Links
to Journal Articles
Delivered Directly to Your Computer
The latest links to journal article abstracts on Respiratory, Pulmonary, COPD, Mechanical Ventilation,
Ventilator Weaning, Respiratory Therapy, Asthma, Cardio-Vascular, Sleep
Apnea, CPAP, BiPAP, Decannulation and other related clinical topics. Add the Northeast Center for Special
Care Journal Watch
to your favorite RSS program.
Congenital central hypoventilation syndrome is a rare disorder characterised by chronic alveolar hypoventilation, which becomes more pronounced during sleep and may be associated with
neurocristopathies, such as Hirchsprung's disease. A mutation in the PHOX2B gene has recently been identified.
Clinical Neurology and Neurosurgery Volume 109, Issue 2 , February 2007, Pages 200-202
We report a patient with genetically confirmed Friedreich's ataxia (FRDA) who developed a previously unreported feature of a mixed sleep apnea. Initial mutation analysis, by
PCR, of the parental frataxin alleles showed an apparent de novo mutation in the maternal
germline.
The questions of whether the use of antibiotics that are active against atypical organisms is beneficial in the treatment of community-acquired pneumonia and of the potential mechanisms of any beneficial effects remain unresolved. Proposed mechanisms include activity against atypical organisms vs the immunomodulatory effects of these antibiotics.
International Archives of Allergy and Immunology 2007;143:201-210
Improved asthma control by combinations of inhaled glucocorticosteroids (GCs) and long-acting 2-agonists
(LABAs) includes a reduced frequency and severity of exacerbations. In view of the association of exacerbations with increased airway inflammation, the question has arisen as to whether LABAs are able to complement the known anti-inflammatory activity of GCs.
Am J Physiol Lung Cell Mol Physiol 292: L550-L558, 2007
Many extremely preterm infants continue to suffer from bronchopulmonary
dysplasia, which results from abnormal saccular-stage lung development. Here, we show that fibroblast growth factor-10 (FGF-10) is required for saccular lung development and reduced in the lung tissue of infants with bronchopulmonary
dysplasia.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 554-560
Is there a difference in the answers of mothers and fathers to the Paediatric Caregiver's Quality of Life Questionnaire
(PACQLQ)? If so, does this reflect a perception that has any consequence for the medication and health of the child?
Systemic inflammation and oxidative stress are potential mechanisms for muscle wasting in COPD patients. Six-minute walking testing (6MWT) has been suggested as simple and valid exercise test in COPD that is well tolerated, and reflective of activities of daily living.
This study systematically reviews literature regarding the diagnosis of occupational asthma (OA) and compares specific inhalation challenge (SIC) testing with alternative tests.
American Journal of Health-System Pharmacy, Vol. 64, Issue 4, 363-368
The pharmacology, pharmacokinetics, clinical trials, adverse effects, drug interactions, and dosing and administration of the endothelin receptor antagonist, sitaxsentan, and its role in the treatment of pulmonary arterial hypertension (PAH) are reviewed.
Respirology, Volume 12, Number 2, March 2007, pp. 227-233(7)
To understand the effects of asthma and its treatment and to draw accurate conclusions with respect to different management programmes, including clinical trials.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 378-388
In this review, we aim to lead the readers through the historical highlights of pathophysiological concepts and treatment of asthma. Understanding the nature and links of asthma has modeled our diagnostic, pathophysiological and therapeutic thinking and acting. The recognition of its heterogeneous nature in combination with several refined and sophisticated technologies will mark a new era of phenotype-specific approach and treatment of asthma.
PEDIATRICS Vol. 119 No. 2 February 2007, pp. 320-329
The purpose of this study was to determine if reduced time in bed as well as the degree of obstructive sleep-disordered breathing predicted the risk of impaired cognitive function in children with adenotonsillar hypertrophy suspected of having obstructive sleep-disordered breathing.
This study examined the contribution of airway inflammation to the delayed lung function recovery that occurs in some people following virus-induced asthma exacerbations.
Tissue Doppler (TD) echocardiographic imaging of mitral and tricuspid annulus has been applied to assess right ventricular (RV) and left ventricular (LV) function in many cardiac diseases, but its clinical application, including response to long-term targeted therapy in patients with idiopathic pulmonary hypertension (PH), has not been addressed.
Bronchoscopic microsampling (BMS) is a method in which a device consisting of a wire with a polyester probe at the tip is used to collect bronchial epithelial lining fluid with bronchoscopy. In this study, we bacteriologically investigated sample collection using BMS to incorporate BMS into diagnosis of respiratory infection.
Critical Care Medicine. 35(1):222-229, January 2007
Thoracic epidural anesthesia is increasingly used in critically ill patients. This analgesic technique was shown to decrease left ventricular contractility, but effects on right ventricular function have not been reported. A deterioration of right ventricular performance may be clinically relevant for patients with acute pulmonary hypertension, in which right ventricular function is an important determinant of outcome.
In a context of increasing concern for complex care needs in medical patients, this study is intended to document the utility in pneumology patients of INTERMED, a reliable and valid instrument to assess case complexity at the time of hospital admission.
Chronic Respiratory Disease, Volume 3, Number 4, November 2006, pp. 215-216(2)
The development of chronic respiratory care in France faces the same problems of ageing population, technological advancement and budgeting difficulties as other industrially developed countries. We describe the intermediate and home-care systems for treatment of chronic respiratory diseases.
