Links
to Journal Articles Delivered Directly to Your Computer
The latest links to journal article abstracts on Respiratory, Pulmonary,
COPD, Mechanical Ventilation,
Ventilator Weaning, Respiratory Therapy, Asthma, Cardio-Vascular, Sleep
Apnea, CPAP, BiPAP, Decannulation and other related clinical topics. Add the Northeast Center for Special
Care Journal Watch
to your favorite RSS program.
The Primary Care Respiratory Journal Volume 18 Issue 1 March 2009
To investigate the burden of allergic rhinitis (AR) amongst primary care practitioners (PCPs), the impact of AR on
PCPs' professional lives, and the effect on their management of AR patients of
PCPs' personal experience of AR.
The Primary Care Respiratory Journal Volume 18 Issue 1 March 2009
To evaluate whether the Asthma Control TestTM (ACT) score is predictive of Global Initiative for Asthma (GINA) guideline-defined classification levels of asthma control. The ACT is a validated, 5-item, patient-completed measure of asthma control with a recall period of four weeks
The Primary Care Respiratory Journal Volume 18 Issue 1 March 2009
Pakistan has a population exceeding 160 million. Communicable diseases remain the most important health problem in Pakistan, with non-communicable diseases and injuries comprising a quarter of all deaths.
The Primary Care Respiratory Journal Volume 18 Issue 1 March 2009
This paper describes the prevalence of respiratory symptoms, features of asthma, and characteristics associated with respiratory disease in 6-11 year old children in an historical cohort study.
The Primary Care Respiratory Journal Volume 18 Issue 1 March 2009
To document the rate of diagnostic certainty, co-morbidity and use of medication in patients with presumed obstructive airway disease
(OAD) in a primary care setting.
Pulmonary artery sarcoma is a rare intravascular neoplasm usually mistaken for thromboembolic disease. Clues to the correct diagnosis include large, central pulmonary arterial filling defects out of proportion to the patient's symptoms, an enhancing pulmonary arterial filling defect, ipsilateral lung nodules, and ipsilateral pulmonary
oligemia.
The measurement of exhaled nitric oxide, when used in addition to current treatment guidelines for asthma, can result in the use of higher doses of medication without any measurable benefit.
The addition of nocturnal noninvasive positive pressure ventilation to pulmonary rehabilitation in patients with chronic obstructive pulmonary disease and chronic respiratory failure produced improvements in measures of health-related quality of life, functional status, and gas exchange.
Pulmonary embolism is associated with significant morbidity and mortality. Patient outcome depends on early and accurate diagnosis of the disease. Computed tomographic pulmonary angiography is the current reference standard for the diagnosis of acute pulmonary embolism.
Statin drugs inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate limiting step in cholesterol synthesis, and are used primarily to lower cholesterol levels, in particular that of low-density lipoprotein cholesterol. Several studies have confirmed that as a result of their effects the statins reduce or prevent heart disease and stroke in patients with and without a history of cardiovascular disease.
The purpose of this review is to describe the physiology and usefulness of B-type natriuretic peptide
(BNP) during weaning from mechanical ventilation. BNP is a powerful diagnostic and prognostic tool for right and left heart failure.
The finding of a solitary pulmonary nodule is a common dilemma, because of the desire to avoid both a delay in initiating treatment of a lung cancer as well as the risks and morbidity of an invasive biopsy that may not be needed.
Interstitial lung disease is a common manifestation of connective tissue disease, and connective tissue disease-associated interstitial lung disease
(CTD-ILD) is associated with significant morbidity and mortality. The treatment of CTD-ILD is often complex and challenging. This review focuses on the management of
CTD-ILD.
Aspergillus, a ubiquitous fungus, may cause a variety of clinical syndromes in the lung, depending on immune status of the host as well as the presence of underlying lung disease.
Chronic obstructive pulmonary disease (COPD) affects millions of people worldwide and is predicted to become the fourth leading cause of death by 2030. The importance of systemic effects of the disease is increasingly recognized, in particular loss of skeletal muscle bulk and skeletal muscle weakness.
Southern Medical Journal:Volume 102(3)March 2009pp 301-303
Broken heart syndrome, otherwise known as takotsubo syndrome, is stress-induced
cardiomyopathy. Clinical presentation mimics acute ST segment elevation myocardial infarction, but with characteristic left ventricular apical ballooning.
The Clinical Respiratory Journal Published Online: 11 Mar 2009
The study was performed in accordance with the principles of the Declaration of Helsinki and approved by the Medical Ethics Committee at Lund University. All included patients agreed to participate.
The Clinical Respiratory Journal Published Online: 11 Mar 2009
The study procedures were approved by the Columbia University Institutional Review Board and the Ethical Committee of the Bangladesh Medical Research Council.
Thrombosis and Haemostasis 2009 20090311 PrePrint Online: TH First 11th Mar 2009
Bleeding is the most frequent complication of antithrombotic therapy for venous thromboembolism
(VTE). However, little attention has been paid to the impact of bleeding after VTE in the community setting. The purpose of this investigation was to describe the incidence rate of bleeding after
VTE, to characterize patients most at risk for bleeding, and to assess the impact of bleeding on rates of recurrent VTE and all-cause mortality.
Journal of Molecular and Cellular Cardiology Volume 46, Issue 4, Pages 579-586 (April 2009)
Ischemic cardiovascular disease and obstructive pulmonary disease involve inflammation. Leukotrienes may be important pro-inflammatory mediators. We tested the hypothesis that the (-1072)G>A and (-444)A>C promoter polymorphisms of leukotriene C4 synthase confer risk of transient ischemic attack (TIA), ischemic stroke, ischemic heart disease
(IHD), asthma, and chronic obstructive pulmonary disease
(COPD).
The International Journal of Tuberculosis and Lung Disease, Volume 13, Number 3, March 2009 , pp. 394-399(6)
To determine sex and age variations in hospital readmissions for chronic obstructive pulmonary disease
(COPD) associated with overall and cardiac comorbid conditions.
The Journal of Thoracic and Cardiovascular Surgery Received 6 May 2008; received in revised form 28 October 2008; accepted 21 December 2008. published online 12 March 2009
We evaluated our results from our prospective database to identify possible modifications that may improve our fast-tracking protocols in selected high-risk patients.
International Journal of Cardiology Volume 133, Issue 1, Pages 129-131 (20 March 2009)
The aim of the present study was to examine subclinical effect of the severity of obstructive sleep apnea
(OSA) on myocardial structural changes and function using echocardiographic integrated backscatter and tissue Doppler imaging.
International Journal of Cardiology Volume 133, Issue 1, Pages 122-125 (20 March 2009)
Anticoagulant therapy is the standard treatment of venous thrombo-embolism
(VTE). Permanent inferior vena cava (IVC) filter is an important adjunctive therapy in these patients to prevent the complications like potentially fatal pulmonary embolism and chronic
thrombo-embolic pulmonary hypertension.
