Pulmonary Complications in Adult Patients With Cystic Fibrosis
American Journal of the Medical Sciences. 335(1):55-59, January 2008
Early diagnosis, treatments of acute exacerbations, and chronic therapies have all improved the lifespan of cystic fibrosis patients; however, the natural history remains one of worsening bronchiectasis and obstructive airways impairment.
02/14/2008
05:02 PM
Genetics of chronic obstructive pulmonary disease
International Journal of COPD Issue: 2007, Volume 2 Issue 4
Chronic obstructive pulmonary disease (COPD) is a complex disease with multifactorial background, based on the interaction of environmental and genetic factors. Environmental factors are clearly related to the development of the disease.
02/14/2008
05:01 PM
Clinical Implications of Unexpandable Lung Due to Pleural Disease
American Journal of the Medical Sciences. 335(1):21-25, January 2008
Unexpandable lung due to pleural disease may manifest itself as a hydropneumothorax after pleural drainage procedure or as an inability to completely drain a pleural effusion due to chest pain. The condition is a mechanical complication of a variety of pleural disorders.
02/14/2008
04:59 PM
A Case Report of Transfusion-related Acute Lung Injury During Plasma Exchange Therapy for Thrombotic Thrombocytopenia Purpura
Therapeutic Apheresis and Dialysis Volume 12 Issue 1 Page 78-81, February 2008
Transfusion-related acute lung injury (TRALI) is a transfusion reaction that is often under recognized and underreported. Implications for diagnosis not only influence treatment considerations but also extend to donor selection, donor deferral and ultimately the safety of the final blood product.
02/14/2008
04:59 PM
Rare Manifestation of Sarcoidosis as Endobronchial Mass
Journal of Bronchology. 15(1):44-45, January 2008
Sarcoidosis is a systemic granulomatous disorder of unknown origin that most frequently involves the hilar lymph nodes and lungs.
02/14/2008
04:57 PM
Iatrogenic Swallowing of Dentures With Resultant Tracheal Compression Requiring Mechanical Ventilation - A Case Report
Journal of Bronchology. 15(1):67-68, January 2008
Swallowing and aspiration of dentures have commonly been reported in the literature. The esophageal complications have been well described, but tracheal complications are yet to be reported. We report a case of tracheal compromise with acute respiratory failure from an aspirated denture.
02/14/2008
04:56 PM
Endobronchial Colorectal Metastasis - Case Report and Review of the Literature
Journal of Bronchology. 15(1):46-48, January 2008
Endobronchial metastases from extrapulmonary malignancies are uncommon. A patient presenting with distal tracheal endobronchial colorectal metastasis is reported.
02/14/2008
04:55 PM
Effect of thixotropy conditioning of inspiratory muscles on the chest wall response to CPAP
Respirology doi:10.1111/j.1440-1843.2007.01228.x
Thixotropy conditioning of inspiratory muscles changes the end-expiratory position of the respiratory system during resting breathing. We examined the immediate effects of thixotropy conditioning of inspiratory muscles on chest wall inflation induced by CPAP.
02/14/2008
04:54 PM
Review of dyspnoea quantification in the emergency department - Is a rating scale for breathlessness suitable for use as an admission prediction tool
Emergency Medicine Australasia, Volume 19, Number 5, October 2007 , pp. 394-404(11)
Acute shortness of breath is a potential marker of serious cardiopulmonary disease and requires rapid assessment. In our current health-care system, increasing pressure on the ED to limit costs and waiting times has resulted in the development of many clinical decision aids and admission prediction tools designed to assist ED physicians in meeting these demands.
02/14/2008
04:53 PM
Identifying severe community-acquired pneumonia in the emergency department - A simple clinical prediction tool
Emergency Medicine Australasia, Volume 19, Number 5, October 2007 , pp. 418-426(9)
To identify independent predictors of severe pneumonia in a local population, and create a simple severity score that would be useful in the ED.
02/14/2008
04:52 PM
Electronic interface for emergency department management of asthma - A randomized control trial of clinician performance
Emergency Medicine Australasia, Volume 20, Number 1, February 2008 , pp. 38-44(7)
To evaluate the effectiveness of an integrated and dynamic electronic decision support system for management of acute asthma in the ED.
02/14/2008
04:51 PM
Relief of Dyspnea Involves a Characteristic Brain Activation and a Specific Quality of Sensation
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 440-449, (2008)
Central processing of dyspnea relief remains largely unknown.
02/14/2008
04:50 PM
Deposition, Retention, and Translocation of Ultrafine Particles from the Central Airways and Lung Periphery
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 426-432, (2008)
Little is known about clearance of ultrafine carbon particles from the different regions of the human lung. These particles may accumulate and present a health hazard because of their high surface area.
