| 11/26/2008
12:58 PM
Tiotropium is better than ipratropium at reducing exacerbations, hospital referrals and hospital admissions in patients in general practice
Respiratory Medicine: COPD Update Volume 4, Issue 4, Page 135 (November 2008)
This small randomised controlled trial compares the effect of a treatment of tiotropium and a combination inhaler of salmeterol and fluticasone, with tiotropium alone, or salmeterol and fluticasone alone.
11/26/2008
12:57 PM
Up date nutritional support for patients with COPD
Respiratory Medicine: COPD Update Volume 4, Issue 4, Pages 127-131 (November 2008)
Chronic Obstructive Pulmonary disease (COPD) is associated with multiple comorbid conditions including ischemic heart disease, peripheral muscular dysfunction, osteoporosis, osteopenia, glaucoma, anemia, anxiety , depression, caquexia and malnutrition.
11/26/2008
12:56 PM
Salmeterol with fluticasone and tiotropium is better at improving lung function in moderate to severe COPD than any one or two elements of the combination
Respiratory Medicine: COPD Update Volume 4, Issue 4, Page 134 (November 2008)
This small randomised controlled trial compares the effect of a treatment of tiotropium and a combination inhaler of salmeterol and fluticasone, with tiotropium alone, or salmeterol and fluticasone alone.
11/26/2008
12:54 PM
What is the survival benefit in COPD from lung transplantation?
Respiratory Medicine: COPD Update Volume 4, Issue 4, Page 139 (November 2008)
Although chronic obstructive pulmonary disease is the first indication for lung transplantation, the benefit of the procedure in terms of survival remains debated.
11/26/2008
12:54 PM
Depression is worse in COPD patients who are frequent exacerbators, and at the time of COPD exacerbations: Cause or effect?
Respiratory Medicine: COPD Update Volume 4, Issue 4, Page 132 (November 2008)
11/26/2008
12:53 PM
Clinical Consensus on COPD 2009
Respiratory Medicine: COPD Update Volume 4, Issue 4, Pages 125-126 (November 2008)
11/26/2008
12:52 PM
ATS 2008 Conference Report: Much PROgress
Respiratory Medicine: COPD Update Volume 4, Issue 4, Pages 120-124 (November 2008)
11/26/2008
12:52 PM
Are shorter courses of antibiotics adequate in exacerbations of COPD?
Respiratory Medicine: COPD Update Volume 4, Issue 4, Page 140 (November 2008)
A study was undertaken to determine whether a short course of antibiotic treatment (< or=5 days) is as effective as the conventional longer treatment in acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease (COPD).
11/26/2008
12:51 PM
A non-typeable Haemophilus influenzae (NTHi) causes COPD-like changes in mice
Respiratory Medicine: COPD Update Volume 4, Issue 4, Page 138 (November 2008)
Nontypeable Haemophilus influenzae (NTHi) commonly colonizes the lower airways of patients with chronic obstructive pulmonary disease (COPD).
11/26/2008
12:50 PM
A new prognostic index for health outcomes in COPD
Respiratory Medicine: COPD Update Volume 4, Issue 4, Pages 136-137 (November 2008)
Chronic obstructive pulmonary disease (COPD) is a debilitating and progressive disease. The severity of the condition has typically been characterized by a single physiological measurement: forced expiratory volume in 1second, which has been shown to be prognostic for mortality.
11/26/2008
12:49 PM
Sniff and Muller manoeuvres to measure diaphragmatic muscle strength
Respiratory Medicine Volume 102, Issue 12, Pages 1737-1743 (December 2008)
We hypothesized that peak values of oesophageal (Poes) and transdiaphragmatic pressure (Pdi) swings during a maximal sniff manoeuvre and a maximal static inspiratory manoeuvre (Muller manoeuvre) are comparable or give complementary information for assessing diaphragmatic and global inspiratory muscle strength.
11/26/2008
12:48 PM
Slow-onset asthma deaths have more eosinophils and health care utilization than rapid-onset deaths
Respiratory Medicine Volume 102, Issue 12, Pages 1819-1826 (December 2008)
Patients with fatal asthma have been hypothesized as representing two distinct subgroups according to the onset of symptoms prior to death.
11/26/2008
12:47 PM
Respiratory disorders are not more common in farmers. Results from a study on Icelandic animal farmers
Respiratory Medicine Volume 102, Issue 12, Pages 1839-1843 (December 2008)
The current prevalence of respiratory disorders and symptoms in Icelandic farmers is unknown, but a high prevalence of respiratory symptoms has been reported in the past.
11/26/2008
12:46 PM
Recombinant tissue plasminogen activator in the treatment of pleural infections in adults
Respiratory Medicine Volume 102, Issue 12, Pages 1694-1700 (December 2008)
Intrapleural recombinant tissue plasminogen activator (r-TPA) has been successfully evaluated in pediatric patients with complicated parapneumonic pleural effusion (CPE) and pleural empyema (PE).
