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Clinical & Experimental Immunology, Volume 148, Number 1, April 2007, pp. 53-63(11)
Our purpose was to determine whether numbers of CD4+CD25+ T [T regulatory (Treg)] cells and mRNA expression of functional molecules of Treg are related to airway allergy and disease severity in 51 paediatric patients with allergic rhinitis or bronchial asthma and 47 healthy controls.
Allergy, Volume 62, Number 2, February 2007, pp. 170-177(8)
Allergic bronchopulmonary aspergillosis (ABPA) is a rare variant of severe asthma resulting from hypersensitivity to Aspergillus fumigatus (Asp f) present in the airways.
Clinical & Experimental Immunology, Volume 147, Number 3, March 2007, pp. 526-532(7)
T-bet is a novel transcription factor regulating lineage commitment of T helper (Th) lymphocytes to a predominant Th1 phenotype. Previous studies on T-bet and asthma focused mainly on bronchial biopsy specimens.
Disease Management & Health Outcomes, Volume 15, Number 1, 2007, pp. 41-55(15)
To compare health expenditures among elderly Medicaid patients with asthma or chronic obstructive pulmonary disease (COPD) who used either nebulized levalbuterol (levosalbutamol) or racemic albuterol (salbutamol) for bronchodilation.
The impact of a contributive result of open-lung biopsy on the outcome of patients with acute respiratory distress syndrome (ARDS) has not been extensively investigated. The aim of this study was therefore to determine the rate of contributive open-lung biopsy and whether it improved the prognosis of ARDS patients.
New England Journal of Medicine Volume 356:1367-1369 March 29, 2007 Number 13
The precise role of airway smooth muscle in the pathogenesis of asthma remains uncertain. The contraction of airway smooth muscle certainly causes acute narrowing of the airway and airflow obstruction in asthma, and smooth-muscle mass is increased in asthmatic airways.
New England Journal of Medicine Volume 356:1344-1351 March 29, 2007 Number 13
Inhaled short-acting b2-agonists are indicated for short-term relief of symptoms related to bronchospasm in patients with asthma and chronic obstructive pulmonary disease (COPD). Albuterol (called salbutamol outside the United States) is delivered by a metered-dose inhaler, the most widely used drug and delivery method in this class of agents worldwide.
New England Journal of Medicine Volume 356:1327-1337 March 29, 2007 Number 13
Bronchial thermoplasty is a bronchoscopic procedure to reduce the mass of airway smooth muscle and attenuate bronchoconstriction. We examined the effect of bronchial thermoplasty on the control of moderate or severe persistent asthma.
Current Opinion in Pulmonary Medicine. 13(3):199-204, May 2007
Invasive fungal infections of the lung have been increasing due to the increase of the population most at risk. This review aims to describe some of the emerging fungal pathogens and their complex management.
Respiratory Medicine Volume 101, Issue 4 , April 2007, Pages 833-838
The characteristics of dyspnoea in idiopathic pulmonary fibrosis (IPF) during a 6-min walk test are not clear. This study was designed to evaluate dyspnoea and desaturation during the 6-min walk test in IPF in comparison with that in chronic obstructive pulmonary disease (COPD), which is one of the most studied chronic lung diseases.
Respiratory Medicine Volume 101, Issue 4 , April 2007, Pages 850-853
Chronic severe heart failure is frequently associated with disturbances in the central control of breathing. During wakefulness, central breathing disorders could be ameliorated with beta-blocker treatment, but nothing is known about the effects of beta-blockers on the control of breathing during sleep.
Current Opinion in Pediatrics. 19(2):142-144, April 2007
Bronchopulmonary dysplasia continues to be an important cause of morbidity in premature infants who require mechanical ventilation. Management strategies have historically focused on normalizing blood gases but new research suggests that a higher PCO2 level may be well tolerated in premature infants.
The objective of our study was to describe the CT features of "hot tub lung" caused by exposure to Mycobacterium avium complex (MAC) organisms in contaminated water.
Current Opinion in Pulmonary Medicine. 13(3):170-176, May 2007
Due to the exponential growth of international exchange, millions of travelers are exposed to respiratory pathogens in the tropics and may return ill. Community-acquired pneumonia is one of the more prevalent infections.
