Proteomics of Transformed Lymphocytes from a Family with Familial Pulmonary Arterial Hypertension
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 99-107, (2008)
Not all family members with BMPR2 mutations develop pulmonary arterial hypertension (PAH), implying that additional modifier genes or proteins are necessary for full expression of the disease.
12/22/2007
10:27 AM
Deep vein thrombosis and pulmonary embolus associated with a ruptured popliteal aneurysm - a cautionary note
World Journal of Emergency Surgery 2007, 2:34
Popliteal artery aneurysms representing 80% of peripheral artery aneurysms rarely rupture (a reported incidence of 0.1-2.8 %) and second commonest in frequency after aorto-iliac aneurysms.
12/22/2007
10:26 AM
Antimicrobial susceptibilities of Streptococcus pneumoniae isolated from adult patients with community-acquired pneumonia in Japan
Respirology doi:10.1111/j.1440-1843.2007.01214.x
Streptococcus pneumoniae (S. pneumoniae) is the most common pathogen associated with community-acquired pneumonia and its resistance to antimicrobials is a worldwide problem. The aim of this study was to investigate the current drug susceptibilities of S. pneumoniae isolated from adult patients with community-acquired pneumonia in Japan.
12/22/2007
10:25 AM
The Prevention of Chronic Obstructive Pulmonary Disease Exacerbations by Salmeterol/Fluticasone Propionate or Tiotropium Bromide
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 19-26, (2008)
Exacerbations are key drivers of morbidity and mortality in chronic obstructive pulmonary disease (COPD).
12/22/2007
10:24 AM
Pulmonary Hypertension Associated with Myeloproliferative Disorders - A Retrospective Study of Ten Cases
Respiration (DOI: 000112822)
Pulmonary hypertension (PH) is a severe hemodynamic disorder in which the pulmonary artery pressure is persistently elevated, leading to right-sided heart failure. Some studies have suggested an association between PH and myeloproliferative diseases (MPD).
12/22/2007
10:23 AM
The Healthy Worker Effect in Asthma
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 4-10, (2008)
Despite the increasing attention to the relationship between asthma and work exposures, occupational asthma remains underrecognized and its population burden underestimated.
12/22/2007
10:22 AM
Evaluation of enzyme-linked immunosorbent assay for Chlamydophila pneumoniae-specific immunoglobulin M in acute respiratory tract infection
Respirology doi:10.1111/j.1440-1843.2007.01196.x
The study evaluated a newly developed ELISA (Hitazyme Chlamydophila pneumoniae) for detecting anti-C. pneumoniae-specific IgM antibody, by comparing the ELISA assay to a microimmunofluorescence (MIF) test and immunoblotting.
12/22/2007
10:22 AM
Pesticides and Atopic and Nonatopic Asthma among Farm Women in the Agricultural Health Study
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 11-18, (2008)
Risk factors for asthma among farm women are understudied.
12/22/2007
10:21 AM
Bronchoalveolar Lavage and Response to Cyclophosphamide in Scleroderma Interstitial Lung Disease
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 91-98, (2008)
The presence of inflammatory cells on bronchoalveolar lavage is often used to predict disease activity and the need for therapy in systemic sclerosis-associated interstitial lung disease.
12/22/2007
10:20 AM
Prevalence of HIV-related Pulmonary Arterial Hypertension in the Current Antiretroviral Therapy Era
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 108-113, (2008)
The prevalence of HIV-associated pulmonary arterial hypertension (PAH) has not been evaluated since introduction of combined, highly active antiretroviral treatments.
12/22/2007
10:18 AM
Outcomes after Lung Retransplantation in the Modern Era
American Journal of Respiratory and Critical Care Medicine Vol 177. pp. 114-120, (2008)
Characteristics of and survival estimates for recipients of lung retransplantation in the modern era are unknown.
12/22/2007
10:16 AM
Challenges in pulmonary fibrosis 6 -middledot- Problematic granulomatous lung disease
Thorax 2008;63:78-84
Granulomatous inflammation in lung biopsies is a relatively non-specific finding that can occur in a range of inflammatory and neoplastic conditions. This review focuses on the patterns of granulomatous inflammation that can cause diffuse lung disease, highlighting histopathological features helpful in differential diagnosis.
