| 05/15/2008
03:19 PM
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Mortality from heart, respiratory, and kidney disease in coal mining areas of Appalachia
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International Archives of Occupational and Environmental Health 0340-0131 (Print) 10.1007/s00420-008-0328-y
The purpose of this study was to test whether population mortality rates from heart, respiratory and kidney disease were higher as a function of levels of Appalachian coal mining after control for other disease risk factors.
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| 05/15/2008
03:18 PM
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Subcutaneous Emphysema and Pneumomediastinum Due to Foreign Body Aspiration
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Eur J Pediatr Surg 2008; 18: 129-130
Pneumomediastinum is a result of perforation of the tracheobronchial tree. When air enters the interstitial space, air diffuses along the perivascular sheaths toward the mediastinum.
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| 05/15/2008
03:17 PM
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Respiratory Distress Secondary to Nasopharyngeal Glial Heterotopia
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Eur J Pediatr Surg 2008; 18: 117-118
Nasal glial heterotopia (nasal glioma) is a rare congenital malformation of neural origin. We present a newborn baby with life-threatening respiratory distress secondary to nasopharyngeal glial heterotopia that obstructed the nasopharyngeal or nasal airway.
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| 05/15/2008
03:16 PM
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Maternal versus fetal inflammation and respiratory distress syndrome: a 10 year hospital cohort study
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Arch. Dis. Child. Fetal Neonatal Ed.. Published Online First: 7 May 2008
To determine the impact of maternal and fetal intrauterine inflammatory responses (chorioamnionitis and umbilical vasculitis) on the development of neonatal respiratory distress syndrome (RDS) in preterm infants.
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| 05/15/2008
03:15 PM
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Epidemiologic Evidence for Serotype-Specific Acquired Immunity to Pneumococcal Carriage
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The Journal of Infectious Diseases 2008;197:1511-1518
Nasopharyngeal carriage of Streptococcus pneumoniae is required for transmission of the bacteria and for invasive disease. There have been conflicting reports as to whether protection against carriage is serotype specific and which immune mechanisms drive carriage.
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| 05/15/2008
03:15 PM
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Podcasts - Brain Injury, Respiratory
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Listen to an archive of audio programs about brain injury, respiratory-pulmonary, rehabilitation, disabilities, and other related subjects.
Download to your iPod or MP3 player or listen on your computer.
New programs posted regularly.
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| 05/15/2008
03:15 PM
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Paradoxical Air Embolism Successfully Treated With Hyperbaric Oxygen
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Journal of Intensive Care Medicine, Vol. 23, No. 3, 204-209 (2008)
The use of the central venous catheter may be complicated by air embolism when central venous pressure is subatmospheric and the catheter is open to the surrounding air.
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| 05/15/2008
03:13 PM
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Elevated CCR6+CD4+ T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response
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Clinical & Experimental Immunology, Volume 152, Number 3, June 2008 , pp. 440-447(8)
CCR6 is expressed by multiple leucocyte subsets, including peripheral blood memory T cells, and mouse models implicate a role for this receptor in diverse inflammatory responses that include allergic airway disorders, inflammatory bowel disease and autoimmune encephalitis.
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| 05/15/2008
03:13 PM
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Primary prevention of occupational asthma: identifying and controlling exposures to asthma-causing agents
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American Journal of Industrial Medicine Published Online: 5 May 2008
Primary prevention of occupational asthma requires timely identification and regulation of asthma-causing agents.
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| 05/15/2008
03:11 PM
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Preliminary Study of Randomly-Amplified Polymorphic DNA Analysis for Typing Extended-Spectrum Beta-Lactamase (ESBL)-Producing Klebsiella pneumoniae
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Journal of the Medical Association of Thailand Vol91 No.4 527 5731
Extended-spectrum beta-lactamases (ESBLs) are most prevalent in Klebsiella pneumoniae. This organism is frequently isolated from clinical specimens and can cause septicemia, pneumonia or urinary tract infection. There were occasionally suspicious outbreaks of ESBL-producing K. pneumoniae in patients’ wards. The objective is to determine whether the randomly amplified polymorphic DNA (RAPD), which is a polymerase chain reaction (PCR)-based typing technique, can be used as a typing method for studying the molecular epidemiology of ESBL-producing K. pneumoniae.