Current Opinion in Pulmonary Medicine. 13(3):177-185, May 2007
Community-acquired pneumonia is associated with significant morbidity and mortality and is the most common cause of death from infectious diseases in North America. The purpose of this review is to highlight recent advances in epidemiology, risk factors, severity criteria and antibiotic therapeutic regimens used for community-acquired pneumonia management.
To prospectively investigate the effects of radiation dose and section thickness on quantitative multidetector computed tomographic (CT) indexes of pulmonary emphysema.
Allergy, Volume 62, Number 3, March 2007, pp. 310-316(7)
Allergic rhinitis (AR) and asthma coexist frequently and a dual treatment is recommended by prescribing topical nasal plus oral inhaled corticosteroids. The purpose of this study was to assess the efficacy of a nasally inhaled corticosteroid aiming at concomitant control of AR and asthma.
Allergy, Volume 62, Number 2, February 2007, pp. 102-112(11)
Clinical guidelines are systematically developed statements designed to help practitioners and patients make decisions regarding the appropriate health care for specific circumstances. Guidelines are based on the scientific evidence on therapeutic interventions.
Allergy, Volume 62, Number 2, February 2007, pp. 126-133(8)
Characterization of uncontrolled asthma burden in a natural treatment setting can influence treatment recommendations and clinical practice. The objective was to characterize and compare the economic burden of severe or difficult-to-treat asthma in uncontrolled and controlled patients.
New England Journal of Medicine Volume 356:1283 March 22, 2007 Number 12
Diagnosis of Ventilator-Associated Pneumonia . Dr. Kollef's disclosure statement should have read "Dr. Kollef reports receiving consulting fees or honoraria from Pfizer, Merck, Kimberly Clark, and Elan, and grant support from Pfizer, Merck, Elan, and Bard Medical. No other potential conflict of interest relevant to this article was reported." The text has been corrected on the Journal's Web site at www.nejm.org.
Current Opinion in Pulmonary Medicine. 13(3):230-235, May 2007
Pulmonary involvement in leptospirosis has been reported to be increasing in the last few years and is emerging as a serious life threat and the main cause of death due to leptospirosis in some countries. In this review, we present the main clinical and pathological manifestations of pulmonary involvement in leptospirosis, and recent data on the pathophysiology of lung damage and therapeutic implications.
Current Opinion in Pulmonary Medicine. 13(3):225-229, May 2007
In developing countries, where resources are scarce, it is paramount that the clinician be familiar with the most cost-effective diagnostic and therapeutic modalities available. The fiberoptic bronchoscope is an expensive piece of equipment, but can be an economical diagnostic tool in tropical pneumonias.
Nitric oxide (NO) is generally increased during inflammatory airway diseases. This increased NO stimulates the secretion of mucin from the goblet cells and submucosal glands, but the exact mechanism is still unknown. In this study, we investigated potential signaling pathways involving protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) in the NO-induced MUC5AC mucin gene, and protein expression in A549 cells.
We tested the hypothesis that maternal interleukin-1beta (IL-1beta) pretreatment and induction of fetal cortisol synthesis activates MAP kinases and thereby affects lung fluid absorption in preterm guinea pigs.
The range and relative impact of microbial pathogens, particularly viral pathogens, as a cause of community-acquired pneumonia (CAP) in hospitalized adults has not received much attention. The aim of this study was to determine the microbial etiology of CAP in adults and to identify the risk factors for various specific pathogens.
In contrast to asthma, the indication for bronchodilators prior to bronchoscopy in patients with COPD has not been properly investigated. We therefore performed a randomized, double-blind, placebo-controlled trial to determine whether use of a short-acting bronchodilator provides a protective effect in patients with COPD undergoing bronchoscopy.
Current Opinion in Infectious Diseases. 20(2):157-164, April 2007
Molecular techniques offer the promise of improving diagnosis of lower respiratory tract infections. This review focuses on currently used molecular diagnostic techniques for various types of pneumonia and highlights potential future applications of this technology.
