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August 1-15 2008 Postings (Note: Some archived links may become inactive)


08/15/2008 02:49 PM

Occupational asthma caused by sculptured nails containing methacrylates

American Journal of Industrial Medicine Published Online: 13 Aug 2008

In recent decades, the use of artificial nails including methacrylates (MAs) has increased. This study presents the first two clinical cases of occupational asthma (OA) caused by sculptured nails containing MAs.


08/15/2008 02:49 PM

Inhibition of endothelin receptors in the treatment of pulmonary arterial hypertension: does selectivity matter?

European Heart Journal 2008 29(16):1936-1948

Treatment options for pulmonary arterial hypertension (PAH) have considerably improved in the past few years. Endothelin (ET)-receptor antagonism has been established as a first-line option for the majority of PAH patients


08/15/2008 02:48 PM

Capnovolumetry: a new tool for lung function testing in children with asthma

Clinical Physiology and Functional Imaging, Volume 28, Number 5, September 2008 , pp. 332-336(5)

In capnovolumetry, the expiratory CO2 concentration of exhaled air is plotted against the volume and thereby allows to determine functional dead space volumes.


08/15/2008 02:47 PM

Successful removal of a giant intrathoracic lipoma: a case report and review of the literature

Cases Journal 2008, 1:87

We report a case of a 44-year old female who presented to her physician complaining of mild dyspnea. A follow-up chest X-ray and chest computed tomography scan revealed a giant bilateral intrathoracic mass, filling the right thoracic cavity and extending across the anterior mediastinum into the left chest cavity.


08/15/2008 02:45 PM

How epithelial cells detect danger: aiding the immune response

Allergy, Volume 63, Number 9, September 2008 , pp. 1110-1123(14)

The epithelial layer occupies a strategic important location between an organisms' interior and exterior environment. Although as such it forms a physical barrier between both environments, it became clear that the role of the epithelium extends far beyond this rather passive role.


08/15/2008 02:44 PM

Impaired spermatogenesis by testicular sarcoidosis

Respirology Published Online: 10 Aug 2008

Testicular involvement by sarcoidosis is a rare condition. A 23-year-old Japanese man had asymptomatic bilateral testicular lesions, which were detected by gallium scintigram, together with lesions located bilaterally in the uvea, lungs and hilar, and mediastinal lymph nodes and unilateral supraclavicular lymph nodes.


08/15/2008 02:44 PM

Superoxide Dismutase 3 Polymorphism Associated with Reduced Lung Function in Two Large Populations

Am. J. Respir. Crit. Care Med. 2008, doi:10.1164/rccm.200804-549OC

Superoxide dismutase 3 (SOD3) inhibits oxidative fragmentation of lung matrix components collagen I, hyaluronan, and heparan sulfate.


08/15/2008 02:43 PM

Obstructive sleep apnoea and nocturnal gastroesophageal reflux are common in lung transplant patients

Respirology Published Online: 10 Aug 2008

Gastroesophageal reflux (GOR) has been implicated in the pathogenesis of bronchiolitis obliterans syndrome (BOS), possibly due to pulmonary aspiration of refluxed acid. Risk of aspiration of gastric contents is increased during sleep due to decreased oesophageal clearance mechanisms and may be further increased by the presence of OSA.


08/15/2008 02:42 PM

Obesity in aspirin-tolerant and aspirin-intolerant asthmatics

Respirology Published Online: 10 Aug 2008

Obesity is an important factor in the development of asthma. Aspirin hypersensitivity affects 5-10% of asthmatics. The association between obesity and aspirin hypersensitivity in asthma is unclear. This study evaluated the association of BMI and asthma in patients with aspirin-tolerant asthma (ATA) and aspirin-intolerant asthma (AIA).


08/15/2008 02:41 PM

Risk factors and outcome of community-acquired pneumonia due to Gram-negative bacilli

Respirology Published Online: 10 Aug 2008

Several sets of guidelines have advocated initial antibiotic treatment for community-acquired pneumonia due to Gram-negative bacilli in patients with specific risk factors. However, evidence to support this recommendation is scarce.


08/15/2008 02:40 PM

Duration of Withdrawal of Life Support in the ICU and Association with Family Satisfaction

Am. J. Respir. Crit. Care Med. 2008, doi:10.1164/rccm.200711-1617OC

Most deaths in the intensive care involve withholding or withdrawing multiple life-sustaining therapies, but little is known about how to proceed practically and how it affects family satisfaction.


08/15/2008 02:39 PM

Pulmonary Nontuberculous Mycobacterial Disease: Prospective Study of a Distinct Preexisting Syndrome

Am. J. Respir. Crit. Care Med. 2008, doi:10.1164/rccm.200805-686OC

Pulmonary nontuberculous mycobacterial (PNTM) disease is increasing, but predisposing features have been elusive.


08/15/2008 02:39 PM

Serum Inter-{alpha}-trypsin Inhibitor and Matrix Hyaluronan Promote Angiogenesis in Fibrotic Lung Injury

Am. J. Respir. Crit. Care Med. 2008, doi:10.1164/rccm.200803-386OC

The etiology and pathogenesis of angiogenesis in idiopathic pulmonary fibrosis (IPF) is poorly understood. Inter-alpha-trypsin inhibitor (IaI) is a serum protein that can bind to hyaluronan and may contribute to the angiogenic response to tissue injury.


08/15/2008 02:38 PM

IL-32, A Novel Proinflammatory Cytokine in Chronic Obstructive Pulmonary Disease

Am. J. Respir. Crit. Care Med. 2008, doi:10.1164/rccm.200804-646OC

COPD is a chronic inflammatory disorder of the lung; yet the mechanisms that regulate this immune-inflammatory response are not fully understood.


08/15/2008 02:37 PM

Combination therapy with prostacyclin and tadalafil for severe pulmonary arterial hypertension: A pilot study

Respirology Published Online: 31 Oct 2007

Despite the introduction of new drugs that have changed the course of pulmonary arterial hypertension (PAH), some patients are still refractory to treatment and deteriorate rapidly.


08/14/2008 03:52 PM

Mineral Status of COPD Patients under Long-Term Inhaled Corticosteroid Therapy

Journal of Prosthodontics, Volume 17, Number 6, August 2008 , pp. 462-467(6)

The aim of this study was to determine the mineral status of mandibles, femurs, and spines in chronic obstructive pulmonary disease (COPD) patients under long-term inhaled corticosteroid therapy.


08/14/2008 03:51 PM

The Role of Treprostinil in the Management of Pulmonary Hypertension

American Journal of Cardiovascular Drugs, Volume 8, Number 4, 2008 , pp. 213-217(5)

Pulmonary arterial hypertension (PAH) is a severely disabling disorder characterized by sustained elevations of pulmonary vascular resistance, ultimately leading to right-heart failure and death. Intravenous epoprostenol has been widely used in patients with PAH, leading to long-term clinical benefits and improved survival.