02/14/2008
04:49 PM
The Impact of Critical Illness on Perceived Health-Related Quality of Life During ICU Treatment, Hospital Stay, and After Hospital Discharge
Chest. 2008; 133:377-385
The time course of changes in health-related quality of life (HRQOL) following discharge from the ICU and during a general ward stay has not been studied. We therefore studied the immediate impact of critical illness on HRQOL and its recovery over time.
02/14/2008
04:48 PM
The Modified APACHE II Score Outperforms Curb65 Pneumonia Severity Score as a Predictor of 30-Day Mortality in Patients With Methicillin-Resistant Staphylococcus aureus Pneumonia
Chest. 2008; 133:363-369
To compare the predictive accuracy for 30-day mortality of the CURB65 score adopted by the British Thoracic Society and the simpler CRB65 score to APACHE (acute physiology and chronic health evaluation) II in patients with methicillin-resistant Staphylococcus aureus (MRSA) pneumonia.
02/14/2008
04:47 PM
Gender differences in the association between C-reactive protein lung function impairment and COPD
International Journal of COPD Issue: 2007, Volume 2 Issue 4
Individuals with COPD have systemic inflammation that can be assessed by measuring C-reactive protein (CRP). In this paper we evaluated whether CRP is related to COPD, lung function and rate of lung function decline.
02/14/2008
04:46 PM
Physicochemical compatibility of fluticasone-17-propionate nebulizer suspension with ipratropium and albuterol nebulizer solutions
International Journal of COPD Issue: 2007, Volume 2 Issue 4
The objective of this in-vitro study was to determine whether mixtures of three nebulizable drugs are physicochemically compatible.
02/14/2008
04:45 PM
Obstructive Sleep Apnea, Cardiovascular Disease and Pulmonary Hypertension
The Proceedings of the American Thoracic Society 5:200-206 (2008)
With the growing epidemic of obesity in an aging population, obstructive sleep apnea (OSA) is increasingly encountered in clinical practice.
02/14/2008
04:44 PM
Pathophysiology of Pediatric Obstructive Sleep Apnea
The Proceedings of the American Thoracic Society 5:253-262 (2008)
Sleep-disordered breathing is a common and serious cause of metabolic, cardiovascular, and neurocognitive morbidity in children. The spectrum of obstructive sleep-disordered breathing ranges from habitual snoring to partial or complete airway obstruction, termed obstructive sleep apnea (OSA).
02/14/2008
04:44 PM
Facial and Ocular Deposition of Nebulized Budesonide
Chest. 2008; 133:482-488
In vivo case reports and in vitro studies have indicated that aerosol therapy using face masks can result in drug deposition on the face and in the eyes, and that face mask design may affect drug delivery.
02/14/2008
04:43 PM
Role of angiogenesis and vascular remodeling in chronic obstructive pulmonary disease
International Journal of COPD Issue: 2007, Volume 2 Issue 4
Inflammatory tissue- a pivotal pathological feature of COPD- often hypoxic, can induce angiogenesis through upregulation of factors such as VEGF or FGF and regulators of angiogenesis such as chemokines (CXC family), acting either as angiogenic or angiostatic. Angiopoietins are distinct molecules that act in association with VEGF at different stages of angiogenic process.
02/14/2008
04:42 PM
Pathophysiology of viral-induced exacerbations of COPD
International Journal of COPD Issue: 2007, Volume 2 Issue 4
Inflammation of the lower airways is a central feature of chronic obstructive pulmonary disease (COPD). Infl ammatory responses are associated with an increased expression of a cascade of proteins including cytokines, chemokines, growth factors, enzymes, adhesion molecules and receptors.
02/14/2008
04:41 PM
Airway Geometry Models of Children's Lungs for Use in Dosimetry Modeling
Inhalation Toxicology, Volume 20, Issue 2 January 2008 , pages 101 - 126
Single-path whole-lung and lobar models of the lungs of 11 children between 3 mo and 21 yr of age were developed based on a combination of cast data and published information on distal airway dimensions. The cast data used to generate these models were taken from one of the largest databases of actual measurements in children.
02/14/2008
04:40 PM
Percutaneous needle biopsy of lung nodules under CT fluoroscopic guidance with use of the 'I-I device'
British Journal of Radiology (2008) 81, 107-112
The aim of this study is to evaluate the feasibility and safety of CT fluoroscopic-guided needle biopsy with the use of the "I-I device", which was developed to assist in precisely advancing the needle while avoiding irradiation to the operator's hand.
