, no consensus exists on their use. When mechanical ventilation (MV) becomes mandatory, postintubation tracheal aspiration (PITA) could be a simple, fast, and cheap diagnostic tool. Our aim was to compare the diagnostic accuracy of PITA to that of PSB, BAL, or PTC in patients requiring MV for suspected NP.
To assess the discriminative properties of the EuroQol five-dimension questionnaire (EQ-5D) with respect to COPD severity according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria in a large multinational study.
Patients with obstructive sleep apnea (OSA) have a very high incidence of gastroesophageal reflux (GER). Previous studies have shown that the use of continuous positive airway pressure (CPAP) reduces the frequency of reflux events, but these studies only assessed the effect of a single night of treatment. The aim of this study was to assess the effect of 1 week of CPAP treatment on reflux in patients with OSA and GER.
Respiratory Medicine Volume 100, Issue 10 , October 2006, Pages 1767-1774
The aim of our study was to assess the prevalence of anxiety and depression in the whole chronic obstructive pulmonary disease (COPD) population and in subgroups according to sex and severity classification.
Respiratory Medicine Volume 100, Issue 10 , October 2006, Pages 1760-1766
Assessment of the bronchodilation response to short-acting B2-adrenoreceptor agonists on pharmacologically induced bronchoconstriction has often been used to investigate airway smooth muscle B2-adrenoreceptor function. However, little is known about factors affecting this response.
American Journal of Respiratory and Critical Care Medicine Vol 174. pp. 982-989, (2006)
A prospective, open label, single-center, pilot study was conducted to determine the ability of electromagnetic navigation bronchoscopy to sample peripheral lung lesions and mediastinal lymph nodes with standard bronchoscopic instruments and demonstrate safety.
American Journal of Respiratory and Critical Care Medicine Vol 174. pp. 1042-1047, (2006)
We investigated the role of sildenafil in preventing rebound (an increase in PA pressure of 20% or greater, or failure to discontinue NO) in patients in whom previous attempts had not been made to wean from NO.
American Journal of Respiratory and Critical Care Medicine Vol 174. pp. 1034-1041, (2006)
To test whether the degree of tricuspid annular displacement (tricuspid annular plane systolic excursion [TAPSE]) is a useful echo-derived measure of RV function with prognostic significance in pulmonary hypertension.
American Journal of Respiratory and Critical Care Medicine Vol 174. pp. 990-996, (2006)
To assess the accuracy of troponin T and of amino-terminal pro–brain natriuretic peptide
(NT-proBNP) in the diagnosis of AECOPD associated with left ventricular (LV) dysfunction.
American Journal of Hypertension Volume 19, Issue 10 , October 2006, Pages 1064-1069
Obstructive sleep apnea (OSA) is associated with hypertension. In the current study we sought to determine whether the evening/morning differences in blood pressure (BP) would correlate with the severity of OSA and whether there are gender-related differences.
Levels of the soluble form of the triggering receptor expressed on myeloid cells (sTREM)-1 are elevated in severe sepsis. However, it is not known whether sTREM-1 measurements can distinguish milder bacterial infections from noninfectious inflammation. The present authors studied whether serum sTREM-1 levels differ in community-acquired pneumonia, exacerbations of chronic obstructive pulmonary disease (COPD), asthma and controls, and whether sTREM-1 may be used as a surrogate marker for the need for antibiotics.
Patients with mild intermittent asthma sometimes show signs of inflammation, and guidelines suggesting bronchodilator therapy alone as needed may be questioned.
Respiratory Medicine Volume 100, Issue 10 , October 2006, Pages 1671-1681
Oral vaccines using killed bacterial extracts have been used to prevent acute exacerbations of chronic obstructive pulmonary disease (COPD); however, they are not recommended by current clinical guidelines. Two systematic reviews have been published on the efficacy of oral vaccines.
Respiratory Medicine Volume 100, Issue 10 , October 2006, Pages 1807-1816
Many chronic obstructive pulmonary disease (COPD) patients are dissatisfied with the information they are given. A brief questionnaire completed prior to the clinical encounter would assist health professionals identify areas of information need.