Journal of Infection Volume 54, Issue 2 , February 2007, Pages e87-e90
This is the first report to describe an apparently healthy girl, who developed recurrent occult bacteremia by the same Streptococcus pneumoniae strain, at 11 and 15 months of age. The two separately isolated organisms were demonstrated to have the identical serotype (type 6B), antibiotic susceptibility (intermediately penicillin-resistant), genotypes of penicillin-binding proteins, and patterns of pulse-field gel electrophoresis.
International Archives of Allergy and Immunology 2007;143:21-30
Airway inflammation and Th2 responses play central roles in allergic asthma. We have previously reported that Ganoderma tsugae supplementation could attenuate airway inflammation in the murine model.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 610-615
In the choice of, or switch between, various inhaled corticosteroids (ICS) it is important to know equipotent doses for clinical treatment effects of the alternatives. Various ICS do have different inherent potency.
Respirology, Volume 12, Number 2, March 2007, pp. 272-276(5)
Upper airway pathologies often accompany asthma. Because this represents a single airway, the diagnosis, follow up and treatment of both upper and lower respiratory diseases is essential. Samter Syndrome (SS) is known to be associated with more severe asthma. The presence of nasal polyps (NPs) is also associated with asthma. However, the incidence of NPs in asthma and the effect of NPs on asthma severity are not well documented.
European Journal of Radiology Volume 61, Issue 1 , January 2007, Pages 124-129
Different ECG gating techniques are available for MR phase-contrast (PC) flow measurements. Until now no study has reported the impact of different ECG gating techniques on quantitative flow parameters. The goal was to evaluate the impact of the gating method and the breathing schema on the pulmonary, systemic and bronchosystemic circulation.
To investigate the upper airway (UA) characteristics of patients with obstructive sleep apnea syndrome
(OSAS) using computer-assisted fiberoptic pharyngoscopy with Müller's maneuver
(CFPMM).
European Journal of Echocardiography Volume 7, Issue 6 , December 2006, Pages 439-446
Patients with autoimmune disease, and in particular limited systemic sclerosis (CREST syndrome), are at risk of developing pulmonary artery hypertension (PAH) which is associated with a poor prognosis. With improvements in therapy offering improved survival and functional capacity, there has been an emphasis on screening to identify patients at risk. Assessment of patients during exercise may enable early identification of patients with this condition.
Journal of Telemedicine and Telecare, Volume 12, Number 8, December 2006, pp. 379-381(3)
Over one-third of adults are at risk of developing sleep disorders. Telemedicine is emerging as an effective tool in sleep medicine by allowing people to undergo sleep studies without overnight hospital stays (e.g. monitoring at home). Telemedicine has the potential to overcome several obstacles in the diagnosis and treatment of sleep disorders by offering increased access to sleep specialists, enhancing health-care support for patients in their homes and providing cost-effective professional education.
In 2001, a survey of emergency departments in the UK showed wide variation in the management of acute undifferentiated chest pain. There has since been substantial development of chest pain services and research into chest pain units (CPUs).
Clinical Physiology and Functional Imaging, Volume 27, Number 1, January 2007, pp. 2-6(5)
Previous studies have indicated that, during mechanical ventilation, an inspiratory pause enhances gas exchange. This has been attributed to prolonged time during which fresh gas of the tidal volume is present in the respiratory zone and is available for distribution in the lung periphery.
Respirology, Volume 12, Number 1, January 2007, pp. 81-87(7)
Bacterial infection is one of the major causes of acute exacerbation of COPD (AECOPD). This study was undertaken to investigate the microbiology of AECOPD.
Respirology, Volume 12, Number 2, March 2007, pp. 267-271(5)
Determining the aetiology of an effusion involves assessing if it is an exudate or a transudate. However, a reliable test for determining the aetiology of a pleural effusion is lacking. Pleural viscosity has a high sensitivity and specificity and a high positive and negative predictive value for discriminating exudative and transudative pleural effusions.
Respirology, Volume 12, Number 2, March 2007, pp. 240-247(8)
A significant proportion of patients with lung cancer have associated COPD, which is considered an independent risk factor and cause of morbidity and mortality. However, the effect of COPD on respiratory status and quality of life in lung cancer has not been evaluated.
Severe acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) is a common reason for emergency room (ER) visit about which little has been documented from India.
Journal of Cardiopulmonary Rehabilitation. 26(6):405-409, November/December 2006
The purpose of this study was to investigate changes that occur in pulmonary function when postural changes in the sagittal plane are made in a seated position in patients diagnosed with chronic obstructive pulmonary disease (COPD).
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 547-553
Impaired skeletal muscle function has been reported in patients with chronic obstructive disease (COPD), but such impairment is not homogenous and its distribution between the upper and the lower limbs is still unclear.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 561-567
The aim of the present study was to predict the prognosis of Chronic obstructive pulmonary disease (COPD) patients who underwent comprehensive pulmonary rehabilitation (PR). A total of 144 patients who performed PR between 1992 and 1999 was assessed.
PEDIATRICS Vol. 119 No. 2 February 2007, pp. e320-e324
The objective of this study was to determine whether long-term steroid therapy is associated with increased peak cough flow in patients with Duchenne muscular dystrophy and to determine which pulmonary function test variable is most predictive of peak cough flow.
Journal of Pediatric Psychology 2007 32(2):154-166;
The combined contribution of neonatal, perinatal, and maternal health, demographic, environmental, and family psychosocial factors to early onset asthma and wheezing in a healthy birth cohort was examined.
