Exercise-induced asthma, respiratory and allergic disorders in elite athletes: epidemiology, mechanisms and diagnosis: Part I of the report from the Joint Task Force of the European Respiratory Society (ERS) and the European Academy of Allergy and Clinical Immunology (EAACI) in cooperation with GA2LEN
Allergy, Volume 63, Number 4, April 2008 , pp. 387-403(17)
To analyze the changes in the prevalence of asthma, bronchial hyperresponsiveness (BHR) and allergies in elite athletes over the past years, to review the specific pathogenetic features of these conditions and to make recommendations for their diagnosis.
03/10/2008
01:12 PM
Anti-proliferative and anti-remodelling effect of beclomethasone dipropionate, formoterol and salbutamol alone or in combination in primary human bronchial fibroblasts
Allergy, Volume 63, Number 4, April 2008 , pp. 432-437(6)
Bronchial asthma is characterized by lower airway inflammation and remodelling. Anti-inflammatory treatment with inhaled corticosteroids (ICS) provides the mainstay of asthma therapy together with bronchodilation induced by short- and long-acting inhaled beta2-agonists.
03/10/2008
01:11 PM
Increased Concordance of Severe Respiratory Syncytial Virus Infection in Identical Twins
PEDIATRICS Vol. 121 No. 3 March 2008, pp. 493-496
We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors.
03/10/2008
01:10 PM
Brief Report: The Temporal Relationships Between Sleep, Cortisol, and Lung Functioning in Youth with Asthma
Journal of Pediatric Psychology 2008 33(3):312-316
This study tested the directionality of the association between sleep and health outcomes in youth with asthma.
03/10/2008
01:09 PM
Responding to Simulated Pandemic Influenza in San Antonio, Texas
Infect Control Hosp Epidemiol 2008;29:320-326
To describe the results of a simulation study of the spread of pandemic influenza, the effects of public health measures on the simulated pandemic, and the resultant adequacy of the surge capacity of the hospital infrastructure and to investigate the adequacy of key elements of the national pandemic influenza plan to reduce the overall attack rate so that surge capacity would not be overwhelmed.
03/10/2008
01:08 PM
Complex two-gene modulation of lung disease severity in children with cystic fibrosis
J. Clin. Invest. 118(3): 1040-1049 (2008)
Although cystic fibrosis (CF) is a monogenic disease, its clinical manifestations are influenced in a complex manner. Severity of lung disease, the main cause of mortality among CF patients, is likely modulated by several genes.
03/10/2008
01:07 PM
Multidisciplinary interobserver agreement in the diagnosis of idiopathic pulmonary fibrosis
Eur Respir J 2008; 31:585-591
The purpose of the present study was to evaluate the accuracy of the diagnosis of idiopathic pulmonary fibrosis (IPF) by respiratory physicians in six European countries, and to calculate the interobserver agreement between high-resolution computed tomography reviewers and histology reviewers in IPF diagnosis.
03/10/2008
01:06 PM
Simvastatin attenuates release of neutrophilic and remodeling factors from primary bronchial epithelial cells derived from stable lung transplant recipients
Am J Physiol Lung Cell Mol Physiol 294: L592-L599, 2008
Obliterative bronchiolitis (OB), the major cause of chronic lung allograft dysfunction, is characterized by airway neutrophilia, inflammation, and remodeling, with progressive fibroproliferation and obliteration of small airways that ultimately leads to patient death.
03/10/2008
01:05 PM
Household chemicals, persistent wheezing and lung function: effect modification by atopy?
Eur Respir J 2008; 31:547-554
In the Avon Longitudinal Study of Parents and Children, a cohort study, a maternal composite household chemical exposure (CHCE) score was derived. Wheezing phenotypes from birth to age 7 yrs were assigned on the basis of reported wheeze.
03/10/2008
01:04 PM
The Relationship Between the Components of Pulmonary Artery Pressure Remains Constant Under All Conditions in Both Health and Disease
Chest. 2008; 133:633-639
The relationships among systolic pulmonary artery pressure (SPAP), diastolic pulmonary artery pressure (DPAP), and mean pulmonary artery pressure (MPAP) have been found to be constant in humans breathing air, at rest, while supine.