02/14/2008
04:39 PM
Regulation of hepatocyte growth factor secretion by fibroblasts in patients with acute lung injury
Am J Physiol Lung Cell Mol Physiol 294: L334-L343
The mechanisms of pulmonary repair in acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are poorly known. Hepatocyte growth factor (HGF) and keratinocyte growth factor (KGF) are key factors involved in alveolar epithelial repair, present in the bronchoalveolar lavage fluid (BALF) from patients with ALI/ARDS.
02/14/2008
04:38 PM
The impact of the 2004 NICE guideline and 2003 General Medical Services contract on COPD in primary care in the UK
QJM 2008 101(2):145-153
The introduction of the NICE guideline on COPD and the inclusion of COPD in the new Quality and Outcomes Framework (QOF) were designed to improve the care of people with COPD in primary care in the UK.
02/14/2008
04:37 PM
Management and outcome of spontaneous pneumothoraces at three urban EDs
Emergency Medicine Australasia, Volume 19, Number 5, October 2007 , pp. 449-457(9)
Spontaneous pneumothoraces predominantly affect young people. Substantial morbidity arises from the disease, invasive procedures and hospitalization. The literature is inconsistent regarding optimal management. This retrospective study aimed to define factors affecting the outcome of these patients.
02/14/2008
04:36 PM
Pulmonary Arterial Hypertension
American Journal of the Medical Sciences. 335(1):40-45, January 2008
It is important for the general internist to maintain a high degree of suspicion for pulmonary hypertension in appropriate cases. This article reviews the definition and classification of pulmonary hypertension, epidemiology and risk factors, signs and symptoms, diagnostic approach, and treatment strategies.
02/14/2008
04:35 PM
Organizing Pneumonia
American Journal of the Medical Sciences. 335(1):34-39, January 2008
Organizing pneumonia (OP) is a histologic term characterized by patchy filling of alveoli and bronchioles by loose plugs of connective tissue. OP may be an incidental finding in lung biopsy specimens or may be found nearby areas of lung involved by other diseases.
02/14/2008
04:34 PM
Anesthetic management of children with pulmonary arterial hypertension
Paediatric Anaesthesia, Volume 18, Number 3, March 2008 , pp. 208-216(9)
Pulmonary arterial hypertension (PAH) is associated with significant perioperative risk for major complications, including pulmonary hypertensive crisis and cardiac arrest. Several mechanisms of hemodynamic deterioration, including acute increases in pulmonary vascular resistance (PVR), alterations of ventricular contractility and function and coronary hypoperfusion can contribute to morbidity.
02/14/2008
04:32 PM
Exacerbations worsen the quality of life of chronic obstructive pulmonary disease patients in primary healthcare
International Journal of Clinical Practice
doi:10.1111/j.1742-1241.2008.01707.x
To investigate the evolution of the quality of life of patients with chronic obstructive pulmonary disease (COPD) and quantify the impact of exacerbations on the deterioration of quality of life over 2 years.
02/14/2008
04:31 PM
Formoterol fumarate inhalation powder vs albuterol nebulizer for the treatment of asthma in the acute care setting
Annals of Allergy, Asthma and Immunology, Volume 100, Number 2, February 2008 , pp. 146-152(7)
Although albuterol remains the standard treatment for asthma in the emergency department, formoterol fumarate may be more advantageous, with its rapid and long-lasting bronchodilation.
02/14/2008
04:29 PM
Development of a Web-based questionnaire to collect exposure and symptom data in children and adolescents with asthma
Annals of Allergy, Asthma and Immunology, Volume 100, Number 2, February 2008 , pp. 112-119(8)
Questionnaires are an important component of epidemiologic studies. Maintaining compliance in longitudinal studies is a challenge, particularly from children and adolescents.
02/14/2008
04:28 PM
Clinical Utility of Echocardiography for the Diagnosis and Management of Pulmonary Vascular Disease in Young Children With Chronic Lung Disease
PEDIATRICS Vol. 121 No. 2 February 2008, pp. 317-325
The goal was to determine the clinical utility of Doppler echocardiography in predicting the presence and severity of pulmonary hypertension in patients with chronic lung disease who subsequently underwent cardiac catheterization.
02/14/2008
04:27 PM
Positive Pressure Therapy
The Proceedings of the American Thoracic Society 5:161-172 (2008)
The sleep medicine community has increasingly recognized the necessity that clinical care be based on high-quality levels of evidence. Although research supports a favorable influence of positive airway pressure (PAP) therapy on risk for significant adverse outcomes in patients with severe obstructive sleep apnea-hypopnea (OSAH), well-designed trials are still required to elucidate the effect of PAP on health, quality of life, and economic risks in patients with milder OSAH.