11/26/2008
12:45 PM
Rational timing of combination therapy with tiotropium and formoterol in moderate and severe COPD
Respiratory Medicine Volume 102, Issue 12, Pages 1701-1707 (December 2008)
To determine which timing of therapy with formoterol (FOR) and/or tiotropium (TIO) shows the greater and more continuous functional improvement during 24h in patients with moderate to severe COPD.
11/26/2008
12:44 PM
Pulmonary rehabilitation in idiopathic pulmonary fibrosis: A call for continued investigation
Respiratory Medicine Volume 102, Issue 12, Pages 1675-1680 (December 2008)
Idiopathic pulmonary fibrosis (IPF) is a devastating disease that afflicts patients with relentlessly progressive shortness of breath [Joint Statement of the American Thoracic Society and the European Respiratory Society. Idiopathic pulmonary fibrosis: diagnosis and treatment.
11/26/2008
12:44 PM
Peripheral endothelial dysfunction in patients with pulmonary arterial hypertension
Respiratory Medicine Volume 102, Issue 12, Pages 1791-1796 (December 2008)
Pulmonary endothelium plays an important role in the mechanism of pulmonary arterial hypertension (PAH). However, there is only a few data regarding the systemic endothelium in this syndrome. This study focused on the systemic endothelial involvement in PAH.
11/26/2008
12:43 PM
Non-reversible airway obstruction in never smokers: Results from the Austrian BOLD study
Respiratory Medicine Volume 102, Issue 12, Pages 1833-1838 (December 2008)
The presence of non-reversible airway obstruction (AO) in never smokers has only received limited attention until now.
11/26/2008
12:42 PM
No further increase of incidence of asthma: Incidence, remission and relapse of adult asthma in Sweden
Respiratory Medicine Volume 102, Issue 12, Pages 1730-1736 (December 2008)
Knowledge about time trends of disease patterns in society is essential for planning and prioritizing health care resources.
11/26/2008
12:41 PM
Inspired fraction of carbon dioxide in oxygen supply to chronic pulmonary disease
Respiratory Medicine Volume 102, Issue 12, Pages 1827-1829 (December 2008)
Hypoxemic patients with chronic obstructive pulmonary disease (COPD) are at risk of carbon dioxide (CO2) retention during oxygen therapy and hypercapnia in COPD is associated with an ominous prognosis.
11/26/2008
12:40 PM
Inspiratory muscle training in adults with chronic obstructive pulmonary disease: An update of a systematic review
Respiratory Medicine Volume 102, Issue 12, Pages 1715-1729 (December 2008)
The purpose was to update an original systematic review to determine the effect of inspiratory muscle training (IMT) on inspiratory muscle strength and endurance, exercise capacity, dyspnea and quality of life for adults with chronic obstructive pulmonary disease (COPD).
11/26/2008
12:39 PM
Increased intraepithelial T-cells in stable COPD
Respiratory Medicine Volume 102, Issue 12, Pages 1812-1818 (December 2008)
The airway epithelium is the first line of defence in the response to inhaled particles and irritants. Chronic obstructive pulmonary disease (COPD) is an inflammatory disease characterised by an irreversible loss of lung function, with cigarette smoking as a major risk factor.
11/26/2008
12:39 PM
HRCT and histopathological evaluation of fibrosis and tissue destruction in IPF associated with pulmonary emphysema
Respiratory Medicine Volume 102, Issue 12, Pages 1753-1761 (December 2008)
Idiopathic pulmonary fibrosis has been associated with emphysema in cigarette smokers as a new clinical entity: combined pulmonary fibrosis and emphysema (CPFE).
11/26/2008
12:38 PM
Epidemiology and clinical features of Mycoplasma pneumoniae infection in children
Respiratory Medicine Volume 102, Issue 12, Pages 1762-1768 (December 2008)
Mycoplasma pneumoniae (MP) is, considered to affect rarely children less than 5yrts of age. This study was performed to describe the epidemiology and the clinical features of MP lower respiratory tract infection (LRTI) in children, presenting to a tertiary children hospital.
11/26/2008
12:37 PM
Economic burden prior to COPD diagnosis: A matched case-control study in the United States
Respiratory Medicine Volume 102, Issue 12, Pages 1744-1752 (December 2008)
In the United States, chronic obstructive pulmonary disease (COPD) diagnosis is often a lengthy process, and consequently results in delays in treatment in early stages.
11/26/2008
12:36 PM
Does the relationship between asthma and obesity differ by neighborhood?
Respiratory Medicine Volume 102, Issue 12, Pages 1797-1804 (December 2008)
Prior studies suggest that obesity may cause asthma. Obesity and asthma are prevalent in low-income urban neighborhoods, but the impact of obesity on asthma in such neighborhoods has not been examined.
11/26/2008
12:35 PM
Diagnostic value of interleukine-6, transforming growth factor-beta 1 and vascular endothelial growth factor in malignant pleural effusions
Respiratory Medicine Volume 102, Issue 12, Pages 1708-1714 (December 2008)
We evaluate the accuracy of pleural interleukine-6 (IL-6), transforming growth factor-beta 1 (TGF-{beta}1), and vascular endothelial growth factor (VEGF) levels for differentiating benign from malignant pleural exudates.