Doppler ultrasound of extracranial internal carotid artery (ICA) and vertebral artery (VA) were performed and total cerebral blood flow volume (tCBFV) was evaluated in chronic obstructive pulmonary disease (COPD) patients. CBFV changes due to blood gas changes were also evaluated.
We assessed the effects of an influenza season on patients with COPD. Data from 2,215 veterans in a multicenter, randomized, double-blind influenza vaccine efficacy study were analyzed for changes in spirometric and functional status, comparing patients with laboratory-documented influenza (LDI)-caused illness, non-LDI-caused respiratory illness, or no illness, and for association with influenza vaccination.
Respirology, Volume 11, Number 6, November 2006, pp. 731-740(10)
The present study was performed to clarify the clinical characteristics of patients with COPD classified into phenotypes according to the dominancy of emphysema and the presence of bronchial wall thickening (BWT) evaluated by chest high-resolution CT.
The objective of this study was to examine the relationship between respiratory symptom intensity and quality and dynamic lung hyperinflation (DH) during induced bronchoconstriction in asthma.
Pediatric Transplantation, Volume 10, Number 7, November 2006, pp. 826-829(4)
Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection in infants and young children. In immunocompromised children, RSV infection poses a serious health threat with significantly increased and prolonged virus shedding and the development of severe respiratory disease.
Surgery Volume 140, Issue 4 , October 2006, Pages 640-648
Postinjury organ dysfunction is a result of unbridled systemic hyperinflammation. According to the two-event construct, patients are resuscitated into an early vulnerable window of systemic hyperinflammation (primed) in which a second otherwise innocuous event precipitates uncontrolled hyperinflammation, leading to secondary organ damage and dysfunction (activated).
Journal of Stroke and Cerebrovascular Diseases Volume 15, Issue 5 , 10 September 2006, Pages 209-213
Patients with acute stroke are at risk for pneumonia and urinary tract infection (UTI). Identifying patients with stroke at high risk for common infections could enhance timely treatment and improve clinical outcomes. We aimed to identify risk factors associated with the occurrence of pneumonia and UTI during stroke hospitalization.
Immunity Volume 25, Issue 4 , October 2006, Pages 665-675
Aspergillus fumigatus is a mold that causes a spectrum of diseases, including lethal lung infections in immunocompromised humans and allergic asthma in atopic individuals. T helper 1 (Th1) CD4+ T cells protect against invasive A.
Cardiovascular Research Volume 72, Issue 1 , 1 October 2006, Pages 41-50
Almost one mountain trekker or climber out of two develops several symptoms of high altitude illness after a rapid ascent (> 300 m/day) to an altitude above 4000 m. Individual susceptibility is the most important determinant for the occurrence of high altitude pulmonary oedema (HAPE).
Pediatric Allergy and Immunology, Volume 17, Number 7, November 2006, pp. 501-507(7)
Mannose-binding lectin (MBL), a member of the innate immune system, initiates complement deposition on microbial surfaces. MBL deficiency is associated with severe respiratory infections.
Pediatric Allergy and Immunology, Volume 17, Number 7, November 2006, pp. 533-537(5)
In the last decades, an increase in bronchial asthma and type 1 diabetes occurrence has been observed in affluent countries, and a positive association between the two disorders has been demonstrated at the population level. This association could be explained by common risk factors predisposing to both disorders.
PEDIATRICS Vol. 118 No. 4 October 2006, pp. 1774-1793
Bronchiolitis is a disorder most commonly caused in infants by viral lower respiratory tract infection. It is the most common lower respiratory infection in this age group. It is characterized by acute inflammation, edema, and necrosis of epithelial cells lining small airways, increased mucus production, and bronchospasm.
Respirology, Volume 11, Number 6, November 2006, pp. 805-808(4)
Chronic cough is one of the more common respiratory symptoms. Controversy exists as to whether Chlamydia infection is associated with chronic cough. As such, the association of chronic cough with serological evidence of Chlamydia pneumoniae (C. P) infection and a systemic inflammatory marker was assessed.