02/14/2008
04:26 PM
Exercise Oscillatory Ventilation - Instability of Breathing Control Associated With Advanced Heart Failure
Chest. 2008; 133:474-481
Instability of breathing control due to heart failure (HF) manifests as exercise oscillatory ventilation (EOV).
02/14/2008
04:25 PM
Epidemiology of Pediatric Obstructive Sleep Apnea
The Proceedings of the American Thoracic Society 5:242-252 (2008)
Pediatric obstructive sleep apnea (OSA) has become widely recognized only in the last few decades as a likely cause of significant morbidity among children. Many of the clinical characteristics of pediatric OSA, and the determinants of its epidemiology, differ from those of adult OSA.
02/14/2008
04:24 PM
Effects of One-Legged Exercise Training of Patients With COPD
Chest. 2008; 133:370-376
Most patients with severe COPD are limited by dyspnea and are obliged to exercise at low intensity.
02/14/2008
04:23 PM
Tree Pollen and Hospitalization for Asthma in Urban Canada
Int Arch Allergy Immunol 2008;146:241-247
Allergy to tree pollen is common and aeroallergens have been associated with severe asthma exacerbations in the community setting. To determine the impact of different trees on asthma, we tested the association between daily hospitalizations for asthma and daily concentrations of different tree pollens in 10 large Canadian cities.
02/14/2008
04:22 PM
Race-ethnicity language and asthma care - findings from a 4-state survey
Annals of Allergy, Asthma and Immunology, Volume 100, Number 2, February 2008 , pp. 120-127(8)
Latino and African American children have poorer asthma control than non-Latino white children, but few studies examine the association among race/ethnicity, language, and specific processes of asthma care.
02/14/2008
04:21 PM
Novel conjugate vaccine for the prevention of Pseudomonas aeruginosa infection in cystic fibrosis patients
Drug Development Research Volume 68, Issue 8 , Pages 512 - 521
The published literature evaluating the safety and immunogenicity of the polyvalent O-polysaccharide-toxin A conjugate vaccine is reviewed.
02/14/2008
04:20 PM
Ventilation Strategy Using Low Tidal Volumes, Recruitment Maneuvers, and High Positive End-Expiratory Pressure for Acute Lung Injury and Acute Respiratory Distress Syndrome
JAMA. 2008;299(6):637-645
Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung injury and acute respiratory distress syndrome. Instituting additional strategies to open collapsed lung tissue may further reduce mortality.
02/14/2008
04:19 PM
Quality control chart method for analyzing PEF variability in occupational asthma
American Journal of Industrial Medicine Volume 51, Issue 3 , Pages 223 - 228
Asthma is the most common occupational respiratory disorder in the industrialized world. In this research we investigated the effectiveness of quality control chart as a method to explore the work-relatedness of asthma using peak expiratory flow (PEF) as the variable of interest.
02/14/2008
04:18 PM
A rapid pneumococcal serotyping system based on monoclonal antibodies and PCR
J Med Microbiol 57 (2008), 171-178
Streptococcus pneumoniae expresses at least 91 different polysaccharide (PS) capsules and the currently available serotyping methods are tedious to perform.
02/14/2008
04:17 PM
Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways
Eur Respir J 2008; 31:241-251
The epidemiological association between cancer and exposure to ambient air pollution particles (particles with a 50% cut-off aerodynamic diameter of 10 µm (PM10)) has been related to the ability of PM10 and its constituent nanoparticles (NPs) to cause reactive oxidative species
(ROS)-driven DNA damage. However, there are no data on the molecular response to these genotoxic effects.
02/14/2008
04:16 PM
Mucosal inflammation in idiopathic bronchiectasis - cellular and molecular mechanisms
Eur Respir J 2008; 31:396-406
Bronchiectasis is a chronic and debilitating lung disease, characterised by irreversible dilatation of the bronchi as consequence of airway injury and remodelling due to recurrent or chronic airway inflammation and infection.
02/14/2008
04:15 PM
Epidemiology of sarcoidosis in Japan
Eur Respir J 2008; 31:372-379
The present study was designed to identify recent clinical phenotypes using the National Epidemiological Survey and to compare findings with those of previous surveys in Japan.
02/14/2008
04:14 PM
Vitamin D receptor genotypes influence quadriceps strength in chronic obstructive pulmonary disease
American Journal of Clinical Nutrition, Vol. 87, No. 2, 385-390, February 2008
Quadriceps weakness is an important complication of chronic obstructive pulmonary disease (COPD) and is associated with impaired exercise capacity and greater mortality. Its etiology is multifactorial, and evidence is growing that it is partly determined by genetic susceptibility.