03/10/2008
01:03 PM
The Presence of Pneumococcal Bacteremia Does Not Influence Clinical Outcomes in Patients With Community-Acquired Pneumonia
Chest. 2008; 133:618-624
It remains unknown whether pneumococcal bacteremia increases the risk of poor outcomes in hospitalized patients with community-acquired pneumonia (CAP). The objective of this study was to investigate whether the presence of pneumococcal bacteremia influences the clinical outcomes of hospitalized patients with CAP.
03/10/2008
01:02 PM
Troponin T elevation and long-term mortality after chronic obstructive pulmonary disease exacerbation
Eur Respir J 2008; 31:563-570
Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of cardiovascular disease, exacerbations of which increase strain on the heart. The prognostic value of elevated circulating levels of cardiac Troponins seen during COPD exacerbations has been investigated.
03/10/2008
01:01 PM
Donepezil Improves Obstructive Sleep Apnea in Alzheimer Disease
Chest. 2008; 133:677-683
There is an association between Alzheimer disease and sleep-disordered breathing. Donepezil is the drug most frequently used to treat cognitive symptoms in Alzheimer disease. This study evaluates the effects of donepezil on obstructive sleep apnea in patients with Alzheimer disease.
03/08/2008
11:53 AM
Bronchiectasis: new findings in the pathogenesis and treatment of this disease
Current Opinion in Infectious Diseases. 21(2):163-167, April 2008
Bronchiectasis is an under-appreciated cause of chronic lung disease in the USA. We highlight developments in diagnosis and treatment of this debilitating disease.
03/08/2008
11:52 AM
Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking
Eur Respir J 2008; 31:555-562
Tobacco smoking induces an inflammatory response in the lungs of all smokers but, for reasons that are still poorly understood, only a proportion of them develop chronic obstructive pulmonary disease (COPD).
03/08/2008
11:51 AM
Stable prevalence of asthma symptoms in school-aged children in the Torres Strait region
Respirology doi:10.1111/j.1440-1843.2008.01239.x
A population-based cross-sectional study of school-aged children was conducted. Five schools in four communities were selected: 361 children aged 5-17 years participated.
03/08/2008
11:48 AM
High adenosine deaminase activity in the pleural effusion of a patient with Legionnaires' disease
Respirology doi:10.1111/j.1440-1843.2008.01235.x
Although Legionnaires' disease (LD) is frequently accompanied by pleural effusion, the characteristics of pleural effusions in LD have not been well studied. Levels of adenosine deaminase (ADA) activity in pleural fluid >40 IU/L have a high sensitivity (81-100%) and specificity (83-100%) for tuberculosis.
03/08/2008
11:48 AM
An Essential Role for Fibronectin Extra Type III Domain A in Pulmonary Fibrosis
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 638-645, (2008)
Tissue fibrosis is considered a dysregulated wound-healing response. Fibronectin containing extra type III domain A (EDA) is implicated in the regulation of wound healing. EDA-containing fibronectin is deposited during wound repair, and its presence precedes that of collagen.
03/08/2008
11:47 AM
Association between Systemic Chemotherapy before Chemoradiation and Increased Risk of Treatment-Related Pneumonitis in Esophageal Cancer Patients Treated with Definitive Chemoradiotherapy
Journal of Thoracic Oncology. 3(3):277-282, March 2008
There is limited information on risk factors for treatment-related pneumonitis in esophageal cancer patients.
03/08/2008
11:46 AM
Virological diagnosis in community-acquired pneumonia in immunocompromised patients
Eur Respir J 2008; 31:618-624
Community-acquired pneumonia (CAP) is a serious lower respiratory tract infection associated with significant morbidity and mortality in immunocompromised patients.
03/08/2008
11:45 AM
Exhaled nitric oxide and asthma control: a longitudinal study in unselected patients
Eur Respir J 2008; 31:539-546
Controlled studies have shown that monitoring of the exhaled nitric oxide fraction (FeNO) improves asthma management. However, the studies seldom consider the full range of patients seen in clinical practise.
03/08/2008
11:44 AM
Medication and Dosage Considerations in the Prophylaxis and Treatment of High-Altitude Illness
Chest. 2008; 133:744-755
With increasing numbers of people traveling to high altitude for work or pleasure, there is a reasonable chance that many of these travelers have preexisting medical conditions or are receiving various medications at the time of their sojourn.