11/26/2008
12:34 PM
Comparison of size classification of primary spontaneous pneumothorax by three international guidelines: A case for international consensus?
Respiratory Medicine Volume 102, Issue 12, Pages 1830-1832 (December 2008)
The aim of this study was to compare classification of pneumothoraces into size groups for treatment using the British Thoracic Society [BTS], American College of Chest Physicians [ACCP] and Belgian Society of Pulmonology [BSP] guidelines and the range of pneumothorax sizes in each group calculated using the volumetrically-derived Collins' method.
11/26/2008
12:33 PM
Clarithromycin inhibits fibroblast migration
Respiratory Medicine Volume 102, Issue 12, Pages 1769-1776 (December 2008)
The aim of the current study was to investigate the effect of 14-membered ring macrolide clarithromycin (CAM) on migration induced by human plasma fibronectin (HFn) or on contraction of human fetal lung fibroblasts (HFL-1).
11/26/2008
12:32 PM
Capsaicin provocation using two different inhalation devices
Respiratory Medicine Volume 102, Issue 12, Pages 1784-1790 (December 2008)
Sensory hyperreactivity (SHR) has been suggested as one explanation for chemically induced airway symptoms; it can be diagnosed with a capsaicin inhalation test.
11/26/2008
12:31 PM
Association of IL-6 gene polymorphisms and COPD in a Spanish Population
Respiratory Medicine Volume 102, Issue 12, Pages 1805-1811 (December 2008)
Interleukin-6 (IL-6) is a potential mediator of systemic effects of Chronic Obstructive Pulmonary Disease (COPD).
11/26/2008
12:30 PM
Argument for changing criteria for bronchodilator responsiveness
Respiratory Medicine Volume 102, Issue 12, Pages 1777-1783 (December 2008)
Extensively used current guidelines of the American Thoracic Society/European Respiratory Society (ATS/ERS) define a positive aerosolized bronchodilator
11/26/2008
12:28 PM
Achieving asthma control in practice: Understanding the reasons for poor control
Respiratory Medicine Volume 102, Issue 12, Pages 1681-1693 (December 2008)
Achieving asthma control remains an elusive goal for the majority of patients worldwide. Ensuring a correct diagnosis of asthma is the first step in assessing poor symptom control; this requires returning to the basics of history taking and physical examination, in conjunction with lung function measurement when appropriate.
11/26/2008
12:27 PM
Is the Effect of Prenatal Paracetamol Exposure on Wheezing in Preschool Children Modified by Asthma in the Mother?
Int Arch Allergy Immunol 2009;149:33-37
There seems to be an association between paracetamol consumption during late pregnancy and the prevalence of wheezing in infancy and childhood. The aim of the present study is to determine whether the aforementioned association is modified by the presence of asthma in the mother.
11/26/2008
12:26 PM
High-Resolution Computed Tomographic Imaging of Airways in Sarcoidosis Patients With Airflow Obstruction
Journal of Computer Assisted Tomography. 32(6):905-912, November/December 2008
To investigate airway involvement in patients with pulmonary sarcoidosis and airflow obstruction (AO) using high-resolution computed tomography.
11/26/2008
12:26 PM
Sirolimus Ameliorated Post Lung Transplant Chylothorax in Lymphangioleiomyomatosis
Ann Thorac Surg 2008;86:e7-e8. doi:10.1016/j.athoracsur.2008.07.062
We report a successful case of sirolimus treatment for chylous pleural and peritoneal effusions of lymphangioleiomyomatosis after lung transplantation. A 32-year-old woman underwent living donor lung transplantation.
11/26/2008
12:25 PM
Tetralogy of Fallot With Total Anomalous Pulmonary Venous Drainage
Ann Thorac Surg 2008;86:1937-1940. doi:10.1016/j.athoracsur.2008.07.093
The association of tetralogy of Fallot with total anomalous pulmonary venous drainage (TAPVD) is rare. We report our experience with this condition and review the literature.
11/26/2008
12:24 PM
Imaging of Lung Hamartomas by Multidetector Computed Tomography and Positron Emission Tomography
Ann Thorac Surg 2008;86:1769-1772. doi:10.1016/j.athoracsur.2008.08.033
Hamartomas constitute 8% of solitary lung nodules and 75% of benign nodules. Most are discovered on routine x-ray film and require further evaluation. Computed tomography (CT) is insufficient for a benign versus malignant diagnosis in about 30% of cases.
11/26/2008
12:24 PM
Should We Change Antibiotic Prophylaxis for Lung Surgery? Postoperative Pneumonia Is the Critical Issue
Ann Thorac Surg 2008;86:1727-1733. doi:10.1016/j.athoracsur.2008.08.005
The recommended antibiotic prophylaxis by second-generation cephalosporins reduces the incidence of wound infection and empyema, but its effectiveness on postoperative pneumonias (POPs) after major lung resection lacks demonstration.
11/26/2008
12:23 PM
Giant viable hydatid cyst of the lung: a case report
Journal of Medical Case Reports 2008, 2:359doi:10.1186/1752-1947-2-359
Hydatid disease is a parasitic infestation caused by Echinococcus granulosus. The resulting large cysts in the lung are a special clinical entity called giant hydatid cysts.