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| 05/15/2008
03:10 PM
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A randomized, controlled, crossover study of a noncustomized tongue retaining device for sleep disordered breathing
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Sleep and Breathing 1520-9512 (Print) 10.1007/s11325-008-0187-5
Tongue retaining devices (TRDs) are one type of oral appliance used to treat sleep disordered breathing. Previous studies have evaluated customized TRDs in comparison to mandibular repositioner appliances.
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| 05/15/2008
03:09 PM
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General practitioners' knowledge of childhood asthma in Delhi, India
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The International Journal of Tuberculosis and Lung Disease, Volume 12, Number 6, June 2008 , pp. 677-682(6)
To assess knowledge of childhood asthma among general practitioners (GPs) in Delhi, India.
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| 05/15/2008
03:09 PM
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Respiratory-Pulmonary Journal Watch
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The latest links to journal article abstracts on Respiratory, Pulmonary, COPD, Mechanical Ventilation, Ventilator Weaning, Respiratory Therapy, Asthma, Cardio-Vascular, Sleep Apnea, CPAP, BiPAP, and other related clinical topics
Updated regularly. Available as an RSS feed or on our web site.
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| 05/15/2008
03:09 PM
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Pulmonary arterial hypertension in children: a medical update
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Current Opinion in Pediatrics. 20(3):288-293, June 2008
With rapid advances in the understanding and treatment of pulmonary arterial hypertension, navigating the pediatric literature becomes challenging. A comprehensive review of the most recent literature over the past year on available and emerging novel therapies as well as an approach to target pediatric populations will provide insight into the current management of pediatric pulmonary hypertension patients.
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| 05/15/2008
03:07 PM
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Role of dynamic MR imaging in obstructive sleep apnoea
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Indian Journal of Otolaryngology and Head & Neck Surgery Volume 60, Number 1 / March, 2008 25-29
The purpose of this study is to assess the role of dynamic MR imaging in the evaluation of obstructive sleep apnea. In this prospective study, MRI was performed in 22 patients (eighteen male and four female, ranging in age from 26 to 70 years) suspected of having obstructive sleep aponea (OSA).
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| 05/15/2008
03:07 PM
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Longitudinal Decline of Diffusing Capacity of the Lung for Carbon Monoxide in Community Subjects With the PiMZ {alpha}1-Antitrypsin Phenotype
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Chest. 2008; 133:1095-1100
It is well known that homozygous deficiency of {alpha}1-antitrypsin, PiZZ, is associated with an increased risk of emphysema. However, studies evaluating associations between the heterozygous form PiMZ with emphysema and impaired lung function have provided conflicting results.
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| 05/15/2008
03:06 PM
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Website of the Month: 'Its Not Who I Am'
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Its Not Who I Am - a website created co-created by a 13-year old epilepsy survivor who is an advocate for public education of this condition and removing the sigma for other survivors.
Its Not Who I Am is a website that tells Sara-Elizabeth's story. It is also an interactive site where other young people with epilepsy (as well as their siblings, family members, parents, and friends) can visit and learn about how to move beyond being "someone with epilepsy."
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| 05/15/2008
03:06 PM
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Use of B-Type Natriuretic Peptide in the Risk Stratification of Acute Exacerbations of COPD
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Chest. 2008; 133:1088-1094
In patients with COPD, prognosis might be determined at least in part by the extent of cardiac stress induced by hypoxia and pulmonary arterial hypertension.
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| 05/15/2008
03:05 PM
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Cost-effectiveness of Competing Strategies for the Treatment of Pediatric Empyema
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PEDIATRICS Vol. 121 No. 5 May 2008, pp. e1250-e1257
The optimal management of pediatric empyema is controversial. The purpose of this decision analysis was to assess the relative merits in terms of costs and clinical outcomes associated with competing treatment strategies.