03/08/2008
11:43 AM
Large and Medium-Sized Pulmonary Artery Obstruction Does Not Play a Role of Primary Importance in the Etiology of Sickle-Cell Disease-Associated Pulmonary Hypertension
Chest. 2008; 133:646-652
Pulmonary hypertension (PHT) occurs in approximately 30% of adult patients with sickle-cell disease (SCD) and is a risk factor for early death. The potential role of pulmonary artery obstruction, whether due to emboli or in situ thrombosis, in the etiology of SCD-related PHT is unknown.
03/08/2008
11:43 AM
Automatic Titration and Calculation by Predictive Equations for the Determination of Therapeutic Continuous Positive Airway Pressure for Obstructive Sleep Apnea
Chest. 2008; 133:670-676
It is unknown to what extent therapeutic continuous positive airway pressure (CPAP) levels obtained by various methods for the treatment of obstructive sleep apnea syndrome (OSAS) differ. This study aimed to explore the relationships among pressures titrated by an automatic CPAP (APAP) device and those calculated using different predictive equations, and to compare different ranges of calculated pressures with pressure values titrated by APAP.
03/08/2008
11:42 AM
Environmental Epigenetics and Asthma
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 567-573, (2008)
Recent studies suggest that epigenetic regulation (heritable changes in gene expression that occur in the absence of alterations in DNA sequences) may in part mediate the complex gene-by-environment interactions that can lead to asthma.
03/08/2008
11:41 AM
Ventilator Advisory System Employing Load and Tolerance Strategy Recommends Appropriate Pressure Support Ventilation Settings
Chest. 2008; 133:697-703
Loads on the respiratory muscles, reflected by noninvasive measurement of the real-time power of breathing (POBn), and tolerance of these loads, reflected by spontaneous breathing frequency (f) and tidal volume (VT), should be considered when evaluating patients with respiratory failure.
03/08/2008
11:40 AM
Systemic Inflammation Caused by White Smoke Inhalation in a Combat Exercise
Chest. 2008; 133:722-728
White smoke inhalation is an uncommon but potentially deadly cause of acute lung injury. No clinical spectrum or treatment protocol have been developed.
03/08/2008
11:38 AM
Endurance shuttle walking test: responsiveness to salmeterol in COPD
Eur Respir J 2008; 31:579-584
Few studies have shown that the endurance shuttle walking test (ESWT) is responsive to treatment in patients with chronic obstructive pulmonary disease (COPD). This exercise test needs to be further investigated because of its relevance for activity of daily living. The aim of the present study was to evaluate, in patients with COPD, the responsiveness of the ESWT in detecting improvement in walking performance after a single dose of salmeterol.
03/06/2008
03:07 PM
Use of salmeterol with and without concurrent use of inhaled corticosteroids and the risk of asthma-related hospitalization among patients with asthma
Current Medical Research and Opinion, Volume 24, Number 3, March 2008 , pp. 859-867(9)
Studies evaluating the safety of salmeterol are inconclusive, which might be the result from not taking into account the impact of concomitant inhaled corticosteroids (ICS).
03/06/2008
03:07 PM
Plasma Biomarkers of Oxidative Stress: Relationship to Lung Disease and Inhaled Nitric Oxide Therapy in Premature Infants
PEDIATRICS Vol. 121 No. 3 March 2008, pp. 555-561
Inhaled nitric oxide treatment for ventilated premature infants improves survival without bronchopulmonary dysplasia. However, there has been no information regarding possible effects of this therapy on oxidative stress. We hypothesized that inhaled nitric oxide therapy would not influence concentrations of plasma biomarkers of oxidative stress.
03/06/2008
03:05 PM
In Vitro Activity of AR-709 against Streptococcus pneumoniae
Antimicrobial Agents and Chemotherapy, March 2008, p. 1182-1183, Vol. 52, No. 3
We investigated the in vitro activity of AR-709, a novel diaminopyrimidine antibiotic currently in development for treatment of community-acquired upper and lower respiratory tract infections, against 151 Streptococcus pneumoniae strains from various European countries. AR-709 showed excellent activity against both drug-susceptible and multidrug-resistant pneumococci.
03/06/2008
03:04 PM
Dectin-1 Fc Targeting of Aspergillus fumigatus Beta-Glucans Augments Innate Defense against Invasive Pulmonary Aspergillosis
Antimicrobial Agents and Chemotherapy, March 2008, p. 1171-1172, Vol. 52, No. 3
Invasive pulmonary aspergillosis (IPA) has significantly increased over the last decade. Here, a fusion protein consisting of the Dectin-1 extracellular domain linked to the Fc portion of murine immunoglobulin G1 augmented alveolar macrophage killing of Aspergillus fumigatus and shifted mortality associated with IPA via attenuation of A. fumigatus growth in the lung.