08/14/2008 03:50 PM

T-cell activation during exacerbations: a longitudinal study in refractory asthma

Allergy, Volume 63, Number 9, September 2008 , pp. 1202-1210(9)

Asthma exacerbations represent the main source of costs and morbidity in asthma care, and drugs specifically designed to prevent exacerbations are needed. A prerequisite is to dispose of a precise knowledge of inflammatory events leading to exacerbations.


08/14/2008 03:49 PM

Lung transplantation in patients with connective tissue disorders and esophageal dysmotility

Diseases of the Esophagus Published Online: 2 May 2008

Lung and esophageal dysfunction are common in patients with connective tissue disease (CTD). Recent reports have suggested a link between pathologic gastroesophageal reflux and bronchiolitis obliterans syndrome (BOS) after lung transplant.


08/14/2008 03:48 PM

Stem/Progenitor Cells in Lung Development, Injury Repair, and Regeneration

The Proceedings of the American Thoracic Society 5:703-706 (2008)

At least two populations of epithelial stem/progenitor cells give rise to the lung anlage, comprising the laryngo-tracheal complex versus the distal lung below the first bronchial bifurcation. Amplification of the distal population requires FGF9-FGF10-FGFR2b-Sprouty signaling. Residual pools of adult stem cells are hypothesized to be the source of lung regeneration and repair.


08/14/2008 03:47 PM

Mesenchymal Stem Cells as Vectors for Lung Disease

The Proceedings of the American Thoracic Society 5:711-716 (2008)

Stem cells divide asymmetrically, leading to self-renewal and the production of a daughter cell committed to differentiation.


08/14/2008 03:46 PM

Prevalence and Risk Factors for Depressive Symptoms in Persons with Chronic Obstructive Pulmonary Disease

Journal of General Internal Medicine 0884-8734 (Print) 10.1007/s11606-008-0749-z

Although depression is a risk factor for adverse outcomes in chronic illness, little is known about the prevalence or risk factors for depressive symptoms in chronic obstructive pulmonary disease (COPD).


08/14/2008 03:45 PM

Disseminated Varicella Infection in a Child Receiving Short-Term Steroids for Asthma

Pediatric Dermatology, Volume 25, Number 4, July/August 2008 , pp. 484-486(3)

An 8-year-old boy, treated with a short course of steroids for asthma, developed a fever with abdominal pain and a generalized vesicular rash after contact with varicella-infected classmates.


08/14/2008 03:43 PM

Impact of Preexisting Pulmonary Fibrosis Detected on Chest Radiograph and CT on the Development of Gefitinib-Related Interstitial Lung Disease

American Journal of Clinical Oncology. 31(4):340-344, August 2008

Although preexisting pulmonary fibrosis (PF) on chest radiograph is known to be a risk factor of gefitinib-related interstitial lung disease (ILD), the significance of PF detected by chest computed tomography (CT) on the development of gefitinib-related ILD has not been investigated sufficiently.


08/14/2008 03:42 PM

Efficacy and Safety of Erythromycin as Sclerosing Agent in Patients With Recurrent Malignant Pleural Effusion

American Journal of Clinical Oncology. 31(4):384-389, August 2008

The aim of pleurodesis in malignant pleural effusions is to prevent reaccumulation of the fluid, symptoms, and avoid the need for repeated hospitalization for thoracentesis. The purpose of this study was to evaluate the efficacy and safety of erythromycin as a pleural sclerosing agent.


08/14/2008 03:41 PM

Pulmonary Hypertension Associated with Lung Transplantation Obliterative Bronchiolitis and Vascular Remodeling of the Allograft

American Journal of Transplantation Volume 8 Issue 9, Pages 1921 - 1930

Pathologic obliterative bronchiolitis (OB)/Bronchiolitis obliterans syndrome (pathologic OB/BOS) is the major obstacle to long-term survival post-lung transplantation (LT). Our group has demonstrated that pulmonary hypertension (PH) complicates the course of chronic inflammatory lung diseases that have similarities to pathologic OB/BOS and that vascular remodeling of the bronchial circulation occurs during BOS. Consequently, we hypothesized that PH is associated with pathologic OB/BOS and may result from a vasculopathy of the allograft pulmonary circulation.


08/14/2008 03:41 PM

Hyaluronidase Expression and Activity Is Regulated by Pro-Inflammatory Cytokines in Human Airway Epithelial Cells

American Journal of Respiratory Cell and Molecular Biology. Vol. 39, pp. 289-295, 2008

Hyaluronan (HA) is present at the apical surface of airway epithelium as a high-molecular-weight polymer. Since HA depolymerization initiates a cascade of events that results in kinin generation and growth factor processing, in the present work we used primary cultures of human bronchial epithelial (HBE) cells grown at the air-liquid interface (ALI) to assess hyaluronidase (Hyal) activity by HA zymography, gene expression by quantitative real-time PCR, and localization by confocal microscopy.


08/14/2008 03:40 PM

Functional Expression of GABAB Receptors in Airway Epithelium

American Journal of Respiratory Cell and Molecular Biology. Vol. 39, pp. 296-304, 2008

The GABAB receptor is a dimer composed of R1 and R2 components and classically couples to the heterotrimeric Gi protein. In addition to their location on neurons, GABA and functional GABAB receptors have been detected in peripheral tissue such as airway smooth muscle.


08/14/2008 03:39 PM

Activation of Neurokinin-1 Receptors during Ozone Inhalation Contributes to Epithelial Injury and Repair

American Journal of Respiratory Cell and Molecular Biology. Vol. 39, pp. 279-288, 2008

We investigated the importance of neurokinin (NK)-1 receptors in epithelial injury and repair and neutrophil function.


08/14/2008 03:38 PM

Nasal versus face mask for multiple-breath washout technique in preterm infants

Pediatric Pulmonology Published Online: 4 Aug 2008

The large dead space associated with face masks might impede the accuracy and feasibility of multiple-breath washout (MBW) measurements in small infants. We asked if a low dead space nasal mask would provide measurements of resting lung volume and ventilation inhomogeneity comparable to those obtained with a face mask, when using the MBW technique. Unsedated preterm infants breathing without mechanical assistance and weighing between 1.50 and 2.49 kg were studied.


08/14/2008 03:37 PM

Using diffusion-weighted MR imaging for tumor detection in the collapsed lung: a preliminary study

European Radiology 0938-7994 (Print) 10.1007/s00330-008-1134-3

The usefulness of diffusion-weighted magnetic resonance (MR) imaging (DWI) for differentiating central lung cancer from postobstructive lobar collapse (POC) was investigated.


08/14/2008 03:35 PM

Prevalence and correlates of pulmonary emphysema in smokers and former smokers. A densitometric study of participants in the ITALUNG trial

European Radiology 0938-7994 (Print) 10.1007/s00330-008-1131-6

We assessed with computed tomography (CT) densitometry the prevalence of emphysema in 266 smokers and former smokers enrolled in the ITALUNG trial of lung cancer screening with low-dose thin-slice CT.