12/22/2007
10:16 AM
Validation of FEV6 in the elderly - correlates of performance and repeatability
Thorax 2008;63:60-66
Forced expiratory volume in 6 s (FEV6) has been proposed as a more easily measurable parameter than forced vital capacity (FVC) to diagnose airway disease using spirometry. A study was undertaken to estimate FEV6 repeatability, to identify correlates of a good quality FEV6 measurement and of volumetric differences between FEV6 and FVC in elderly patients.
12/22/2007
10:14 AM
Incidence and characteristics of viral community-acquired pneumonia in adults
Thorax 2008;63:42-48
In adults, viral causes of community-acquired pneumonia (CAP) are poorly characterised. The aims of this study were to characterise the viral aetiology of CAP in adults by using an extensive array of viral diagnostic tests and to compare the characteristics of viral pneumonia with those of pneumococcal pneumonia.
12/22/2007
10:13 AM
Pulmonary puzzle
Thorax 2008;63:94
Direct inspection of the lesion during video assisted thoracoscopic surgery was undertaken to ensure neither pleural seeding nor pulmonary or diaphragm invasion.
12/22/2007
10:12 AM
Passive smoking exposure is associated with an increased risk of COPD
Thorax 2008;63:48
More than 15% of patients with chronic obstructive pulmonary disease (COPD) are never smokers. This study attempted to correlate passive smoking exposure with the risk of developing COPD in a South Chinese population.
12/22/2007
10:11 AM
Inhibition of NKCC1 may be beneficial in sepsis
Thorax 2008;63:34
Mortality related to bacteraemic pneumonia remains high, and previous studies have shown that the Na+-K+-Cl cotransporter (NKCC1) may have an important role in causing acute lung injury secondary to compromise of the alveolar-capillary barrier.
12/22/2007
10:10 AM
CT and lung function patterns in bronchopulmonary dysplasia BPD in the post-surfactant era
Thorax 2008;63:7
Advances in neonatal management, particularly the use of surfactant, have been associated with the emergence of a new form of bronchopulmonary dysplasia (BPD).
12/22/2007
10:09 AM
A potential method for development of a bird flu vaccine
Thorax 2008;63:84
The mechanisms by which animal strains of the influenza virus adapt themselves to invade human hosts are not fully understood, leading to difficulty in effective immunisation and treatment. Attempts are now being made to use structurally modified mutants to develop vaccines and therapeutic antibodies to pre-empt the emergence of human-adapted H5N1 strains of the avian influenza virus
12/22/2007
10:08 AM
A large chest wall tumour in an asymptomatic 15-year-old girl
Thorax 2008;63:41
A 15-year-old girl that had plain chest x ray as part of a routine medical examination was found to have a large left lower chest wall mass associated with rib destruction that was later shown to be painless and non-palpable.
12/22/2007
10:08 AM
Diagnostic accuracy of tumour markers for malignant pleural effusion: a meta-analysis
Thorax 2008;63:35-41
The role of tumour markers such as carbohydrate antigen (CA) 125, CA 15-3, CA 19-9 and CYFRA 21-1 (a fragment of cytokeratin 19) in differentiating malignant pleural effusions (MPE) from benign effusions is not yet clear.
12/22/2007
10:07 AM
Interstitial lung disease and anti-Jo-1 antibodies - difference between acute and gradual onset
Thorax 2008;63:53-59
A multicentre retrospective study was undertaken to examine patients with interstitial lung disease (ILD) with the initial clinical manifestation of an anti-synthetase syndrome (anti-Jo-1 antibodies), and to analyse the characteristics and long-term outcome of these patients according to their clinical presentation (acute or gradual onset), treatment and adverse events related to treatment.
12/22/2007
10:06 AM
Tracheal bronchus in a 6-month-old infant identified by CT with three-dimensional airway reconstruction
A 6 month old infant presented with a history of cough and noisy breathing since 5 weeks of age. He had been evaluated many times in a local emergency department for episodes of cough, wheeze and retractions. His parents reported that his symptoms seemed to be worse when he was supine and did not respond well to steroids or bronchodilators. He had been feeding and growing normally.