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| 05/15/2008
03:04 PM
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Lessons from Mycobacterium avium complex-associated pneumonitis: a case report
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Journal of Medical Case Reports 2008, 2:152
Mycobacterium avium complex (MAC) is an increasingly recognized cause of pulmonary disease in immunocompetent individuals. An acute form of MAC lung disease, MAC-associated pneumonitis, has generally been associated with the use of hot tubs. There is controversy in the literature about whether MAC-associated pneumonitis is a classic hypersensitivity pneumonitis or is a direct manifestation of mycobacterial infection.
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| 05/15/2008
03:03 PM
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Podcast: Impairments of Consciousness Part One - Introduction to the States of Consciousness Including the Vegetative State
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Host: Gerry Brooks, MA, CCC, CBIST, Director of Brain Injury Programs, Northeast Center for Special Care
Guest: Nathan Zasler, MD, FAAPM&R, FAADEP, DAAPM, CIME, Medical Director, The Tree of Life Brain Injury Rehabilitation Center in Glen Allen, VA., Editor of the journal: "Brain Injury," and chairperson of the International Brain Injury Association.
Time: 32:25
Synopsis: Impairments of Consciousness and States of Consciousness Including the Vegetative State, is one that has been in the news over the past few years and one that has generated discussion not only with the public but also clinicians and professionals who specialize in treating brain injury. The question of individuals in a vegetative state was brought to the forefront with Terri Schaivo in 2005 and again recently with reports of enhanced arousal in some individuals in persistent vegetative states who had been given ambien.
Dr. Nathan Zasler discusses states of consciousness, coma, coma rating scales and gives an informative introduction to this topic.
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| 05/15/2008
03:03 PM
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Intensive Care Management of the Patient With Cystic Fibrosis
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Journal of Intensive Care Medicine, Vol. 23, No. 3, 159-177 (2008)
Cystic fibrosis was previously thought to be a disease of childhood. With a better understanding of this condition along with improvements in therapy, patients with cystic fibrosis are now living well into adulthood.
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| 05/15/2008
03:03 PM
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Bronchiolitis obliterans in children
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Current Opinion in Pediatrics. 20(3):272-278, June 2008
In this review, we discuss recent advances in our understanding of the etiology, pathology and pathogenesis, clinical presentation, diagnosis, treatment, and outcome of bronchiolitis obliterans in the nontransplant, pediatric population.
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| 05/15/2008
03:02 PM
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Safety of Long-Acting {beta}-Agonists in Stable COPD
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Some studies have suggested that use of long-acting {beta}2-agonists (LABAs) leads to an increased risk for adverse events in patients with stable COPD. The purpose of this review was to assess the safety, and secondarily the efficacy of LABAs.
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| 05/15/2008
03:01 PM
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Is Metalloproteinase-7 Specific for Idiopathic Pulmonary Fibrosis?
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Chest. 2008; 133:1101-1106
Matrix metalloproteinase (MMP)-7 was reported to be a key molecule in the pathogenesis of idiopathic pulmonary fibrosis (IPF) based on the result of microarray analysis and knockout mice. However, the role of MMP-7 has not been determined in other types of idiopathic interstitial pneumonia (IIP).
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| 05/15/2008
03:00 PM
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Brain Injury Conference
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The 4th Annual Mid-Hudson Brain Injury Rehabilitation Conference will be held again this year in Kingston, NY, presented by Northeast Center for Special Care.
Clinicians and support persons working with this population are invited to attend this highly-rated conference with cutting-edge educational sessions to increase knowledge and skills in this highly specialized area.
October 2, 2008.
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| 05/15/2008
03:00 PM
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Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium
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Particle and Fibre Toxicology 2008, 5:8
Epidemiological studies have demonstrated adverse health effects of environmental pollution. Diesel exhaust (DE) is a major contributor to particulate matter pollution. DE exposure has been shown to induce a pronounced inflammatory response in the airways, together with an enhanced epithelial expression of cytokines such as IL-8, Gro-alpha, IL-13 and activation of redox sensitive transcription factors (NFKB, AP-1), and MAP kinases (p38, JNK).