Cost Effectiveness and Resource Allocation 2006, 4:17
Little is known about cost implications of anemia and its association with mortality in chronic obstructive pulmonary disease (COPD). This claims analysis addresses these questions.
NEJM Volume 355:1682-1689 October 19, 2006 Number 16
Reduced lung function in early infancy has been associated with later obstructive airway diseases. We assessed whether reduced lung function shortly after birth predicts asthma 10 years later.
The Heart Surgery Forum Volume 9, Number 6 / October 2006 E813 - E817
There is a paucity of clinical information regarding therapy for ischemic heart disease (IHD) in patients with obstructive sleep apnea syndrome (OSAS). We evaluated our experience with surgical revascularization in this subset of patients.
Clinical Neurology and Neurosurgery Volume 108, Issue 7 , October 2006, Pages 670-674
We report a 69-year-old man who developed paralytic poliomyelitis in childhood and then decades later suffered from fatal respiratory failure. Six months before this event, he had progressive weight loss and shortness of breath. He had severe muscular atrophy of the entire right leg as a sequela of the paralytic poliomyelitis.
International Archives of Allergy and Immunology 2007;142:116-126
Respiratory syncytial virus (RSV) is known as a causal factor of severe bronchiolitis in young children. It has also been detected in patients with chronic obstructive pulmonary disease (COPD), a disease that is associated with an increased number of T cells in the bronchial mucosa.
To describe the 30-year cumulative incidence of chronic bronchitis and COPD in relation to smoking habits. The effect of chronic bronchitis on pulmonary function and mortality was also examined.
Respirology, Volume 11, Number 6, November 2006, pp. 799-804(6)
The benefits of inspiratory muscle strength training in decreasing symptoms, disability or handicap of patients affected by COPD are not well established.
nnals of Allergy, Asthma and Immunology, Volume 97, Number 4, October 2006, pp. 457-463(7)
To evaluate the effect of clarithromycin on serum and nasopharyngeal cytokine and chemokine concentrations in children with an acute exacerbation of recurrent wheezing.
The high burden of asthma appears to be related to poor asthma control. Although previous studies have reported associations between depressive disorders (DDs) and anxiety disorders (ADs) and worse asthma control and quality of life, the relative impact of these disorders on asthma control and quality of life has not been explored.
Annals of Allergy, Asthma and Immunology, Volume 97, Number 4, October 2006, pp. 432-439(8)
To summarize the outcomes used to evaluate inhaled corticosteroid intervention in terms of the Economic, Clinical, and Humanistic Outcomes (ECHO) model and to discuss the value of this more comprehensive approach in assessing therapeutic efficacy in asthma.
Heart & Lung: The Journal of Acute and Critical Care Volume 35, Issue 5 , September-October 2006, Pages 342-350
The study objective was to validate among patients with chronic obstructive pulmonary disease (COPD) clinical predictors of emergency department (ED) disposition (admission vs discharge) found in a previous study.
International Journal of Pediatric Otorhinolaryngology Volume 70, Issue 10 , October 2006, Pages 1799-1803
Recurrent respiratory papillomatosis is a rare, but devastating, cause of airway lesions in children and adults. This disease is caused by human papilloma virus subtypes 6 and 11. At this time there are two vaccines in late stages of development seeking Food and Drug Administration (FDA) approval to prevent cervical cancer, which is also caused by human papilloma virus.
Annuals of Internal Medicine 17 October 2006 Volume 145 Issue 8 Pages 599-609
To determine whether transfusion with influenza-convalescent human blood products reduced the risk for death in patients with Spanish influenza pneumonia.
Intensive and Critical Care Nursing Volume 22, Issue 5 , October 2006, Pages 253-263
A prolonged period of mechanical ventilation is costly for both the patient, in terms of the risk of complications such as ventilator-acquired pneumonia, and to the health service due to the high cost of maintaining a patient in intensive care.