12/22/2007
10:05 AM
Aspirin sensitivity and eicosanoids
Thorax 2008;63:2-4
Aspirin sensitive respiratory disease (ASRD) was first described in 1922 by the French physician Widal.1 It is characterised by asthma, chronic rhinosinusitis and nasal polyps on a background of aspirin sensitivity.
12/22/2007
10:04 AM
Randomised placebo controlled trial of non-invasive ventilation for hypercapnia in cystic fibrosis
Thorax 2008;63:72-77
The clinical benefits of domiciliary non-invasive positive pressure ventilation (NIV) have not been established in cystic fibrosis (CF).
12/22/2007
10:03 AM
Early-life pulmonary arterial hypertension with subsequent development of diffuse pulmonary arteriovenous malformations in hereditary haemorrhagic telangiectasia type 1
Thorax 2008;63:85-86
The case history is presented of a male infant who was thought to have idiopathic pulmonary arterial hypertension (PAH) at 3 months of age. Subsequently the PAH decreased unexpectedly and diffuse pulmonary arteriovenous malformations (PAVMs) were seen at 6.9 years of age for the first time.
12/22/2007
10:02 AM
Severity of obstructive airways disease by age 2 years predicts asthma at 10 years of age
Thorax 2008;63:8-13
Predicting school-age asthma from obstructive airways disease (OAD) in early life is difficult, even when parental and children’s atopic manifestations are taken into consideration.
12/22/2007
10:01 AM
Prostaglandin E2 systemic production in patients with asthma with and without aspirin hypersensitivity
Thorax 2008;63:27-34
A special regulatory role for prostaglandin E2 has been postulated in aspirin-induced asthma. A study was undertaken to investigate the effects of aspirin on the systemic production of prostaglandin E2 and cysteinyl leucotrienes in patients with asthma.
12/22/2007
10:00 AM
Plasma phospholipase A2 activity in patients with asthma - association with body mass index and cholesterol concentration
Thorax 2008;63:21-26
Secretory phospholipases A2 (sPLA2) have functions relevant to asthmatic inflammation, including eicosanoid synthesis and effects on dendritic cells and T cells. The aim of this study was to measure sPLA2 activity in patients with stable and acute asthma and to assess potential associations with body mass index (BMI), and plasma cholesterol and vitamin C concentrations.
12/22/2007
09:59 AM
Body mass index and asthma severity in the National Asthma Survey
Thorax 2008;63:14-20
The association between obesity and asthma severity remains controversial and limited to small studies.
12/22/2007
09:59 AM
Results of endoscopic surgery and intralesional steroid therapy for airway compromise due to tracheobronchial Wegenera's granulomatosis
Thorax 2008;63:49-52
Upper airway compromise due to tracheobronchial stenosis commonly occurs in patients with Wegenera's granulomatosis (WG). There is at present no consensus on the optimal management of this life threatening condition.
12/22/2007
09:57 AM
What are the needs of patients following discharge from hospital after an acute exacerbation of chronic obstructive pulmonary disease COPD
Primary Care Respiratory Journal Volume 16 Issue 6 December 2007
To identify patient needs following discharge from hospital after an exacerbation of COPD.
12/22/2007
09:56 AM
The use of exhaled nitric oxide monitoring in primary care asthma clinics - a pilot study
Primary Care Respiratory Journal Volume 16 Issue 6 December 2007
Although asthma is defined as a chronic inflammatory disease, inflammation is rarely assessed. The fraction of exhaled nitric oxide (FeNO) is a biomarker of airways inflammation. We assessed the feasibility of FeNO monitoring in general practice.
12/22/2007
09:55 AM
The ADMIT series - Issues in Inhalation Therapy - The goals of asthma treatment: can they be achieved
Primary Care Respiratory Journal Volume 16 Issue 6 December 2007
Abstract
The widespread use of inhaled corticosteroids (ICS) since the early 1970’s has meant that asthma is generally better controlled in comparison with previous decades.
12/22/2007
09:54 AM
Monitoring of exhaled nitric oxide in primary care
Primary Care Respiratory Journal Volume 16 Issue 6 December 2007
12/22/2007
09:53 AM
Issues in Inhalation Therapy - a new series of papers from the ADMIT Working Group
Primary Care Respiratory Journal Volume 16 Issue 6 December 2007
12/22/2007
09:52 AM
Initial temporary misdiagnosis of bronchiectasis following pumpkin seed aspiration
Primary Care Respiratory Journal Volume 16 Issue 6 December 2007
Undiagnosed and retained foreign bodies may result in serious complications such as pneumonia, atelectasis, or bronchiectasis.