Pediatric Transplantation, Volume 11, Number 2, March 2007, pp. 209-213(5)
We report the case of an infant with severe combined immunodeficiency who was presented with PIV3 infection. Aerosolized ribavirin was administered for 10 months until the child gained a functional immune system through an allogeneic hematopoietic stem cell transplant and cleared PIV3 infection.
Sleep Medicine Volume 8, Issue 1 , January 2007, Pages 94-95
A 66-year-old Caucasian male with a history of ischemic heart disease, hypertension and tonsillectomy presented with complaints of fatigue, excessive daytime somnolence, snoring and witnessed apneas.
European Radiology, Volume 17, Number 1, January 2007, pp. 11-21(11)
Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe disease that has been ignored for a long time. However, with the development of improved therapeutic modalities, cardiologists and thoracic surgeons have shown increasing interest in the diagnostic work-up of this entity.
Airway stenting is a procedure that is performed increasingly often, and the availability of metallic stents placed by flexible bronchoscopy may have contributed to the increased usage. These procedures have an impact on the required physician skill set and practice management. We review the indications for airway stenting, and how the requirement of combined therapies and technical aspects of central airway stenting pertain to practice management.
Sputum induction (SI) is considered to be a safe tool for assessing airway inflammation in stable patients with COPD, but little is known about its safety during exacerbations. We therefore assessed the safety of SI during COPD exacerbations. SI data from 44 COPD patients were assessed both in the stable phase and during exacerbation.
Respirology, Volume 12, Number 2, March 2007, pp. 248-253(6)
Erectile dysfunction (ED) has important negative effects on male quality of life and self-esteem. The aim of this study was to acquire an insight into the sexual status of COPD patients.
Respirology, Volume 12, Number 2, March 2007, pp. 277-282(6)
The need for routine use of bronchial washing in addition to forceps biopsy has been debated in the diagnosis of endoscopically visible lung tumours. Moreover, the optimal sequence for obtaining bronchial washing and forceps biopsy specimens from endoscopically visible tumours through a flexible bronchoscope has not been well established.
Current authoritative spirometry guidelines use conflicting percentage of FEV1/FVC ratios (FEV1/FVC%) to define airway obstruction. The American Thoracic Society/European Respiratory Society Task Force characterizes obstruction as a FEV1/FVC% below the statistically defined fifth percentile of normal.
Cigarette smoke disrupts the protective barrier established by the airway epithelium through direct damage to the epithelial cells, leading to cell death. Since the morphology of the airway epithelium of smokers does not typically demonstrate necrosis, the most likely mechanism for epithelial cell death in response to cigarette smoke is apoptosis.
Few studies on bacteraemia in Africa have been published. We aimed to prospectively identify the causative organisms of bacteraemia in The Gambia and their relation to clinical diagnoses, outcome and antimicrobial susceptibility.
A quantitative PCR method was established to quantify human bocavirus (HBoV) genomic copies in clinical specimens from children with lower respiratory tract infections
(LRTI) in China. A total of 257 respiratory tract specimens were tested, and 7 (2.7%) of these (all sputum samples) were positive, with genomic copies that ranged from 8.0 × 103 to 8.0 × 109 in the samples. The main clinical symptom of patients who were positive for HBoV DNA was a pneumonia-like syndrome represented by high fever and cough. Our results suggest that HBoV may be an important etiological agent of LRTI in children in China.
Emergency Radiology, Volume 13, Number 4, January 2007, pp. 161-169(9)
Recent advances in pharmacotherapeutics and interventional techniques have resulted in resurgence in interest regarding the optimal means of management of hemodynamically significant pulmonary embolic disease. However, these various techniques have many associated disadvantages, and it is of paramount importance that the responsible physician has a detailed understanding of each of these so that the appropriate intervention be requested and performed.
GABABR (gamma-amino butyric acid B receptor)-mediated neurotransmission has been implicated in the pathophysiology of a variety of neuropsychiatric disorders.
Clinical Microbiology & Infection, Volume 13, Number 1, January 2007, pp. 78-85(8)
Between January 1980 and December 1998, 3458 cases of Legionnaires' disease were reported to the national surveillance scheme in England and Wales. Of these, 463 (13.4%) were reported as proven by culture and isolation of Legionella spp., with 96.3% being Legionella pneumophila.
Diffuse malignant mesothelioma is the most common primary tumor involving the pleura. Unfortunately, it also poses the most difficulty for physicians to diagnose and treat. Latency from the time of initial asbestos exposure, clinical features of chest pain and dyspnea, and radiographic findings of pleural effusion or pleural thickening are the characteristic features.
Respiratory syncytial virus (RSV) respiratory infections are very common during infancy and account for the majority of hospitalizations during the fall and winter seasons. Patients vary in the severity of their illnesses, with most hospitalized patients needing oxygen and intravenous fluids.
CardioVascular and Interventional Radiology, Volume 30, Number 1, February 2007, pp. 136-139(4)
Hemoptysis is a known complication in patients with bronchial artery hypertrophy due to a variety of chronic pulmonary disorders. Bronchial artery hypertrophy is observed in most patients with chronic thromboembolic pulmonary hypertension (CTEPH), but surprisingly little is known about the incidence of hemoptysis in these patients.
CardioVascular and Interventional Radiology, Volume 30, Number 1, February 2007, pp. 143-145(3)
Subclavian artery pseudoaneurysm and occlusion in young patients are usually post-traumatic. We report the case of a 33-year-old diabetic woman with subclavian artery occlusion and pseudoaneurysm formation caused by pulmonary mucormycosis infection.