Current Opinion in Infectious Diseases. 20(2):190-197, April 2007
The aim of this article is to analyze the aspects related to the endotracheal tube which may influence the development of ventilator-associated pneumonia and to review the possible measures of prevention.
Current Opinion in Infectious Diseases. 20(2):182-189, April 2007
Pneumonia has been the target of large national initiatives to measure and report quality of care. Measures of pneumonia care are now being used for public reporting and pay-for-performance in an effort to increase provider accountability for healthcare quality in the USA. Increasingly, concerns have been raised about the potential for unintended consequences of performance measurement and reporting that might lead to patient harm.
Current Opinion in Infectious Diseases. 20(2):170-176, April 2007
Community-acquired pneumonia is a major cause of morbidity and mortality, and is the leading cause of death from an infectious disease. International societies have published and revised guidelines aiming to improve the management of adult community-acquired pneumonia, based on the best available evidence. The aim of this review is to compare the current guideline recommendations.
Current Opinion in Infectious Diseases. 20(2):177-181, April 2007
The studies reviewed in this article suggest that a shorter duration of antibiotic therapy is comparable to standard therapy in the treatment of community-acquired pneumonia and promotes reduction of adverse events, microbial resistance, cost, and improved patient compliance.
American Journal of Respiratory and Critical Care Medicine Vol 175. pp. 726-730, (2007)
It has been recognized that mandibular advancement splint (MAS) treatment is effective in some, but not all, patients with obstructive sleep apnea
(OSA). Hence there is a need for a simple and reliable clinical tool to assist in the differentiation of treatment responses. We hypothesized that abnormalities of flow–volume curves, together with other clinical variables, may have clinical utility in the prediction of MAS treatment outcome.
American Journal of Respiratory and Critical Care Medicine Vol 175. pp. 712-719, (2007)
Lung cancer is a frequent cause of death among patients with chronic obstructive pulmonary disease (COPD). We examined whether the use of inhaled corticosteroids among patients with COPD was associated with a decreased risk of lung cancer.
Acta Paediatrica, Volume 95, Number 1, Number 1/January 2006, pp. 38-43(6)
We tested whether interleukin-6 (IL-6) in tracheal aspirate (TA) at birth, as a marker of fetal pulmonary inflammation, can be a predictor of bronchopulmonary dysplasia (BPD) in preterm infants.
Current Opinion in Pediatrics. 19(2):150-154, April 2007
Respiratory distress syndrome is the leading cause of mortality and morbidity among infants born prematurely. The disorder arises from the developmental and biochemical abnormalities associated with preterm delivery.
Canadian Respiratory Journal March 2007, Volume 14, Number 2 : 111-117
The Ontario Ministry of Health and Long-Term Care funded the Ontario Lung Association to develop and implement a continuing medical education program to promote implementation of the Canadian asthma guidelines in primary care.
American Journal of Respiratory and Critical Care Medicine Vol 175. pp. 676-685, (2007)
Impaired endothelial cell dependent vasodilation, inflammation, apoptosis, and proliferation are manifestations of endothelial dysfunction in chronic obstructive pulmonary disease (COPD). Prostacyclin (PGI2) is a major product of the cyclooxygenase pathway with potent vasodilatory and antimitogenic properties and may be relevant to endothelial dysfunction in COPD.
Canadian Respiratory Journal March 2007, Volume 14, Number 2 : 87-92
Pulmonary rehabilitation (PR) is recognized as the prevailing standard of care for patients with chronic respiratory conditions. National surveys of PR programs provide important information regarding the structure, content and organization of these programs.
Allergy, Volume 62, Number 4, April 2007, pp. 447-450(4)
Sinapis alba (white mustard) is a entomophilic species included in the Brassicaceae family. To date it has not been related to allergic sensitization or clinical respiratory disease.
American Journal of Respiratory and Critical Care Medicine Vol 175. pp. 731-736, (2007)
Early detection of bronchiolitis obliterans syndrome (BOS) is important because therapies are more likely to be effective if employed early in the disease process.
Acute pulmonary embolism is a serious condition and despite diagnostic and therapeutic advances, mortality is still high. Anticoagulation, thrombolytic therapy, catheter embolectomy, and open pulmonary embolectomy are therapeutic options.