12/22/2007
09:51 AM
Do practices comply with key recommendations of the British Asthma Guideline - If not why not
Primary Care Respiratory Journal Volume 16 Issue 6 December 2007
Amongst general practices in the NHS Borders region of Scotland, we aimed to determine compliance with the three key recommendations of the British Guideline for the Management of Asthma and to understand the nature of barriers and facilitators to their implementation.
12/22/2007
09:50 AM
Application and implementation of the GINA asthma guidelines by specialist and primary care physicians - a longitudinal follow-up study on 264 children
Primary Care Respiratory Journal Volume 16 Issue 6 December 2007
To implement GINA guidelines and to assess their impact on the management of childhood asthma.
12/22/2007
09:49 AM
A 24-year old man with persistent progressive breathlessness - early onset COPD
Primary Care Respiratory Journal Volume 16 Issue 6 December 2007
We describe the case of a 24-year old male who had been a heavy smoker since the age of 9 and who presented with an 8-year history of respiratory symptoms.
12/22/2007
09:48 AM
Am
I going to see the next morning? A qualitative study of
patients' perspectives of sleep in COPD
Primary Care Respiratory Journal Volume 16 Issue 6 December 2007
To investigate patients' perspectives of sleep in COPD. METHOD: Patients with moderate to severe COPD underwent semi-structured interviews about their sleep experiences. Contextual questionnaire data were collected.
12/20/2007
11:59 AM
Percutaneous mechanical thrombectomy for the treatment of acute massive pulmonary embolism - case report
Thrombosis Journal 2007, 5:20
To our knowledge we report the first case of percutaneous mechanical thrombectomy used for the treatment of massive pulmonary embolism in the United Kingdom.
12/20/2007
11:59 AM
Noninvasive Positive Airway Pressure and Risk of Myocardial Infarction in Acute Cardiogenic Pulmonary Edema
Chest. 2007; 132:1804-1809
The addition of both noninvasive continuous positive airway pressure (n-CPAP) or noninvasive intermittent positive pressure ventilation (n-IPPV) to medical treatment has been shown to improve the outcome of patients with acute cardiogenic pulmonary edema (ACPE).
12/20/2007
11:55 AM
Learning Curve of Conventional Transbronchial Needle Aspiration in Pulmonologists Experienced in Bronchoscopy
Respiration (DOI: 000112793)
Despite its proven efficacy, transbronchial needle aspiration (TBNA) remains an underutilized technique for sampling enlarged mediastinal lymph nodes in the staging of lung cancer. Previous investigators have reported on TBNA experience, but without mentioning individual learning curves related to lymph node size in pulmonologists experienced in bronchoscopy.
12/20/2007
11:54 AM
Exacerbation-Free COPD - A Goal Too Far
The Proceedings of the American Thoracic Society 4:583-585 (2007)
The seventh Lund COPD workshop focused on exacerbations. As chronic obstructive pulmonary disease (COPD) progresses, exacerbations, events characterized by acute worsening of symptoms, increase in frequency and severity.
12/20/2007
11:54 AM
Oral or IV Prednisolone in the Treatment of COPD Exacerbations
Chest. 2007; 132:1741-1747
Treatment with systemic corticosteroids for exacerbations of COPD results in improvement in clinical outcomes. On hospitalization, corticosteroids are generally administered IV. It has not been established whether oral administration is equally effective. We conducted a study to demonstrate that therapy with oral prednisolone was not inferior to therapy with IV prednisolone using a double-blind, double-dummy design.
12/20/2007
11:53 AM
Radiographic follow-up of community-acquired pneumonia in children
Acta Paediatrica doi:10.1111/j.1651-2227.2007.00567.x
To evaluate the value of radiographic follow-up of community-acquired pneumonia in children who are previously healthy.
12/20/2007
11:52 AM
Correlation between spirometry and impulse oscillometry in children with asthma
Acta Paediatrica doi:10.1111/j.1651-2227.2007.00526.x
In certain patients, such as young children or individuals with cerebral palsy or severe mental retardation, it is difficult to perform forced expiratory manoeuvres to measure expiratory flow volume. In such cases, we could evaluate obstructive lung disease through the measurement of airway resistance instead of expiratory flow volume.