11/26/2008
12:22 PM
Is COPD a rare disease? Prevalence and identification rates in smokers aged 40 years and over within general practice in Germany
Family Practice, doi:10.1093/fampra/cmn084
According to literature, COPD rates are high in spite of decreasing rates of main risk factors smoking and air pollution in developed countries.
11/26/2008
12:21 PM
Age- and Serotype-Specific Pediatric Invasive Pneumococcal Disease: Insights from Systematic Surveillance in Santiago, Chile, 1994-2007
The Journal of Infectious Diseases 2008;198:1809-1817
We monitored pediatric invasive pneumococcal disease (IPD) in Santiago, Chile, from 1994 to 2007.
11/26/2008
12:19 PM
Induction of CC and CXC Chemokines in Human Antigen-Presenting Dendritic Cells by the Pneumococcal Proteins Pneumolysin and CbpA, and the Role Played by Toll-Like Receptor 4, NF-{kappa}B, and Mitogen-Activated Protein Kinases
The Journal of Infectious Diseases 2008;198:1823-1833
Choline-binding protein A (CbpA) and pneumolysin (Ply) can induce the expression and release of chemokines by human cells, which might modulate specific immune responses. In dendritic cells (DCs), such effects could be important for the size and character of the immunity induced if administered as vaccines. We studied the induction of CCL and CXCL chemokines by CbpA and Ply in DCs and related signaling pathways.
11/26/2008
12:18 PM
What have we learned from prospective cohort studies of asthma in children?
Chronic Respiratory Disease, Vol. 5, No. 4, 225-231 (2008)
Prospective cohort studies have provided a useful tool for the study of the natural history of asthma and lung function and for the development of concepts of asthma phenotypes during childhood.
11/26/2008
12:18 PM
Chronic cough - occupational considerations
Chronic Respiratory Disease, Vol. 5, No. 4, 211-221 (2008)
Chronic cough is a common symptom in a wide range of respiratory conditions, and may also occur as a result of upper airway or gastro-esophageal problems.
11/26/2008
11:57 AM
The influence of obesity on pulmonary rehabilitation outcomes in patients with COPD
Chronic Respiratory Disease, Vol. 5, No. 4, 205-209 (2008)
Although obesity is increasing in prevalence, relatively little attention has been given to its impact on outcomes in patients with chronic obstructive pulmonary disease (COPD) completing pulmonary rehabilitation.
11/25/2008
01:02 PM
Uplifting times for COPD
Primary Care Respiratory Journal Volume 17 Issue 4 December 2008 197-198
11/25/2008
01:01 PM
The use of microspirometry in detecting lowered FEV1 values in current or former cigarette smokers
Primary Care Respiratory Journal Volume 17 Issue 4 December 2008 232-237
COPD is an underdiagnosed disease. This study was undertaken to assess the value of microspirometry in detecting reduced FEV1 values in cigarette smokers i.e. subjects at high risk for COPD.
11/25/2008
01:00 PM
The use and abuse of office spirometry
Primary Care Respiratory Journal
Volume 17 Issue 4 December 2008 238-242
Spirometry programs (outside of primary care settings) designed to detect COPD in the general adult population are not justified, since the true positive yield (airway obstruction with an FEV1 below 60% predicted) is very low, and the false positive rate is very high.
11/25/2008
12:59 PM
Prolonged cough in children: a summary of the Belgian primary care clinical guideline
Primary Care Respiratory Journal Volume 17 Issue 4 December 2008 206-211
Prolonged cough is a frequent problem in the community. Several studies in the school setting have found that as many as 4.8% to 10.4% of children suffer from prolonged cough. There is no consensual definition of prolonged cough.
11/25/2008
12:58 PM
Prevention of COPD exacerbations by salmeterol/fluticasone propionate or tiotropium - the INSPIRE study
Primary Care Respiratory Journal Volume 17 Issue 4 December 2008 255-256
11/25/2008
12:57 PM
Perceptions, impact and management of asthma in South Africa: a patient questionnaire study
Primary Care Respiratory Journal Volume 17 Issue 4 December 2008 212-216
A number of studies from around the world have indicated that asthma morbidity is still unacceptably high. In the AIRE study over one-third of children and half of the adults reported daytime symptoms at least once a week.
11/25/2008
12:56 PM
Night-time cough in children with acute wheezing and with upper respiratory tract infection
Primary Care Respiratory Journal Volume 17 Issue 4 December 2008 217-221
To evaluate night-time cough patterns in children with either acute wheezing or an URTI, and to correlate them to the clinical diagnosis.
11/25/2008
12:56 PM
New guidelines on recurrent wheeze in preschool children: implications for primary care
Primary Care Respiratory Journal Volume 17 Issue 4 December 2008 243-245
11/25/2008
12:55 PM
Investigating the role of vasopressin in anaphylactic shock
Primary Care Respiratory Journal Volume 17 Issue 4 December 2008 257
11/25/2008
12:54 PM
Frequency and severity of allergic rhinitis in patients with asthma
Primary Care Respiratory Journal Volume 17 Issue 4 December 2008 258
11/25/2008
12:53 PM
Does use of a corticosteroid/long-acting beta-agonist combination inhaler increase adherence to inhaled corticosteroids?