03/06/2008
03:03 PM
Activity of the Diaminopyrimidine AR-709 against Recently Collected Multidrug-Resistant Isolates of Invasive Streptococcus pneumoniae from North America
Antimicrobial Agents and Chemotherapy, March 2008, p. 1147-1149, Vol. 52, No. 3
03/06/2008
03:01 PM
Symptoms of Sleep Apnea and Polysomnography as Predictors of Poor Quality of Life in Overweight Children and Adolescents
Journal of Pediatric Psychology 2008 33(3):269-278
The goal of this study was to examine the relationship between quality of life (QOL) and symptoms of obstructive sleep apnea (OSA) as well as objectively measured severity of OSA using polysomnography (PSG) in a cohort of overweight and at risk for overweight children and adolescents.
03/06/2008
02:58 PM
Dietary supplement use in pediatric patients with cystic fibrosis
American Journal of Health-System Pharmacy, Vol. 65, Issue 6, 562-565
The use of dietary supplements and their perceived effectiveness in pediatric patients with cystic fibrosis (CF) were studied.
03/06/2008
02:57 PM
Serum markers in community-acquired pneumonia and ventilator-associated pneumonia
Current Opinion in Infectious Diseases. 21(2):157-162, April 2008
This article reviews recent data on the usefulness of serum markers in community-acquired pneumonia and ventilator-associated pneumonia. The focus is on clinical studies, with an emphasis on adult critically ill patients.
03/06/2008
02:57 PM
Respiratory infection complicating HIV infection
Current Opinion in Infectious Diseases. 21(2):184-190, April 2008
Respiratory infections remain a major cause of morbidity among HIV-infected persons. Thus, knowledge of recent advances regarding HIV-associated opportunistic pneumonias is crucial for optimal care of HIV-infected persons.
03/06/2008
02:56 PM
Diagnosis of ventilator-associated pneumonia: is there a gold standard and a simple approach?
Current Opinion in Infectious Diseases. 21(2):174-178, April 2008
Diagnosis of ventilator-associated pneumonia remains controversial. Different approaches are advocated, but none has yet demonstrated superiority. Diagnosis based on clinical data and aetiological diagnosis of ventilator-associated pneumonia episodes are two concepts that should be combined in an integrative evaluation for ventilator-associated pneumonia. Recent findings in diagnosis are reviewed here.
03/06/2008
02:55 PM
Identification of Bordetella spp. in respiratory specimens from individuals with cystic fibrosis
Clinical Microbiology and Infection doi:10.1111/j.1469-0691.2008.01968.x
Bordetella spp. are not normally included when considering the opportunistic bacterial species that are typically involved in respiratory tract infections in individuals with cystic fibrosis (CF).
03/06/2008
02:54 PM
The Relationship Between Air Pollutants and Heart-Rate Variability Among Community Residents in Korea
Inhalation Toxicology, Volume 20, Issue 4 February 2008 , pages 435 - 444
Air pollution, both particulate and gaseous, is known to cause adverse health effects and is associated with increased cardiovascular mortality and morbidity. With a growing recognition in the importance of the autonomic nervous system in air pollution, we examined the effects of air pollutants, namely, particulate matter (PM10), sulfur dioxide (SO2), and nitric dioxide (NO2), on cardiac autonomic function by measuring heart-rate variability (HRV) among community residents.
03/06/2008
02:53 PM
Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia
Critical Care Medicine. 36(3):737-744, March 2008
The study included 740 mechanically ventilated patients who developed suspected ventilator-associated pneumonia after 96 hrs in the intensive care unit. Patients known to be colonized or infected with Pseudomonas or methicillin-resistant Staphylococcus aureus or who were immunocompromised were excluded from the study.
03/06/2008
02:52 PM
Phosphodiesterase-4 inhibition attenuates pulmonary inflammation in neonatal lung injury
Eur Respir J 2008; 31:633-644
Phosphodiesterase-4 (PDE4) inhibitors may offer novel therapeutic strategies in respiratory diseases, including asthma and chronic obstructive pulmonary disease.