12/20/2007
11:51 AM
A New Method for Sampling and Detection of Exhaled Respiratory Virus Aerosols
Clinical Infectious Diseases 2008;46:93-95
We have developed a mask sampler for exhaled respiratory viruses. Among a group of 9 patients with cold symptoms who had virus-positive nasal mucus specimens, as analyzed by multiplexed polymerase chain reaction, virus-positive mask samples were obtained after coughing (20 times), talking (20 min), or breathing (20 min) from 6, 5, and 3 patients, respectively.
12/20/2007
11:46 AM
Reducing antibiotic use in influenza - challenges and rewards
Clinical Microbiology and Infection doi:10.1111/j.1469-0691.2007.01910.x
Respiratory tract infections are a frequent cause of medical consultations. Although the majority of such infections are viral in aetiology, they account for three-quarters of all antibiotic consumption, since bacterial infections of the upper and lower respiratory tract, notably bronchitis, sinusitis and pneumonia, are the most frequent complications resulting from virus infections, especially influenza in adults and children.
12/20/2007
11:44 AM
Long-Acting beta2-Adrenoceptor Agonists Synergistically Enhance Glucocorticoid-Dependent Transcription in Human Airway Epithelial and Smooth Muscle Cells
Mol Pharmacol 73:203-214, 2008
Addition of an inhaled long-acting beta2-adrenoceptor agonist (LABA) to an inhaled corticosteroid (ICS) is more effective at improving asthma control and reducing exacerbations than increasing the dose of ICS.
12/20/2007
11:42 AM
Exhaled NO and iNOS expression in sputum cells of healthy obese and OSA subjects
Journal of Internal Medicine Volume 263 Issue 1 Page 70-78, January 2008
Obstructive sleep apnoea (OSA) is associated with airways inflammation; a key role in this regard seems to be played by nitric oxide (NO). The aim of this study was to measure exhaled NO and expression of its enzyme, the inducible nitric oxide synthase (iNOS) in cells of induced sputum in OSA patients and in obese subjects without sleep apnoea and to correlate these inflammatory markers with severity of OSA.
12/20/2007
11:41 AM
Aberrant fibrillin-1 expression in early emphysematous human lung - a proposed predisposition for emphysema
Modern Pathology 14 December 2007
Parenchymal destruction, airspace enlargement, and loss of elasticity are hallmarks of pulmonary emphysema. Although the basic mechanism is unknown, there is a consensus that malfunctioning of the extracellular matrix is a major contributor to the pathogenesis of emphysema.
12/20/2007
11:40 AM
Using the Synergy Model as Best Practice in Endotracheal Tube Suctioning of Critically Ill Patients
Dimensions of Critical Care Nursing. 27(1):10-15, January/February 2008
Endotracheal suctioning with normal saline is a common practice in intensive care units. This unit reviews research concerning this practice as well as the adverse effects of saline instillation. In addition, the role of the critical care nurse as it pertains to the synergy model when caring for these patients is highlighted.
12/20/2007
11:39 AM
High D-dimer level is associated with increased 15-d and 3 months mortality through a more central localization of pulmonary emboli and serious comorbidity
British Journal of Haematology, Volume 140, Number 2, January 2008 , pp. 218-222(5)
High D-dimer levels are predictors of death in patients with pulmonary embolism (PE), as are more proximally located, larger emboli. The direct link between these three has not yet been described.
12/20/2007
11:38 AM
Respiratory Syncytial Virus Infection and Disease in Infants and Young Children Observed from Birth in Kilifi District Kenya
Clinical Infectious Diseases 2008;46:50-57
In developing countries, there are few data that characterize the disease burden attributable to respiratory syncytial virus (RSV) and clearly define which age group to target for vaccine intervention.
12/20/2007
11:37 AM
Identification of a human immunodominant B-cell epitope within the immunoglobulin A1 protease of Streptococcus pneumoniae
BMC Microbiology 2007, 7:113
The IgA1 protease of Streptococcus pneumoniae is a proteolytic enzyme that specifically cleaves the hinge regions of human IgA1, which dominates most mucosal surfaces and is the major IgA isotype in serum.