Primary Care Respiratory Journal Volume 17 Issue 4 December 2008 246-247
This 12-month retrospective pilot study analysed prescription data of 82 patients with asthma from six practices in Norfolk.
11/25/2008
12:52 PM
Co-morbidities in people with COPD: a result of multiple diseases, or multiple manifestations of smoking and reactive inflammation?
Primary Care Respiratory Journal Volume 17 Issue 4 December 2008 199-205
There has been increased awareness and recognition of COPD in both developed and developing nations. As people with COPD are identified and treated before they reach end-stage lung disease, the multiple morbidities associated with COPD have been recognised.
11/25/2008
12:51 PM
Asthma Programme in Finland: the quality of primary care spirometry is good
Primary Care Respiratory Journal Volume 17 Issue 4 December 2008 226-231
To assess the quality of primary care spirometry by visual inspection of the flow-volume expiratory curve and to study the quantity of clinical information provided on the spirometry report sheets.
11/25/2008
12:50 PM
Asthma and allergic rhinitis co-morbidity: a cross-sectional questionnaire study on adolescents aged 13-14 years
Primary Care Respiratory Journal Volume 17 Issue 4 December 2008 222-225
There is scarce epidemiological population-based data on the prevalence of asthma and allergic rhinitis (AR) co-morbidity in adolescents.
11/25/2008
12:47 PM
A review of the TORCH study
Primary Care Respiratory Journal Volume 17 Issue 4 December 2008 253-254
11/25/2008
12:39 PM
Relative receptor affinity comparisons among inhaled/intranasal corticosteroids: perspectives on clinical relevance
Respiratory Research 2008, 9:75doi:10.1186/1465-9921-9-75
Pharmacokinetic properties, dosing regimen, and potency at the site of action are among the factors that influence activity of a corticosteroid.
11/25/2008
12:37 PM
Compliance with medical regimens, self-management programs, and self-care in childhood asthma
Clinical Reviews in Allergy and Immunology Volume 5, Number 3 / August, 1987 231-247
Compliance with medical regimens is as poor or poorer in childhood asthma than it is for other chronic illnesses. A spate of self-management programs for childhood asthma has been developed to counteract nonadherence and to enable patients to be more confident and competent in their ability to prevent or control asthmatic episodes.
11/25/2008
12:35 PM
The role of health education in medical management of asthma some program applications
Clinical Reviews in Allergy and Immunology Volume 5, Number 3 / August, 1987 195-205
Various asthma health education programs have been developed for different settings and populations. Many have been evaluated by an experimental research design.
11/25/2008
12:34 PM
Renal function and sleep-disordered breathing in older men
Nephrology Dialysis Transplantation 2008 23(12):3908-3914
Sleep-disordered breathing (SDB) is common in severe chronic kidney disease (CKD) and may contribute to morbidity and mortality in this population. However, the association between mild to moderate CKD and likelihood of SDB is uncertain.
11/25/2008
12:33 PM
Kickin' Asthma: School-Based Asthma Education in an Urban Community
The Journal of School Health, Volume 78, Number 12, December 2008 , pp. 655-665(11)
In urban communities with high prevalence of childhood asthma, school-based educational programs may be the most appropriate approach to deliver interventions to improve asthma morbidity and asthma-related outcomes.
11/25/2008
12:33 PM
Anterior segment granuloma and optic nerve involvement as the presenting signs of systemic sarcoidosis
Clinical Ophthalmology Issue: ON-LINE EARLY
To report a case with anterior and posterior nodules associated with systemic sarcoidosis.
11/25/2008
12:32 PM
Predicting the Need for Mechanical Ventilation and/or Inotropic Support for Young Adults Admitted to the Hospital with Community-Acquired Pneumonia
Clinical Infectious Diseases 2008;47:1571-1574
The UK Department of Health has published concerns that pneumonia severity scores determined at hospital admission may underestimate the severity of pneumonia in young adults.
11/25/2008
12:31 PM
Genetic Relationships between Respiratory Pathogens Isolated from Dental Plaque and Bronchoalveolar Lavage Fluid from Patients in the Intensive Care Unit Undergoing Mechanical Ventilation
Clinical Infectious Diseases 2008;47:1562-1570
Ventilator-associated pneumonia (VAP) is a leading cause of morbidity and mortality in patients hospitalized in intensive care units.
11/25/2008
12:30 PM
Meta- and pooled analyses of the effect of glutathione S-transferase M1 and T1 deficiency on chronic obstructive pulmonary disease
The International Journal of Tuberculosis and Lung Disease, Volume 12, Number 12, December 2008 , pp. 1474-1481(8)
Chronic obstructive pulmonary disease (COPD) is a complex polygenic disease in which gene-environment interactions are very important.