02/14/2008
04:12 PM
Survey of Adult Flexible Bronchoscopy Practice in Cairo
Journal of Bronchology. 15(1):27-32, January 2008
Data regarding the standards of bronchoscopic practice in Cairo hospitals, where the main bulk of the procedures in Egypt takes place, are lacking and have not been studied.
02/14/2008
04:11 PM
Positive End-Expiratory Pressure Setting in Adults With Acute Lung Injury and Acute Respiratory Distress Syndrome
JAMA. 2008;299(6):646-655
The need for lung protection is universally accepted, but the optimal level of positive end-expiratory pressure (PEEP) in patients with acute lung injury (ALI) or acute respiratory distress syndrome remains debated.
02/14/2008
04:10 PM
Effect of a Gonadotrophin-Releasing Hormone Analogue on Lung Function in Lymphangioleiomyomatosis
Chest. 2008; 133:448-454
Lymphangioleiomyomatosis (LAM), a multisystem disease occurring primarily in women, is characterized by cystic lung destruction, and kidney and lymphatic tumors, caused by the proliferation of abnormal-appearing cells (ie, LAM cells) with a smooth muscle cell phenotype that express melanoma antigens and are capable of metastasizing.
02/14/2008
04:10 PM
Lipid Pleural Effusions
American Journal of the Medical Sciences. 335(1):16-20, January 2008
Traditionally, a lipid pleural effusion has been described as milky or turbid appearing. However, lipid effusions may have varied presentations making a diagnosis by appearance problematic. Distinguishing between a chylothorax and a cholesterol effusion, the 2 types of lipid effusions, is essential.
02/14/2008
04:09 PM
Hypoxia During Air Travel in Adults With Pulmonary Disease
American Journal of the Medical Sciences. 335(1):71-79, January 2008
At the present time, commercial aircraft cabins are required to be pressurized to the equivalent of 8,000 feet or less. Although in-flight medical emergencies are infrequent, some adults with pulmonary disease may experience significant physiological stress, exacerbation of their underlying illness, and severe hypoxemia during air travel.
02/14/2008
04:06 PM
HIV-Related Pneumococcal Lung Disease - Does Highly Active Antiretroviral Therapy or Bacteremia Modify Radiologic Appearance
AIDS Patient Care and STDs. February 1, 2008, 22(2): 105-111
We reviewed chest radiographs of 57 HIV-infected patients with pulmonary diseases in whom Streptococcus pneumoniae was the sole respiratory pathogen isolated to evaluate whether highly active antiretroviral therapy (HAART) or bacteremia modify radiographic appearance.
02/14/2008
04:05 PM
Reasons for discontinuation of antiasthma drugs in children with asthma coming from lower socioeconomic classes in a developing country
Allergy and Asthma Proceedings, Volume 28, Number 6, November/December 2007 , pp. 695-697(3)
Although asthma guidelines recommend regular use of controller therapies in both adults and children with moderate to severe asthma, most of the patients with asthma discontinue antiasthma drugs for various reasons.
02/14/2008
04:03 PM
Cutting Balloon Treatment for Recurrent Benign Bronchial Strictures
AJR 2008; 190:W130-W132
Benign airway strictures refractory to balloon dilatation or stent placement remain a challenge in interventional radiology. This article describes the successful use of a cutting balloon to treat three cases of recurrent tuberculous bronchial strictures.
02/14/2008
04:02 PM
Antipsychotic Drug Use and Risk of Pneumonia in Elderly People
Journal of the American Geriatrics Society doi:10.1111/j.1532-5415.2007.01625.x
To investigate the association between antipsychotic drug use and risk of pneumonia in elderly people.
02/14/2008
04:01 PM
The Direct Medical Costs of Undiagnosed Chronic Obstructive Pulmonary Disease
Value in Health doi:10.1111/j.1524-4733.2007.00305.x
To estimate the costs of undiagnosed chronic obstructive pulmonary disease (COPD) by describing inpatient, outpatient, and pharmacy utilization in the years before and after the diagnosis.
02/14/2008
04:00 PM
Pulmonary Chondroma - A Tumor Associated With Carney Triad and Different From Pulmonary Hamartoma
American Journal of Surgical Pathology. 31(12):1844-1853, December 2007
The Carney triad is the clinical association of gastric stromal sarcomas, pulmonary cartilaginous tumors, and extra-adrenal paragangliomas. The pulmonary tumors are its second commonest component and have been misinterpreted clinically and pathologically as metastases from the gastric tumors and pulmonary cartilaginous hamartomas, respectively.