Current Opinion in Pulmonary Medicine. 13(3):159-169, May 2007
Pneumonia is one of the major infectious diseases responsible for significant morbidity and mortality throughout the world. Radiological imaging plays a prominent role in the evaluation and treatment of patients with pneumonia. This paper reviews recent innovations in the radiologic diagnosis and management of suspected pulmonary infections.
European Journal of Pediatrics, Volume 166, Number 4, April 2007, pp. 365-376(12)
Recurrent acute respiratory tract infections (ARTI) are a common problem in childhood. Some evidence suggests a benefit regarding the prevention of ARTI in children treated with the immunomodulator OM-85 BV (Bronchovaxom).
QT dispersion has been proposed to be a predictor of adverse outcomes in a variety of cardiac disease states. The objective of this study was to examine QT dispersion in patients with sickle cell disease (SCD) and to assess the effect of pulmonary hypertension (PHT) on QT dispersion.
Acta Paediatrica, Volume 95, Number 1, Number 1/January 2006, pp. 56-61(6)
Bronchial hyperresponsiveness (BHR) is a characteristic feature of asthma, but it is also frequently demonstrated by children and adults with chronic obstructive lung diseases. BHR is usually measured by bronchial challenges using direct or indirect stimuli.
Australasian Radiology, Volume 51, Number 2, April 2007, pp. 196-198(3)
In Europe, the Light index is used for estimating the size of pneumothorax. It is based on the proportional relationship between the collapsed lung and the hemithorax. Other methods rely on absolute measurements on radiographs.
International Journal of Pediatric Otorhinolaryngology Volume 71, Issue 2 , February 2007, Pages 241-246
Children with undiagnosed and retained foreign bodies (FBs) may present with persistent respiratory symptoms. Delayed diagnosis is an important problem in developing countries and several factors affect the delay.
American Journal of Managed Care March 2007. TRENDS FROM THE FIELD. Pages: 129-132.
Patients admitted from September 2004 through January 2005 to a community teaching hospital with a principal diagnosis of community-acquired pneumonia were included.
A 32-year-old man presented with a 2-month history of worsening fever, chills, and cough despite therapy with oral antibiotics. Chest radiographs demonstrated migrating, peripheral upper lobe infiltrates.
International Journal of Clinical Practice, Volume 61, Number 2, February 2007, pp. 207-211(5)
The association of obstructive sleep apnoea (OSA) and chronic obstructive pulmonary disease (COPD) is not rare as COPD and OSA are both frequent diseases. The aim of this study was to determine the effect of OSA on quality of life (QOL) in patients with overlap syndrome (OVS).
International Journal of Clinical Practice, Volume 61, Number 2, February 2007, pp. 200-206(7)
The aim of the study was to analyse the clinical and economic indicators of the treatment of acute exacerbations of chronic obstructive pulmonary disease (COPD). The study focused specifically on antimicrobial therapy and the use of fluoroquinolones in the management of exacerbations.
This was a pilot study to test the feasibility of use of the ultrathin-walled two-stage twin endotracheal tube (UTTS-T-ETT), with one half to one third the resistance to gas flow and one third to one seventh the dead space of a conventional tracheal tube, in very premature infants.
The International Journal of Tuberculosis and Lung Disease, Volume 11, Number 4, April 2007, pp. 463-469(7)
Juniper's Asthma Quality of Life Questionnaire with standardised activities (AQLQ(S)) is commonly used to evaluate the effect of interventions in pharmaceutical trials, but rarely, if ever, used clinically in long-term follow-up of undiagnosed or diagnosed asthma patients.
Canadian Respiratory Journal March 2007, Volume 14, Number 2 : 105-109
The primary objective of asthma management is to help patients establish and maintain optimal disease control. Simple and efficient tools are needed to assess patient-reported symptoms so that they can be used with or without airway function to evaluate asthma control.
Canadian Respiratory Journal March 2007, Volume 14, Number 2 : 93-98
Little is known about the comparative impact of chronic obstructive pulmonary disease
(COPD) between women and men and about women's response to pulmonary rehabilitation.