11/25/2008
12:29 PM
Air pollution and asthma severity in adults
Occup Environ Med. Published Online First: 18 November 2008. doi:10.1136/oem.2007.038349
There is evidence that exposure to air pollution affects asthma, but the effect of air pollution on asthma severity has not been addressed. The aim was to assess the relation between asthma severity during the past 12 months and home outdoor concentrations of air pollution.
11/25/2008
12:29 PM
Specific Antibodies to Diisocyanate and Work-related Respiratory Symptoms in Apprentice Car-Painters
Occup Environ Med. Published Online First: 18 November 2008. doi:10.1136/oem.2007.038125
Isocyanates are the main cause of occupational asthma in most countries. Study of immunological markers of diisocyanate asthma may identify individuals at risk.
11/25/2008
12:27 PM
17{beta}-Estradiol inhibits Ca2+-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia
J. Clin. Invest. doi:10.1172/JCI33893
Normal airways homeostatically regulate the volume of airway surface liquid (ASL) through both cAMP- and Ca2+-dependent regulation of ion and water transport.
11/25/2008
12:27 PM
ORMDL3 Associated Gene Variants are Associated with Asthma and Exacerbations but not Atopy in Early Childhood
Am. J. Respir. Crit. Care Med. 2008, doi:10.1164/rccm.200809-1436OC
An asthma predisposition locus on chromosome 17q12-q21 has recently been replicated in different ethnic groups. Here we describe the associated asthma and atopic phenotypes assessed longitudinally from birth to school age.
11/25/2008
12:26 PM
Attenuated P2X7 Pore Function as a Risk Factor for Virus Induced Loss of Asthma Control
Am. J. Respir. Crit. Care Med. 2008, doi:10.1164/rccm.200802-293OC
Upper respiratory tract infection is a guideline accepted risk domain for the loss of asthma control. The ionotrophic nucleotide receptor P2X7 regulates compartmentalized acute inflammation and the immune response to airway pathogens.
11/25/2008
12:25 PM
End-expiratory lung volume during mechanical ventilation: a comparison to reference values and the effect of PEEP in ICU patients with different lung conditions
Critical Care 2008, 12:R145 doi:10.1186/cc7125
Functional residual capacity (FRC) reference values are obtained from spontaneous breathing patients, measured in the sitting or standing position. During mechanical ventilation, FRC is determined by the level of PEEP and therefore it is better to speak of end-expiratory lung volume.
11/25/2008
12:24 PM
Posttranscriptional Regulation of uPAR Expression in Lipopolysaccharide-induced Acute Lung Injury
Am. J. Respir. Crit. Care Med. 2008, doi:10.1164/rccm.200712-1787OC
uPAR is required for the recruitment of neutrophils in response to infection. uPA induces its own expression in lung epithelial cells, which involves its interaction with cell surface uPAR. Regulation of uPAR expression is therefore crucial for uPA-mediated signaling in infectious acute lung injury (ALI).
11/25/2008
12:23 PM
Comparison of multidetector computed tomography-virtual bronchoscopy and conventional bronchoscopy in children with suspected foreign body aspiration
Emergency Radiology 1070-3004 (Print) 10.1007/s10140-008-0779-1
The aim of this study is to compare the diagnostic capability of multidetector computerized tomography (MDCT) and virtual bronchoscopy (VB) versus conventional bronchoscopy (CB) for the evaluation of children with suspected foreign body aspiration.
11/25/2008
12:22 PM
Incidence, clinical characteristics, and long-term prognosis of travel-associated pulmonary embolism
European Heart Journal,
doi:10.1093/eurheartj/ehn500
Prolonged air travel is considered a risk factor for pulmonary embolism (PE). The clinical characteristics as well as the long-term prognosis of patients suffering from travel-associated PE (‘economy-class syndrome',
ECS) remain largely unknown.
11/25/2008
12:21 PM
Maternal tolerance achieved during pregnancy is transferred to the offspring via breast milk and persistently protects the offspring from allergic asthma
Clinical & Experimental Allergy, Volume 38, Number 12, December 2008 , pp. 1950-1958(9)
Maternal, more than paternal, asthma is a risk factor for the development of asthma in children. Recently, epidemiologic studies have shown that environmental exposures during pregnancy might influence the development of childhood asthma and allergies.
11/25/2008
12:20 PM
Chronic Pseudomonas aeruginosa Infection in Chronic Obstructive Pulmonary Disease
Clinical Infectious Diseases 2008;47:1526-1533
Pseudomonas aeruginosa infections are increasingly associated with acute exacerbations in chronic obstructive pulmonary disease (COPD).
11/25/2008
12:19 PM
Safety and feasibility of aerobic training on cardiopulmonary function and quality of life in postsurgical nonsmall cell lung cancer patients
Cancer Published Online: 5 Nov 2008
A feasibility study examining the effects of supervised aerobic exercise training on cardiopulmonary and quality of life (QOL) endpoints among postsurgical nonsmall cell lung cancer (NSCLC) patients was conducted.