12/20/2007
11:36 AM
Gene Expression in Asthmatic Airway Smooth Muscle
The Proceedings of the American Thoracic Society 5:113-118 (2008)
Airway smooth muscle abnormalities are central to the pathophysiology of asthma. These airway smooth muscle cell abnormalities may include changes in cell number, size, phenotype, or function. Gene expression studies performed using asthmatic airway smooth muscle cells represent one approach to identifying the abnormalities of airway smooth muscle that occur in asthma in vivo.
12/20/2007
11:35 AM
Factors That Influenced Rates of Influenza Vaccination Among Employees of Wisconsin Acute Care Hospitals and Nursing Homes During the 2005-2006 Influenza Season
Infect Control Hosp Epidemiol 2007;28:1398-1400
Hospitals and nursing homes were surveyed in 2006 to obtain information on employee influenza vaccination programs and baseline rates of influenza vaccination among employees.
12/20/2007
11:33 AM
Utility of the Rapid B-Type Natriuretic Peptide Assay for Detection of Cardiovascular Problems in Newborn Infants with Respiratory Difficulties
Neonatology 2008;94:16-21
Because the major problems of respiratory difficulties in newborn infants are due to cardiopulmonary problems, improving the early detection and referral of newborn infants with cardiovascular problems has been considered one of the primary goals of care in the neonatal intensive care unit.
12/20/2007
11:32 AM
The Efficacy and Safety of Combination Salmeterol 50 microg Fluticasone Propionate Inhalation 500 microg Twice Daily Via Accuhaler in Chinese Patients With COPD
Chest. 2007; 132:1756-1763
Few studies of the efficacy and safety of therapy with combinations of salmeterol/fluticasone propionate (SFCs) have been conducted in Chinese patients with COPD, and the benefits of combination therapy in nonsmoking patients with COPD are, to our knowledge, not known.
12/20/2007
11:31 AM
Vascular endothelial growth factor in epithelial lining fluid of patients with acute respiratory distress syndrome
Respirology doi:10.1111/j.1440-1843.2007.01193.x
Vascular endothelial growth factor (VEGF) is known to contribute to the development of pulmonary oedema, and has been suggested to have a protective role against lung injury. To determine the role of VEGF in acute lung injury (ALI) and ARDS, VEGF levels were measured in lung epithelial lining fluid (ELF) collected from patients with ALI/ARDS.
12/20/2007
11:29 AM
A Recently Identified Rhinovirus Genotype Is Associated with Severe Respiratory-Tract Infection in Children in Germany
The Journal of Infectious Diseases 2007;196:1754-1760
Acute respiratory infection is a significant cause of morbidity and mortality in children worldwide. Accurate identification of causative agents is critical to case management and to prioritization in vaccine development.
12/20/2007
11:27 AM
Computed Tomographic Pulmonary Angiography vs Ventilation-Perfusion Lung Scanning in Patients With Suspected Pulmonary Embolism
JAMA. 2007;298(23):2743-2753
Ventilation-perfusion scanning has been largely replaced by CTPA in many centers despite limited comparative formal evaluations and concerns about CTPA's low sensitivity (ie, chance of missing clinically important pulmonary embuli).
12/20/2007
11:26 AM
Diagnosis and treatment of severe sepsis
Critical Care 2007, 11(Suppl 5):S2
The burden of infection in industrialized countries has prompted considerable effort to improve the outcomes of patients with sepsis. This has been formalized through the Surviving Sepsis Campaign 'bundles', derived from the recommendations of 11 professional societies, which have promoted global improvement in those practices whose primary goal it is to reduce sepsis-related death.
12/20/2007
11:25 AM
Multistate Outbreak of Burkholderia cenocepacia Colonization and Infection Associated With the Use of Intrinsically Contaminated Alcohol-Free Mouthwash
Chest. 2007; 132:1825-1831
No guidelines exist for the type of mouthwash that should be used in patients at increased risk for pneumonia. In 2005, we investigated a multistate outbreak of Burkholderia cenocepacia associated with an intrinsically contaminated alcohol-free mouthwash (AFM).