02/14/2008
03:59 PM
Diagnosis of pulmonary arterial hypertension in a patient with systemic sclerosis
Nature Clinical Practice Rheumatology doi:10.1038/ncprheum0728
Pulmonary arterial hypertension (PAH) contributes significantly to the morbidity and mortality of patients with systemic sclerosis. Clinical symptoms of PAH are unspecific and are late manifestations of disease. This Case Study highlights the challenges of diagnosing PAH in patients with systemic sclerosis and includes discussion of screening options.
02/14/2008
03:57 PM
Longitudinal lung function decline and wood dust exposure in the furniture industry
Eur Respir J 2008; 31:334-342
The aim of the present study was to investigate the relationship between change in lung function and cumulative exposure to wood dust.
02/14/2008
03:55 PM
Adjuvant interferon gamma in patients with pulmonary atypical Mycobacteriosis - a randomized double-blind placebo-controlled study
BMC Infectious Diseases 2008, 8:17
High antibiotic resistance is described in atypical Mycobacteriosis, mainly by Mycobacterium avium complex (MAC).
02/14/2008
03:54 PM
Assessing the Value of the Routine Chest X-ray
Clinical Pulmonary Medicine. 15(1):50-51, January 2008
The utility of the routine chest radiograph in the ICU is quite low and can be replaced by specific indication-driven ordering of x-rays.
02/14/2008
03:53 PM
Static pressure-volume curves of the respiratory system - were they just a passing fad
Current Opinion in Critical Care. 14(1):80-86, February 2008
The aim of this article is to describe the physiologic utility, correlation with lung morphology, difficulties in interpretation and current clinical applications of static respiratory system pressure-volume curves at the bedside in patients with acute lung injury or acute respiratory distress syndrome.
02/14/2008
03:52 PM
Ketolides - pharmacological profile and rational positioning in the treatment of respiratory tract infections
Expert Opinion on Pharmacotherapy, Volume 9, Number 2, February 2008 , pp. 267-283(17)
Ketolides differ from macrolides by removal of the 3-O-cladinose (replaced by a keto group), a 11,12- or 6,11-cyclic moiety and a heteroaryl-alkyl side chain attached to the macrocyclic ring through a suitable linker.
02/14/2008
03:51 PM
Obstructive Sleep Apnea Is a Risk Factor for Death in Patients With Stroke
Arch Intern Med. 2008;168(3):297-301
Sleep apnea occurs frequently among patients with stroke, but it is still unknown whether a diagnosis of sleep apnea is an independent risk factor for mortality. We aimed to investigate whether obstructive or central sleep apnea was related to reduced long-term survival among patients with stroke.
02/14/2008
03:50 PM
Predicting Pertussis in Infants
Pediatric Emergency Care. 24(1):16-20, January 2008
The incidence of reported cases of pertussis is increasing, despite high rates of vaccination among infants and children. The burden of disease, and rates of complication and death are highest among infants. The limited availability of a timely reliable confirmatory test for pertussis hinders early identification of infected infants.
02/14/2008
03:49 PM
Relation between Shunt Aeration and Perfusion in Experimental Acute Lung Injury
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 292-300, (2008)
In a pulmonary process characterized by spatially heterogeneous loss of aeration, the impairment of gas exchange is expected to depend on the regional distribution of perfusion relative to that of aeration.
02/14/2008
03:48 PM
Potential Value of Regionalized Intensive Care for Mechanically Ventilated Medical Patients
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 285-291, (2008)
Regionalization has been proposed as a method to improve outcomes for medical patients receiving mechanical ventilation in the intensive care unit.
02/14/2008
03:47 PM
Horner's syndrome in a patient presenting with a spontaneous pneumothorax
Emergency Medicine Journal 2008;25:119-120
Spontaneous pneumothoraces are a common thoracic problem presenting to an Accident and Emergency (A&E) department. The symptoms and signs are well described and a chest x-ray examination is usually diagnostic.
02/14/2008
03:46 PM
Helical Computed Tomography Inaccuracy in the Detection of Pulmonary Metastases - Can It Be Improved
Ann Thorac Surg 2007;84:1830-1836
In thoracic surgery, manual lung palpation for detection of pulmonary metastases during resection is the standard of care, despite improvements in computed tomography (CT) imaging.
02/14/2008
03:45 PM
Stair Climbing in the Functional Assessment of Lung Resection Candidates
Respiration (DOI: 10.1159/000116873)
Algorithms for the pre-operative evaluation of lung resection candidates with impaired lung function invariably include maximum oxygen uptake (O2MAX) as a critical parameter of functional reserves, with a O2MAX 20 ml/kg/min generally considered sufficient for pneumonectomy.