A global definition of asthma control does not currently exist. The purpose of this study was to validate two new guideline-based composite measures of asthma control, defined as totally controlled (TC) asthma and well controlled (WC) asthma.
Rheumatology International, Volume 27, Number 5, March 2007, pp. 459-466(8)
The aim was to evaluate the findings of high resolution computed tomography (HRCT) and pulmonary function tests (PFT) in the rheumatoid arthritis (RA) patients with and without pulmonary symptoms and to determine their role in prediction of respiratory system involvement.
Therapeutic Apheresis and Dialysis, Volume 11, Number 2, April 2007, pp. 138-145(8)
Endotoxin-removal direct hemoperfusion column containing polymyxin-B immobilized fibers (PMX-DHP) is an effective procedure for the treatment of sepsis-induced acute respiratory distress syndrome (ARDS).
Medicine & Science in Sports & Exercise. 39(2):220-226, February 2007
A diminished mechanical efficiency (work/O2 consumed) accompanies chronic obstructive pulmonary disease (COPD), and increased mechanical efficiency has been attained by maximal strength training (MST) with an emphasis on the maximal rate of force mobilization in the concentric phase in healthy subjects. This study combined these observations and evaluated the impact of short-term MST on patients with COPD.
Canadian Respiratory Journal November/December 2006, Volume 13, Number 8 : 427-431
Asthma remains uncontrolled in a large number of asthmatic patients. Recent surveys have shown that a minority of asthmatic patients are referred to asthma educators.
Canadian Respiratory Journal November/December 2006, Volume 13, Number 8 : 433-437
The diagnosis of asthma is based on clinical symptoms, physical examination and pulmonary function tests, and can be very challenging. Most patients with asthma have a significant postbronchodilator response on spirometry indicating airway hyperresponsiveness.
Canadian Respiratory Journal November/December 2006, Volume 13, Number 8 : 421-426
The present study was designed to compare the performance of a new oxygen delivery device, the OxyArm (OA) (Southmedic Inc, Canada), with a standard nasal cannula (NC) (Salter-Style 1600, Salter Labs, USA) for both oxygen delivery and patient preference in patients on long-term oxygen therapy (LTOT).
Pediatric Infectious Disease Journal. 26(3):271-273, March 2007
A 14-year-old girl presented with florid watery diarrhea, vomiting and hypotension without respiratory prodrome. Shock, multiorgan system failure and death rapidly ensued. Influenza A was detected from her nasopharynx and CA-MRSA (USA400), positive for pvl, mecA, sea, sec and seh genes was cultured from a deep tracheal aspirate.
Volume 119, Issue 2 , February 2007, Pages 351-358
Journal of Allergy and Clinical Immunology We reconstructed allergen-dependent switching patterns in vivo to identify the level or levels at which farm exposure acts to protect against atopy.
Journal of Allergy and Clinical Immunology Volume 119, Issue 2 , February 2007, Pages 314-321
Previous studies support a strong association between viral respiratory tract infections and asthma exacerbations. The effect of newly discovered viruses on asthma control is less well defined.
Pediatrics International, Volume 49, Number 1, February 2007, pp. 48-52(5)
In many countries, the burden of asthma is sufficient to warrant recognition as a high-priority disorder in governmental health strategies. However, the components of the total health-care costs for pediatric patients with asthma have not been well studied, and an overall understanding of health-care utilization patterns in this population is lacking in Taiwan.
The American Journal of Emergency Medicine Volume 25, Issue 3 , March 2007, Pages 285-290
Diagnostic evaluation for suspected pulmonary embolism (PE) is challenging. Dimerized plasmin fragment D (D-dimer) assays are increasingly used but have been validated only in "low-risk" patients.
Clinical Pulmonary Medicine. 14(2):55-64, March 2007
There is increasing evidence associating differences in drug response to genetic variants. Pharmacogenetics is the rapidly evolving discipline that identifies these genetic variants to help individually customize treatment regimen and synthesize new agents. Studies on asthma pharmacogenetics have to date focused on three main areas-[beta]2 adrenergic receptor agonists, leukotriene modifiers, and inhaled corticosteroids.