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| 05/15/2008
02:59 PM
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Assessment of the alveolar volume when sampling exhaled gas at different expired volumes in the single breath diffusion test
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BMC Pulmonary Medicine 2007, 7:18
Alveolar volume measured according to the American Thoracic Society-European Respiratory Society (ATS-ERS) guidelines during the single breath diffusion test can be underestimated when there is maldistribution of ventilation.
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| 05/15/2008
02:58 PM
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Assessing airway inflammation in clinical practice - experience with spontaneous sputum analysis
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BMC Pulmonary Medicine 2008, 8:5
The assessment of airway inflammation for the diagnosis of asthma or COPD is still uncommon in pneumology-specialized general practices. In this respect, the measurement of exhaled nitric oxide (NO), as a fast and simple methodology, is increasingly used. The indirect assessment of airway inflammation, however, does have its limits and therefore there will always be a need for methods enabling a direct evaluation of airway inflammatory cell composition. Sampling of spontaneous sputum is a well-known, simple, economic and non-invasive method to derive a qualitative cytology of airway cells and here we aimed to assess today's value of spontaneous sputum cytology in clinical practice.
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| 05/15/2008
02:57 PM
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Mechanical ventilation or phrenic nerve stimulation for treatment of spinal cord injury-induced respiratory insufficiency
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Spinal Cord May 2008
To compare mechanical ventilation (MV) with phrenic nerve stimulation (PNS) for treatment of respiratory device-dependent (RDD) spinal cord-injured (SCI) patients.
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| 05/15/2008
02:56 PM
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Sustained Endothelial Progenitor Cell Dysfunction After Chronic Hypoxia-Induced Pulmonary Hypertension
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Stem Cells Vol. 26 No. 4 April 2008, pp. 1017 -1026
Circulating endothelial progenitor cells (EPCs) contribute to neovascularization of ischemic tissues and repair of injured endothelium. The role of bone marrow-derived progenitor cells in hypoxia-induced pulmonary vascular remodeling and their tissue-engineering potential in pulmonary hypertension (PH) remain largely unknown.
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| 05/15/2008
02:55 PM
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Characterization and intracellular localization of putative Chlamydia pneumoniae effector proteins
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Medical Microbiology and Immunology 0300-8584 (Print) 10.1007/s00430-008-0097-y
We here describe four proteins of Chlamydia pneumoniae, which might play a role in host-pathogen interaction. The hypothetical bacterial proteins CPn0708 and CPn0712 were detected in Chlamydia pneumoniae-infected host cells by indirect immunofluorescence tests with polyclonal antisera raised against the respective proteins.
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| 05/15/2008
02:54 PM
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Northeast Center for Special Care
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www.ventilatorcare.com - ventilator care, ventilator weaning, pulmonary rehabilitation, respiratory resources.
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| 05/15/2008
02:54 PM
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Quantitative and qualitative assessment of non-contrast-enhanced pulmonary MR imaging for management of pulmonary nodules in 161 subjects
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European Radiology 0938-7994 (Print) 10.1007/s00330-008-1001-2
This study aimed at prospectively compared efficacy of non-contrast-enhanced (non-CE) MRI and MDCT for management of pulmonary nodules.
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| 05/15/2008
02:53 PM
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Fluctuation in measurements of pulmonary nodule under tidal volume ventilation on four-dimensional computed tomography: preliminary results
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European Radiology 0938-7994 (Print) 10.1007/s00330-008-1002-1
The present study aimed to assess the feasibility of four-dimensional (4D) chest computed tomography (CT) under tidal volume ventilation and the impact of respiratory motion on quantitative analysis of CT measurements.
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| 05/15/2008
02:52 PM
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Prevalence of and factors associated with current asthma symptoms in school children aged 6-7 and 13-14-yr old in Bogotá, Colombia
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ediatric Allergy and Immunology, Volume 19, Number 4, June 2008 , pp. 307-314(8)
This cross-sectional study of children aged 6-7-years and adolescents aged 13-14-years in Bogotá, Colombia, assessed the prevalence of asthma symptoms and their associations with dietary, health, and behavioral habits.