12/20/2007
11:24 AM
Goal-Directed Intraoperative Therapy Reduces Morbidity and Length of Hospital Stay in High-Risk Surgical Patients
Chest. 2007; 132:1817-1824
Postoperative organ failures commonly occur after major abdominal surgery, increasing the utilization of resources and costs of care.
12/20/2007
11:22 AM
Recent Developments in the Diagnosis and Management of Severe Sepsis
Chest. 2007; 132:1967-1976
The last 5 years have brought dramatic changes to the care of patients with severe sepsis. While early diagnosis remains a challenge and, regrettably, a rapid, sensitive, and specific diagnostic test is still lacking, the methods to identify those critically ill patients who are likely to die have become clearer.
12/20/2007
11:21 AM
Developing a Cardiopulmonary Exercise Testing Laboratory
Chest. 2007; 132:2000-2007
Cardiopulmonary exercise testing is a noninvasive and cost-effective technique that adds significant value to the assessment and management of a variety of symptoms and diseases. The penetration of this testing in medical practice may be limited by perceived operational and financial barriers.
12/20/2007
11:20 AM
Long-term Effect of Continuous Positive Airway Pressure on BP in Patients With Hypertension and Sleep Apnea
Chest. 2007; 132:1847-1852
To analyze the long-term effect of continuous positive airway pressure (CPAP) on ambulatory BP in patients with obstructive sleep apnea (OSA) and hypertension, and to identify subgroups of patients for whom CPAP could be more effective.
12/20/2007
11:18 AM
Pulmonary cryptococcosis - Clinical radiographical and serological markers of dissemination
Respirology doi:10.1111/j.1440-1843.2007.01202.x
This study aimed to identify markers of disseminated infection in patients presenting with pulmonary cryptococcosis.
12/20/2007
11:17 AM
Efficacy of Adaptive Servoventilation in Treatment of Complex and Central Sleep Apnea Syndromes
Chest. 2007; 132:1839-1846
Complex sleep apnea syndrome (CompSAS) is recognized by the concurrence of mixed or obstructive events with central apneas, the latter predominating on exposure to continuous positive airway pressure (CPAP). Treatment of CompSAS or central sleep apnea (CSA) syndrome with adaptive servoventilation (ASV) is now an option, but no large series exist describing the application and effectiveness of ASV.
12/20/2007
11:16 AM
Influence of Gender on the Outcome of Severe Sepsis
Chest. 2007; 132:1786-1793
The influence of gender on survival of patients with severe sepsis is unclear. Earlier studies suggested better survival in women, possibly related to the sex-steroid profile.
12/20/2007
11:15 AM
Ozone Exposure and Lung Function
Chest. 2007; 132:1890-1897
Ozone has heterogeneous effects on lung function. We investigated whether obesity and airways hyperresponsiveness (AHR) modify the acute effects of ozone on lung function in the elderly.
12/20/2007
11:13 AM
Validation of the Spanish Version of the Asthma Control Test ACT
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 867 - 872
Validation of the Spanish version of the Asthma Control Test (ACT).
12/20/2007
11:12 AM
The Relationship of Physical Activity and Percentage of Body Fat to the Risk of Asthma in 8- to 10-year-old Children
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 885 - 889
To evaluate physical activity, obesity and asthma, we analyzed information from children attending a racially diverse middle-class suburban school district.
12/20/2007
11:11 AM
The Relationship between Age of Asthma Onset and Cardiovascular Disease in Canadians
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 849 - 854
To quantify the association between cardiovascular disease (CVD) and asthma in Canadian adults and to determine whether age of asthma onset is a moderator of this association.
12/20/2007
11:10 AM
The Potential Biases in Studying the Relationship between Asthma and Microbial Infection
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 827 - 832
To assess bias in parent reports of asthma status of children and detection bias of medical records-based asthma ascertainment and to examine effects of such bias on the association between asthma status and infections.
12/20/2007
11:09 AM
Risk Factors for Pediatric Asthma in the South Bronx
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 855 - 859
We identified main asthma risk factors for children living in the South Bronx, where asthma rates are eight times higher than the national average. This case-control study enrolled 261 children at Lincoln Medical and Mental Health Center from 2002 to 2003.