08/14/2008 03:34 PM

Optimal level of physical activity in children with chronic lung diseases

Acta Paediatrica Published Online: 30 Jul 2008

To determine the optimal level of physical activity and its relationship with disease severity in children with chronic lung diseases (CLD).


08/14/2008 03:32 PM

Incidence rates of asthma, rhinitis and eczema symptoms and influential factors in young children in Sweden

Acta Paediatrica Volume 97 Issue 9, Pages 1210 - 1215

To estimate the incidence rates for asthma, rhinitis and eczema symptoms and to investigate the importance of different influential factors for the incidence of these symptoms.


08/14/2008 03:31 PM

Evidence for an asthma risk locus on chromosome Xp: a replication linkage study

Allergy, Volume 63, Number 9, September 2008 , pp. 1235-1238(4)

Asthma is a complex genetic disorder characterized by chronic inflammation in the airways. Identification of genetic risk factors for asthma has been complicated due to genetic heterogeneity and influence from environmental risk factors.


08/14/2008 03:30 PM

Pulmonary function studies in children treated by chemoradiotherapy and stem cell transplantation

Pediatric Blood & Cancer Published Online: 12 Aug 2008

Management of pediatric patients with malignant and hematological diseases is frequently associated with pulmonary complications. We assessed pulmonary function at diagnosis and during a 5-year follow-up to identify risk factors associated with pulmonary deterioration.


08/14/2008 03:29 PM

Seasonal variation of the onset of presentations in stage 1 sarcoidosis

International Journal of Clinical Practice Published Online: 8 Mar 2006

Sarcoidosis is a chronic disease with an unknown aetiology. Our aim was to evaluate the pattern of seasonality of stage 1 sarcoidosis subjects who had symptoms by all cases, by age and by both genders. In this study, we used Roger's test for cyclic variation to prove that this seasonal variation was more than chance.


08/14/2008 03:28 PM

Relative impact of respiratory muscle activity on tidal flow and end expiratory volume in healthy neonates

Pediatric Pulmonology Published Online: 30 Jul 2008

It has been suggested that infants dynamically regulate their tidal flow and end-expiratory volume level. The interaction between muscle activity, flow and lung volume in spontaneously sleeping neonates is poorly studied, since it requires the assessment of transcutaneous electromyography of respiratory muscles (rEMG) in matched comparison to lung function measurements.


08/14/2008 03:27 PM

Proinflammatory Cytokines, Fibrinolytic System Enzymes, and Biochemical Indices in Children With Infectious Para-pneumonic Effusions

Pediatric Infectious Disease Journal. 27(8):699-703, August 2008

In children, pleural empyema is a recognized complication of severe pneumonia and is characterized by loculated effusions with fibrin septations. The aim of this study was to evaluate the relationship between proinflammatory cytokines [tumor necrosis factor-[alpha] (TNF-[alpha]), interleukin-1[beta] (IL-1[beta]), and IL-6], intrapleural fibrinolytic system enzymes [tissue-type plasminogen activator (tPA) and plasminogen activator inhibitor type 1 (PAI-1)], and common biochemical indices during pleural infection.


08/14/2008 03:26 PM

Increased Risk of Stroke in Patients With Coronary Artery Disease and Sleep Apnea. A 10-Year Follow-Up

doi: 10.1161/CIRCULATIONAHA.108.783290

The effect of sleep apnea on mortality and cardiovascular morbidity is mainly unknown. We aimed to study whether sleep apnea is related to stroke, death, or myocardial infarction in patients with symptomatic coronary artery disease.


08/14/2008 03:24 PM

Sputum neurokinin A in Egyptian asthmatic children and adolescents: relation to exacerbation severity

Allergy, Volume 63, Number 9, September 2008 , pp. 1244-1247(4)

Neurogenic inflammation may participate in the development and progression of bronchial asthma. The molecular mechanisms underlying neurogenic inflammation are orchestrated by a large number of neuropeptides including tachykinins such as neurokinin A (NKA) and substance P. Tachykinins are secreted from sensory airway nerves and inflammatory cells after allergens exposure.


08/14/2008 03:06 PM

Seasonality of primary care utilization for respiratory diseases in Ontario: A time-series analysis

BMC Health Services Research 2008, 8:160

Respiratory diseases represent a significant burden in primary care. Determining the temporal variation of the overall burden of respiratory diseases on the health care system and their potential causes are keys to understanding disease dynamics in populations and can contribute to the rational management of health care resources.


08/14/2008 03:05 PM

Discriminative and predictive properties of disease-specific and generic health status indexes in elderly COPD patients

Published: 13 August 2008

The association between bronchial obstruction severity and mortality in Chronic Obstructive Pulmonary Disease (COPD) is well established, but it is unknown whether disease-specific health status measures and multidimensional assessment (MDA) have comparable prognostic value.


08/14/2008 03:05 PM

Hospital acquired pneumonia with high-risk bacteria is associated with increased pulmonary matrix metalloproteinase activity

BMC Pulmonary Medicine 2008, 8:12

Neutrophil products like matrix metalloproteinases (MMP), involved in bacterial defence mechanisms, possibly induce lung damage and are elevated locally during hospital- acquired pneumonia (HAP).


08/14/2008 03:03 PM

Wood smoke-associated lung disease: a clinical, functional, radiological and pathological description

The International Journal of Tuberculosis and Lung Disease, Volume 12, Number 9, September 2008 , pp. 1092-1098(7)

Approximately half of the world's population, and up to 90% of households in rural areas of developing countries, depend on biomass for cooking and heating.


08/14/2008 03:02 PM

Time course of airway remodelling after an acute chlorine gas exposure in mice

Respiratory Research 2008, 9:61

Accidental chlorine (Cl2) gas inhalation is a common cause of acute airway injury. However, little is known about the kinetics of airway injury and repair after Cl2 exposure.


08/12/2008 03:41 PM

Maintenance of Wakefulness test, obstructive sleep apnea syndrome, and driving risk

Annals of Neurology Published Online: 7 Aug 2008

Sleepiness at the wheel is a major risk factor for traffic accidents. Because of the potential medical and legal implications, in this study, we evaluated the correlation between subjective and objective measures of sleepiness and driving performances in patients suffering from excessive daytime sleepiness.


08/12/2008 03:41 PM

Occupational asthma secondary to enzymes used in cheese production

Allergy and Asthma Proceedings, Volume 29, Number 4, 7/8 2008 , pp. 376-379(4)

Occupational asthma (OA) accounts for 5-10% of all asthma in adults. Although OA secondary to enzymes has been reported, it is rare in the context of food preparation.


08/12/2008 03:40 PM

Variation in Mortality Rates Among Long-Term Care Facilities for Residents With Lower Respiratory Tract Infection

Infect Control Hosp Epidemiol 2008;29:754-759

To identify variables contributing to interfacility differences in mortality among residents of long-term care facilities who have lower respiratory tract infection.