Am. J. Respir. Crit. Care Med. 2009, doi:10.1164/rccm.200901-0055CC
The decision by the FDA to issue a "black box" warning for long-acting beta-agonists has been followed by a series of pharmacoepidemiological studies focusing on the safety of these drugs.
An examination of the upper airway in patients with suspected sleep disordered breathing
(SDB) is recommended prior to nighttime polysomnography (PSG) despite a reported low predictive value of those examinations. The aim of this study was to evaluate the data of the clinical examination and to create a clinical prediction model.
Acta Radiologica First Published on: 10 March 2009
Mixed connective tissue disease (MCTD) is associated with several chest manifestations. Only a few studies have focused on chest manifestations in juvenile-onset MCTD
(jMCTD), and the true prevalence of pulmonary abnormalities on high-resolution computed tomography
(HRCT) in these patients is unknown.
The International Journal of Tuberculosis and Lung Disease, Volume 13, Number 3, March 2009 , pp. 387-393(7)
Chronic obstructive pulmonary disease (COPD) is underdiagnosed. One barrier to diagnosis is the limited availability of spirometry testing, but in adults at risk for
COPD, a normal pre-bronchodilator (pre-BD) peak expiratory flow
(PEF) may rule out clinically significant COPD.
Chinese Journal of Lung Cancer, Vol 12, No 2 (2009)
Background and objective Main airway severe obstruction is a problem facing difficulty flexible bronchoscope because the patient is not able to breath smoothly under prostration, and death from suffocation is a frequent outcome.
The International Journal of Tuberculosis and Lung Disease, Volume 13, Number 3, March 2009 , pp. 381-386(6)
To assess the value of vascular endothelial growth factor (VEGF) and endostatin in the differential diagnosis of malignant and tuberculous pleural effusions (PE).
Am. J. Respir. Crit. Care Med. 2009, doi:10.1164/rccm.200808-1324OC
We previously demonstrated that children with obstructive sleep apnea have increased blood pressure associated with changes in left ventricular mass index. Others have shown in adults that blood pressure variability is an important predictor of changes in left ventricular mass.
Am. J. Respir. Crit. Care Med. 2009, doi:10.1164/rccm.200712-1809OC
Cross-sectional epidemiologic studies show an association between sleep-disordered breathing and hypertension, but only one cohort study has examined sleep-disordered breathing as a risk factor for incident hypertension.
Am. J. Respir. Crit. Care Med. 2009, doi:10.1164/rccm.200807-1148OC
Cigarette smoke (CS) is the primary cause of chronic obstructive pulmonary disease
(COPD), an effect that is, in part, due to intense oxidant stress. Clearance of apoptotic cells
(efferocytosis) is a critical regulator of lung homeostasis, which is defective in smokers and in patients with
COPD, suggesting a role in disease pathogenesis.
J Am Acad Orthop Surg, Vol 17, No 3, March 2009, 183-196
This clinical practice guideline is based on a systematic review of published studies on the management of adult patients undergoing total hip replacement
(THR) or total knee replacement (TKR) aimed specifically at preventing symptomatic pulmonary embolism (PE).
This article discusses the history of the ICU and critical care medicine (CCM). It also discusses the certification of critical care nurses and allied health professionals, as well as CCM societies and congresses, education and board certification, evidence-based
CCM, research and publications, and future challenges to the field.
To examine the relationship between maternal intimate partner violence (IPV) and asthma onset in children and the role of supportive caregiving factors in modifying this relationship.
Severe status asthmaticus (SA) in children may require intubation and mechanical ventilation with a subsequent increased risk of death. In the patient with SA and refractory hypercapneic respiratory failure, use of extracorporeal life support
(ECLS) has been anecdotally reported for carbon dioxide removal and respiratory support.
Pediatric Critical Care Medicine:Volume 10(2)March 2009pp 242-245
The objective of this article is to review the findings and discuss the implications of the effect of oral decontamination with chlorhexidine
(CHX) or CHX/colistin on ventilator-associated pneumonia (VAP) incidence and time to development of
VAP.
Annals of Clinical Microbiology and Antimicrobials 2009, 8:10doi:10.1186/1476-0711-8-10
Mycoplasma pneumoniae and Chlamydophila pneumoniae are major causes of lower and upper respiratory infections that are difficult to diagnose using conventional methods such as culture.
As part of our influenza pandemic preparedness, we studied the dispersion distances of exhaled air and aerosolized droplets during application of a jet nebulizer to a human patient simulator
(HPS) programmed at normal lung condition and different severities of lung injury.
Prospective single-center study to determine whether the presence of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) has diagnostic utility in patients with pulmonary infiltrates receiving mechanical ventilation and undergoing BAL.
Thorax. Published Online First: 22 February 2009. doi:10.1136/thx.2008.107979
We sought to determine if KL-6 is a useful biomarker in differentiating neuroendocrine cell hyperplasia of infancy
(NEHI), a benign form of children’s interstitial lung disease, from the more severe inborn errors of surfactant metabolism
(IESM), since their clinical presentation can be similar.
Thorax. Published Online First: 22 February 2009. doi:10.1136/thx.2008.106609
Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) measured the global prevalence and severity of asthma symptoms in children.
Thorax. Published Online First: 22 February 2009. doi:10.1136/thx.2008.102053
We set out to estimate the contribution of polymorphisms in the
positionally-cloned asthma candidate genes ADAM33, PHF11, DPP10, GPRA and PTGDR to the risk of asthma, total and specific immunoglobulin E level, lung function and wheezing in a large, nationally representative, population.
Although depression among COPD patients is a common problem with important consequences for the management of COPD and overall outcomes, the proportion of those who receive guideline-concordant depression care is low.
Autoimmune pulmonary alveolar proteinosis (APAP) is characterized by autoantibodies against granulocyte-macrophage colony-stimulating factor
(GM-CSF) in blood and tissues, resulting in alveolar surfactant protein accumulation.
Health-care-associated pneumonia (HCAP) is a relatively new concept. Epidemiologic studies are limited, and initial empirical antibiotic treatment is still under discussion.
Although pulse oximetry is a widely accepted and frequently used tool, the reporting and reimbursement of the three related codes, 94760, 94761, and 94762, are often confusing.
We assessed the value of an ultrasound (US) examination in the diagnostic workup of patients with sleeprelated breathing disorders by correlating US measurements with known parameters for the presence and severity of obstructive sleep apnea.
International Journal of Cardiology Volume 133, Issue 1, Pages e11-e13 (20 March 2009)
Heparin induced thrombocytopenia and thrombosis (HITT) syndrome is a rare but potentially life threatening disorder, which is increasingly recognized with the widespread use of heparin.
Cardiac arrest represents a dramatic event that can occur suddenly and often without premonitory signs, characterized by sudden loss of consciousness and breathing after cardiac output ceases and both coronary and cerebral blood flows stop.
Recent advances in the field of pulmonary hypertension (PH) have provided clinicians with a range of treatment options, but effective disease management in children presents a unique challenge.