12/20/2007
11:08 AM
Patient-Centered Education - Applying Learner-Centered Concepts to Asthma Education
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 799 - 804
To review studies of patient-centered asthma education. Method. CINAHL, Medline, Psycinfo, Eric, PsycARTICLES, and web of science databases were searched.
12/20/2007
11:03 AM
Off-Line Fractional Exhaled Nitric Oxide Measurement Is Useful to Screen Allergic Airway Inflammation in an Adult Population
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 805 - 810
To determine whether off-line fractional exhaled nitric oxide (FeNO) measurement is applicable to screen allergic airway inflammation for epidemiologic studies, we examined 280 adults, measuring off-line FeNO samplings, pulmonary function, and serum immunoglobulin E (IgE).
12/20/2007
10:59 AM
N 'Carboxymethyl' Lysine - a Major Advanced Glycation End Product in Exhaled Breath Condensate as a Biomarker of Small Airway Involvement in Asthma
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 861 - 866
We compared CML levels in exhaled breath condensate (EBC) between 19 asthmatics and 10 normal control subjects and its levels before and after tiotropium therapy in 11 non-smoking asthmatics and 10 smoking asthmatics.
12/20/2007
10:57 AM
Influenza Vaccination in Adults with Asthma: Safety of an Inactivated Trivalent Influenza Vaccine
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 817 - 822
Despite recommendations in most countries for giving inactivated influenza vaccine to people with asthma, only a minority currently receive it. One reason for low vaccine coverage has been concern that vaccination may induce exacerbations of asthma.
12/20/2007
10:56 AM
Influence of House Dust Mite Impermeable Covers on Health-Related Quality of Life of Adult Patients with Asthma - Results of a Randomized Clinical Trial
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 843 - 848
The aim of this study was to evaluate the effect of house dust mite impermeable covers on asthma-specific health-related quality of life in adult asthmatic patients that were trained in guided self-management.
12/20/2007
10:55 AM
Hoarseness in Asthmatic Patients - The Side Effect of Inhaled Steroid or Not
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 823 - 826
Hoarseness is one of the possible side effects of inhaled steroid in asthmatic patients as well as a common presenting feature of laryngeal tuberculosis.
12/20/2007
10:54 AM
Does Spatial Accessibility of Pharmacy Services Predict Compliance with Long-Term Control Medications
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 881 - 883
Disadvantaged urban children with asthma are at high risk for undermanagement of their disease and poor compliance with inhaled corticosteroids (ICS). Objective: To determine whether spatial accessibility (SA) of retail pharmacy services is associated with ICS compliance.
12/20/2007
10:53 AM
Disparities in Asthma Hospitalizations among Children Seen in the Emergency Department
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 833 - 837
We examined the race/ethnicity variation in the risk of hospitalization among children seen in the emergency department (ED) for asthma. ED and hospitalization records for children 1 to 19 years of age in New Jersey for 2004 and 2005 were linked.
12/20/2007
10:52 AM
Descriptors and Perception of Dyspnea in African-American Asthmatics
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 811 - 815
This study explores self-reported perception of asthma symptoms in African-Americans.
12/20/2007
10:51 AM
Case Report - Allergic Bronchopulmonary Aspergillosis and Allergic Fungal Sinusitis Successfully Treated with Voriconazole
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 891 - 895
Allergic bronchopulmonary aspergillosis and allergic fungal sinusitis are closely related disorders that rarely present in the same individual. The mainstay of treatment for allergic bronchopulmonary aspergillosis is systemic corticosteroids. Itraconazole is used as adjunctive therapy in refractory cases.
12/20/2007
10:49 AM
An Association between Asthma and BMI in Adolescents - Results from the California Healthy Kids Survey
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 873 - 879
Abstract
We examined the relationship between asthma prevalence and BMI in a cross-sectional survey of 471,969 adolescents. The size of the survey allowed us to investigate this relationship with much greater resolution than previously possible.
12/20/2007
10:48 AM
Air Quality and Pediatric Asthma-Related Emergencies
Journal of Asthma, Volume 44, Issue 10 December 2007 , pages 839 - 841
Previous studies suggest a relationship between air pollutants, aeroallergens, and asthma exacerbations. Objective. To simultaneously examine the role of seasonality, air quality, aeroallergens, and climate on asthma-related pediatric emergency department (ED) visits.
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