Clinical Pulmonary Medicine. 14(2):110-111, March 2007
An evaluation of noninvasive ventilation (NIV) distinguishes two different types of respiratory failure with different implications for failure of NIV to reverse respiratory failure.
Clinical Pulmonary Medicine. 14(2):111-112, March 2007
A database of patients with pulmonary embolism highlights the natural history of the disease and highlights differences in outcomes based on presenting symptoms.
Obstructive sleep apnea (OSA) is associated with endothelial dysfunction. In the current study, we assessed the effect of long-term modified Herbst mandibular advancement splint (MAS) treatment on OSA, oxidative stress markers, and on endothelial function (EF).
Clinical Pulmonary Medicine. 14(2):76-81, March 2007
Sarcoidosis is a multisystem disease of unknown cause that primarily affects the lungs. Although the lung is involved in over 90% of the cases, hemoptysis as a presenting feature is rare.
Journal of Allergy and Clinical Immunology Volume 119, Issue 2 , February 2007, Pages 359-365
We investigated differences in total IgE and in the prevalence of wheezing related to the observation that high exposure to dust mite allergens induces high titers of IgE antibodies.
American Journal of Respiratory Cell and Molecular Biology. Vol. 36, pp. 504-512, 2007
Severe weakness of the respiratory muscles, with attendant respiratory failure and death, has been documented in sepsis. In this study, we show that during murine pulmonary infection with Pseudomonas aeruginosa, multiple proinflammatory genes are up-regulated not only within the lungs, but also within the diaphragm.
The Journal of Pediatrics Volume 150, Issue 3 , March 2007, Pages 235-240.e1
To report the neurodevelopmental outcome of infants enrolled in a randomized multicenter trial of early inhaled nitric oxide (iNO) in term and near-term neonates with hypoxic respiratory failure and pulmonary hypertension.
The Journal of Pediatrics Volume 150, Issue 3 , March 2007, Pages 256-261
To investigate the respiratory health of preterm infants with bronchopulmonary dysplasia (BPD) at preschool age and to determine whether lung function (measured by forced oscillation technique (FOT) and interruption technique (Rint) is affected by BPD in preterm infants compared with preterm infants without BPD.
Journal of Allergy and Clinical Immunology Volume 119, Issue 2 , February 2007, Pages 398-404
TNF-a is a pivotal proinflammatory cytokine increased in asthmatic airways. The TNF-a gene family might be linked to asthma or bronchial hyperresponsiveness (BHR), and TNF-a production might be modulated by CD14+ cells.
Air leakage after pulmonary lobectomy is a well-known problem often contributing to extended hospitalization. Many techniques have been proposed to prevent and treat air leakage, but none have been proved incontrovertibly effective. We evaluated the role of an autologous blood patch after pulmonary lobectomy.
Southern Medical Journal. 100(1):49-53, January 2007
Chronic eosinophilic pneumonia (CEP) is a disease of unknown cause. The hallmark of CEP is eosinophil accumulation in the lungs. While the triggering factor is unknown, eosinophil accumulation in the lungs is now believed to be secondary to the actions of eosinophil-specific chemoattractants, including eotaxin and regulated upon activation, normal T-cell expressed and secreted (RANTES), and IL-5 released from Th2 lymphocytes in the lungs.
Planning public health responses against pandemic influenza relies on predictive models by which the impact of different intervention strategies can be evaluated. Research has to date rather focused on producing predictions for certain localities or under specific conditions, than on designing a publicly available planning tool which can be applied by public health administrations.
Clinical Pulmonary Medicine. 14(2):93-98, March 2007
The signs and symptoms indicating the possible presence of ventilator-associated pneumonia (VAP) have a low specificity and sensitivity. Moreover, microbiological confirmation may be delayed up to 3 days and influenced by the previous use of antibiotics. However, VAP is one of the most frequent infectious complications in patients admitted to intensive care units and it is, therefore, necessary to improve the diagnostic arsenal for this infection.
Treatment of hospitalized infants with respiratory syncytial virus (RSV) bronchiolitis is mainly supportive. Bronchodilators and systemic steroids are often used but do not reduce the length of hospital stay.