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| 05/15/2008
02:51 PM
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Apoptosis, airway inflammation and anti-asthma therapy: From immunobiology to clinical application
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Pediatric Allergy and Immunology, Volume 19, Number 4, June 2008 , pp. 287-295(9)
T lymphocyte apoptosis is essential for maintaining immune system homeostasis. Experimental evidence suggests apoptosis control mechanisms may be impaired in inflammatory conditions, particularly airway Th2-type allergic diseases.
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| 05/15/2008
02:50 PM
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Pulmonary complications of sickle cell disease in children
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Current Opinion in Pediatrics. 20(3):279-287, June 2008
Sickle cell disease is one of the most prevalent genetic diseases, affecting 1 in 600 African-Americans. The lung is one of the major organs affected in sickle cell disease and the pulmonary complications of sickle cell disease result in significant morbidity and mortality in children.
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| 05/15/2008
02:49 PM
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Improving Transition From Pediatric to Adult Cystic Fibrosis Care: Lessons From a National Survey of Current Practices
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PEDIATRICS Vol. 121 No. 5 May 2008, pp. e1160-e1166
More than 500000 adolescents with special health care needs age into adulthood each year in the United States, and there is growing recognition of the need for support of their transition to adult-oriented health care. Because of improved survival, cystic fibrosis has experienced this increasing transition need, and cystic fibrosis policy leaders responded by mandating the transition of adults with cystic fibrosis to adult-focused cystic fibrosis care programs by 2000.
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| 05/15/2008
02:49 PM
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Surfactant proteins SP-B and SP-C and their precursors in bronchoalveolar lavages from children with acute and chronic inflammatory airway disease
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BMC Pulmonary Medicine 2008, 8:6
The surfactant proteins B (SP-B) and C (SP-C) are important for the stability and function of the alveolar surfactant film. Their involvement and down-regulation in inflammatory processes has recently been proposed, but their level during neutrophilic human airway diseases are not yet known.
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| 05/15/2008
02:48 PM
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Reproducibility of exhaled nitric oxide in smokers and non-smokers: relevance for longitudinal studies
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BMC Pulmonary Medicine 2008, 8:4
Currently, there is much interest in measuring fractional exhaled nitric oxide (FENO) in populations. We evaluated the reproducibility of FENO in healthy subjects and determined the number of subjects necessary to carry out a longitudinal survey of FENO in a population containing smokers and non-smokers, based on the assessed reproducibility.
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| 05/15/2008
02:47 PM
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Predictors of diagnostic yield in bronchoscopy: a retrospective cohort study comparing different combinations of sampling techniques
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BMC Pulmonary Medicine 2008, 8:2
All bronchoscopies performed on suspicion of lung malignancy in 2003 and 2004 were reviewed, and 363 patients with proven malignant lung disease were included in the study.
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| 05/15/2008
02:46 PM
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Effect of a 14-day course of systemic corticosteroids on the hypothalamic-pituitary-adrenal-axis in patients with acute exacerbation of chronic obstructive pulmonary disease
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BMC Pulmonary Medicine 2008, 8:1
As supra-physiological intake of corticosteroids is a well known risk factor for the development of adrenal insufficiency, we investigated the function of the hypothalamic-pituitary-adrenal (HPA) axis during a 14-day course of systemic corticosteroids in patients with acute exacerbation of chronic obstructive pulmonary disease using clinical and laboratory measures.
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| 05/15/2008
02:45 PM
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OUTCOMES - The Northeast Center for Special Care online newsletter SUBSCRIBE FOR FREE
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Subscribe for FREE and receive our regular mailings with information about brain injury, spinal cord injury, respiratory care, and more.
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| 05/15/2008
02:45 PM
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Do airway metallic stents for benign lesions confer too costly a benefit?