American Journal of Medicine Volume 122, Issue 3, Pages 257-264 (March 2009)
To investigate the prognostic value of electrocardiography (ECG) alone or in combination with echocardiography in patients with acute pulmonary embolism and normal blood pressure.
Critical Care Medicine:Volume 37(3)March 2009pp 1046-1053
Limiting tidal volume (VT) may minimize ventilator-induced lung injury (VILI). However, atelectasis induced by low VT ventilation may cause ultrastructural evidence of cell disruption. Apoptosis seems to be involved as protective mechanisms from VILI through the involvement of
mitogen-activated protein kinases (MAPKs). We examined the hypothesis that atelectasis may influence the response to protective ventilation through
MAPKs.
April 2009, Vol 99, No. 4 | American Journal of Public Health 690-697
We assessed the relative contribution of Hispanic ethnicity, country of origin, and nativity to lifetime prevalence of asthma among mothers and children enrolled in the Project on Human Development in Chicago Neighborhoods.
Pediatric Pulmonology Published Online: 9 Mar 2009
Infant pulmonary function testing (IPFT) has become an important clinical tool for the evaluation of lung function in infants with Cystic Fibrosis (CF); however, it is still unclear whether lung function in infancy is predictive of lung function later in life.
Pulmonary arterial hypertension (PAH) is a severe disease with marked morbidity and mortality for which therapeutic strategies have been limited. Basic research in vascular biology has implicated endothelin-1 (ET-1) and its receptors (ETA and
ETB) in diverse preclinical models of PAH, and ET-1 has been shown to contribute significantly to PAH in human patients.
This review focuses on sublingual immunotherapy (SLIT), toll-like receptor-9 (TLR-9) vaccines using cytosine phosphorothioate guanosine
(CpG)-allergen conjugates, and anti-IL-5 as novel immunomodulating therapies in allergy.
The objective of the present analysis is to describe the outcomes of high-intensity non-invasive positive pressure ventilation
(NPPV) aimed at maximally decreasing PaCO2 as an alternative to conventional NPPV with lower ventilator settings in stable hypercapnic COPD patients.
The American Journal of Cardiology Volume 103, Issue 6, Pages 881-886 (15 March 2009)
The clinical diagnosis of pulmonary embolism (PE) is difficult in coronary care units
(CCUs) because many findings of PE are similar to those of acute coronary syndromes and heart failure. Immobilization of only 1 or 2 days may predispose to PE.
European Journal of Heart Failure 2009 11(3):292-298
Chronic obstructive pulmonary disease is an independent predictor of mortality in patients with myocardial infarction (MI). However, the impact on mode of death and risk of atherosclerotic events is unknown.
EUROPEAN RESPIRATORY REVIEW, 2009;18: 35-41. doi:10.1183/09059180.00011112
The prognosis for patients with pulmonary hypertension remains poor despite recent treatment advances, and there is a need for therapies with new modes of action.
Thorax. Published Online First: 22 February 2009. doi:10.1136/thx.2008.110916
Regular use of inhaled beta-2-agonists has been associated with a paradoxical loss of asthma control and a deterioration of airway
hyperresponsiveness, but the underlying mechanism is unknown.
Respiratory Research 2009, 10:21doi:10.1186/1465-9921-10-21
Variation in ADAM33 has been shown to be important in the development of asthma and altered lung function.This relationship however, has not been investigated in the population susceptible to
COPD; long term tobacco smokers.
The d- and l-forms of N-acetylcysteine (NADC, NAC) were tested in antagonizing the toxicity mediated by hydrogen peroxide (H2O2) or tertiary butyl hydroperoxide
(tBHP) in two lung cell lines to assess the effectivity of glutathione synthesis against peroxides.
Localization of hydatid cysts in the heart is a rare phenomenon, with an incidence of 0.5-2%. In almost half these cases, the heart is the sole organ to be involved.
J Med Genet. Published Online First: 11 February 2009. doi:10.1136/jmg.2008.062703
Pulmonary arterial hypertension (PAH) is a progressive disorder characterized by raised pulmonary artery pressures with pathological changes in small pulmonary arteries.
European Journal of Heart Failure 2009 11(3):273-280
The combined therapeutic impact of atrial overdrive pacing (AOP) and cardiac resynchronization therapy (CRT) on central sleep apnoea (CSA) in chronic heart failure
(CHF) so far has not been investigated.
Critical Care Medicine:Volume 37(3)March 2009pp 1121-1124
Extracorporeal membrane oxygenation (ECMO) is known to improve cardiorespiratory function and outcome in neonates with severe respiratory failure. In this study, we tested two hypotheses: 1) neonates with severe respiratory failure exhibit alterations of the microcirculation and 2) after ECMO therapy these microcirculatory alterations are improved.
Critical Care Medicine:Volume 37(3)March 2009pp 1011-1017
To investigate the effects of low and high levels of positive end-expiratory pressure (PEEP), without recruitment maneuvers, during lung protective ventilation in an experimental model of acute lung injury (ALI).
Journal of Thoracic Imaging:Volume 24(1)February 2009pp 59-61
Late-onset pulmonary complications after peripheral blood stem cell transplantation include various conditions such as opportunistic infections and interstitial pneumonias. It is sometimes difficult to diagnose interstitial pneumonias because there is substantial overlap in their computed tomography appearances.
Journal of Thoracic Imaging:Volume 24(1)February 2009pp 66-68
We present a case of pulmonary sarcoidosis showing the reversed halo sign on high-resolution computed tomography
(HRCT). A 27-year-old man presented with nonproductive cough and high fever lasting for 3 weeks.
Journal of Thoracic Imaging:Volume 24(1)February 2009pp 62-65
The authors describe 2 cases in which thymoma spontaneously regressed. The first patient was a 49-year-old woman with myasthenia gravis. A chest radiograph on admission showed an anterior mediastinal mass that spontaneously decreased in size as shown on a radiograph obtained 2 weeks later.
It is well known that the sleeping position influences the rate of
apnea-hypopnea events; however, whether events in one position may have more influence on daytime sleepiness than events in another position has not been thoroughly investigated.
Academic Emergency Medicine Published Online: 6 Mar 2009
The utility of D-dimer testing for suspected pulmonary embolism (PE) can be limited by test specificity. The authors tested if the threshold of the quantitative
D-dimer can be varied according to pretest probability (PTP) of PE to increase specificity while maintaining a negative predictive value
(NPV) of >99%
Critical Care Medicine:Volume 37(3)March 2009pp 980-986
CHF was induced by supracoronary aortic banding whereas sham-operated rats served as controls. CHF rats or controls inhaled NO, aerosolized
iloprost, or 0.9% NaCl for 3 minutes each.
Arch Dis Child. Published Online First: 1 March 2009. doi:10.1136/adc.2007.132100
Inhaled corticosteroids (ICS) are commonly used to treat wheezing disorders in children but few studies have investigated the effect of ICS on lung function in infants. We evaluated the efficacy of inhaled budesonide for decreased specific airways conductance
(sGaw) as an indication of bronchial obstruction in very young children with recurrent cough and/or wheeze.