The sleep apnoea syndrome is a particularly common health problem associated with increased cardiovascular morbidity and mortality, as well as harmful socioeconomical and familial complications.
To describe the 30-year cumulative incidence of chronic bronchitis and COPD in relation to smoking habits. The effect of chronic bronchitis on pulmonary function and mortality was also examined.
Medical Hypotheses Volume 67, Issue 6 , 2006, Pages 1406-1410
Elderly patients with asthma, particularly those above the age of 80 years, appear less able to detect early worsening of their airflow resistance and hence might not take ‘rescue’ bronchodilator medication promptly. No consistent explanation for the observation has been posited.
Respirology, Volume 11, Number 6, November 2006, pp. 799-804(6)
The benefits of inspiratory muscle strength training in decreasing symptoms, disability or handicap of patients affected by COPD are not well established.
Respirology, Volume 11, Number 6, November 2006, pp. 809-813(5)
Clinical analysis of nine cases without a history of old pulmonary tuberculosis in whom CNPA was found to be a complication during the follow-up period for MAC disease.
Chylothorax occurring during thoracic aortic surgery is an infrequent but serious complication. The purpose of this study was to analyze our experience with this complication and the resulting outcomes.
Pulmonary arterial hypertension related to scleroderma (PAH-Scl) is associated with high morbidity and mortality as well as poorer response to therapy and worse outcomes compared with the idiopathic form of PAH (IPAH). Scleroderma is an autoimmune disease that can affect left and right heart function directly through inflammation and fibrosis and indirectly through systemic and pulmonary hypertension.
Thrombosis Research Volume 118, Issue 5 , 2006, Pages 547-553
Expertly interpreted pulmonary vascular imaging (either ventilation–perfusion scan or computed tomography chest angiography) is not uniformly available at most hospitals, including those in the US. When evaluating a patient with suspected pulmonary embolism during times when pulmonary vascular imaging is not available, clinicians frequently face the decision of whether to administer heparin while awaiting availability of imaging.
Arch Otolaryngol Head Neck Surg. 2006;132:1123-1127
To assess the efficacy of adenotonsillar surgery on respiratory sleep parameters and avoiding continuous positive airway pressure (CPAP) treatment in morbidly obese children with obstructive sleep apnea syndrome (OSAS).
In patients with COPD, both laboratory exercise tests and field walking tests are used to assess physical performance. In laboratory tests, peak exercise capacity in watts (W peak) and/ or peak oxygen uptake (VO2 peak) are assessed, whereas the performance on walking tests usually is expressed as distance walked.
Previous genetic analysis has shown that a deletion in the complement component 5 gene-coding region renders mice more susceptible to allergen-induced airway hyperresponsiveness (AHR) due to reduced IL-12 production. We investigated the role of complement in a murine model of asthma-like pulmonary inflammation.
Highly pathogenic avian H5N1 influenza virus is a major public health concern. Given the lack of effective vaccine and recent evidence of antiviral drug resistance in some isolates, alternative strategies for containment of a possible future pandemic are needed.
Tumor necrosis factor alpha (TNFa) is the most widely studied pleiotropic cytokine of the TNF superfamily. In pathophysiological conditions, generation of TNFa at high levels leads to the development of inflammatory responses that are hallmarks of many diseases.
Ultimately, asthma is a disease characterized by constriction of airway smooth muscle (ASM). The earliest approach to the treatment of asthma comprised the use of xanthines and anti-cholinergics with the later introduction of anti-histamines and anti-leukotrienes.
Gap junctions are membrane channels formed by an array of connexins which links adjacent cells realizing an electro- metabolic synapse. Connexin-mediated communication is crucial in the regulation of cell growth, differentiation, and development.
In guinea pigs, we have previously demonstrated that the contribution of Rho-kinase to airway responsiveness in vivo and ex vivo is enhanced after active sensitization with ovalbumin (OA). Using conscious, unrestrained OA-sensitized guina pigs, we now investigated the role of Rho-kinase in the development of airway hyperresponsiveness (AHR) after the allergen-induced early (EAR) and late asthmatic reaction (LAR) in vivo.