11/25/2008
12:18 PM
Office-Based Treatment and Outcomes for Febrile Infants With Clinically Diagnosed Bronchiolitis
PEDIATRICS Vol. 122 No. 5 November 2008, pp. 947-954
The goals were to describe the (1) frequency of sepsis evaluation and empiric antibiotic treatment, (2) clinical predictors of management, and (3) serious bacterial illness frequency for febrile infants with clinically diagnosed bronchiolitis seen in office settings.
11/25/2008
12:18 PM
Expectant Management of Pneumothorax in Ventilated Neonates
PEDIATRICS Vol. 122 No. 5 November 2008, pp. e975-e97
The purpose of this study was to assess the incidence and outcome of managing a pneumothorax without tube thoracostomy and to determine the clinical and laboratory characteristics that distinguish infants with a pneumothorax who can be treated without chest-tube insertion.
11/25/2008
12:17 PM
Mannose-binding lectin is present in the infected airway: a possible pulmonary defence mechanism
Thorax. Published Online First: 6 November 2008. doi:10.1136/thx.2008.100073
Mannose-binding lectin (MBL)-deficiency has been associated with infections of the respiratory tract and with increased disease severity in cystic fibrosis (CF). The mechanism is uncertain, and could relate either to systemic or local effects. The aim of this study was to determine, in a large human cohort, whether MBL is present on the airway surface in health or disease.
11/25/2008
12:16 PM
Expiratory Pharyngeal Narrowing during Central Hypocapnic Hypopnea
Am. J. Respir. Crit. Care Med. 2008, doi:10.1164/rccm.200805-741OC
Ventilatory motor output is an important determinant of upper airway patency during sleep.
11/25/2008
12:16 PM
Intraoperative Ventilator Settings and Acute Lung Injury after Elective Surgery: a Nested Case-Control Study
Thorax. Published Online First: 6 November 2008. doi:10.1136/thx.2008.102228
While acute lung injury (ALI) is among the most serious postoperative pulmonary complications, its incidence, risk factors and outcome have not been prospectively studied.
11/25/2008
12:15 PM
Lung function and clinical risk factors for asthma in infants and young children with recurrent wheeze
Thorax. Published Online First: 13 November 2008. doi:10.1136/thx.2008.099903
Although several risk factors for asthma have been identified in infants and young children with recurrent wheeze, the relevance of assessing lung function in this group remains unclear.
11/25/2008
12:14 PM
Pediatric athletic asthmatics
Current Allergy and Asthma Reports Volume 8, Number 6 / November, 2008 500-504
The main goals of this review are to help the reader to recognize the common symptoms and signs of exercise-induced asthma and the common objective tests used to confirm or rule out the diagnosis and to understand that different forms and intensities of exercise have different asthmagenicity.
11/25/2008
12:12 PM
Structural aspects of airway remodeling in asthma
Current Allergy and Asthma Reports Volume 8, Number 6 / November, 2008 540-547
Airway remodeling in asthma is a complex process that involves structural changes in virtually all tissues of the airway wall. The histologic changes to the airways consist of epithelial proliferation and goblet cell differentiation, subepithelial fibrosis, airway smooth muscle (ASM) growth, angiogenesis, matrix protein deposition, gland hyperplasia and hypertrophy, and nerve proliferation.
11/25/2008
12:12 PM
Factors leading to tracheobronchial self-expandable metallic stent fracture
J Thorac Cardiovasc Surg 2008;136:1328-1335
This retrospective study was to determine factors that contribute to self-expandable metallic stent fracture in patients with tracheobronchial disease.
11/25/2008
12:10 PM
Tube Thoracostomy: The Struggle to the "Standard of Care"
Ann Thorac Surg 2008;86:2019-2022. doi:10.1016/j.athoracsur.2008.08.006
Tube thoracostomy for thoracic injuries has been standard for only the last 40 years. Its theoretic roots trace back to World War II, where the goal of treatment was restoration of intrathoracic organ function.
11/25/2008
12:10 PM
Cryopreserved Arterial Allograft Reconstruction After Excision of Thoracic Malignancies
Ann Thorac Surg 2008;86:1753-1761. doi:10.1016/j.athoracsur.2008.06.027
The purpose of this study was to evaluate the long-term clinical and immunologic outcome of cryopreserved arterial allograft (CAA) revascularization of intrathoracic vessels invaded by malignancies.
11/25/2008
12:08 PM
Changes in emotional state of snoring and obstructive sleep apnea patients following radiofrequency tissue ablation
European Archives of Oto-Rhino-Laryngology 0937-4477 (Print) 10.1007/s00405-008-0866-7
A total of 37 primary snoring and obstructive sleep apnea hypopnea syndrome (OSAHS) patients were treated with two sessions of radiofrequency tissue ablation (RFTA) to assess the relationship among RFTA and sleepiness, anxiety and depression in patients with OSAHS.
11/25/2008
12:07 PM
Breathing intensity and word use in individuals with COPD
Chronic Respiratory Disease, Vol. 5, No. 4, 197-204 (2008)
Shifts in natural or spontaneous language have been reported with psychological and physical changes, as well as shifts in predetermined words selected to describe dyspnea.