The aim of the study was to estimate the prevalence, characteristics, and prognostic factors of interstitial lung disease
(ILD) in patients with polymyositis (PM) and dermatomyositis (DM).
Screening for active tuberculosis (TB) and latent TB infection (LTBI) is mandatory prior to the initiation of tumour necrosis factor-{alpha} inhibitor therapy.
Cell culture methods commonly used to represent alveolar epithelial cells in vivo have lacked airflow, a 3-dimensional air-liquid interface, and dynamic stretching characteristics of native lung tissue-physiological parameters critical for normal phenotypic gene expression and cellular function.
Obstructive sleep apnea syndrome (OSAS) may predispose patients to congestive heart failure, suggesting a deleterious effect of OSAS on myocardial contractility.
Journal of Hospital Medicine Published Online: 5 Mar 2009
Venous thromboembolism (VTE) is a life-threatening condition for which thrombolytic therapy may be beneficial. The appropriate setting for the use of thrombolytic therapy remains controversial.
Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening condition in which organised thrombi obstruct the pulmonary vessels, causing increased pulmonary vascular resistance, progressive pulmonary hypertension (PH) and right heart failure.
The aim of the study was to compare a retrospective case note review of all cases of Pneumocystis carinii (now Pneumocystis
jirovecii) pneumonia (PJP) over the period 1997-2004 at North Manchester General Hospital with a previous audit covering the years 1986-1995. During 1986-1995, 777 patients were diagnosed with HIV.
Journal of Sleep Research, Volume 18, Number 1, March 2009 , pp. 20-25(6)
Continuous positive airway pressure (CPAP) causes a variable immediate reduction in the frequency of central apnoeas and hypopnoeas in patients with congestive heart failure
(CHF) and central sleep apnoea (CSA), but has beneficial mid-term effects on factors known to destabilize the ventilatory control system.
Journal of Sleep Research, Volume 18, Number 1, March 2009 , pp. 36-48(13)
Patients with obstructive sleep apnea (OSA) show neuropsychological impairments ranging from vigilance decrements, attentional lapses and memory gaps to decreased motor coordination, but their cognitive profile, and the origin of the impairments, remain unclear.
Journal of Sleep Research, Volume 18, Number 1, March 2009 , pp. 26-35(10)
A lateral position (LP) during sleep is effective in reducing sleep disorder symptoms in mild or moderate sleep apnea patients. However, the effect of head and shoulder posture in LP on reducing sleep disorders has not been reported.
Obstructive sleep apnoea/hypopnoea syndrome (OSAHS) is a common condition affecting ~2-4% of the middle-aged population. A hereditary component to the condition has long been recognised but its genetic basis has been difficult to elucidate.
Post-natal exposure to air pollution is associated with diminished lung growth during school age. The current authors aimed to determine whether pre-natal exposure to air pollution is associated with lung function changes in the newborn.
Tobacco smoking continues to be the largest preventable cause of premature morbidity and mortality throughout the world, including chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease.
The aim of the present study was to compare the efficacy of automatic titration of noninvasive ventilation
(NIV) with conventional NIV in stable neuromuscular and chest wall disorder patients established on long-term ventilatory support.
The Journal of Thoracic and Cardiovascular Surgery Received 1 August 2008; received in revised form 17 September 2008; accepted 26 October 2008. published online 09 March 2009
Between November 2001 and October 2007, 136 patients with suspected or histologically documented lung cancer were enrolled. Patients with no air leak and increased drainage underwent removal of the chest tube on the day after thoracoscopic lobectomy independent of the drainage volume.
The Journal of Thoracic and Cardiovascular Surgery Received 30 April 2008; received in revised form 11 September 2008; accepted 2 November 2008. published online 23 February 2009
Lobectomy with partial (n = 90) or circumferential (n = 3) pulmonary artery resection was carried out in 93 patients. Indications for surgical intervention were non-small cell lung cancer in 87 patients and other malignancy in the remaining 6 patients.
The Journal of Thoracic and Cardiovascular Surgery Received 17 July 2008; received in revised form 20 September 2008; accepted 26 October 2008. published online 23 February 2009
Bronchopleural fistula is a severe complication after pneumonectomy or
lobectomy. Local application of silver nitrate to seal bronchopleural fistulae was reported once 25 years ago with considerable success but was never repeated.
Intensive Care Medicine 0342-4642 (Print) 10.1007/s00134-009-1413-8
Angiopoietin-2 (Ang-2) is a potent regulator of vascular permeability and inflammation in acute lung injury and acute respiratory distress syndrome
(ARDS).
Am. J. Respir. Crit. Care Med. 2009, doi:10.1164/rccm.200812-1860OC
Association studies have implicated many genes in asthma pathogenesis, with replicated associations between single nucleotide polymorphisms
(SNPs) and asthma reported for more than 30 genes.
Clinical signs often fail to identify stroke patients who are at increased risk of aspiration. We hypothesized that objective measure of voluntary cough would improve the accuracy of the clinical evaluation of swallow to predict those patients who are at risk.
European Journal of Pediatrics 0340-6199 (Print) 10.1007/s00431-009-0961-9
The aims of this study were to determine whether caffeine administration increased respiratory muscle function and if this was associated with lung function improvement in prematurely born infants being weaned from mechanical ventilation.
Alcoholism: Clinical and Experimental Research Published Online: 6 Mar 2009
Adenosine uptake into cells by nucleoside transporters plays a significant role in governing extracellular adenosine concentration. Extracellular adenosine is an important signaling molecule that modulates many cellular functions via 4 G-protein-coupled receptor subtypes (A1, A2A, A2B, and A3). Previously, we demonstrated that adenosine is critical in maintaining airway homeostasis and airway repair and that airway host defenses are impaired by alcohol.
Journal of Clinical Microbiology, March 2009, p. 569-576, Vol. 47, No. 3
In-house PCR (hPCR) could speed differential diagnosis between tuberculosis (TB) and nontuberculous mycobacterial disease in patients with positive smears and pulmonary infiltrates, but its reported accuracy fluctuates across studies.
The International Journal of Tuberculosis and Lung Disease, Volume 13, Number 3, March 2009 , pp. 335-340(6)
To determine predictive factors for mortality among pulmonary tuberculosis (PTB) patients without human immunodeficiency virus (HIV) infection and in need of mechanical ventilation
(TBMV).
Respiratory Research 2009, 10:18doi:10.1186/1465-9921-10-18
Synthetic peptides containing the RGD sequence inhibit integrin-related functions in different cell systems. Here, we investigated the effects of synthetic Arg-Gly-Asp-Ser
(RGDS) peptide on key inflammatory responses to intratracheal
(i.t.) lipopolysaccharide (LPS) treatment and on the integrin signaled
mitogen-activated protein (MAP) kinase pathway during the development of acute lung injury.