The purpose of our study was to assess the presence and extent of delayed contrast enhancement of ventricular myocardium in pulmonary artery hypertension.
The purpose of our study was to assess differences in volumetric measurements of pulmonary nodules obtained using different CT slice thicknesses; correlate these differences with nodule size, shape, and margination; and compare measurements generated by two different software packages.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 439-445
It is not always possible to collect information about health from patients, so information from proxies (relatives and others) is used to aid medical decision-making, but there has been no formal evaluation of the reliability of their reports. The aim of this study was to analyse the reliability and validity of the St. George's Respiratory Questionnaire (SGRQ) answered by proxies and to determine their accuracy as raters.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 399-410
There is a plethora of assessment tools available to measure breathlessness, the most common and disabling symptom of advanced cardio-respiratory disease. The aim of this systematic review was to identify all measures available via standard search techniques and review their usefulness for patients with advanced disease.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 371-377
Chronic obstructive pulmonary disease (COPD) is characterized by symptoms of cough, sputum and breathlessness, which become worse during acute exacerbations. The airway inflammation associated with COPD has led to trials of the effect of systemic corticosteroids in COPD assessed in two Cochrane systematic reviews.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 481-489
The objective of this analysis was to investigate whether patients with severe or difficult-to-treat asthma who experienced recent severe asthma exacerbations are at increased risk of future asthma exacerbations.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 389-398
Pulmonary hypertension is a rare disease with a poor prognosis. It was first described in the late 19th century as a clinical-pathological syndrome characterised by obstruction of the small pulmonary arteries and right ventricular hypertrophy in patients presenting with severe dyspnoea and cyanosis.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 431-438
Although pleural effusion is a common disorder among patients presenting with respiratory symptoms, there is limited evidence on the accuracy and reliability of symptoms and signs for the diagnosis of pleural effusion.
Airway remodelling is a complex process that involves all of the component tissues of the airway from the epithelium to the adventitia. Each of the changes has the potential to alter airway physiology so as to promote airway narrowing, hyperresponsiveness and inflammation.
Clinical Microbiology & Infection, Volume 13, Number 1, January 2007, pp. 70-77(8)
Nasopharyngeal Streptococcus pneumoniae isolates colonising young children are representative of isolates causing clinical disease. This study determined the frequency of macrolide-non-susceptible pneumococci, as well as their phenotypic and genotypic characteristics, among pneumococci collected during two cross-sectional surveillance studies of the nasopharynx of 2847 children attending day-care centres in the Athens metropolitan area during 2000 and 2003.
Clinical Microbiology & Infection, Volume 13, Number 1, January 2007, pp. 63-69(7)
Human B-defensins (hBDs) are the most abundant antimicrobial peptides in epithelial cells, and function in the host immune system. Respiratory epithelial cells express hBDs to inhibit bacterial proliferation during respiratory tract infections.
To estimate the risk of elevated blood pressure (BP) in children with obstructive sleep-disordered breathing (SDB) and to explore heterogeneity among published studies.
Journal of Pediatric Health Care Volume 21, Issue 1 , January-February 2007, Pages 44-48
In response to the need to improve the diagnosis and management of asthma, the NHLBI initiated the National Asthma Education and Prevention Program to educate patients, health care providers, and the public about asthma and its treatment.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 670-675
Trans-bronchial needle aspiration (TBNA) is a simple, safe technique that can be performed without additional resources in any centre with a bronchoscopy service.
Respiratory Medicine
Volume 101, Issue 3 , March 2007, Pages 628-637
The reduction of oral prednisone use by mometasone furoate (MF) delivered by HFA-227 metered dose inhaler (MDI) was examined in oral corticosteroid (OCS)-dependent patients with severe persistent asthma.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 661-669
To assess and compare health status among chronic obstructive pulmonary disease (COPD) patients presenting for treatment in six countries and in two healthcare settings using a generic health status instrument.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 581-586
Smoking is associated with an accelerated loss of lung function and inhalation accelerates the decline further. Exhaled CO reflects the exposure of smoke to the lungs.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 516-524
The most common symptoms in chronic obstructive pulmonary disease (COPD) patients are breathlessness and exercise limitation. Although both general and inspiratory muscle training have shown clinical benefits, the effects of specific expiratory muscle training remain controversial.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 655-660
The purpose of this study was to assess the role of bronchoalveolar lavage (BAL) in differentiating usual interstitial peumonia (UIP) from non-specific interstitial pneumonia (NSIP) and in predicting the prognosis in fibrotic idiopathic interstitial pneumonia (IIP).
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 638-644
Demographic factors, symptom severity, and psychopathology, in particular anxiety and depression, are known to influence health care use and quality of life in asthma. Because depression and anxiety are typically correlated, we sought to explore whether depression specifically is associated with health care utilization and quality of life when effects of anxiety are controlled for.
Clinical Nuclear Medicine. 32(2):117-121, February 2007
Mediastinal lymphadenopathy is usually a sign of serious underlying disease. A patient who had nodular patchy opacity of the right hilum from a routine screening chest radiograph was referred for the whole-body PET/CT scan with FDG.
Rheumatology International, Volume 27, Number 4, February 2007, pp. 399-402(4)
We report the cases of two middle-aged male smokers who presented to the early synovitis clinic with an acute phase response, synovitis of the wrists and ankles and clubbing of the fingers, but no respiratory symptoms. Both proved to have primary lung tumours with hypertrophic pulmonary osteoarthropathy, in one case resolving promptly with treatment of the carcinoma. We review the literature, including theories on pathogenesis.