08/12/2008 03:39 PM

Bronchial thermoplasty for asthma: A critical review of a new therapy

Allergy and Asthma Proceedings, Volume 29, Number 4, 7/8 2008 , pp. 365-370(6)

Bronchial thermoplasty (BT) is a novel experimental procedure involving the application of controlled heat from a radiofrequency source to the airway wall as a means to reduce airway smooth muscle in the airway wall.


08/12/2008 03:38 PM

The Role of Gastroesophageal Reflux in Exercise-Triggered Asthma: A Randomized Controlled Trial

Digestive Diseases and Sciences 0163-2116 (Print) 10.1007/s10620-008-0396-6

Exercise-triggered asthma (ETA) develops when physical activity triggers asthma symptoms during or directly after exercise.


08/12/2008 03:37 PM

Effectiveness of home treatment for patients with cystic fibrosis: The intravenous administration of antibiotics to treat respiratory infections

Pediatric Pulmonology Published Online: 4 Aug 2008

Patients with cystic fibrosis (CF) experience repeated infectious respiratory exacerbations leading to a continuous decline in lung function. The exacerbations are treated in hospital or at home.


08/12/2008 03:36 PM

Hypoxia Selectively Activates the CREB Family of Transcription Factors in the in vivo Lung

Am. J. Respir. Crit. Care Med. 2008, doi:10.1164/rccm.200712-1890OC

Pulmonary hypertension is a common complication of chronic hypoxic lung diseases and is associated with increased morbidity and reduced survival. The pulmonary vascular changes in response to hypoxia, both structural and functional, are unique to this circulation.


08/12/2008 03:35 PM

Serine/threonine kinase-protein kinase B and extracellular signal regulated kinase regulate ventilator-induced pulmonary fibrosis after bleomycin-induced acute lung injury - a prospective, controlled animal experiment

Critical Care 2008, 12:R103

Lung fibrosis, reduced lung compliance and severe hypoxemia found in patients with acute lung injury often result in the need for the support of mechanical ventilation.


08/12/2008 03:34 PM

Proteomic Analysis of Undiluted Lung Epithelial Lining Fluid

Chest. 2008; 134:338-345

Proteomics is increasingly leading to biomarker discovery in human disease. Epithelial lining fluid (ELF), until now only recovered indirectly, diluted in BAL fluid, is an attractive sample for lung disease proteomics.


08/12/2008 03:34 PM

Synergy Between Natriuretic Peptides and PDE5 Inhibitors Ameliorates Pulmonary Arterial Hypertension

Am. J. Respir. Crit. Care Med. 2008, doi:10.1164/rccm.200801-121OC

Phosphodiesterase (PDE) 5 inhibitors (e.g. Sildenafil) are selective pulmonary vasodilators in patients with pulmonary arterial hypertension (PAH).


08/12/2008 03:33 PM

Pleural Effusion After Ventricular Assist Device Placement

Chest. 2008; 134:382-386

The occurrence of pleural effusion after ventricular assist device (VAD) implantation has been described; however, little has been elucidated about the nature, prevalence, or characteristics of the effusions. Our study details the prevalence of pleural effusion and pleural fluid characteristics in VAD patients at our institution.


08/12/2008 03:32 PM

Leptin, a Novel Predictor of Lung Function in Heart Failure

Chest. 2008; 134:346-350

Leptin is a protein hormone produced by adipose tissue. Leptin has proinflammatory properties and is usually elevated in patients with chronic heart failure. We assessed if serum leptin relates to the loss in lung function in noncachectic patients with chronic heart failure.


08/12/2008 03:31 PM

A Significant Increase in Breathing Amplitude Precedes Sleep Bruxism

Chest. 2008; 134:332-337

Sleep bruxism (SB) is a stereotyped movement disorder that is characterized by rhythmic masticatory muscle activity (RMMA) and tooth grinding. Evidence has suggested that SB is associated with sleep arousals and that most RMMA episodes are preceded by physiologic changes occurring in sequence, namely, a rise in autonomic sympathetic-cardiac activity followed by a rise in the frequency of EEG and suprahyoid muscle activity.


08/12/2008 03:31 PM

Effect of inhaled corticosteroid treatment on exhaled breath condensate leukotriene E4 in children with mild asthma

Allergy and Asthma Proceedings, Volume 29, Number 4, 7/8 2008 , pp. 371-375(5)

Chronic airway inflammation in children with asthma might be present even in the absence of pathological lung function tests and is known to increase the risk of permanent pulmonary damage.


08/12/2008 03:30 PM

Yellow Nail Syndrome

Chest. 2008; 134:375-381

Yellow nail syndrome (YNS) is a rare condition defined by the presence of yellow nails associated with lymphedema and/or chronic respiratory manifestations. Several aspects of this disorder remain poorly defined.


08/12/2008 03:29 PM

Addressing steroid phobia: Improving the risk-benefit ratio with new agents

Allergy and Asthma Proceedings, Volume 29, Number 4, 7/8 2008 , pp. 358-364(7)

Inhaled corticosteroids (ICSs) are the preferred first-line preventative therapy for asthma of all severity levels.


08/12/2008 03:28 PM

Observational Study of the Additive Effects of Pranlukast on Inflammatory Markers of Clinically Stable Asthma with Inhaled Corticosteroids and Long-Acting Beta 2 Agonists

Respiration (DOI: 10.1159/000151289)

The present study examines the anti-inflammatory effects of the LTRA pranlukast in addition to ICS and LABA, among asthmatic patients with normal pulmonary function and unremarkable clinical symptoms.


08/12/2008 03:27 PM

Structural and Functional Lung Disease in Primary Ciliary Dyskinesia

Chest. 2008; 134:351-357

High-resolution CT (HRCT) scan data on primary ciliary dyskinesia (PCD) related lung disease are scarce.


08/12/2008 03:27 PM

High-Resolution CT Scan Findings in Patients With Symptomatic Scleroderma-Related Interstitial Lung Disease

Chest. 2008; 134:358-367

Lung disease has become the leading cause of mortality and morbidity in scleroderma (SSc) patients. The frequency, nature, and progression of interstitial lung disease seen on high-resolution CT (HRCT) scans in patients with diffuse SSc (dcSSc) compared with those with limited SSc (lcSSc) has not been well characterized.


08/12/2008 03:26 PM

Restoration of Cough Reflex in Lung Transplant Recipients

Chest. 2008; 134:310-316

Lung transplantation involves vagal nerve interruption resulting in sensory airway denervation and impairment of the cough reflex. Following lung transplantation, it is unclear whether functional recovery of the cough reflex occurs over time. Our objective was to evaluate the afferent limb of the cough reflex in lung transplant recipients.


08/12/2008 03:25 PM

Obesity and Asthma

Chest. 2008; 134:317-323

Obesity is associated with an increased prevalence of asthma, especially in women, and appears to be more severe in the obese. This study aimed to determine if obese subjects have a specific asthma phenotype.


08/12/2008 03:24 PM

Asbestos Fibre Concentrations in the Lungs of Brake Workers: Another Look

Annals of Occupational Hygiene 2008 52(6):455-461

To reanalyse data on the lung content of asbestos fibres among brake mechanics.