Airway remodeling present in the large airways in asthma or asthma models has been associated with airway dysfunction in humans and mice. It is not clear if airways distal to the large conducting airways have similar degrees of airway remodeling following chronic allergen exposure in mice.
Respirology, Volume 11, Number 6, November 2006, pp. 830-832(3)
The relationship between the blood level of rheumatoid factor (RF) and the peripheral blood eosinophil
(Eo) count (white blood cells × %Eo, Eo count) in a patient diagnosed with chronic eosinophilic pneumonia was evaluated from before the onset till resolution of the disease.
International Journal of Colorectal Disease Volume 21, Number 8 / December, 2006 754-757
One-third of patients with inflammatory bowel disease (IBD) has extracolonic manifestations. Inflammatory bowel-associated pulmonary disease is one of the less commonly recognized and more recently described manifestations. Here, we report the experience of our patients with inflammatory bowel-associated bronchiectasis.
COPD affects up to one third of patients with chronic heart failure. The coexistence of COPD and chronic heart failure presents clinicians with diagnostic and therapeutic challenges.
Exacerbations of asthma and COPD are major causes of morbidity, mortality, and health-care costs. Over the last decade, studies using new molecular diagnostic techniques have established that respiratory viruses are a major cause of exacerbations of both asthma and COPD. The most prevalent viruses detected during exacerbations are the rhinoviruses.
Journal of Allergy and Clinical Immunology Volume 118, Issue 4, Supplement 1 , October 2006, Pages S1-S15
In spite of the wide prevalence of asthma and its substantial consequences, the diagnosis and assessment of asthma has not been standardized, and the goals of therapy currently are not being achieved. Our purpose is to help delineate what the most important asthma end points are and what kinds of strategies we should use to guide therapy.
The American Journal of Medicine Volume 119, Issue 10, Supplement 1 , October 2006, Pages 12-20
Dyspnea is a common symptom that accompanies a diagnosis of chronic obstructive pulmonary disease
(COPD). Dyspnea often interferes with the patient’s health-related quality of life
(HRQOL), yet it is often underreported by the patient and underrecognized by the clinician.
The American Journal of Medicine Volume 119, Issue 10 , October 2006, Pages 877-883
The objective of this study was to update the incidence and natural history of empyema in patients admitted to hospital with community-acquired pneumonia (CAP).
Modern Rheumatology Volume 16, Number 5 / October, 2006 316-320
We describe two cases of leflunomide-related interstitial pneumonia (IP). A 75-year-old woman with rheumatoid arthritis (RA) developed rapidly progressing IP 45 days after institution of leflunomide. She died of respiratory failure, and an autopsy revealed a mixed pattern of acute and organizing diffuse alveolar damage.
Respirology, Volume 11, Number 6, November 2006, pp. 786-792(7)
The aims of this study were to investigate the frequency of Mycobacterium tuberculosis as a cause of community-acquired pneumonia (CAP) requiring hospitalization in Malaysia, and to define the clinical features of pulmonary tuberculosis (PTB) that distinguish it from non-TB CAP.
The American Journal of Medicine Volume 119, Issue 10, Supplement 1 , October 2006, Pages 54-62
Chronic obstructive pulmonary disease (COPD) remains a leading cause of disability and death in the United States. The identification and amelioration of systemic manifestations of COPD may improve long-term outcomes, including survival.
The American Journal of Medicine Volume 119, Issue 10 , October 2006, Pages 851-858
The diagnosis of pulmonary embolism (PE) is often unreliable in patients with chronic obstructive pulmonary disease (COPD) or congestive heart failure (CHF).
Annals of Allergy, Asthma and Immunology, Volume 97, Number 4, October 2006, pp. 477-483(7)
To describe participants' perceptions of their roles in caring for an asthmatic child, to compare family patterns of caring for an asthmatic child by parents' country of origin, to identify barriers to caring for an asthmatic child, and to evaluate specific coping needs of low-income immigrant Hispanic families caring for an asthmatic child.
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