11/25/2008
12:06 PM
Alveolar dead space and capnographic variables before and after thrombolysis in patients with acute pulmonary embolism
Vascular Health and Risk Management
Pulmonary embolism (PE) is a common condition. The central aim of this study was to describe the use of volumetric capnography (VCap) before and after fibrinolytic treatment of major PE. Lung scintigraphy was used as a base of comparison for the results of this treatment.
11/25/2008
12:05 PM
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11/25/2008
12:05 PM
Anomalous Systemic Arterial Supply to the Left Lung Base Without Sequestration
Heart, Lung, and Circulation Volume 17, Issue 6, Pages 505-507 (December 2008)
Systemic arterial supply from the descending thoracic aorta to the basal segment of the left lower lobe without a pulmonary arterial supply is a rare congenital anomaly within the spectrum of the sequestration lung disease.
11/25/2008
12:04 PM
Background sodium current underlying respiratory rhythm regularity
European Journal of Neuroscience Published Online: 21 Nov 2008
Rhythm-generating neural circuits underlying diverse behaviors such as locomotion, sleep states, digestion and respiration play critical roles in our lives. Irregularities in these rhythmic behaviors characterize disease states - thus, it is essential that we identify the ionic and/or cellular mechanisms that are necessary for triggering these rhythmic behaviors on a regular basis.
11/25/2008
12:03 PM
Risk of perinatal mortality associated with asthma during pregnancy
Thorax. Published Online First: 13 November 2008. doi:10.1136/thx.2008.102970
Thirteen studies investigating the association between asthma during pregnancy and perinatal mortality reported generally no increased risk. Most of these studies should be interpreted with caution because they were limited in terms of statistical power.
11/25/2008
12:03 PM
The effect of breastfeeding duration on lung function at age 10 years: a prospective birth cohort study
Thorax. Published Online First: 10 November 2008. doi:10.1136/thx.2008.101543
The protective effects of breastfeeding on early life respiratory infections are established, but there have been conflicting reports on protection from asthma in late childhood. We assessed the association of breastfeeding duration and lung function in 10-year olds.
11/25/2008
12:01 PM
Genome-wide Transcriptional Profiling Linked to Social Class in Asthma
Thorax. Published Online First: 10 November 2008. doi:10.1136/thx.2007.095091
Low socioeconomic status (SES) is one of the most robust social factors associated with disease morbidity, including more severe asthma in childhood. However, our understanding of the biological processes that explain this link is limited. In this study, we tested whether the social environment could get "under the skin" to alter genomic activity in children with asthma.
11/25/2008
12:00 PM
Aerobic and Anaerobic Exercise Capacities in Obstructive Sleep Apnea and Associations with Subcutaneous Fat Distributions
Lung 0341-2040 (Print) 10.1007/s00408-008-9128-0
Obesity is a strong risk factor for the development and progression of sleep apnea. Responses to exercise by patients with obstructive sleep apnea syndrome (OSAS) are clinically relevant to reducing body weight and cardiovascular risk factors.
11/25/2008
11:59 AM
Strategies for primary prevention of atopy in children
Current Allergy and Asthma Reports Volume 8, Number 6 / November, 2008 493-499
In recent decades, the prevalence of atopic diseases such as asthma, hayfever, food allergy, and atopic dermatitis has been steadily increasing. Unfortunately, more advances have been made in secondary prevention of symptoms and exacerbations than in primary prevention.
11/25/2008
11:57 AM
Small airways disease in asthma
Current Allergy and Asthma Reports Volume 8, Number 6 / November, 2008 533-539
A mounting body of physiologic and pathologic evidence indicates that asthma involves the central and the more distal airways. In patients with asthma, the peripheral lung accounts for a significant portion of airway resistance and, similar to the large airways, the small airways have been shown to be hyperresponsive to nonspecific stimuli, such as methacholine.
11/25/2008
11:56 AM
Obesity and respiratory diseases
Chronic Respiratory Disease, Vol. 5, No. 4, 233-242 (2008)
Obesity is a worldwide epidemic and is known to increase the risk of cardiovascular disease, type 2 diabetes, and certain forms of cancer. In addition, obesity is now recognized as an important risk factor in the development of several respiratory diseases.
11/25/2008
11:55 AM
Plasma markers of inflammation and incidence of hospitalizations due to chronic obstructive pulmonary disease. Results from a population-based cohort study
Thorax. Published Online First: 6 November 2008. doi:10.1136/thx.2008.102079
The relationship between plasma markers of inflammation and incidence of chronic obstructive pulmonary disease (COPD) is still unclear. This population-based study explored whether elevated levels of five inflammation-sensitive plasma proteins (ISPs) predicted COPD hospitalizations during 25 years of follow-up.
11/25/2008
11:53 AM
Lung Sound Analysis in the Diagnosis of Obstructive Airway Disease
Respiration (DOI: 10.1159/000178023)
Dyspnea is prevalent and has a broad differential diagnosis. Difficulty in determining the correct etiology can delay proper treatment. Non-invasively obtained acoustic signals may offer benefit in identifying patients with dyspnea due to obstructive airway disease (OAD).
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