08/12/2008 03:23 PM

Induced sputum and bronchial mucosal expression of interleukin-13 is not increased in chronic obstructive pulmonary disease

Allergy, Volume 63, Number 9, September 2008 , pp. 1239-1243(5)

The Th2 cytokine interleukin-13 (IL-13) has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). We sought to examine IL-13 expression in COPD subjects in induced sputum and bronchus specimens. We hypothesized that inflammatory cells expressing IL-13 localize to the airway smooth muscle bundle and bronchial glands.


08/12/2008 03:23 PM

Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults

Allergy, Volume 63, Number 9, September 2008 , pp. 1211-1217(7)

Filaggrin (FLG) null mutations are important genetic predisposing factors for atopic asthma and have recently been shown to influence controller and reliever medication needs in asthmatic children. Our objective was to study the role of FLG null alleles in asthma exacerbations.


08/12/2008 03:22 PM

Allergen inhalation decreases adenosine receptor expression in sputum and blood of asthma patients

Allergy, Volume 63, Number 9, September 2008 , pp. 1186-1194(9)

Adenosine is a signalling nucleoside that has been proposed to contribute to the pathogenesis of asthma. Adenosine is produced in inflammatory environments and acts via adenosine receptors (A1R, A2AR, A2BR, and A3R) expressed by a wide variety of cells, resulting in pro- and anti-inflammatory effects.


08/12/2008 03:21 PM

Diode laser for paediatric airway procedures: a useful tool

International Journal of Clinical Practice Published Online: 14 Apr 2008

A wide range of lasers have been used in the larynx. Diode laser is a portable and relatively inexpensive laser which is delivered via a glass fibre hand-held probe. The objective of this study was to report our experience with the use of diode laser in a variety of paediatric airway pathologies.


08/12/2008 03:20 PM

Horseshoe Lung Associated with Cardiac-Type Total Anomalous Pulmonary Venous Return in a Newborn

Pediatric Cardiology 0172-0643 (Print) 10.1007/s00246-008-9277-1

Horseshoe lung is a rare pulmonary anomaly characterized by fusion of the posterobasal portions of the right and left lung behind the heart anterior to the aorta and the spinal column.


08/12/2008 03:19 PM

Successful Bilateral Lung Transplantation for Lymphangiomatosis

American Journal of Transplantation Published Online: 28 Jul 2008

Lymphangiomatosis is a rare disease of lymphatic proliferation for which no adequate treatment is known. We report the first successful case of bilateral lung transplantation for the treatment of end-stage pulmonary lymphangiomatosis.


08/12/2008 03:18 PM

Renal Histopathological Lesions After Lung Transplantation in Patients with Cystic Fibrosis

American Journal of Transplantation Published Online: 28 Jul 2008

We have analyzed the evolution of renal status beyond the perioperative period in patients with cystic fibrosis (CF) undergoing lung transplantation and presented histological analysis of 15 patients biopsied for an episode of accelerated renal function loss (RFL).


08/12/2008 03:17 PM

A School-Based Program for Control of Group A Streptococcal Upper Respiratory Tract Infections: A Controlled Trial in Southern China

Pediatric Infectious Disease Journal. 27(8):753-755, August 2008

A prospective, school-based study included daily monitoring for incidence of symptomatic streptococcal-associated pharyngitis and monthly determinations of group A streptococcal prevalence.


08/12/2008 03:17 PM

Relapse after Emergency Department Discharge for Acute Asthma

Academic Emergency Medicine Published Online: 11 Jul 2008

The objectives were to determine patient and treatment-response factors associated with relapse after emergency department (ED) treatment for acute asthma.


08/12/2008 03:15 PM

Sleep abnormalities in type 2 diabetes may be associated with glycemic control

Acta Diabetologica 0940-5429 (Print) 10.1007/s00592-008-0047-6

Sleep disturbances may be associated with impaired glucose metabolism. The aim of this study was to evaluate sleep duration and quality in relation to glycemic control in patients with type 2 diabetes.


08/12/2008 03:14 PM

Treatment characteristics in elderly asthmatics

International Journal of Clinical Practice Published Online: 29 Oct 2007

In this study, we evaluated the effect of ageing on treatment response by comparing two groups of patients with asthma.


08/12/2008 03:13 PM

Sex hormone alterations and systemic inflammation in chronic obstructive pulmonary disease

International Journal of Clinical Practice Published Online: 16 Nov 2007

Decreased anabolic hormone levels are described in chronic obstructive pulmonary disease (COPD), leading to important clinical consequences.


08/12/2008 03:13 PM

Sphingosine 1-Phosphate Potentiates Human Lung Fibroblast Chemotaxis through the S1P2 Receptor

American Journal of Respiratory Cell and Molecular Biology. Vol. 39, pp. 356-363, 2008

Migration of fibroblasts plays an essential role in tissue repair after injury. Sphingosine 1-phosphate (S1P) is a multifunctional mediator released by many cells that can be released in inflammation and after injury.


08/12/2008 03:12 PM

Loss of RAGE in Pulmonary Fibrosis

American Journal of Respiratory Cell and Molecular Biology. Vol. 39, pp. 337-345, 2008

The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of the Ig superfamily.


08/12/2008 03:11 PM

Endogenous beta-Adrenergic Receptors Inhibit Lipopolysaccharide-Induced Pulmonary Cytokine Release and Coagulation

American Journal of Respiratory Cell and Molecular Biology. Vol. 39, pp. 373-379, 2008

{beta}2-adrenergic receptors are expressed on different cell types in the lung, including respiratory epithelial cells, smooth muscle cells, and macrophages.


08/12/2008 03:10 PM

DNA Vector Augments Inflammation in Epithelial Cells via EGFR-Dependent Regulation of TLR4 and TLR2

American Journal of Respiratory Cell and Molecular Biology. Vol. 39, pp. 305-311, 2008

Gene delivery applications to treat lung diseases are, in some instances, suboptimal due to deleterious host inflammatory reactions.


08/12/2008 03:09 PM

Curcumin Restores Corticosteroid Function in Monocytes Exposed to Oxidants by Maintaining HDAC2

American Journal of Respiratory Cell and Molecular Biology. Vol. 39, pp. 312-323, 2008

Oxidative stress as a result of cigarette smoking is an important etiologic factor in the pathogenesis of chronic obstructive pulmonary disease (COPD), a chronic steroid-insensitive inflammatory disease of the airways.


08/12/2008 03:08 PM

What Is the Burden of Chronic Cough for Families?

Chest. 2008; 134:303-309

The burden of children's chronic cough to parents is largely unknown. The objectives of this study were as follows: (1) to determine the burden of chronic cough using a purposely designed questionnaire, and (2) to evaluate psychological (child's anxiety and parental emotional distress) and other influences on the reported burden of cough.