Respiratory Research 2009, 10:19doi:10.1186/1465-9921-10-19
Bronchopulmonary dysplasia (BPD) is closely associated with ventilator-induced lung injury
(VILI) in very preterm infants. The greatest risk of VILI may be in the immediate period after birth, when the lungs are surfactant deficient, still partially filled with liquid and not uniformly aerated.
Respiratory Research 2009, 10:17doi:10.1186/1465-9921-10-17
Hypoxia induces the proliferation of lung fibroblasts in vivo and in vitro. However, the subcellular interactions between hypoxia and expression of tumor suppressor p53 and
cyclin-dependent kinase inhibitors p21 and p27 remain unclear.
Journal of Burn Care & Research:Volume 30(2)March/April 2009pp 249-256
To determine whether the combination of aerosolized unfractionated heparin and
N-acetylcystine reduces 28-days mortality and lung injury scores
(LISs) in adult patients with smoke inhalation injury requiring mechanical ventilation. The study was a single-center retrospective study with historical control.
Static stretch is frequently observed in the lung. Both static stretch and cyclic stretch can induce cell death and
Na+/K+-ATPase trafficking, but stretch-induced alveolar epithelial cell
(AEC) functions are much less responsive to static than to cyclic stretch.
Sleep and Breathing 1520-9512 (Print) 10.1007/s11325-009-0247-5
Continuous positive airway pressure (CPAP) is considered the standard therapy for obstructive sleep apnea syndrome. In the absence of standard protocol, CPAP titration may be unsuccessful.
Clinical Microbiology and Infection Published Online: 5 Mar 2009
Recent studies have suggested that procalcitonin (PCT) is a safe marker for the discrimination between bacterial and viral infection, and that PCT-guided treatment may lead to substantial reductions in antibiotic use.
Critical Care Medicine:Volume 37(3)March 2009pp 934-938
The physical examination of peripheral perfusion based on touching the skin or measuring capillary refill time has been related to the prognosis of patients with circulatory shock. It is unclear, however, whether monitoring peripheral perfusion after initial resuscitation still provides information on morbidity in critically ill patients.
Am J Physiol Lung Cell Mol Physiol 296: L267-L274, 2009
Lung alveolar epithelial cells are normally very well oxygenated but may be exposed to hypoxia in many pathological conditions such as pulmonary edema, acute respiratory distress syndrome, chronic obstructive pulmonary diseases, or in some environmental conditions such ascent to high altitude.
Am J Physiol Lung Cell Mol Physiol 296: L534-L546, 2009
Excessive neutrophil elastase (NE) activity and altered vascular endothelial growth factor
(VEGF) signaling have independently been implicated in the development and progression of pulmonary emphysema.
Journal of Thoracic Imaging:Volume 24(1)February 2009pp 49-51
Bronchopulmonary Lophomonas blattarum infection is a new form of disease, for which the clinical features are not fully understood. The present article is a retrospective review and analysis of clinical manifestations, chest x-ray, and computed tomography imaging findings in 15 cases of bronchopulmonary L. blattarum infection reported in China, including 1 case diagnosed and treated in our hospital.
Journal of Thoracic Oncology:Volume 4(3)March 2009pp 426-428
Primary Castleman's disease of the chest wall is unusual. Furthermore, such tumors arising from a surgical wound are extremely rare. We report a 33-year-old female with a history of a thoracic surgery at 5 years of age.
Journal of Thoracic Oncology:Volume 4(3)March 2009pp 432-434
Esophageal cancer with airway invasion with or without fistula presents a challenging therapeutic dilemma with no standard therapy. Recent studies in Japan have focused on the use of definitive
chemoradiotherapy.
Journal of Thoracic Oncology:Volume 4(3)March 2009pp 383-387
The clinical significance of lymph-node metastases, multicentric forms, and tumorlets in bronchial carcinoids is still a matter of debate. Aim of this study was to analyze their prevalence and clinical significance in a series of 123 bronchial
carcinoids.
Intensive Care Medicine 0342-4642 (Print) 10.1007/s00134-009-1447-y
To present a novel algorithm for estimating recruitable alveolar collapse and hyperdistension based on electrical impedance tomography
(EIT) during a decremental positive end-expiratory pressure (PEEP) titration.
Moderate-severe obstructive sleep apnoea (OSA) has been associated with several
pro-atherogenic mechanisms and increased cardiovascular risk, but it is not known if minimally symptomatic OSA has similar effects.
Recently, resistance to additional first-line and injectable drugs was reported to be an independent risk factor for adverse outcomes in
multidrug-resistant (MDR) tuberculosis (TB) patients.
CC chemokines play important roles in the pathogenesis of interstitial lung diseases. Elevated CC chemokine levels have been observed in bronchoalveolar lavage (BAL) fluid of patients with idiopathic pulmonary fibrosis
(IPF).
Journal of Thoracic Imaging:Volume 24(1)February 2009pp 23-30
In patients with suspected sarcoidosis requiring pathologic confirmation of the presence of noncaseating granulomatous inflammation and the exclusion of alternative disorders, bronchoscopic transbronchial lung biopsy and more recently transbronchial needle aspiration of mediastinal lymph nodes have been the standard biopsy procedures in most cases.
Journal of Child Neurology 2009, doi:10.1177/0883073808331362
Respiratory syncytial virus is a common cause of infection in children. The authors summarize the clinical and diagnostic features of 9 patients admitted to the pediatric intensive care unit with neurological consultation.
Prior stroke confers an increased risk of future cardiovascular events. Because the incremental economic impact of this added risk is unknown, we assessed the additional cardiovascular costs and hospitalizations associated with ischemic stroke.
Autoimmune pancreatitis is a unique form of chronic pancreatitis characterised by a high-serum immunoglobulin (Ig)G4 concentration involving various extra pancreatic lesions.
Am J Physiol Lung Cell Mol Physiol 296: L296-L306, 2009
NF-{kappa}B activation is exaggerated in neonatal organisms after oxidant and inflammatory insults, but the reason for this and the downstream effects are unclear.
Little is known about chronic obstructive pulmonary disease (COPD) in Chinese nonsmokers. The present study aimed to investigate the profiles of COPD among nonsmokers based on the Chinese Epidemiological Survey of COPD
(CESCOPD).
Journal of Clinical Microbiology, March 2009, p. 743-750, Vol. 47, No. 3
Respiratory virus infections are a major health concern and represent the primary cause of testing consultation and hospitalization for young children. We developed and compared two assays that allow the detection of up to 23 different respiratory viruses that frequently infect children.
Am J Physiol Heart Circ Physiol 296: H639-H644, 2009. First published January 9, 2009
The purpose of the present study was to determine for the first time the qualitative and quantitative impact of varying degrees of interatrial shunting on right heart dynamics and systemic perfusion in subjects with chronic pulmonary hypertension
(CPH).
Am J Physiol Lung Cell Mol Physiol 296: L307-L319, 2009
Understanding the mechanisms involved in respiratory tolerance to inhaled allergens could potentially result in improved therapies for asthma and allergic diseases. Airway hyperresponsiveness
(AHR) is a major feature of allergic asthma, thus the aim of the current study was to investigate mechanisms underlying suppression of allergen-induced AHR during chronic allergen exposure.