European Journal of Radiology Volume 61, Issue 2 , February 2007, Pages 251-255
Pathological changes of the peripheral pulmonary arteries induce pulmonary arterial hypertension (PAH). Aim of this study was to quantitatively assess the effect of PAH on pulmonary perfusion by 3D-MR-perfusion techniques and to compare findings to healthy controls. Furthermore, quantitative perfusion data were correlated with invasive pressure measurements.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 453-460
The evaluation of therapies requires the development of patient-reported outcomes (PROs) that help clinicians to understanding the symptoms, perceptions and feelings of patients with exacerbations of chronic obstructive pulmonary disease (COPD).
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 411-422
Dyspnea is an impairing symptom in obstructive pulmonary diseases. Besides multiple physiological pathways contributing to this sensation recent research has demonstrated an important role of psychological factors in the perception of dyspnea.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 461-466
Many patients with obstructive sleep apnea (OSA) do not have sleepiness and adherence to nasal continuous positive airway pressure (nCPAP) is unknown when this treatment is primarily recommended for a cardiovascular concern. The aim of this study was to determine the adherence to nCPAP in patients with coronary artery disease (CAD) and OSA without sleepiness.
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 446-452
We studied the relationship between exercise hyperpnea (i.e., ventilatory dynamics) at the onset of exercise and hypercapnic ventilatory response (HCVR), and their differences between the follicular (FP) and luteal (LP) phases of the menstrual cycle in six healthy females
Respiratory Medicine Volume 101, Issue 3 , March 2007, Pages 616-627
Armodafinil is the R-enantiomer of racemic modafinil and has a significantly longer half-life than the S-enantiomer. This study evaluated armodafinil 150 mg/day as an adjunct treatment for residual excessive sleepiness in patients with obstructive sleep apnea/hypopnea syndrome (OSA/HS) who were otherwise well controlled with nasal continuous positive airway pressure (nCPAP). We assessed the ability of armodafinil to improve wakefulness and cognition and reduce fatigue in this population.
Emergency Medicine Australasia, Volume 19, Number 1, February 2007, pp. 59-62(4)
The present paper describes the process, outcomes and lessons learned from a federally funded, multicentre action research project aimed at improving discharge practices for asthma patients who attend ED and are discharged home.
American Journal of Respiratory and Critical Care Medicine Vol 175. pp. 355-359, (2007)
To determine the effects of childhood chest illness and smoking on the rate of decline of adult ventilatory function from the age of 35 to 45 yr in a large, nationally representative sample of British adults.
American Journal of Respiratory and Critical Care Medicine Vol 175. pp. 300-305, (2007)
Progressive pulmonary disease may preclude the option of pregnancy for a number of women in their child-bearing years due to the severity of the disease. For a subset of women with chronic lung disease including cystic fibrosis, pregnancy is possible, but can have a devastating effect both on the prospective mother and fetus.
American Journal of Respiratory and Critical Care Medicine Vol 175. pp. 312-315, (2007)
We tested the hypothesis that morphine sulfate in the dose of 5 mg twice daily would bring about a reduction in cough frequency and severity in patients failing to respond to specific measures.
A 6-min step test (6MST) may constitute a practical method for routinely assessing effort tolerance and exercise-related oxyhaemoglobin desaturation (ERD) in the primary care of patients with interstitial lung disease.
The purpose of this pictorial essay is to illustrate the radiologic manifestations of pulmonary artery aneurysms and pseudoaneurysms with emphasis on the findings on contrast-enhanced CT.
Journal of Anesthesia, Volume 20, Number 4, November 2006, pp. 290-299(10)
The epidural administration of local anesthetics can provide anesthesia without the need for respiratory support or mechanical ventilation. Nevertheless, because of the additional effects of epidural anesthesia on motor function and sympathetic innervation, epidural anesthesia does affect lung function.
European Journal of Radiology Volume 61, Issue 2 , February 2007, Pages 245-250
We evaluated chest X-ray and clinical findings of patients with lower respiratory tract infection due to influenza H5N1 and presented the radiological findings and clinical course of the infection.
Hundreds of millions of people of all ages suffer from chronic respiratory diseases which include asthma and respiratory allergies, chronic obstructive pulmonary disease, occupational lung diseases and pulmonary hypertension. More than 500 million patients live in developing countries or in deprived populations.
American Journal of Respiratory and Critical Care Medicine Vol 175. pp. 306-311, (2007)
Recent advances in the field of innate immunity have driven an important reappraisal of the role of these processes in airway disease. Various strands of evidence indicate that resident cells, such as macrophages and epithelial cells, have central importance in the initiation of inflammation.
Sleep Medicine Volume 8, Issue 1 , January 2007, Pages 37-42
Compliance with continuous positive airway pressure (CPAP) treatment in obstructive sleep apnoea syndrome (OSAS) may be difficult. Patient education is important but strategies and their outcomes are not clear.
The production of indium-tin oxide has increased, owing to the increased manufacture of liquid-crystal panels. It has been reported that interstitial pneumonia occurred in two indium-processing workers; therefore, the present study aimed to evaluate whether interstitial pulmonary disorders were prevalent among indium workers.
Surfactant protein D (SP-D) plays important roles in innate host defense against influenza A virus (IAV) infection. Common human polymorphisms of SP-D have been found in many human populations and associated with increased risk of certain infections.