08/12/2008 03:07 PM

Cysteinyl Leukotriene Receptors Are Expressed by Tonsillar T Cells of Children With Obstructive Sleep Apnea

Chest. 2008; 134:324-331

Increased expression of cysteinyl leukotriene receptors (cysteinyl leukotriene receptor-1 [LT1-R]; cysteinyl leukotriene receptor-2 [LT2-R]) has been detected in adenotonsillar tissue from children with sleep-disordered breathing (SDB) compared to control subjects.


08/12/2008 03:07 PM

Good effect of IgY against Pseudomonas aeruginosa infections in cystic fibrosis patients

Pediatric Pulmonology Published Online: 4 Aug 2008

This is an extended open study of oral prophylactic treatment with egg yolk antibodies against Pseudomonas aeruginosa, Anti-Pseudomonas IgY, of 17 Swedish patients with cystic fibrosis.


08/12/2008 03:06 PM

Inappropriate Use of Antibiotics for Acute Asthma in United States Emergency Departments

Academic Emergency Medicine Published Online: 8 Jul 2008

The aim was to examine the use of antibiotics to treat asthma patients in U.S. emergency departments (EDs).


08/12/2008 03:05 PM

Are Patients With COPD More Active After Pulmonary Rehabilitation?

Chest. 2008; 134:273-280

Despite a variety of benefits brought by pulmonary rehabilitation to patients with COPD, it is unclear whether these patients are more active during daily life after the program.


08/12/2008 03:04 PM

Predictors of 30-Day Mortality and Hospital Costs in Patients With Ventilator-Associated Pneumonia Attributed to Potentially Antibiotic-Resistant Gram-Negative Bacteria

Chest. 2008; 134:281-287

To identify predictors of 30-day mortality and hospital costs in patients with ventilator-associated pneumonia (VAP) attributed to potentially antibiotic-resistant Gram-negative bacteria (PARGNB) [Pseudomonas aeruginosa, Acinetobacter species, and Stenotrophomonas maltophilia].


08/12/2008 03:04 PM

Impact of Cough Across Different Chronic Respiratory Diseases

Chest. 2008; 134:295-302

Cough is a prominent symptom across a range of common chronic respiratory diseases and impacts considerably on patient health status.


08/12/2008 03:02 PM

Comparison of a Combination of Tiotropium Plus Formoterol to Salmeterol Plus Fluticasone in Moderate COPD

Chest. 2008; 134:255-262

Tiotropium plus formoterol was superior in lung function over the day compared to salmeterol plus fluticasone in patients with moderate COPD. Long-term studies in patients with severe COPD are warranted to assess the relative efficacy of different treatment combinations.


08/12/2008 03:02 PM

Tracheostomy Tube Malposition in Patients Admitted to a Respiratory Acute Care Unit Following Prolonged Ventilation

Chest. 2008; 134:288-294

Tracheostomy tube malposition is a barrier to weaning from mechanical ventilation. We determined the incidence of tracheostomy tube malposition, identified the associated risk factors, and examined the effect of malposition on clinical outcomes.


08/12/2008 03:00 PM

Plasma Pro-Adrenomedullin But Not Plasma Pro-Endothelin Predicts Survival in Exacerbations of COPD

Chest. 2008; 134:263-272

Plasma endothelin and adrenomedullin are increased in patients with pulmonary arterial hypertension, hypoxia, and pulmonary infections, conditions that predict survival in patients with COPD.


08/12/2008 03:00 PM

Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex

Respiratory Research 2008, 9:60

Secretory leukoproteinase inhibitor (SLPI) is an important inhibitor of neutrophil elastase (NE), a proteinase implicated in the pathogenesis of lung diseases such as COPD.


08/09/2008 09:34 AM

Apnoeic-hypopnoeic episodes during obstructive sleep apnoea are associated with histological nonalcoholic steatohepatitis

Liver International, Volume 28, Number 8, September 2008 , pp. 1080-1086(7)

Nonalcoholic fatty liver disease (NAFLD) and obstructive sleep apnoea are associated with metabolic syndrome and atherosclerotic heart disease. This study evaluates the potential association between the NAFLD subtypes and a number of polysomnographical (PSG) parameters.


08/09/2008 09:33 AM

Flunking Asthma? When HEDIS Takes the ACT

Am J Manag Care. 2008;14(8):487-494

To test several patient-oriented asthma outcome measures and the Healthcare Effectiveness Data and Information Set (HEDIS) measure of appropriate medication for persistent asthma to determine the most useful quality indicator of asthma care.


08/09/2008 09:32 AM

MR imaging findings of an atypical pulmonary hamartoma in a 12-year-old child

Pediatric Radiology 0301-0449 (Print) 10.1007/s00247-008-0938-2

We present the MR imaging findings in an atypical pulmonary hamartoma in a 12-year-old boy. CT showed no evidence of fat or calcifications in the tumour.


08/09/2008 09:31 AM

Differential proinflammatory and prooxidant effects of bone morphogenetic protein-4 in coronary and pulmonary arterial endothelial cells

Am J Physiol Heart Circ Physiol 295: H569-H577, 2008

There is increasing evidence that TGF-{beta} family member cytokine bone morphogenetic protein (BMP)-4 plays different pathophysiological roles in the pulmonary and systemic circulation.


08/09/2008 09:30 AM

Lung metastases in neuroblastoma at initial diagnosis: A report from the International Neuroblastoma Risk Group (INRG) project

Pediatric Blood & Cancer Published Online: 22 Jul 2008

Neuroblastoma is the most common extracranial pediatric solid cancer. Lung metastasis is rarely detected in children with newly diagnosed neuroblastoma. We aimed to describe the incidence, clinical characteristics, and outcome of patients with lung metastasis at initial diagnosis using a large international database.


08/09/2008 09:28 AM

Proof-of-Concept Trials for Lung Stem Cell Therapy

The Proceedings of the American Thoracic Society 5:731-735 (2008)

Proof-of-concept (PoC) trials are an important component of the new therapeutic development paradigm, contributing to the goal of accelerated progression from bench to bedside.


08/09/2008 09:28 AM

Signaling pathways required for macrophage scavenger receptor-mediated phagocytosis: analysis by scanning cytometry

Respiratory Research 2008, 9:59

Scavenger receptors are important components of the innate immune system in the lung, allowing alveolar macrophages to bind and phagocytose numerous unopsonized targets.


08/09/2008 09:26 AM

Obstructive sleep apnea presenting as recurrent cardiopulmonary arrest

Sleep and Breathing 1520-9512 (Print) 10.1007/s11325-008-0209-3

A non-obese patient who was admitted initially with hypoglycemia had multiple episodes of cardiopulmonary arrests requiring resuscitations and a short period of mechanical ventilation.


08/09/2008 09:26 AM

Deposition of Biomass Combustion Aerosol Particles in the Human Respiratory Tract

nhalation Toxicology, Volume 20, Issue 10 August 2008 , pages 923 - 933

Smoke from biomass combustion has been identified as a major environmental risk factor associated with adverse health effects globally. Deposition of the smoke particles in the lungs is a crucial factor for toxicological effects, but has not previously been studied experimentally.