Journal of Thoracic Imaging:Volume 24(1)February 2009pp 31-33
We describe the clinical case of a thymoma, surgically removed after diagnosis, staging, and preoperative assessment performed by means of cardiac electrocardiogram-gated multidetector computed tomography.
Journal of Clinical Microbiology, March 2009, p. 697-703, Vol. 47, No. 3
An outbreak of acute respiratory tract infection occurred in Shanxi Province, China, from March to April 2006. Of the 254 patients affected by this outbreak, 247 patients were students of a senior high school; 1 of these patients died during the outbreak. Serological tests and blood culture revealed no evidence of bacterial infection.
Current Opinion in Anaesthesiology:Volume 22(1)February 2009p 50-55
In an effort to maximize resource utilization and contain costs, immediate postoperative care after noncardiac thoracic surgery is often done in either the postanesthesia care unit or dedicated step down units, leaving the ICU for complex surgical cases, overtly high-risk patients, or the treatment of severe postoperative complications.
Current Opinion in Anaesthesiology:Volume 22(1)February 2009p 23-30
The purpose of this review is to examine the evidence for and the clinical use of continuous positive airway pressure
(CPAP) and positive end-expiratory pressure (PEEP) for the management of one-lung ventilation during thoracic surgery.
Intensive Care Medicine 0342-4642 (Print) 10.1007/s00134-008-1372-5
Short-term hypoxemia affects diuresis and natriuresis in healthy individuals. No data are available on the impact of the mild hypoxemia levels usually tolerated in critically ill patients receiving mechanical ventilation.
The American Journal of Surgical Pathology:Volume 33(3)March 2009pp 462-469
Current classification of pulmonary adenocarcinoma includes noninvasive bronchioloalveolar carcinoma, mixed subtype
adenocarcinoma, and several patterns of invasive carcinoma. The extent of invasion in mixed subtype adenocarcinoma is variable, and prior studies suggest that estimates of extent of desmoplasia or invasion and gross tumor size are predictors of survival.
Tropical Medicine & International Health Published Online: 2 Mar 2009
To investigate whether visual assessment or microscopic grading of the cellular composition of specimens is a better strategy to screen specimen quality for tuberculosis (TB) diagnosis.
Acta Anaesthesiologica Scandinavica, Volume 53, Number 3, March 2009 , pp. 400-402(3)
The use of thrombolysis as an emergency treatment for cardiac arrest (CA) due to massive pulmonary embolism
(MPE) has been described. However, there are no reports of successful treatment of
MPE-associated CA in patients over 77 years of age.
Journal of Alternative and Complementary Medicine. ahead of print. doi:10.1089/acm.2008.0389
There has been limited study of yoga training as a complementary exercise strategy to manage the symptom of dyspnea in patients with chronic obstructive pulmonary disease
(COPD).
Associations have been observed between exposure to isocyanates, consisting mainly of
oligomers, and respiratory symptoms and isocyanate specific sensitisation in spray painters.
Expert Review of Anti-infective Therapy March 2009, Vol. 7, No. 2, Pages 183-188
Methicillin-resistant Staphylococcus aureus (MRSA) is an important cause of ventilator-associated pneumonia
(VAP), especially in patients who develop VAP late in their hospital course.
Pulmonary artery sarcomas are rare neoplasms that are often confused with chronic
thrombo-embolic disease, as both can have similar clinical and imaging presentation.
The present article reports the case of a 22-yr-old female with new onset Crohn's colitis, anterior uveitis and multiple pulmonary nodules which, on histological examination, were necrobiotic nodules.
We examined how differences in health service utilization among children with asthma are associated with race/ethnicity, socioeconomic status (family income, mother's education), and health insurance coverage.
We recorded scotopic and photopic flash electroretinograms (ERGs) in pediatric subjects with cystic fibrosis, aged 4 to 18 years, who were either pancreatic insufficient (PI) or pancreatic sufficient (PS).
Allergy, Volume 64, Number 3, March 2009 , pp. 439-444(6)
Remarkable relationship exists between upper and lower airways. Bronchial hyperreactivity
(BHR) is a paramount feature of asthma and may be considered a strong risk factor for the onset of asthma in patients with allergic rhinitis.
Allergy, Volume 64, Number 3, March 2009 , pp. 421-426(6)
Evidence regarding habitual physical activity levels and aerobic fitness of asthmatic compared to nonasthmatic children and adolescents is contradictory, and it is unclear if low physical activity levels can contribute to asthma development.
Allergy, Volume 64, Number 3, March 2009 , pp. 427-430(4)
To study the relative contribution of genetic and environmental factors to the correlation between exhaled nitric oxide
(FeNO), airway responsiveness, airway obstruction, and serum total immunoglobulin E
(IgE).
In this research, we performed EMSA experiments and transcriptional analysis of ESAT-6 cluster 3 in Mycobacterium smegmatis (msmeg0615-msmeg0625) and M. tuberculosis.
Although video-assisted thoracoscopic (VATS) lobectomy offers advantages with regard to pain, respiratory function and mobility, concern is often expressed concerning the cost of stapling devices and increased operative time.
To assess in a randomized clinical trial the influence of perioperative short-term ambroxol administration on postoperative complications, hospital stay and costs after pulmonary lobectomy for lung cancer.
To assess computed tomography with volume rendering (CT-VR) as a tool to evaluate parenchymal hyperinflation before and after bronchoscopic lung volume reduction
(BLVR) in patients with advanced stage emphysema.
European Journal of Nuclear Medicine and Molecular Imaging 1619-7070 (Print) 10.1007/s00259-009-1069-1
Individual clinical courses of idiopathic interstitial pneumonia (IIP) are variable and difficult to predict because the pathology and disease activity are contingent, and chest computed tomography (CT) provides little information about disease activity.
Southern Medical Journal:Volume 102(3)March 2009pp 301-303Broken heart syndrome, otherwise known as takotsubo syndrome, is stress-induced
cardiomyopathy. Clinical presentation mimics acute ST segment elevation myocardial infarction, but with characteristic left ventricular apical ballooning.
Southern Medical Journal:Volume 102(3)March 2009pp 277-282
A standardized definition of chronic obstructive pulmonary disease (COPD) exacerbation still represents an unmet need in respiratory medicine; definitions currently rely on clinical empiricism with little evidence-based scientific support.
Am J Physiol Lung Cell Mol Physiol 296: L347-L360, 2009
Mitochondria are proposed to be a major oxygen sensor in hypoxic pulmonary vasoconstriction
(HPV), a unique response of the pulmonary circulation to low oxygen tension.
Am J Physiol Lung Cell Mol Physiol 296: L328-L336, 2009
LPA (lysophosphatidic acid) is a potent bioactive phospholipid, which regulates a number of diverse cellular responses through G protein-coupled LPA receptors. Intracellular LPA is generated by the phosphorylation of monoacylglycerol by acylglycerol kinase
(AGK); however, the role of intracellular LPA in signaling and cellular responses remains to be elucidated.