Journal of Intensive Care Medicine, Vol. 22, No. 1, 38-43 (2007)
The authors retrospectively reviewed their experience with bilevel positive airway pressure (BiPAP) to treat respiratory insufficiency in pediatric patients over a 5-year period.
Bone Volume 40, Issue 2 , February 2007, Pages 493-497
Chronic obstructive pulmonary disease (COPD) appears to be associated with low bone mineral density (BMD). BMD loss can be accelerated by a number of factors associated with COPD, but it is not known whether COPD itself has a direct effect.
Isolated pulmonary hypertension (iPHT) is a near-fatal consequence of systemic sclerosis (SSc); in female patients, the risk of its development is increased during the post-menopausal period, when the protective effects of oestrogens on the endothelium decrease.
New England Journal of Medicine Volume 356:398-407 January 25, 2007 Number 4
A 3-year-old boy was admitted to the hospital because of recurrent episodes of respiratory insufficiency, pulmonary infiltrates, and anemia. He was treated with antibiotics and levalbuterol and budesonide by inhalation at 9, 12, and 23 months of age.
The immediate and long-term clinical events associated with the placement and removal of a retrievable filter (ALN filter; ALN Implants Chirurgicaux; Ghisonaccia, France) remain largely unknown.
CardioVascular and Interventional Radiology, Volume 30, Number 1, February 2007, pp. 140-142(3)
We report the case of a 48-year-old woman presenting with recurrent uterine leiomyosarcoma (LMS) associated with right iliac vein and inferior vena cava (IVC) invasion and left lower lobe pulmonary tumor embolus.
Current Opinion in Pediatrics. 19(1):64-70, February 2007
Pandemic influenza is inevitable, will have significant impact on the population and will challenge healthcare delivery. Planning for an influenza pandemic will improve the ability of healthcare facilities to respond successfully.
Smoking cessation is the one of the most important ways to improve the prognosis of patients with respiratory disease. The Task Force on guidelines for smoking cessation in patients with respiratory diseases was convened to provide evidence-based recommendations on smoking cessation interventions in respiratory patients.
American Journal of Respiratory and Critical Care Medicine Vol 175. pp. 222-227, (2007)
To assess biomarker concentrations in clinical disease and investigate the site of origin of EBC, we compared EBC and bronchoalveolar lavage (BAL) biomarkers in 49 patients undergoing bronchoscopy for clinical indications.
Clinical Pulmonary Medicine. 14(1):7-12, January 2007
Hospital-acquired pneumonia (HAP) associated with mechanical ventilation complicates the course of patients in the intensive care unit (ICU), prolongs hospital stay, and increases the risk of death.
Clinical Pulmonary Medicine. 14(1):52-54, January 2007
Aspiration pneumonia is a common entity, which has many causes. Although not common, Zenker diverticulum is an entity that needs to be considered in the differential diagnosis, although the pathophysiology of Zenker is still in question. There are several treatment modalities, but most require surgical intervention.
Chronic Respiratory Disease, Volume 3, Number 4, November 2006, pp. 187-193(7)
Chronic obstructive pulmonary disease (COPD) accounts for a large number of hospital admissions and numerous interventions have attempted to reduce exacerbations requiring hospitalization.
The within-breath change in reactance (rs) measured by forced oscillation technique (FOT) at 5 Hz reliably detects expiratory flow limitation in chronic obstructive pulmonary disease (COPD). The present study compared this approach to the standard negative expiratory pressure (NEP) method.
Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of ischaemic heart disease (IHD). Statins reduce mortality and morbidity in IHD. It has been hypothesised that statin treatment is associated with reduced long-term mortality in patients with COPD.
The impact of continuous positive airway pressure (CPAP) treatment on the airway responsiveness of asthmatic subjects with obstructive sleep apnoea (OSA) has scarcely been studied.
Pediatric Infectious Disease Journal. 26(1):68-74, January 2007
Severe acute respiratory syndrome (SARS) is a febrile, respiratory tract illness caused by infection with the newly identified SARS-associated coronavirus. A notable feature of the 2003 global SARS outbreak was the relative paucity of cases reported among children.
Respiratory Medicine Volume 101, Issue 2 , February 2007, Pages 300-307
Several in vitro studies have shown that at similar tidal volume (VT), bronchodilator delivery to target sites is significantly lower during controlled mechanical ventilation (CMV) than that during simulated spontaneous breathing. However, the influence of active respiratory efforts on the magnitude of b2-agonist induced bronchodilation in mechanically ventilated patients has not been examined.
Clinical Pulmonary Medicine. 14(1):1-6, January 2007
Standardized methacholine inhalation challenges are useful to detect airway dysfunction. These tests have been used to help assess the presence of asthma in patients with symptoms and normal lung function. Standardized protocols are available for 2 commonly used methods, the 2-minute tidal breathing method and the 5-breath dosimeter method.
The aim of the present study was to measure airway, oropharyngeal and gastrointestinal deposition of 99mTc-labelled hydrofluoroalkane-beclomethasone dipropionate after inhalation via a pressurised metered-dose inhaler and spacer (Aerochamber PlusTM) in asthmatic children.
Current Opinion in Pulmonary Medicine. 13(2):107-113, March 2007
There is growing evidence that genetics plays a role in the development of chronic obstructive pulmonary disease. This review deals with the most recent findings, new methods to detect genetic susceptibility that may be helpful in this field, and how the environment may act on the genetic code of susceptible individuals and chronic obstructive pulmonary disease sufferers.