08/09/2008 09:25 AM

The implementation of Restoring Health - a chronic disease model of care to decrease acute health care utilization

Chronic Respiratory Disease, Vol. 5, No. 3, 133-141 (2008)

The Restoring Health Program, a multi-disciplinary model of care for patients with chronic lung diseases, heart failure, and diabetes, was established to improve the quality of life and function for patients with these target chronic diseases, while reducing their disproportionately high demand on acute health care services.


08/09/2008 09:24 AM

Obstructive sleep disordered breathing in children: Beyond adenotonsillectomy

Pediatric Pulmonology Published Online: 4 Aug 2008

Traditionally, adenotonsillectomy (AT) has long been the treatment of choice for obstructive sleep disordered breathing (SDB) in children. AT is usually considered a safe procedure, which cures 80% of children with SDB. Accumulated data have however challenged this overly simplistic view.


08/09/2008 09:23 AM

FDG-PET in patients at risk for acute respiratory distress syndrome: a preliminary report

Intensive Care Medicine 0342-4642 (Print) 10.1007/s00134-008-1220-7

To compare the pattern of lung uptake of 18F-fluorodeoxyglucose (FDG) by positron emission tomography (PET) imaging in patients with lung contusion that developed or did not progress to acute respiratory distress syndrome (ARDS).


08/09/2008 09:22 AM

A single versus multiple doses of dexamethasone in infants wheezing for the first time

Pediatric Pulmonology Published Online: 30 Jul 2008

Corticosteroid therapy is not routinely recommended in true bronchiolitis. However, since bronchiolitis and the first asthma attack are impossible to distinguish, some infants with the first wheezing episode receive corticosteroids. Optimal duration of corticosteroid therapy in this scenario is unknown. This study compared efficacy of multiple administrations and a single dose of dexamethasone in bronchiolitis


08/09/2008 09:21 AM

Clinical Characteristics of Human Bocavirus Infections Compared With Other Respiratory Viruses in Spanish Children

Pediatric Infectious Disease Journal. 27(8):677-680, August 2008

Human bocavirus (HBoV) can be found in a substantial proportion of children with respiratory tract diseases. The relative importance of HBoV in viral respiratory tract illnesses is not yet well known.


08/09/2008 09:20 AM

Treatment of pulmonary fibrosis for twenty weeks with imatinib mesylate in a patient with mixed connective tissue disease

Arthritis & Rheumatism Volume 58 Issue 8, Pages 2538 - 2542

Interstitial lung disease, which is common in patients with mixed connective tissue disease (MCTD), can progress to severe pulmonary fibrosis. The tyrosine kinase inhibitor imatinib mesylate has recently been shown to prevent experimental pulmonary, dermal, and renal fibrosis.


08/09/2008 09:19 AM

Procalcitonin in stable and unstable patients with bronchiectasis

Chronic Respiratory Disease, Vol. 5, No. 3, 155-160 (2008)

Presently used markers of infection in bronchiectasis are inadequate to judge stability or make decisions about antibiotic treatment during bacterial exacerbations. Procalcitonin (PCT) is a new marker that has been used in community-acquired pneumonia and promises to allow much more specific and sensitive monitoring of patients with bacterial infections.


08/09/2008 09:18 AM

Hypoxemia in patients on chronic opiate therapy with and without sleep apnea

Sleep and Breathing 1520-9512 (Print) 10.1007/s11325-008-0208-4

Animal models have shown a quantal slowing of respiratory pattern when exposed to opioid agonist, in a pattern similar to that observed in central sleep apnea.


08/09/2008 09:18 AM

Catheter-Directed Embolectomy, Fragmentation, and Thrombolysis for the Treatment of Massive Pulmonary Embolism After Failure of Systemic Thrombolysis

Chest. 2008; 134:250-254

The standard medical management for patients in extremis from massive pulmonary embolism (PE) is systemic thrombolysis, but the utility of this treatment relative to catheter-directed intervention (CDI) is unknown. We evaluated the effectiveness of CDI as part of a treatment algorithm for life-threatening PE.


08/09/2008 09:17 AM

Noninvasive ventilation as ceiling of therapy in end-stage chronic obstructive pulmonary disease

Chronic Respiratory Disease, Vol. 5, No. 3, 143-148 (2008)

The benefits of noninvasive ventilation (NIV) for acute hypercapnic respiratory failure caused by chronic obstructive pulmonary disease (COPD) are well recognized and consequently its use is widespread


08/09/2008 09:16 AM

Lung Perfusion Imaging Can Risk Stratify Lung Cancer Patients for the Development of Pulmonary Complications after Chemoradiation

Journal of Thoracic Oncology. 3(8):858-864, August 2008

Introduction: We investigated the value of lung perfusion imaging in predicting the risk of developing pulmonary complications after chemoradiation (CRT) or radiation therapy (RT) for lung cancer.


08/09/2008 09:15 AM

Quality of life and inflammation in exacerbations of bronchiectasis

Chronic Respiratory Disease, Vol. 5, No. 3, 161-168 (2008)

Patients with bronchiectasis often have impaired quality of life (QoL), which deteriorates with exacerbations. The aim of this study was to investigate changes in QoL and how these were influenced by changes in airway physiology and inflammation in patients with bronchiectasis before and after resolution of an exacerbation.


08/09/2008 08:53 AM

Anabolic steroids in COPD: a review and preliminary results of a randomized trial

Chronic Respiratory Disease, Vol. 5, No. 3, 169-176 (2008)

Patients with severe chronic obstructive pulmonary disease (COPD) commonly develop weight loss, muscle wasting, and consequently poor survival. Nutritional supplementation and anabolic steroids increase lean body mass, improve muscle strength, and survival in patients enrolled in comprehensive rehabilitation programs.


08/09/2008 08:53 AM

Ventilatory, hemodynamic, sympathetic nervous system, and vascular reactivity changes after recurrent nocturnal sustained hypoxia in humans

Am J Physiol Heart Circ Physiol 295: H778-H785, 2008

Recurrent and intermittent nocturnal hypoxia is characteristic of several diseases including chronic obstructive pulmonary disease, congestive heart failure, obesity-hypoventilation syndrome, and obstructive sleep apnea.


08/09/2008 08:51 AM

Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcus: Comparison of Diagnosis and Treatment in the Community and at a Specialty Clinic

PEDIATRICS Vol. 122 No. 2 August 2008, pp. 273-278

This study aimed to examine whether pediatric autoimmune neuropsychiatric disorders associated with streptococcus were appropriately diagnosed in the community and to determine subsequent rates of unwarranted use of antibiotic treatment for tics and obsessive-compulsive symptoms without the identification of an infection.