Am J Physiol Lung Cell Mol Physiol 296: L394-L403, 2009
We have developed a potent antithrombin (AT)-heparin conjugate (ATH) that is retained in the lung to prevent pulmonary thrombosis associated with respiratory distress in premature newborns.
Am J Physiol Lung Cell Mol Physiol 296: L361-L371, 2009
We focused on the regulation of inflammatory mediator expression by adenovirus E1A in lung epithelial cells and the role of this viral protein in the pathogenesis of chronic obstructive pulmonary disease
(COPD)
Am J Physiol Lung Cell Mol Physiol 296: L372-L383, 2009
Among the multiple organ disorders caused by the severe acute respiratory syndrome coronavirus
(SARS-CoV), acute lung failure following atypical pneumonia is the most serious and often fatal event.
New England Journal of Medicine Volume 360:973-984 March 5, 2009 Number 10
Exacerbations of asthma are associated with substantial morbidity and mortality and with considerable use of health care resources. Preventing exacerbations remains an important goal of therapy. There is evidence that eosinophilic inflammation of the airway is associated with the risk of exacerbations.
New England Journal of Medicine Volume 360:985-993 March 5, 2009 Number 10
Eosinophilic inflammation, which may be a consequence of interleukin-5 action, is a characteristic feature of some forms of asthma. However, in three previous clinical trials involving patients with asthma, blockade of this cytokine did not result in a significant improvement in outcomes.
Little is known about survival and clinical prognostic factors in females with chronic obstructive pulmonary disease
(COPD). The aim of the present study was to determine the survival difference between males and females with COPD and to compare the value of the different prognostic factors for the disease.
Allergy, Volume 64, Number 3, March 2009 , pp. 354-367(14)
Asthma symptoms are the main reason for healthcare utilization and are a fundamental parameter for the evaluation of asthma control. Currently, asthma is defined as a chronic inflammatory disease.
Hypertension develops in 10% of pregnancies. Snoring, a marker of obstructive sleep
apnoea, is a newly identified risk factor for gestational hypertension. Moreover, obstructive sleep apnoea is an independent risk factor for incident hypertension in the non-pregnant population.
Allergy, Volume 64, Number 3, March 2009 , pp. 322-334(13)
The first few cases of hypersensitivity pneumonitis (HP) were described in the early 20th century in farmers exposed to moldy hay or straw. As then, HP has been ascribed to multiple inhaled antigens found in a large variety of environmental settings.
The Pediatric Infectious Disease Journal:Volume 28(2)February 2009pp 135-140
Respiratory syncytial virus (RSV)-induced lower respiratory tract disease is a common problem in children and adults in Western societies. The clinical range of RSV infection from asymptomatic to respiratory distress syndrome is believed to be the outcome of viral and host immunity interactions.
Stents may be indicated as treatment of benign and malignant conditions of the central airways. Occasionally, aberrant and/or distorted airways secondary to therapy or surgery may preclude the use of commercially manufactured
stents. The customization of stents is well described for nonpulmonary diseases, but to date there are only limited data in the literature on prosthesis customization for airway disease.
Obstructive Sleep Apnea Syndrome (OSAS) is a common condition in children, and is characterized by intermittent partial or complete occlusion of the upper airway during sleep, leading to profound disturbances in homeostatic gas exchange, frequent arousals and disturbed sleep architecture.
Obstructive sleep apnea (OSA) is associated with significant cardiovascular morbidity and excess in mortality. Atherosclerosis has been shown to occur in OSA patients free of any other significant risk factors. In particular, intima media thickness, an early marker of atherosclerosis, may be increased at the carotid level in
OSA.
Internal and Emergency Medicine 1828-0447 (Print) 10.1007/s11739-009-0231-x
Chronic thromboembolic pulmonary hypertension (CTPH) is a potential complication of pulmonary embolism (PE). Only few studies have assessed the role of brain natriuretic peptide
(BNP) in patients with chronic pulmonary hypertension, and there are no data on the potential utility of BNP as a preclinical biomarker of
CTPH.
Data from animal and human studies provide a biological plausibility to the notion that obstructive sleep apnea activates pathways that lead to insulin resistance, atherosclerosis and hypertension.
Untreated obstructive sleep apnea (OSA) is an independent risk factor for hypertension, myocardial infarction, and stroke. The repetitive
hypoxia/reoxygenation and sleep fragmentation associated with OSA impair endothelial function.
Respiratory infections are the commonest cause of pulmonary change on chest radiographs of HIV-infected children. However, HIV-related neurological,
oropharyngeal, oesophageal, cardiac and haematological abnormalities may also manifest with pulmonary changes and must be considered in the interpretation of the chest radiograph in HIV-infected children.
Current Opinion in Anaesthesiology:Volume 22(1)February 2009p 61-67
The present review evaluates the evidence available in the literature tracking perioperative mortality and morbidity as well as the pathogenesis and management of acute lung injury (ALI) in patients undergoing
thoracotomy.
Bronchioloalveolar carcinoma (BAC) is classified as a subset of lung adenocarcinoma but has a distinct clinical presentation, tumor biology, response to therapy, and prognosis compared with other subtypes of lung
adenocarcinoma.
Obstructive sleep apnea, aldosterone excess, and resistant hypertension are common comorbidities in obese patients. The mechanisms that link these conditions are not fully elucidated, but sympathetic nervous system activation, sodium retention, renin-angiotensin-aldosterone system stimulation, endothelial dysfunction, and increased production of reactive oxidative species may be contributing factors.
Obstructive sleep apnea (OSA) is associated with repetitive nocturnal arterial oxygen desaturation and
hypercapnia, large intrathoracic negative pressure swings, and acute increases in pulmonary artery pressure.
Markers of airway inflammation and oxidative stress have been mainly investigated in moderate/severe chronic obstructive pulmonary disease
(COPD) or during its exacerbation.
Anaemia occurs in 13-28% of sarcoidosis patients. It is associated with bone marrow infiltration by epitheliod granulomas in about 50% of cases, but its pathophysiology remains unclear.
Inhalation Toxicology First Published on: 25 February 2009
Numerous studies have suggested the association of reactive oxygen species (ROS) with adverse health effects derived from exposure to airborne particulate matter (PM) and diesel exhaust particles
(DEP).
Previous studies on welding-fume-induced lung fibrosis have indicated that recovery is possible when the degree of exposure is short-term and moderate.
The Pediatric Infectious Disease Journal:Volume 28(2)February 2009pp 118-122
Invasive pneumococcal disease (IPD) in children may manifest as
bacteremia/sepsis, bacteremic pneumonia, or meningitis, with serious outcomes that include hospitalization, neurologic
sequelae, or death.
Journal of Clinical Microbiology, March 2009, p. 837-840, Vol. 47, No. 3
Serotype 19A Streptococcus pneumoniae strains are now more frequent in French children than before the introduction of a
seven-valent conjugate vaccine (PCV7).