02/14/2008
03:44 PM
Human skin keratins are the major proteins in exhaled breath condensate
Eur Respir J 2008; 31:380-384
Exhaled breath condensate (EBC) may be an attractive noninvasive alternative to bronchoscopy, bronchoalveolar lavage and induced sputum for diagnosis and monitoring of pulmonary disease.
02/14/2008
03:43 PM
Obesity and Obstructive Sleep Apnea
The Proceedings of the American Thoracic Society 5:185-192 (2008)
Obstructive sleep apnea is a common disorder whose prevalence is linked to an epidemic of obesity in Western society. Sleep apnea is due to recurrent episodes of upper airway obstruction during sleep that are caused by elevations in upper airway collapsibility during sleep.
02/14/2008
03:43 PM
Non-Positive Airway Pressure Modalities
The Proceedings of the American Thoracic Society 5:179-184 (2008)
Although positive airway pressure is the most efficacious treatment for obstructive sleep apnea (OSA), its clinical effectiveness is limited by its obtrusive interface. Two alternative treatment modalities used in clinical practice are mandibular advancement devices (MADs) and positional therapy.
02/14/2008
03:42 PM
Marginal Zone B-Cell Lymphoma of Bronchus-Associated Lymphoid Tissue
Chest. 2008; 133:433-440
Few articles have been published on imaging findings of marginal zone B-cell lymphoma of bronchus-associated lymphoid tissue (BALT) of the lung. We present CT scan and 18F-fluorodeoxyglucose (FDG) PET scan findings of the disease.
02/14/2008
03:41 PM
Power Spectral Analysis of EEG Activity During Sleep in Cigarette Smokers
Chest. 2008; 133:427-432
Research on the effects of cigarette smoking on sleep architecture is limited. The objective of this investigation was to examine differences in sleep EEG between smokers and nonsmokers.
02/14/2008
03:40 PM
A Multicenter Clinical Trial on the Diagnostic Value of Dual-Tracer PET/CT in Pulmonary Lesions Using 3'-Deoxy-3'-18F-Fluorothymidine and 18F-FDG
Journal of Nuclear Medicine Vol. 49 No. 2 186-194
Some new radiotracers might add useful information and improve diagnostic confidence of 18F-FDG imaging in tumors. A multicenter clinical trial was designed to investigate the diagnostic performance of dual-tracer (18F-FDG and 3'-deoxy-3'-18F-fluorothymidine [18F-FLT]) PET/CT in pulmonary nodules.
02/14/2008
03:38 PM
Transient Pulmonary Eosinophilia Incidentally Found on Low-Dose Computed Tomography - Findings in 40 Individuals
Journal of Computer Assisted Tomography. 32(1):101-107, January/February 2008
To describe computed tomography (CT) findings of transient pulmonary eosinophilia (TPE) incidentally found on low-dose CT (LDCT) and to identify suggestive CT features helpful in initial diagnosis.
02/14/2008
03:37 PM
Respiratory infections and lung function in an Australian Aboriginal community
Respirology doi:10.1111/j.1440-1843.2007.01221.x
To investigate the association between serological evidence of past infections with common respiratory pathogens and lung function in members of an isolated community of Aborigines from tropical coastal north-western Australia.
02/14/2008
03:36 PM
Erythromycin attenuates MUC5AC synthesis and secretion in cultured human tracheal cells infected with RV14
Respirology doi:10.1111/j.1440-1843.2007.01227.x
The common cold is a major cause of asthma exacerbation and chronic obstructive lung disease. Rhinovirus is reported to be responsible for more than 50% of cases of the common cold.
02/14/2008
03:35 PM
Spontaneous pneumothorax in Wegener's granulomatosis - a case report
Modern Rheumatology Volume 18, Number 1 / February, 2008 1439-7595
Wegener's granulomatosis (WG) is a multiorgan system disease of unknown etiology characterized by granulomatous inflammation, tissue necrosis, and variable degrees of vasculitis in small- and medium-sized blood vessels.
02/14/2008
03:33 PM
Prevalence of COPD in Five Colombian Cities Situated at Low Medium and High Altitude PREPOCOL Study
Chest. 2008; 133:343-349
The prevalence of COPD in Colombia is unknown. This study aimed to investigate COPD prevalence in five Colombian cities and measure the association between COPD and altitude.
02/14/2008
03:32 PM
Short-Term Effects Of Air Pollution Levels On Pulmonary Function Of Young Adults
The Internet Journal of Pulmonary Medicine. 2008. Volume 9 Number 2
Sixty-six young healthy persons repeatedly underwent spirometry after having spent five hours at school located close to a polluted environment.