08/09/2008 08:47 AM

Erratum to 'Development of the obstructive sleep apnea knowledge and attitudes (OSAKA) questionnaire'

Sleep Medicine Volume 9, Issue 6, Page 705 (August 2008)


08/09/2008 08:46 AM

Central apneas in a case of Crisponi syndrome

Sleep Medicine Volume 9, Issue 6, Pages 703-704 (August 2008)


08/09/2008 08:45 AM

Restless legs syndrome (RLS): An unrecognized cause for bedtime problems and insomnia in children

Sleep Medicine Volume 9, Issue 6, Pages 701-702 (August 2008)


08/09/2008 08:44 AM

Sleep quality in a family with hereditary parkinsonism (PARK6)

Sleep Medicine Volume 9, Issue 6, Pages 684-688 (August 2008)

The autosomal recessive disorder PARK6 manifests as early-onset Parkinson’s disease (PD) with a particularly mild progression. PARK6 is of particular scientific interest, since it is caused by loss-of-function mutations in the mitochondrial protein kinase PINK1 and may thus serve as a model for oxidative damage in PD and in other basal ganglia disorders.


08/09/2008 08:43 AM

Hypersomnolence, insomnia and the pathophysiology of upper airway resistance syndrome

Sleep Medicine Volume 9, Issue 6, Pages 675-683 (August 2008)

In order to test the hypothesis that upper airway resistance syndrome (UARS) is merely an extension of the pathophysiology of obstructive sleep apnea/hypopnea (OSA/H) to less severe pharyngeal collapse during sleep, we compared the severity of hypersomnolence and the prevalence of insomnia in UARS patients to the patterns observed for OSA/H patients.


08/09/2008 08:42 AM

Increased plasma levels of inflammatory markers and upper airway resistance during sleep in pre-eclampsia

Sleep Medicine Volume 9, Issue 6, Pages 667-674 (August 2008)

To evaluate pregnancy-associated sleep disorders, pregnancy outcomes and inflammatory markers in pre-eclampsia and normal pregnancy (control).


08/09/2008 08:40 AM

Cardiac function after CPAP therapy in patients with chronic heart failure and sleep apnea: A multicenter study

Sleep Medicine Volume 9, Issue 6, Pages 660-666 (August 2008)

Continuous positive airway pressure (CPAP) is an effective treatment for sleep apnea (SA), although the evidence for improving chronic heart failure (CHF) is inconclusive. Our aim was to evaluate the effect of CPAP treatment on the left ventricle ejection fraction (LVEF) among other cardiological variables in a randomized, multicenter, placebo (sham-CPAP)-controlled study.


08/09/2008 08:39 AM

Bi-level positive pressure ventilation and adaptive servo ventilation in patients with heart failure and Cheyne-Stokes respiration

Sleep Medicine Volume 9, Issue 6, Pages 652-659 (August 2008)

Nocturnal positive pressure ventilation (PPV) has been shown to be effective in patients with impaired left ventricular ejection fraction (LVEF) and Cheyne-Stokes respiration (CSR). We investigated the effect of a bi-level PPV and adaptive servo ventilation on LVEF, CSR, and quantitative sleep quality.


08/09/2008 08:38 AM

Quality of life in patients with congestive heart failure and central sleep apnea

Sleep Medicine Volume 9, Issue 6, Pages 646-651 (August 2008)

To assess the impact of Cheyne-Stoke respiration-central sleep apnea (CSR-CSA) on quality of life (QOL) in patients with congestive heart failure (CHF). QOL was established using the MLHFQ (Minnesota Living with Heart Failure Questionnaire), and the FOSQ (Functional Outcomes of Sleep Questionnaire).


08/09/2008 08:37 AM

Reduced renal function and sleep-disordered breathing in community-dwelling elderly men

Sleep Medicine Volume 9, Issue 6, Pages 637-645 (August 2008)

Sleep-disordered breathing (SDB) may increase the risk of cardiovascular disease (CVD) and death in chronic kidney disease (CKD). However, the association between mild reductions in renal function and SDB is uncertain.


08/09/2008 08:36 AM

Quality of life in patients with chronic heart failure and Cheyne-Stokes respiration

Sleep Medicine Volume 9, Issue 6, Pages 601-602 (August 2008)


08/09/2008 08:34 AM

Sleep-disordered breathing and reductions in renal function: Are they associated in the elderly?

Sleep Medicine Volume 9, Issue 6, Pages 598-600 (August 2008)


08/07/2008 02:56 PM

Signaling pathways required for macrophage scavenger receptor-mediated phagocytosis: analysis by scanning cytometry

Respiratory Research 2008, 9:59

Scavenger receptors are important components of the innate immune system in the lung, allowing alveolar macrophages to bind and phagocytose numerous unopsonized targets.


08/07/2008 02:54 PM

Differential expression of lipoprotein genes in Mycoplasma pneumoniae after contact with human lung epithelial cells, and under oxidative and acidic stress

BMC Microbiology 2008, 8:124

Mycoplasma pneumoniae is a human pathogen that is a common cause of community-acquired pneumonia. It harbours a large number of lipoprotein genes, most of which are of unknown function.


08/07/2008 02:54 PM

Neutrophil degranulation mediates severe lung damage triggered by streptococcal M1 protein

Eur Respir J 2008; 32:405-412

Streptococcus pyogenes of the M1 serotype can cause streptococcal toxic shock syndrome commonly associated with acute lung injury. The aim of the present study was to investigate the role of neutrophils and their secretion products in M1 protein-induced lung damage.


08/07/2008 02:53 PM

Functional single nucleotide polymorphisms of the CCL5 gene and nonemphysematous phenotype in COPD patients

Eur Respir J 2008; 32:372-378

It was previously reported that the gain-of-function -28 guanine allele of the promoter single nucleotide polymorphism (SNP; cytosine to guanine substitution of nucleotide -28 (-28C>G)) in the CC chemokine ligand 5 gene (CCL5) was associated with susceptibility to late-onset asthma in patients who developed asthma at age >40 yrs.


08/07/2008 02:51 PM

Pulmonary Neuroendocrine Cell System in Health and Disease

Current Respiratory Medicine Reviews, Volume 4, Number 3, August 2008 , pp. 174-186(13)

Pulmonary neuroendocrine cell (PNEC) system consists of solitary cells and innervated clusters, neuroepithelial bodies (NEB), widely distributed throughout the airway mucosa of mammalian lungs.


08/07/2008 02:50 PM

Proliferation is not increased in airway myofibroblasts isolated from asthmatics

Eur Respir J 2008; 32:362-371

Airway mesenchymal cells, such as myofibroblasts and airway smooth muscle cells, contribute to inflammation, airway remodelling and hyperresponsiveness in asthma by excessive proliferation and inflammatory mediator production.


08/07/2008 02:50 PM

Increased urinary leukotriene E4 concentration in patients with eosinophilic pneumonia

Eur Respir J 2008; 32:437-442

Although eosinophils produce cysteinyl leukotrienes (CysLTs) in large quantities, information on the relationship between CysLTs and eosinophilic pneumonia (EP) is lacking. Inflammatory mediator concentrations in urine were quantified to clarify the relationship between CysLT concentrations and EP severity.


08/07/2008 02:49 PM