Tropical Medicine & International Health Published Online: 1 Mar 2009
To compare the simple, swab 'Kudoh method' for culturing Myobacterium tuberculosis from sputum samples, to the standard Petroff digestion-decontamination procedure. The Kudoh method, which requires no centrifugation and takes only 4-5 min per sample, was also evaluated for its performance in a rural setting.
Journal of Thoracic Imaging:Volume 24(1)February 2009pp 56-58
A 60-year-old woman was referred for 64-slice multidetector computed tomography because of the incidental findings of abnormality on a chest radiograph. Her computed tomography showed an absent right lung and a rudimentary main bronchus ending in a blind pouch; this established the diagnosis of pulmonary
aplasia.
The subepithelial fibrosis component of airway remodeling in asthma is mediated through induction of transforming growth factor-{beta}1
(TGF-{beta}1) expression with consequent activation of myofibroblasts to produce extracellular matrix proteins.
Journal of Pediatric Infectious Diseases Volume 4, Number 1 / 2009 17-26
Anaerobes are the predominant components of oropharyngeal mucous membranes bacterial flora, and are therefore a common cause of bacterial infections of endogenous origin of upper respiratory tract and head and neck in children.
The Pediatric Infectious Disease Journal:Volume 28(2)February 2009pp 131-134
Breastfeeding is a well-known protective factor against severe respiratory tract infections. Recently, a gender specific role for human milk has been described in very low birth weight infants and neonates: breast milk protected girls but not boys.
Journal of Clinical Microbiology, March 2009, p. 527-532, Vol. 47, No. 3
We evaluated the Prodesse ProFlu-1 real-time reverse transcription-PCR multiplex assay with the SmartCycler instrument for the detection of human respiratory syncytial virus (RSV) and influenza A and B viruses in comparison to conventional cell culture and antigen immunoassays with the BD Directigen A+B and Binax NOW RSV assays over two successive respiratory virus seasons.
Journal of the Neurological Sciences Volume 279, Issue 1, Pages 62-65 (15 April 2009)
Opioids are an effective treatment for the signs and symptoms of Restless Legs Syndrome
(RLS) and the signs and symptoms of RLS return when the opiate receptor blocker naloxone is given to opioid treated RLS patients in a blinded fashion.
Forced vital capacity (FVC) and maximal inspiratory pressure correlate with nocturnal hypoventilation in adults with neuromuscular disease, but children may not be able to perform these volitional tests.
Respiratory Medicine Volume 103, Issue 4, Pages 508-515 (April 2009)
In hypersensitivity pneumonitis (HP), survival can be predicted on the basis of the severity of fibrosis in surgical lung biopsy, but few data are available on the influence of clinical, functional, tomographic and histologic findings on prognosis.
Hospital admissions for exacerbations of chronic obstructive pulmonary disease
(COPD) impact considerably on disease evolution and healthcare provision.
Respiratory Medicine Volume 103, Issue 4, Pages 582-588 (April 2009)
Using a general practice research database with general practitioner (GP) clinical records, it has been observed that among the 617,280 subjects registered with 400 Italian GPs, 15,229 (2.47%) patients were suffering from chronic obstructive pulmonary disease
(COPD).
Respiratory Medicine Volume 103, Issue 4, Pages 621-628 (April 2009)
This study identifies equations for predicting lung function values in a population of ‘healthy’, nonsmoking older adults, explores the applicability of prediction equations derived from younger adult populations to the elderly, and examines the justification of developing population-specific reference equations for older age.
Respiratory Medicine Volume 103, Issue 4, Pages 535-541 (April 2009)
The non-specific bronchial hyper-responsiveness reported in mild to moderate COPD is usually attributed to reduced airway calibre accentuating the effect of airway smooth muscle shortening.
Respiratory Medicine Volume 103, Issue 4, Pages 595-600 (April 2009)
The intrapleural instillation of a sclerosing agent produces an inflammatory process frequently followed by pain. The treatment can include the use of analgesics or anti-inflammatory drugs.
Respiratory Medicine Volume 103, Issue 4, Pages 496-502 (April 2009)
Patients with COPD usually experience mucus hypersecretion as a result of airway inflammation and response to noxious stimuli. These in turn lead to worsening airway resistance, impaired airflow, increased work of breathing, dyspnoea and exercise intolerance.
Respiratory Medicine Volume 103, Issue 4, Pages 629-635 (April 2009)
The proportion of patients with cystic fibrosis (CF) who are middle-aged is increasing - and is likely to continue to do so. We surveyed a population of long-term CF survivors to assess their burden of illness and profile their disease characteristics.
Respiratory Medicine Volume 103, Issue 4, Pages 552-557 (April 2009)
Airflow limitation in COPD patients is not fully reversible. However, there may be large variability in bronchodilator responsiveness
(BDR) among COPD patients, and familial aggregation of BDR suggests a genetic component.
Respiratory Medicine Volume 103, Issue 4, Pages 485-495 (April 2009)
Chronic obstructive pulmonary disease (COPD) can lead to peripheral muscle atrophy and weakness. Electrical stimulation (ES) is commonly used to improve muscle function and structure.
Respiratory Medicine Volume 103, Issue 4, Pages 614-620 (April 2009)
There is a paucity of information on the differential effects of systemic versus inhaled corticosteroids on airway inflammation in patients with acute asthma.
Respiratory Medicine Volume 103, Issue 4, Pages 516-524 (April 2009)
Current guidelines support using in combination more than one class of long-acting bronchodilator for COPD patients whose symptoms are not controlled by mono-therapy.
Respiratory Medicine Volume 103, Issue 4, Pages 607-613 (April 2009)
Methacholine testing is an important diagnostic tool for asthma. Newly available dosimeter and software technology allows for simplification of the test.
Respiratory Medicine Volume 103, Issue 4, Pages 503-507 (April 2009)
Idiopathic pulmonary fibrosis (IPF) is increasing in incidence. One of the authors noted that many of his patients with IPF were taking
statins, and suspected an association. A case-control study was undertaken to investigate the association of statins with interstitial lung disease.
Respiratory Research 2009, 10:16doi:10.1186/1465-9921-10-16
The present document is the result of a consensus reached by a panel of experts from European and non-European countries on Occupational Rhinitis (OR), a disease of emerging relevance which has received little attention in comparison to occupational asthma.
Respiratory Research 2009, 10:15doi:10.1186/1465-9921-10-15
To evaluate the sensitivity, specificity and predictive values of fractional exhaled nitric oxide
(FENO) for the diagnosis of asthma in general practice.
Archives of Physical medicine and Rehabilitation Volume 90, Issue 3, Pages 395-401 (March 2009)
To analyze the influence of a home care (HC) program on outcomes of patients with chronic obstructive pulmonary disease
(COPD) receiving long-term oxygen therapy (LTOT) in comparison with outcomes of patients receiving standard care (SC).
What
is RSS?