03/06/2008
02:51 PM
Total Anomalous Pulmonary Venous Connection to the Supradiaphragmatic Inferior Vena Cava
Ann Thorac Surg 2008;85:1089-1092
Total anomalous pulmonary venous connection to the inferior vena cava is a rare form of total anomalous pulmonary venous connection infrequently described in the literature. We report two cases where the pulmonary venous connection was to the supradiaphragmatic portion of the inferior vena cava.
03/06/2008
02:50 PM
Presentation of Pulmonary Artery Intimal Sarcoma in an Infant With a History of Neonatal Valvular Pulmonic Stenosis
Ann Thorac Surg 2008;85:1092-1094
Intimal sarcoma of the pulmonary artery is rare in the adult population. It is usually diagnosed postmortem in patients thought to have pulmonary emboli. We present a case of intimal sarcoma of the pulmonary artery in an infant with a history of neonatal pulmonic stenosis.
03/06/2008
02:49 PM
Left-Sided Partial Anomalous Pulmonary Venous Connections
Ann Thorac Surg 2008;85:1007-1014
Left-sided partial anomalous pulmonary venous connection (PAPVC) is a congenital defect where pulmonary veins from the left lung drain into the right atrium. If left untreated, PAPVC may result in severe right ventricular failure and pulmonary vascular disease. We sought to determine the effectiveness and long-term outcome after surgical correction of this anomaly.
03/06/2008
02:49 PM
IRF-1 Gene Variations Influence IgE Regulation and Atopy
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 613-621, (2008)
The development of atopic diseases is characterized by skewed immune responses to common allergens. Only recently, interferons have been identified to play a crucial role in these mechanisms.
03/06/2008
02:48 PM
Fluticasone or Salmeterol Alone vs. Combination Therapy for COPD
American family Physician March 1, 2008
This was a randomized, double-blind trial of 6,112 patients with COPD (defined as airway disease that is less than 10 per-cent reversible with beta agonists). The par-ticipants were randomized to one of four groups: (1) fluticasone (Flovent); (2) salme-terol (Serevent); (3) a combination of flutica-sone and salmeterol (Advair); or (4) placebo.
03/06/2008
02:47 PM
Idiopathic Pulmonary Fibrosis: Physiologic Tests, Quantitative CT Indexes, and CT Visual Scores as Predictors of Mortality
Radiology 2008;246:935-940
To retrospectively evaluate quantitative computed tomographic (CT) indexes, pulmonary function test results, and visual CT scoring as predictors of mortality and to describe serial changes in quantitative CT indexes over 12 months in patients with idiopathic pulmonary fibrosis (IPF).
03/06/2008
02:46 PM
Survival After Lung Transplantation of Cystic Fibrosis Patients Infected with Burkholderia cepacia Complex
American Journal of Transplantation doi:10.1111/j.1600-6143.2008.02186.x
Within the Burkholderia cepacia complex (Bcc), B. cenocepacia portends increased mortality compared with other species. We investigated the impact of Bcc infection on mortality and re-infection following lung transplant (LT).
03/06/2008
02:45 PM
Massive Pulmonary Embolism: What Level of Aggression?
Semin Respir Crit Care Med 2008; 29: 047-055
Massive pulmonary embolism (PE) with hemodynamic instability (e.g., hypotension and cardiac shock) is associated with a poor prognosis and high mortality rates (> 50%). Accordingly patients with massive PE should be treated aggressively with thrombolytic agents (or surgical or interventional procedures).
03/06/2008
02:44 PM
Childhood sarcoidosis: long-term follow-up
Eur Respir J 2008; 31:592-598
The aim of the present study was to describe clinical features and long-term survival in childhood sarcoidosis.
03/06/2008
02:43 PM
Mechanisms of Dyspnea during Cycle Exercise in Symptomatic Patients with GOLD Stage I Chronic Obstructive Pulmonary Disease
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 622-629, (2008)
To examine ventilatory constraints during exercise in symptomatic smokers with GOLD (Global Initiative for Chronic Obstructive Lung Disease) stage I chronic obstructive lung disease (COPD) so as to uncover potential mechanisms of dyspnea and exercise curtailment.
03/06/2008
02:43 PM
Growth Velocity Predicts Recurrence of Sleep-disordered Breathing 1 Year after Adenotonsillectomy
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 654-659, (2008)
Adenotonsillectomy, the first line of treatment of sleep-disordered breathing (SDB), is the most commonly performed pediatric surgery. Predictors of the recurrence of SDB after adenotonsillectomy and its impact on cardiovascular risk factors have not been identified.