02/14/2008
03:32 PM
Utilization Of Ventilation - Perfusion Lung Scan In A Cancer Hospital
The Internet Journal of Pulmonary Medicine. 2008. Volume 9 Number 2
Malignant neoplasms have been frequently associated with pulmonary embolism (PE). Ventilation/perfusion lung scan (V/Q) is the most frequent initial imaging study requested by clinicians for the evaluation of PE. Because our institution is dedicated to cancer care, we decided to study the utilization of V/Q scan and evaluate the rationale for its use and outcome of patients.
02/14/2008
03:31 PM
Obstructive Sleep Apnea and Metabolic Syndrome
The Proceedings of the American Thoracic Society 5:207-217 (2008)
Metabolic syndrome (MS), the commonly used term for the clustering of obesity, insulin resistance, hypertension, and dyslipidemia, affects millions of people worldwide, and is associated with an increased risk of cardiovascular disease and type 2 diabetes.
02/14/2008
03:30 PM
A Study on Prevalence of Allergic Bronchopulmonary Aspergillosis in Patients of Bronchial Asthma
The Internet Journal of Pulmonary Medicine. 2008. Volume 9 Number 2
To determine the prevalence of allergic bronchopulmonary aspergillosis (ABPA) in patients of bronchial asthma.
02/14/2008
03:29 PM
Comparison of Wright scale and European scale peak flow meters with digital spirometer
The Internet Journal of Pulmonary Medicine. 2008. Volume 9 Number 2
Peak expiratory flow (PEF) monitoring has been in use to measure airflow obstruction in patients with asthma. Most of the peak flow meter uses a traditional Wright scale to record PEF whilst after 2004 Peak flow meters with new European scale have been introduced. This study was done to assess the limits of agreement of PEF values measured with mini Wright's peak flow meter (Wright scale) or with new European scale with digital spirometer.
02/14/2008
03:28 PM
Drug induced pulmonary diseases
The Internet Journal of Pulmonary Medicine. 2008. Volume 9 Number 2
Drug reactions present to the clinician as a syndrome that may be due to a number of different causes, the patient's treatment being one possibility. In most clinical instances, a correct clinical diagnosis can be made if the physician is knowledgeable of the drugs which have been implicated in the pathogenesis of drug-induced lung reactions and recognizes the characteristic clinical and roentgenographic features present in each case. Management of pulmonary drug reactions consists in stopping the offending drug and if necessary, substituting a less harmful one. Corticosteroid therapy may be used in some cases.
02/14/2008
03:21 PM
How Drugs Affect The Lungs
The Internet Journal of Pulmonary Medicine. 2008. Volume 9 Number 2
Drug-induced lung disease is a major source of iatrogenic injury. The numbers of drugs that adversely affect the respiratory system continues to increase and more than 350 (and still counting) have been identified and their effects pose a great challenge to all physicians. Awareness of drug-induced pulmonary disease is essential to make a proper diagnosis for management of such patients. Here we review the various drugs known to induce lung injury and the various patterns of injury seen.
02/14/2008
03:20 PM
Peripheral blood B lymphocytes derived from patients with idiopathic pulmonary arterial hypertension express a different RNA pattern compared with healthy controls -a cross sectional study
Respiratory Research 2008, 9:20
Idiopathic pulmonary arterial hypertension (IPAH) is a progressive and still incurable disease. Research of IPAH-pathogenesis is complicated by the lack of a direct access to the involved tissue, the human pulmonary vasculature. Various auto-antibodies have been described in the blood of patients with IPAH. The purpose of the present work was therefore to comparatively analyze peripheral blood B lymphocyte RNA expression characteristics in IPAH and healthy controls.
02/14/2008
03:19 PM
Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery
Respiratory Research 2008, 9:19
Endothelial dysfunction is a major complication of pulmonary endarterectomy (PTE) that can lead to pulmonary edema and persistent pulmonary hypertension. We hypothesized that endothelial dysfunction is related to increased endothelial-cell (EC) death.
02/14/2008
03:19 PM
Detection of emphysema progression in alpha 1-antitrypsin deficiency using CT densitometry methodological advances
Respiratory Research 2008, 9:21
Computer tomography (CT) densitometry is a potential tool for detecting the progression of emphysema but the optimum methodology is uncertain. The level of inspiration affects reproducibility but the ability to adjust for this variable is facilitated by whole lung scanning methods. However, emphysema is frequently localised to sub-regions of the lung and targeted densitometric sampling may be more informative than whole lung assessment.
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