Chronic Respiratory Disease, Volume 3, Number 4, November 2006, pp. 181-185(5)
Recent randomized controlled studies have reported success for hospital at home for prevention and early discharge of chronic obstructive pulmonary disease (COPD) patients using hospital based respiratory nurse specialists.
Physical examination demonstrated petechiae, leg oedema and mild dyspnoea. Chest radiograph showed minimal bilateral hazy increased opacification, mainly on the right side, and small bilateral pleural effusions. High-resolution CT demonstrated extensive bilateral ground-glass opacities most severe in the middle and lower lung zones.
Clinical Nuclear Medicine. 32(2):114-116, February 2007
Fluorodeoxyglucose positron emission tomography (FDG PET) has been widely used in the assessment of malignancy. However, FDG can also accumulate in sarcoid lesions. Gallium-67 scan is conventionally used to evaluate sarcoid activity in nuclear medicine. FDG PET may be also useful in the evaluation of sarcoid activity.
The purpose of this study is to assess the utility of the chest high-resolution computed tomography (HRCT) scan for estimating the severity of haemoptysis, localize the bleeding site and to determine a cause of the bleeding.
Journal of Pediatric Surgery Volume 42, Issue 1 , January 2007, Pages 112-116
Infants born with congenital diaphragmatic hernia (CDH) demonstrate a wide variability in postnatal catch-up lung growth. The goals of this study were to assess the pulmonary development of children born with CDH using sequential ventilation-perfusion (V/Q) scintigraphy and to identify the perinatal factors that correspond to a progressive V/Q mismatch.
Current Opinion in Pulmonary Medicine. 13(2):114-119, March 2007
The possible development of pulmonary hypertension is a well-known complication in the course of chronic obstructive pulmonary disease. When present, pulmonary hypertension is in general of mild severity at rest. It is therefore generally considered as a second-rank marker of the disease, mainly because the patients are limited in their exercise capacity for respiratory rather than for circulatory reasons. Apart from the common hemodynamic profile, however, some patients have a moderate-to-severe level of mean pulmonary artery pressure.
Animal models suggest that reduced nitric oxide (NO) synthase activity results in lower values of exhaled NO (eNO) present at birth in those individuals who are going to develop chronic lung disease of infancy (CLDI).
In order to investigate underlying mechanisms, the present authors studied the effect of pulmonary rehabilitation on the regulation of total chest wall and compartmental (ribcage, abdominal) volumes during exercise in patients with chronic obstructive pulmonary disease.
Chronic Respiratory Disease, Volume 3, Number 4, November 2006, pp. 203-214(12)
Amyloidosis is a disorder of protein folding in which normally soluble plasma proteins aggregate in an abnormal fibrillar form causing progressive disruption to tissue structure and organ function.
Journal of Intensive Care Medicine, Vol. 22, No. 1, 38-43 (2007)
The authors retrospectively reviewed their experience with bilevel positive airway pressure (BiPAP) to treat respiratory insufficiency in pediatric patients over a 5-year period.
Bone Volume 40, Issue 2 , February 2007, Pages 493-497
Chronic obstructive pulmonary disease (COPD) appears to be associated with low bone mineral density (BMD). BMD loss can be accelerated by a number of factors associated with COPD, but it is not known whether COPD itself has a direct effect.
Isolated pulmonary hypertension (iPHT) is a near-fatal consequence of systemic sclerosis (SSc); in female patients, the risk of its development is increased during the post-menopausal period, when the protective effects of oestrogens on the endothelium decrease.
New England Journal of Medicine Volume 356:398-407 January 25, 2007 Number 4
A 3-year-old boy was admitted to the hospital because of recurrent episodes of respiratory insufficiency, pulmonary infiltrates, and anemia. He was treated with antibiotics and levalbuterol and budesonide by inhalation at 9, 12, and 23 months of age.
The immediate and long-term clinical events associated with the placement and removal of a retrievable filter (ALN filter; ALN Implants Chirurgicaux; Ghisonaccia, France) remain largely unknown.
CardioVascular and Interventional Radiology, Volume 30, Number 1, February 2007, pp. 140-142(3)
We report the case of a 48-year-old woman presenting with recurrent uterine leiomyosarcoma (LMS) associated with right iliac vein and inferior vena cava (IVC) invasion and left lower lobe pulmonary tumor embolus.
Current Opinion in Pediatrics. 19(1):64-70, February 2007
Pandemic influenza is inevitable, will have significant impact on the population and will challenge healthcare delivery. Planning for an influenza pandemic will improve the ability of healthcare facilities to respond successfully.
Smoking cessation is the one of the most important ways to improve the prognosis of patients with respiratory disease. The Task Force on guidelines for smoking cessation in patients with respiratory diseases was convened to provide evidence-based recommendations on smoking cessation interventions in respiratory patients.
American Journal of Respiratory and Critical Care Medicine Vol 175. pp. 222-227, (2007)
To assess biomarker concentrations in clinical disease and investigate the site of origin of EBC, we compared EBC and bronchoalveolar lavage (BAL) biomarkers in 49 patients undergoing bronchoscopy for clinical indications.
Clinical Pulmonary Medicine. 14(1):7-12, January 2007
Hospital-acquired pneumonia (HAP) associated with mechanical ventilation complicates the course of patients in the intensive care unit (ICU), prolongs hospital stay, and increases the risk of death.
Clinical Pulmonary Medicine. 14(1):52-54, January 2007
Aspiration pneumonia is a common entity, which has many causes. Although not common, Zenker diverticulum is an entity that needs to be considered in the differential diagnosis, although the pathophysiology of Zenker is still in question. There are several treatment modalities, but most require surgical intervention.