Mechanical ventilation is an essential component of the care of patients with ARDS, and a large number of randomized controlled clinical trials have now been conducted evaluating the efficacy and safety of various methods of mechanical ventilation for the treatment of ARDS.
American Journal of Respiratory Cell and Molecular Biology. Vol. 36, pp. 491-496, 2007
Suppressor of cytokine signaling (SOCS) 1 is an essential physiologic regulator of the IFN- signaling that is crucial to lead appropriate immune responses, and impaired IFN- production is considered a hallmark of atopic diseases.
Asian Journal of Andrology, Volume 9, Number 2, March 2007, pp. 259-264(6)
To assess the efficacy of sildenafil and continuous positive airway pressure (CPAP) in the treatment of concurrent erectile dysfunction (ED) with obstructive sleep apnea (OSA), and to gauge the level of treatment satisfaction in patients and their partners.
Several studies have indicated that one of the most potent mediators involved in pulmonary vascular remodeling is vascular endothelial growth factor (VEGF). This study was designed to determine whether airway VEGF level reflects pulmonary vascular remodeling in patients with bronchitis-type of COPD.
Clinical Microbiology & Infection, Volume 13, Number 2, February 2007, pp. 162-171(10)
This study compared patients with moderate-to-severe community-acquired pneumonia (CAP) requiring hospitalisation, who received initial therapy with either intravenous ceftriaxone plus intravenous azithromycin.
Pulmonary capillary hemangiomatosis (PCH) is a rare cause of pulmonary arterial hypertension with no effective medical therapy and a high risk of mortality. The pathogenesis of PCH is unknown.
International Archives of Allergy and Immunology 2007;143:299-310
Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition whose pathogenesis and effect on airways remain unclear. The aim of the study was to evaluate the changes in endothelial-derived mediators following intensive exercise in asthmatic patients.
American Journal of Respiratory Cell and Molecular Biology. Vol. 36, pp. 480-490, 2007
Cigarette smoking is a major risk factor for chronic obstructive pulmonary disease (COPD). Recent reports of increased matrix metalloproteinase-2 (MMP-2) in lungs of patients with emphysema support the paradigm of proteinase/antiproteinase imbalance in the pathogenesis of COPD. We sought to define the signaling pathways activated by smoke and to identify molecules responsible for emphysema-associated MMP-2 expression.
European Journal of Pediatrics, Volume 166, Number 4, April 2007, pp. 365-376(12)
Recurrent acute respiratory tract infections (ARTI) are a common problem in childhood. Some evidence suggests a benefit regarding the prevention of ARTI in children treated with the immunomodulator OM-85 BV (Bronchovaxom).
Journal of Pediatric Hematology/Oncology. 29(3):151-155, March 2007
The present study aimed to investigate pulmonary function tests (PFTs) in children with thalassemia and to assess the relation between the degree respiratory impairment with the body iron status. High resolution computed tomography of chest (CHRCT) and bronchoalveolar lavage (BAL) was performed to study the cause of pulmonary dysfunction. Thirty-one children with thalassemia over 8 years were included.
Clinical Pulmonary Medicine. 14(2):106-109, March 2007
The single-breath carbon monoxide diffusing capacity (Dl,co) is commonly used to test the function of the alveolar capillary membrane (A-C) and is an important test in the evaluation of diseases that destroy or thicken the A-C membrane.
Previous studies have suggested a decreased need for the surgical biopsy of intrathoracic lymph nodes (LNs) due to improved diagnostic rates utilizing transbronchial needle aspiration (TBNA) with endobronchial ultrasound and endoscopic ultrasound. The goal of this study was to determine whether conventional TBNA using combined cytologic and histologic analysis of tissue specimens impacted the rates of surgical diagnostic biopsies of patients with intrathoracic lymphadenopathy.
Atypical cases of primary ciliary dyskinesia (PCD) may present with minimal transmission electron microscopy (TEM) defects. The diagnostic role of nasal nitric oxide (nNO) levels was evaluated in those patients.
Subjective sleep disturbances have been associated with increased risk of coronary artery disease (CAD). We hypothesized that disrupted sleep as verified by polysomnography is associated with increased levels of prothrombotic hemostasis factors previously shown to predict CAD risk.
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