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BMC Pulmonary Medicine 2008, 8:7
Using flexible bronchoscopy, 82 SEMAS (67% Ultraflex, 33% Wallstent) were placed in 35 patients with inoperable lesions, many with significant medical comorbidities (88%). 68% of stents were tracheal, and 83% of patients showed immediate symptomatic improvement. Reversible complications developed in 9% of patients within 24 hrs of stent placement. Late complications (>24hrs) occurred in 77% of patients, of which 37% were clinically significant or required an interventional procedure.
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| 05/15/2008
02:44 PM
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Benefits of short inspiratory muscle training on exercise capacity, dyspnea, and inspiratory fraction in COPD patients
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International Journal of COPD Issue: ON-LINE EARLY
Static lung hyperinflation has important clinical consequences in patients with chronic obstructive pulmonary disease (COPD). Given that most of these patients have respiratory and peripheral muscle weakness, dyspnea and functional exercise capacity may improve as a result of inspiratory muscle training (IMT).
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| 05/15/2008
02:43 PM
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Intra-abdominal Pressures during Voluntary and Reflex Cough
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Cough 2008, 4:2
Involuntary coughing such as that evoked from the larynx, the laryngeal cough reflex (LCR), triggers a coordinated contraction of the thoracic, abdominal and pelvic muscles, which increases intra-abdominal pressure (IAP), displaces the diaphragm upwards and generates the expiratory force for cough and airway clearance.
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| 05/15/2008
02:42 PM
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The "Towards a Revolution in COPD Health" study
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Can Fam Physician Vol. 54, No. 5, May 2008, pp.740 - 741
Does treatment with salmeterol and fluticasone propionate combination (SFPC) reduce all-cause mortality compared with placebo (PL) in patients with chronic obstructive pulmonary disease (COPD)?
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| 05/15/2008
02:42 PM
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Survival of bronchiectatic patients with respiratory failure in ICU
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BMC Pulmonary Medicine 2007, 7:17
The outcome of patients with bronchiectasis during and after their stay in the intensive care unit (ICU) has seldom been reported in the literature. Managing these patients in the ICU can be challenging because of the complex nature of their disease. This study aims to identify the in-hospital and long-term outcome of patients with bronchiectasis and respiratory failure (RF) in ICU.
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| 05/15/2008
02:41 PM
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Features of asthma management: quantifying the patient perspective
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BMC Pulmonary Medicine 2007, 7:16
In the management of asthma, features of care important to patients may not be fully appreciated. This study quantifies the importance of different features of asthma management from the patient perspective. This may assist in the development of personalised management strategies.
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| 05/15/2008
02:40 PM
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Bronchiolitis
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Can Fam Physician Vol. 54, No. 5, May 2008, pp.742 - 743
Bronchiolitis is the most common lower respiratory tract infection in infants. It is the leading cause of hospitalization of infants younger than age 1, and more than 80% of children hospitalized are younger than 6 months of age.
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| 05/15/2008
02:39 PM
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Medication adherence issues in patients treated for COPD
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International Journal of COPD Issue: ON-LINE EARLY
Although medical treatment of COPD has advanced, nonadherence to medication regimens poses a significant barrier to optimal management. Underuse, overuse, and improper use continue to be the most common causes of poor adherence to therapy.
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| 05/15/2008
02:37 PM
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COPD and PE: A clinical dilemma
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International Journal of COPD Issue: ON-LINE EARLY
Dyspnea in patients with known chronic obstructive pulmonary disease (COPD) can be a clinical challenge due to the nonspecific nature of atypical presentations. Typical features of fever, productive cough, and wheezing on presentation support COPD exacerbation, while absence of such findings may warrant further evaluation for underlying etiologies, including pulmonary embolism (PE).
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| 05/15/2008
02:36 PM
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Pulmonary cryptococcosis induces chitinase in the rat
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Respiratory Research 2008, 9:40
We previously demonstrated that chronic pulmonary infection with Cryptococcus neoformans results in enhanced allergic inflammation and airway hyperreactivity in a rat model. Because the cell wall of C. neoformans consists of chitin, and since acidic mammalian chitinase (AMCase) has recently been implicated as a novel mediator of asthma, we sought to determine whether such infection induces chitinase activity and expression of AMCase in the rat.
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