03/06/2008
02:42 PM
Value of chest radiography in phenotyping chronic obstructive pulmonary disease
Eur Respir J 2008; 31:509-515
The objectives of the present study were to reappraise chest radiography for the diagnosis of emphysema, using computed tomography (CT) as the reference standard, and to establish whether or not chest radiography is useful for phenotyping chronic obstructive pulmonary disease (COPD).
03/06/2008
02:41 PM
Anxiety and depression in end-stage COPD
Eur Respir J 2008; 31:667-677
Although feelings of anxiety and depression are common in patients with chronic obstructive pulmonary disease (COPD), estimates of their prevalence vary considerably. This probably reflects the variety of scales and methods used to measure such symptoms. Regardless of whether anxiety and depression are considered separately or as a single construct, their impact on COPD patients is important.
03/06/2008
02:40 PM
Sensitivity of H5N1 influenza viruses to oseltamivir: an update
Future Virology, Volume 3, Number 2, March 2008 , pp. 157-165(9)
Continued worldwide circulation of highly pathogenic influenza A (H5N1) viruses has raised concerns that they might adapt to humans and cause a pandemic. Preparedness plans rely on influenza vaccines and on the prophylactic and therapeutic use of neuraminidase inhibitors, especially the orally available drug oseltamivir.
03/06/2008
02:39 PM
Symptoms of Influenza Virus Infection in Hospitalized Patients
Infect Control Hosp Epidemiol 2008;29:314-319
During influenza outbreaks, fever and cough are the most accurate symptoms in predicting influenza virus infection in the community.
03/06/2008
02:38 PM
Use of a Mandatory Declination Form in a Program for Influenza Vaccination of Healthcare Workers
Infect Control Hosp Epidemiol 2008;29:302-308
To evaluate the utility and impact of using a declination form in the context of an influenza immunization program for healthcare workers.
03/06/2008
02:36 PM
What is healthcare-associated pneumonia and how is it managed
Current Opinion in Infectious Diseases. 21(2):168-173, April 2008
Pneumonia developing before hospital admission in patients in close contact with the health system was recently termed 'healthcare-associated pneumonia' and proposed as a new category of respiratory infection. We focus on the recent literature concerning the epidemiology, causative organisms, antibiotic susceptibilities, and outcomes of and empirical antibiotic therapy for this condition.
03/06/2008
02:34 PM
Acute Pulmonary Embolism
New England Journal of Medicine Volume 358:1037-1052 March 6, 2008 Number 10
Pulmonary embolism, most commonly originating from deep venous thrombosis of the legs, ranges from asymptomatic, incidentally discovered emboli to massive embolism causing immediate death. Chronic sequelae of venous thromboembolism (deep venous thrombosis and pulmonary embolism) include the post-thrombotic syndrome and chronic thromboembolic pulmonary hypertension.
03/06/2008
02:33 PM
Adjunctive Intrapleural Tissue Plasminogen Activator Administered via Chest Tubes Placed with Imaging Guidance: Effectiveness and Risk for Hemorrhage
Radiology 2008;246:956-963
To retrospectively determine the effectiveness of and risk for hemorrhage with intrapleural adjunctive tissue plasminogen activator (tPA) administered via chest tubes placed with imaging guidance.
03/06/2008
02:32 PM
Validation of a Method To Screen for Pulmonary Hypertension in Advanced Idiopathic Pulmonary Fibrosis
Chest. 2008; 133:640-645
We have developed a method to screen for pulmonary hypertension (PH) in idiopathic pulmonary fibrosis (IPF) patients, based on a formula to predict mean pulmonary artery pressure (MPAP) from standard lung function measurements. The objective of this study was to validate this method in a separate group of IPF patients.
03/06/2008
02:32 PM
New Definition and Natural History of Patients With Diffuse Pulmonary Arteriovenous Malformations
Chest. 2008; 133:653-661
Patients with diffuse pulmonary arteriovenous malformations (PAVM), a small but important subset of the PAVM population, have significant morbidity and mortality rates.
03/06/2008
02:31 PM
Monitoring Recovery From Diaphragm Paralysis With Ultrasound
Chest. 2008; 133:737-743
Diaphragmatic paralysis is an uncommon, yet underdiagnosed cause of dyspnea. Data regarding the time course and potential for recovery has come from a few small case series. The methods that have been traditionally employed to diagnose diaphragmatic weakness or paralysis are either invasive or limited in sensitivity and specificity.