Chronic Respiratory Disease, Volume 3, Number 4, November 2006, pp. 187-193(7)
Chronic obstructive pulmonary disease (COPD) accounts for a large number of hospital admissions and numerous interventions have attempted to reduce exacerbations requiring hospitalization.
The within-breath change in reactance (rs) measured by forced oscillation technique (FOT) at 5 Hz reliably detects expiratory flow limitation in chronic obstructive pulmonary disease (COPD). The present study compared this approach to the standard negative expiratory pressure (NEP) method.
Patients with chronic obstructive pulmonary disease (COPD) have an increased risk of ischaemic heart disease (IHD). Statins reduce mortality and morbidity in IHD. It has been hypothesised that statin treatment is associated with reduced long-term mortality in patients with COPD.
The impact of continuous positive airway pressure (CPAP) treatment on the airway responsiveness of asthmatic subjects with obstructive sleep apnoea (OSA) has scarcely been studied.
Pediatric Infectious Disease Journal. 26(1):68-74, January 2007
Severe acute respiratory syndrome (SARS) is a febrile, respiratory tract illness caused by infection with the newly identified SARS-associated coronavirus. A notable feature of the 2003 global SARS outbreak was the relative paucity of cases reported among children.
Respiratory Medicine Volume 101, Issue 2 , February 2007, Pages 300-307
Several in vitro studies have shown that at similar tidal volume (VT), bronchodilator delivery to target sites is significantly lower during controlled mechanical ventilation (CMV) than that during simulated spontaneous breathing. However, the influence of active respiratory efforts on the magnitude of b2-agonist induced bronchodilation in mechanically ventilated patients has not been examined.
Clinical Pulmonary Medicine. 14(1):1-6, January 2007
Standardized methacholine inhalation challenges are useful to detect airway dysfunction. These tests have been used to help assess the presence of asthma in patients with symptoms and normal lung function. Standardized protocols are available for 2 commonly used methods, the 2-minute tidal breathing method and the 5-breath dosimeter method.
The aim of the present study was to measure airway, oropharyngeal and gastrointestinal deposition of 99mTc-labelled hydrofluoroalkane-beclomethasone dipropionate after inhalation via a pressurised metered-dose inhaler and spacer (Aerochamber PlusTM) in asthmatic children.
Current Opinion in Pulmonary Medicine. 13(2):107-113, March 2007
There is growing evidence that genetics plays a role in the development of chronic obstructive pulmonary disease. This review deals with the most recent findings, new methods to detect genetic susceptibility that may be helpful in this field, and how the environment may act on the genetic code of susceptible individuals and chronic obstructive pulmonary disease sufferers.
Chronic Respiratory Disease, Volume 3, Number 4, November 2006, pp. 181-185(5)
Recent randomized controlled studies have reported success for hospital at home for prevention and early discharge of chronic obstructive pulmonary disease (COPD) patients using hospital based respiratory nurse specialists.
Physical examination demonstrated petechiae, leg oedema and mild dyspnoea. Chest radiograph showed minimal bilateral hazy increased opacification, mainly on the right side, and small bilateral pleural effusions. High-resolution CT demonstrated extensive bilateral ground-glass opacities most severe in the middle and lower lung zones.
Clinical Nuclear Medicine. 32(2):114-116, February 2007
Fluorodeoxyglucose positron emission tomography (FDG PET) has been widely used in the assessment of malignancy. However, FDG can also accumulate in sarcoid lesions. Gallium-67 scan is conventionally used to evaluate sarcoid activity in nuclear medicine. FDG PET may be also useful in the evaluation of sarcoid activity.
The purpose of this study is to assess the utility of the chest high-resolution computed tomography (HRCT) scan for estimating the severity of haemoptysis, localize the bleeding site and to determine a cause of the bleeding.
Journal of Pediatric Surgery Volume 42, Issue 1 , January 2007, Pages 112-116
Infants born with congenital diaphragmatic hernia (CDH) demonstrate a wide variability in postnatal catch-up lung growth. The goals of this study were to assess the pulmonary development of children born with CDH using sequential ventilation-perfusion (V/Q) scintigraphy and to identify the perinatal factors that correspond to a progressive V/Q mismatch.
Current Opinion in Pulmonary Medicine. 13(2):114-119, March 2007
The possible development of pulmonary hypertension is a well-known complication in the course of chronic obstructive pulmonary disease. When present, pulmonary hypertension is in general of mild severity at rest. It is therefore generally considered as a second-rank marker of the disease, mainly because the patients are limited in their exercise capacity for respiratory rather than for circulatory reasons. Apart from the common hemodynamic profile, however, some patients have a moderate-to-severe level of mean pulmonary artery pressure.
Animal models suggest that reduced nitric oxide (NO) synthase activity results in lower values of exhaled NO (eNO) present at birth in those individuals who are going to develop chronic lung disease of infancy (CLDI).
In order to investigate underlying mechanisms, the present authors studied the effect of pulmonary rehabilitation on the regulation of total chest wall and compartmental (ribcage, abdominal) volumes during exercise in patients with chronic obstructive pulmonary disease.
Chronic Respiratory Disease, Volume 3, Number 4, November 2006, pp. 203-214(12)
Amyloidosis is a disorder of protein folding in which normally soluble plasma proteins aggregate in an abnormal fibrillar form causing progressive disruption to tissue structure and organ function.
What
is RSS?