03/06/2008
02:30 PM
Prognosis of Patients With Heart Failure and Obstructive Sleep Apnea Treated With Continuous Positive Airway Pressure
Chest. 2008; 133:690-696
Therapy with continuous positive airway pressure (CPAP) provides several benefits for patients with heart failure (HF) complicated by obstructive sleep apnea (OSA). However, the effect on the prognosis of such patients remains unknown.
03/06/2008
02:30 PM
Contemporary Management of Acute Exacerbations of COPD
Chest. 2008; 133:756-766
Systemic corticosteroids, antibiotics, and noninvasive positive pressure ventilation (NPPV) are recommended for patients with acute exacerbation of COPD. However, their clinical benefits in various settings are uncertain. We undertook a systematic review and metaanalysis to systematically evaluate the effectiveness of these therapies.
03/06/2008
02:29 PM
Metaanalysis of the Efficacy of Sublingual Immunotherapy in the Treatment of Allergic Asthma in Pediatric Patients, 3 to 18 Years of Age
Chest. 2008; 133:599-609
Recent studies have documented the efficacy and safety of sublingual immunotherapy (SLIT) in patients with rhinitis, but the value of this treatment in those with asthma is still debated. We evaluated the efficacy of SLIT in the treatment of allergic asthma in children by a metaanalysis of randomized, double-blind, and placebo-controlled (DBPC) clinical trials.
03/06/2008
02:28 PM
Pneumococcal Vaccination for Patients With COPD
Chest. 2008; 133:767-774
Despite a level "A" recommendation by the Centers for Disease Control and Prevention, the use of pneumococcal polysaccharide vaccination in patients with COPD is supported by limited data. Clinical and laboratory studies have suggested that the currently approved vaccine is less effective in the population of COPD patients than in healthier patients, and to date no randomized-controlled trial of pneumococcal vaccination for COPD patients has demonstrated any beneficial effect.
03/06/2008
02:26 PM
Ventilator-Associated Pneumonia
Chest. 2008; 133:625-632
Clinical resolution of ventilator-associated pneumonia (VAP) determines the duration of treatment and mechanical ventilation. The aim of this study was to evaluate the influence of organisms and their susceptibility to treatment on outcomes.
03/06/2008
02:25 PM
Systems for the management of respiratory disease in primary care - an international series: Australia
Primary Care Respiratory Journal Volume 17 Issue 1 March 2008
Australia has a complex health system with policy and funding responsibilities divided across federal and state/territory boundaries and service provision split between public and private providers. General practice is largely funded through the federal government. Other primary health care services are provided by state/territory public entities and private allied health practitioners.
03/06/2008
02:24 PM
Systems for the management of primary care respiratory disease throughout the world
Primary Care Respiratory Journal Volume 17 Issue 1 March 2008
03/06/2008
02:23 PM
Management of chronic obstructive pulmonary disease (COPD) in primary care: a questionnaire survey in western Sweden
Primary care Respiratory Journal Volume 17 Issue 1 March 2008
To assess the primary care management of chronic obstructive pulmonary disease (COPD) in relation to COPD guidelines.
03/06/2008
02:22 PM
End-of-life care for COPD patients
Primary care Respiratory Journal Volume 17 Issue 1 March 2008
Patients with chronic obstructive pulmonary disease (COPD) receive poor end-of-life (EoL) care, in part because their disease course is not predictable.
03/06/2008
02:21 PM
Does continuous use of inhaled corticosteroids improve outcomes in mild asthma? A double-blind randomised controlled trial
Primary Care Respiratory Journal Volume 17 Issue 1 March 2008
To compare the effects of fluticasone and placebo on asthma control in patients with mild asthma. METHOD: Adults with FEV1 >80% predicted and reliever use <2 times/week were randomised to receive fluticasone 250 mcg/day or placebo double-blind for 11 months.
03/06/2008
02:20 PM
Allergic rhinitis-induced nasal congestion: its impact on sleep quality
Primary care Respiratory Journal Volume 17 Issue 1 March 2008
Allergic rhinitis (AR) is an extremely common health problem affecting 20 to 40 million Americans and between 10-25% of the world's population. Patients with AR suffer from both nasal symptoms (congestion,
rhinorrhea, itching, and sneezing) and ocular symptoms (itching, redness, and tearing).
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